WO2014121733A1 - Dispositif de conditionnement pour un excipient lyophilisé - Google Patents

Dispositif de conditionnement pour un excipient lyophilisé Download PDF

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Publication number
WO2014121733A1
WO2014121733A1 PCT/CN2014/071776 CN2014071776W WO2014121733A1 WO 2014121733 A1 WO2014121733 A1 WO 2014121733A1 CN 2014071776 W CN2014071776 W CN 2014071776W WO 2014121733 A1 WO2014121733 A1 WO 2014121733A1
Authority
WO
WIPO (PCT)
Prior art keywords
isolation layer
chassis
receptacles
layer
sealing
Prior art date
Application number
PCT/CN2014/071776
Other languages
English (en)
Chinese (zh)
Inventor
李和伟
Original Assignee
Li Hewei
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Li Hewei filed Critical Li Hewei
Publication of WO2014121733A1 publication Critical patent/WO2014121733A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments

Definitions

  • the present invention relates to the field of packaging technology, and in particular to the field of packaging technology for freeze-dried forming preparations, the categories of which include, but are not limited to, cosmetics, foods, health foods and mouths. Background technique
  • the freeze-dried preparation is a preparation form prepared by freeze-drying forming technology, which is formed by pouring into a molding die and freeze-drying process. Since the preparation adopts a freeze-drying process, it can protect the heat-sensitive component from being destroyed, and at the same time, the preparation itself generates a large number of micropores and pores, so that it can be rapidly disintegrated and dissolved, so that it is widely used and applied to an oral cavity collapse. Tablets, instant release tablets, chewable tablets, special cosmetics and other pharmaceuticals, food, health food and cosmetics.
  • the freeze-dried preparations Due to the large number of micropores and pores in the process of freeze-dried excipients, the freeze-dried preparations have defects such as low strength, easy brittleness and high moisture absorption.
  • Plastic packaging used in most medicines, cosmetics, and foods can protect fragile products.
  • plastic packaging has poor sealing properties and affects product quality. Therefore, plastic materials have not been used as inner packaging in the freeze-dried preparation package on the market.
  • most of the freeze-dried preparations on the market are packaged in a double-aluminum package.
  • the double-aluminum package with good sealing performance can make the moisture in the freeze-dried preparation into a moisture barrier.
  • the double aluminum packaging due to the characteristics of the aluminum material, the double aluminum packaging generally has a low hardness and cannot be used well for the preparation in the package. Support and protection.
  • the object of the present invention is to provide a packaging device for freeze-dried forming preparations, in particular to provide a preparation having sufficient hardness, supportable and protective lyophilized formulation, and having sufficient oxygen barrier properties and sealing sexual packaging device.
  • the packaging device of the present invention comprises the following components:
  • chassis having one or more chassis receptacles, each of the chassis receptacles having an open chassis space;
  • An isolation layer having one or more spacer receptacles having a shape and number consistent with the chassis receptacle, each spacer receptacle having an open-up isolation layer receiving space, the spacer layer being conformable to the chassis;
  • the sealing layer can be covered on the isolation layer for sealing to encapsulate the opening of the isolation layer receptacle.
  • the above “multiple” means 2-100, preferably 2-30, and most preferably 2-20.
  • contained in the barrier receptacle is a lyophilized formulation.
  • the chassis is made of a rigid plastic, polymeric resin, plastic, metal, plexiglass or glass material that acts as a support.
  • hard means that the Brinell hardness (HB) is in the range of 10-100 N/mm 2 .
  • the barrier layer is an aluminum-plastic composite film or aluminum foil. In certain preferred embodiments, the barrier layer is a cold stamped solid composite sheet. The barrier layer and the sealing layer cooperate to form an airtight moisture barrier to form a sealed packaging environment.
  • the sealing layer is an ancillary material that can be sealed from the barrier layer selected from the group consisting of aluminum foil, paper aluminum plastic, aluminum plastic composite film, or heat sealed aluminum compression sheet.
  • each receptacle of the chassis and the barrier layer has a horizontal or spherical bottom wall, a peripheral wall extending upwardly from the edge of the bottom wall, and a top wall extending horizontally outward from a top edge of the peripheral wall
  • the bottom wall and the peripheral wall collectively define a receiving space, and the sealing layer covers the spacer seat and the edge thereof is pressed against the top wall of the separating layer.
  • the sealing layer may leave an unsealed edge that facilitates opening, and its unsealed edge does not affect the sealing effect.
  • the top wall of each of the barrier receptacles has an unsealed press-fit open edge or a pick-up on at least one side thereof, from which the edge or ⁇ can be opened Uncover the seal layer from the hand.
  • each of the isolation layer receptacles is separately filled with a single dose of freeze-dried preparation, and the use of the freeze-dried preparation includes, but is not limited to, food, health food, cosmetics and medicine, and the user is using When the sealing layer is uncovered, the lyophilized formulation can be taken out for use.
