WO2014110698A1 - 一种具备射频约束功能的离子迁移谱 - Google Patents

一种具备射频约束功能的离子迁移谱 Download PDF

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Publication number
WO2014110698A1
WO2014110698A1 PCT/CN2013/000638 CN2013000638W WO2014110698A1 WO 2014110698 A1 WO2014110698 A1 WO 2014110698A1 CN 2013000638 W CN2013000638 W CN 2013000638W WO 2014110698 A1 WO2014110698 A1 WO 2014110698A1
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Prior art keywords
radio frequency
ion mobility
mobility spectrometer
ion
drift tube
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PCT/CN2013/000638
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English (en)
French (fr)
Inventor
唐紫超
史磊
张世宇
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Dalian Institute of Chemical Physics of CAS
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Dalian Institute of Chemical Physics of CAS
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry

Definitions

  • the invention relates to the technical field of ion mobility spectrometers, in particular to an ion mobility spectrum with radio frequency confinement function.
  • IMS Ion mobility spectrometry
  • IMS Ion mobility spectrometry
  • ion mobility spectrometry is a new gas phase separation and detection technique that emerged in the 1970s. It separates and characterizes ions by the difference in ion drift time. Due to its simple structure and high sensitivity, it can be widely used in trace detection of volatile organic compounds due to its use at atmospheric pressure and normal temperature.
  • IMS usually consists of seven parts: ion migration tube, gas path system, sampling and sampling system, ion gate control system, high voltage power supply system, temperature heating control circuit, signal amplification acquisition and data processing system.
  • an object of the present invention to provide an ion mobility spectrum having an RF constraining function that utilizes a radio frequency electric field to constrain ion paths in an ion mobility spectrum for the purpose of improving sensitivity and resolution.
  • the invention provides an ion mobility shift spectrum with radio frequency confinement function, including an ion source, a drift tube, a radio frequency power source and a detector.
  • An opposite phase RF voltage is applied to an adjacent electrode on the drift tube of the ion mobility spectrum, and the collision probability of the ion near the electrode is enhanced by the RF voltage, so that the ion migration path is confined to the center line of the drift tube.
  • the present invention provides an ion mobility spectrum with radio frequency confinement function.
  • the RF field frequency of the RF voltage applied is several hundred KHz to several MHz, and the voltage (Vpp) of the AC or pulse signal is 0-300V.
  • the application of the RF voltage is applied in such a way that adjacent electrodes are in opposite phase and the spaced electrodes are of the same phase.
  • the invention has the beneficial effects that the invention can utilize the radio frequency electric field to constrain the migration path of the ions on the center line of the migration tube, and reduce the sensitivity and resolution reduction caused by the non-uniform time of the ions diffusing onto the electrodes or reaching the detectors. .
  • FIG. 1 is a schematic structural view of an ion mobility spectrum with radio frequency confinement function according to the present invention; (1) is an ion source, (2) is a drift tube, (3) is an RF electrode, and (4) is a detector; The difference between the computer simulation of the ion-free trajectory without the RF-constrained field (a) and the presence of the RF-constrained field (b). detailed description
  • an ion mobility spectrum with radio frequency confinement function of the present invention is composed of a drift tube electrode, a detector, an ion source, and an RF power source.
  • the ions are generated by the ion source and enter the drift region through the electronic gate. Due to the constraint of the RF electric field, the migration path is concentrated on the center line of the drift tube and finally reaches the detector detection.
  • the frequency of the RF field is several hundred KHz to several MHz, and V pp is 0 ⁇ 300V.
  • the RF power supply is applied in such a way that adjacent electrodes are in opposite phase and the spacing electrodes are in the same phase.

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  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

一种具备射频约束功能的离子迁移谱，包括离子源(1)、漂移管(2)、射频电极(3)和探测器(4)；在离子迁移谱的漂移管上的相邻电极上施加相位相反的射频电压，通过射频电压使离子在靠近电极的位置碰撞概率增强，使离子的迁移路径被约束在漂移管的中心线上，提高离子迁移谱的灵敏度和分辨率。