  • Another object of the present invention is to provide a method of packaging a lyophilized formulation comprising the following steps:
  • the chassis has one or more chassis receptacles, each of the chassis receptacles having an open up chassis housing space.
  • the isolation layer has one or more isolation layer receptacles having a shape and a number consistent with the chassis receptacle, each of the isolation layer receptacles having an open upper isolation layer receiving space;
  • Another object of the present invention is to provide a packaged lyophilized formulation which is packaged in a packaging device as described above.
  • Figures 1-1 to 1-7 are diagrams of Embodiment 1.
  • Figure 1-1 is a front plan view of the first embodiment
  • Figure 1-2 is a front elevational view of the first embodiment of the package
  • Figure 1-4 is a front view of the package opening mode of the first embodiment
  • FIG. 1-5 is a cutaway view of the embodiment 1
  • FIGS. 1-6 are cutaway views of the package opening mode of the embodiment 1
  • FIG. 1-7 is a layered exploded view of the package of the embodiment 1.
  • Figures 2-l ⁇ 2-4 are diagrams of Embodiment 2.
  • Figure 2-1 is a view showing the form of the sealing layer of the second embodiment
  • Figure 2-2 is a view showing the form of the insulating layer of the second embodiment
  • Figure 2-3 is a view showing the form of the chassis of the second embodiment
  • Figures 3-1 to 3-2 are diagrams of Embodiment 3.
  • Figure 3-1 is a cross-sectional view of Embodiment 3;
  • Figure 3-2 is a layered exploded view of the package of Embodiment 3. detailed description
  • the chassis 4 is a rigid disk body integrally made of plastic, plastic, metal, plexiglass or glass material, and has a plurality of chassis receptacles 43.
  • an isolating layer 3 which is a soft or hard film made of an aluminum-plastic composite film or aluminum foil and punched out to be closely attached to the chassis receptacle 43.
  • the layer receptacle 32, as well as the buckle 5 which is easy for the user to uncover the sealing layer.
  • a single use amount of lyophilized formulation 2 is packaged in a barrier receptacle 32 for a single use by the user.
  • the sealing layer 1 is an auxiliary material which can be sealed with the separator such as an aluminum foil, a paper aluminum plastic or an aluminum plastic composite film. At the time of sealing, a semi-transparent cut line 31 which is easy to open is cut out on the partition layer 3.
  • the lyophilized formulation 2 is contained in the separator receptacle 32, and the sealing layer 1 is overlaid on the separator receptacle 32, and the sealing layer 1 is isolated by a press machine.
  • the edge of the layer receptacle 32 is sealed.
  • the chassis 4 and the spacer layer 3 are adhered and adhered in advance, or the sealing layer 3 and the spacer layer 3 are pressed and sealed, and then the spacer layer 3 and the chassis 4 are adhered and adhered.
  • the above processes can be automated using automated machines.
  • the chassis 4 is a rigid disk body made of plastic having a plurality of chassis receptacles 43, a connecting edge 42 of each chassis receptacle, and a fold line 41.
  • a barrier layer 3 which is a soft or hard film made of an aluminum-plastic composite film or aluminum foil, and is stamped and attached to the chassis receptacle 43.
  • the isolation layer receptacle 32 A single use amount of lyophilized formulation 2 is packaged in a barrier receptacle 32 for a single use by the user.
  • the sealing layer 1 is a supporting material which can be sealed with the separator 3, such as an aluminum foil, a paper aluminum plastic or an aluminum-plastic composite film. At the time of sealing, a semi-transparent secant line 31 which is easily broken is cut out on the separation layer 3, and a semi-transparent secant line 11 which is easy to tear is cut out on the sealing layer 1.
  • the chassis 4 is a circular, square or irregular shaped bottle made of plastic, plexiglass or glass, having a single chassis receptacle 43, a spacer receptacle 32 and a chassis receptacle The 43 is closely attached, and the insulation layer 3 is stamped from a soft or hard aluminum-plastic composite film, aluminum foil material or plastic.
  • the sealing layer 1 is a heat-sealed aluminum pressing piece, embedded in the screw top cover 7, and after the lyophilized forming preparation 2 is accommodated in the separating layer receptacle 32, the top cover 7 is tightened. , Seal with a bottle sealer. When installed, the above processes can be automated and automated using automated machinery.
  • the packaging device of the present invention can be designed to dispense a single amount of lyophilized formulation into the spacer receptacle 32, and the sealing layer 1 is used to enhance the sealing property and cooperate with the chassis 4 to enhance product support.
  • the single-use lyophilized preparation can be hygienically, safely and effectively protected.
  • the sealing layer 1 can be used and the method can be used. Therefore, the invention has the advantages of safety and convenience.
  • the packaging device of the present invention is not limited to the embodiments shown in the embodiments, and the above embodiments are merely preferred embodiments of the present invention, and the scope of protection is not limited thereto. Variations and modifications of the cartridges made within the scope of the claims of the invention are within the scope of the invention.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Packages (AREA)