Description

一种具备射频约束功能的离子迁移谱
技术领域
本发明涉及离子迁移谱仪技术领域，具体涉及一种具备射频约束 功能的离子迁移谱。
背景技术
离子迁移谱（ion mobility spectrometry, IMS), 也称离子迁移率 谱，是在 20世纪 70年代出现的一种新的气相分离和检测技术。它以 离子漂移时间的差别来进行离子的分离定性， 由于其结构简单，灵敏 度高，能在大气压和常温下使用而被广泛应用于一些挥发性有机化合 物的痕量探测。
IMS通常由离子迁移管、气路系统、采样与进样系统、离子门控 制系统、高压电源系统、温度加热控制电路、信号放大采集和数据处 理系统七部分组成。当样品由载气带入电离反应区后，载气分子和样 品分子在离子源的作用下发生一系列的电离反应和离子 -分子反应， 形成各种产物离子。在电场的驱使下，这些离子通过周期性开启的离 子门进入漂移区。 在与逆流的中性飘逸气体分子不断碰撞的过程中， 由于这些离子在电场中各自迁移速率不同， 使得不同的离子得到分 离， 先后到达收集极被检测。
但是， 当离子在迁移区飞行时，离子随着飞行时间的延长而逐渐 分散， 很多离子会扩散到迁移区周围的电极上， 并且， 由于离子的分 散，使离子到达探测器的时间也不统一，大大的降低了仪器的灵敏度 和分辨率。
发明内容
为了克服现有技术存在的缺陷，本发明的目的是提供一种具备射 频约束功能的离子迁移谱，其利用射频电场来约束离子迁移谱中的离 子路径， 达到提高灵敏度和分辨率的目的。
本发明提供了一种具备射频约束功能的离子迀移谱， 包括离子 源、漂移管、射频电源和探测器。在离子迁移谱的漂移管上的相邻电 极上施加相位相反的射频电压，通过射频电压使离子在靠近电极的位 置碰撞概率增强，使离子的迁移路径被约束在漂移管的中心线上，实 现提高灵敏度和分辨率的目的。
本发明提供的具备射频约束功能的离子迁移谱，所述施加射频电 压的射频电极的射频场频率为几百 KHz到若干 MHz， 交流或脉冲信 号的电压（Vpp) 为 0-300V。 所述施加射频电压的施加方式为相邻的 电极相位相反， 间隔的电极相位相同。
本发明的有益效果是：本发明可以利用射频电场使离子的迀移路 径约束在迁移管的中心线上，减少由于离子扩散到电极上或到达探测 器时间不统一所引起的灵敏度和分辨率降低。
附图说明
图 1 是本发明一种具备射频约束功能的离子迁移谱的结构示意 图； （1 )为离子源， （2)为漂移管， （3)为射频电极， （4)为探测器； 图 2是计算机模拟的没有射频约束场时 (a)和有射频约束场时 (b) 离子迁移轨迹的差异。 具体实施方式
下面结合附图对本发明做进一步详细说明。
如图 1所示，本发明一种具备射频约束功能的离子迁移谱由漂移 管电极、探测器、离子源和射频电源构成。离子由离子源产生后通过 电子门进入漂移区， 由于受到射频电场的约束，使迁移路径集中在漂 移管的中心线上， 最终到达探测器检测。 射频场的频率为几百 KHz 到若干 MHz, Vpp为 0~300V。 射频电源的施加方式为相邻的电极相 位相反， 间隔电极相位相同。

Claims

权 利 要 求 书
1、一种具备射频约束功能的离子迁移谱， 包括离子源、漂移管、 射频电极和探测器，其特征在于：在普通离子迁移谱的漂移管相邻的 电极上施加了相位相反的射频电压，通过射频电压使离子在靠近电极 的位置碰撞概率增强， 使离子的迁移路径被约束在漂移管的中心线 上， 进而提高了分辨率与灵敏度。
2、 按照权利要求 1所述具备射频约束功能的离子迁移谱， 其特 征在于： 所述施加射频电压的射频电极的射频场频率为几百 KHz到 若干 MHz, 交流或脉冲信号的电压 Vpp为 0-300V。
3、 按照权利要求 1所述具备射频约束功能的离子迁移谱， 其特 征在于：所述施加射频电压的施加方式为相邻的电极相位相反， 间隔 的电极相位相同。
PCT/CN2013/000638 2013-01-18 2013-05-30 一种具备射频约束功能的离子迁移谱 Ceased WO2014110698A1 (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116106397A (zh) * 2021-11-10 2023-05-12 立本医疗器械(成都)有限公司 无门式离子迁移谱仪及离子迁移谱-飞行时间质谱联用仪

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Publication number Priority date Publication date Assignee Title
CN103107060A (zh) * 2013-01-18 2013-05-15 中国科学院大连化学物理研究所 一种具备射频约束功能的离子迁移谱
GB201315145D0 (en) 2013-08-23 2013-10-09 Smiths Detection Watford Ltd Ion Modification
CN112288845B (zh) * 2020-09-18 2022-10-21 中国电建集团河北省电力勘测设计研究院有限公司 一种热控仪表快速三维建模方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101606220A (zh) * 2006-11-07 2009-12-16 塞莫费雪科学（不来梅）有限公司 离子迁移装置
CN102723254A (zh) * 2012-06-20 2012-10-10 清华大学 平板型高场非对称波形离子迁移谱仪的聚焦装置及方法
CN103107060A (zh) * 2013-01-18 2013-05-15 中国科学院大连化学物理研究所 一种具备射频约束功能的离子迁移谱

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0503010D0 (en) * 2005-02-14 2005-03-16 Micromass Ltd Mass spectrometer
CN104849342B (zh) * 2007-12-27 2019-07-30 同方威视技术股份有限公司 离子迁移谱仪及其方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101606220A (zh) * 2006-11-07 2009-12-16 塞莫费雪科学（不来梅）有限公司 离子迁移装置
CN102723254A (zh) * 2012-06-20 2012-10-10 清华大学 平板型高场非对称波形离子迁移谱仪的聚焦装置及方法
CN103107060A (zh) * 2013-01-18 2013-05-15 中国科学院大连化学物理研究所 一种具备射频约束功能的离子迁移谱

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116106397A (zh) * 2021-11-10 2023-05-12 立本医疗器械(成都)有限公司 无门式离子迁移谱仪及离子迁移谱-飞行时间质谱联用仪

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