Abstract

La présente invention se rapporte à un dispositif de conditionnement pour un excipient lyophilisé, ledit dispositif de conditionnement comprenant les éléments suivants : une plaque de base (4), une couche isolante (3) et une couche d'étanchéité (1) ; la plaque de base comporte un ou plusieurs logements de plaque de base (43) et chaque logement de plaque de base (43) comporte un espace de réception ayant une ouverture orientée vers le haut ; la couche isolante comporte un ou plusieurs logements de couche isolante (32) dont la forme et le nombre sont identiques à ceux des logements de plaque de base (43), et chaque logement de couche isolante (32) comporte un espace de réception de couche isolante ayant une ouverture orientée vers le haut ; la couche isolante (3) s'adapte à la plaque de base (4) ; la couche d'étanchéité recouvre la couche isolante (3) de sorte à sceller les ouvertures des logements de couche isolante (32). Le dispositif présente une rigidité suffisante pour supporter et protéger l'excipient lyophilisé (2), et présente de bonnes propriétés de barrière à l'oxygène et de barrière à l'humidité ainsi qu'une bonne propriété d'étanchéité.
PCT/CN2014/071776 2013-02-06 2014-01-29 Dispositif de conditionnement pour un excipient lyophilisé WO2014121733A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201310045800.0 2013-02-06
CN201310045800.0A CN103964066B (zh) 2013-02-06 2013-02-06 一种冻干赋型制剂的包装装置

Publications (1)

Publication Number Publication Date
WO2014121733A1 true WO2014121733A1 (fr) 2014-08-14

Family

ID=51234162

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2014/071776 WO2014121733A1 (fr) 2013-02-06 2014-01-29 Dispositif de conditionnement pour un excipient lyophilisé

Country Status (2)

Country Link
CN (1) CN103964066B (fr)
WO (1) WO2014121733A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11452693B2 (en) 2017-07-12 2022-09-27 Conopco, Inc. Freeze dried active composition and a system for using the same
US11730685B2 (en) 2017-07-12 2023-08-22 Conopco, Inc. Skin composition booster oil

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105883218A (zh) * 2014-10-29 2016-08-24 李和伟 一种固液分离即配即用的包装装置及其制备方法
CN106115075B (zh) * 2016-07-04 2018-05-22 万华普曼生物工程有限公司 一种检测试纸类泡罩式包装结构

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941248A (en) * 1973-05-02 1976-03-02 Robert Bosch Verpackungsmaschinen G.M.B.H. Childproof packaging for tablets
US5325968A (en) * 1993-07-14 1994-07-05 Mcneil-Ppc, Inc. Package for holding tablets
US20040149135A1 (en) * 2003-01-31 2004-08-05 Cai Edward Z. Combined coffee package and dispenser
US20080197045A1 (en) * 2005-07-27 2008-08-21 Burkhard Metzger Medicament Blister
CN102462665A (zh) * 2010-11-18 2012-05-23 董玲 冻干赋形制剂的制备方法
CN203199405U (zh) * 2013-02-06 2013-09-18 李和伟 一种冻干赋型制剂的包装装置

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
US5343672A (en) * 1992-12-01 1994-09-06 Scherer Ltd R P Method for manufacturing freeze dried dosages in a multilaminate blister pack
US5775505A (en) * 1996-02-27 1998-07-07 Vasquez; William M. Blister card package
JP2006213369A (ja) * 2005-02-04 2006-08-17 Azegami Seal Insatsu:Kk 易開封性包装体及びその製造方法
EP1775117A1 (fr) * 2005-10-12 2007-04-18 Alcan Technology & Management Ltd. Stratifié formable à froid pour la fabrication de sections de fond de blisters
GB2486100B (en) * 2007-10-12 2012-07-11 Protomed Ltd A packaging system
WO2009061933A1 (fr) * 2007-11-06 2009-05-14 Monosol, Llc Produit et emballage hydrosolubles
CN202201319U (zh) * 2010-11-02 2012-04-25 浙江金石包装有限公司 一种改进型泡罩包装

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941248A (en) * 1973-05-02 1976-03-02 Robert Bosch Verpackungsmaschinen G.M.B.H. Childproof packaging for tablets
US5325968A (en) * 1993-07-14 1994-07-05 Mcneil-Ppc, Inc. Package for holding tablets
US20040149135A1 (en) * 2003-01-31 2004-08-05 Cai Edward Z. Combined coffee package and dispenser
US20080197045A1 (en) * 2005-07-27 2008-08-21 Burkhard Metzger Medicament Blister
CN102462665A (zh) * 2010-11-18 2012-05-23 董玲 冻干赋形制剂的制备方法
CN203199405U (zh) * 2013-02-06 2013-09-18 李和伟 一种冻干赋型制剂的包装装置

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11452693B2 (en) 2017-07-12 2022-09-27 Conopco, Inc. Freeze dried active composition and a system for using the same
US11730685B2 (en) 2017-07-12 2023-08-22 Conopco, Inc. Skin composition booster oil

Also Published As

Publication number Publication date
CN103964066B (zh) 2017-09-19
CN103964066A (zh) 2014-08-06

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