WO2014108917A1 - Procédé pour la préparation de compositions cosmétiques à base d'herbes sans conservateurs - Google Patents

Procédé pour la préparation de compositions cosmétiques à base d'herbes sans conservateurs Download PDF

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Publication number
WO2014108917A1
WO2014108917A1 PCT/IN2014/000014 IN2014000014W WO2014108917A1 WO 2014108917 A1 WO2014108917 A1 WO 2014108917A1 IN 2014000014 W IN2014000014 W IN 2014000014W WO 2014108917 A1 WO2014108917 A1 WO 2014108917A1
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composition
group
herbal
cosmeceutical
preservative free
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PCT/IN2014/000014
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English (en)
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Mandar Agashe
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Mandar Agashe
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Publication of WO2014108917A1 publication Critical patent/WO2014108917A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/738—Rosa (rose)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02—Sterilising, e.g. of complete packages
    • B65B55/04—Sterilising wrappers or receptacles prior to, or during, packaging
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02—Sterilising, e.g. of complete packages
    • B65B55/12—Sterilising contents prior to, or during, packaging

Definitions

  • the present disclosure relates to a process for the preparation of herbal cosmeceutical compositions.
  • the present disclosure particularly relates to a process for the preparation of preservative free herbal cosmeceutical compositions.
  • Cosmeceuticals are cosmetic products with biologically active ingredients purporting to have medicinal or drug-like benefits.
  • a cosmeceutical is a substance with medicinal properties that manifests beneficial topical actions and provides protection against degenerative skin conditions.
  • cosmeceuticals can be effectively used for the nourishment and hydration of the skin and also for avoiding and curing various dermatological conditions.
  • Cosmeceutical preparations, especially those comprising herbal ingredients, have been enjoying an ever increasing popularity with consumers.
  • Herbal drugs or actives have been used since ancient times for different purposes including medicinal and beautification purposes. They have been used in both fresh as well as dried form. Herbal preparations are unique, in that, the herbs may be used by including then in some preparation or by directly applying to the body, with or without the use of additives. However, now-a-days extracts of herbs obtained by various extraction methods such as decoction, infusion, steam distillates, soxhlet extraction and the like are also being used in cosmeceutical formulations rather than the herbs themselves. This necessitates the inclusion of preservatives in the formulations for prolonging their shelf-life.
  • preservatives such as parabens and formaldehyde donating species may, however, elicit allergenic responses in certain users, thereby restricting the consumption of these preparations. There is therefore a need to develop effective processes and products, devoid of preservatives, that may be used for cosmeceutical applications.
  • OBJECTS It is an object of the present disclosure to provide a process for the preparation of preservative free herbal cosmeceutical compositions.
  • a process for preparing a preservative free herbal cosmeceutical composition comprising:
  • obtaining at least one substance derived from at least one botanical selected from the group consisting of Aloe barbadensis, Rosa sinensis, Emblica officinalis, Eclipta alba, Lawsonia inermis, Curcuma longa and Cucumis sativus, wherein the amount of the substance is in the range of 1% to 99% with respect to the total mass of the composition;
  • the excipient is at least one selected from the group consisting of surfactants, emulsifiers, vehicles, gelling agents, oils, waxes, emollients, perfumes, coloring agents, propellants, opacifiers, humectants, antioxidants, suspending agents, penetration enhancers, thickening agents, antifoaming agents, scrub beads and plasticizers.
  • the excipient is at least one selected from the group consisting of carbomer, polyethylene glycol, cocamidopropyl betaine (CAPB), polysorbate 20, disodium EDTA, sodium hydroxide, glycerin and water.
  • carbomer polyethylene glycol
  • CAPB cocamidopropyl betaine
  • polysorbate 20 polysorbate 20
  • disodium EDTA sodium hydroxide
  • glycerin glycerin and water.
  • the sterilization is carried out using at least one method selected from the group consisting of heat sterilization, steam sterilization, radiation sterilization and gaseous sterilization.
  • the sterilization comprises autoclaving at a temperature ranging between 11 °C and 130°C for a time period ranging between 30min. and 2hrs.
  • the sealing is carried out using at least one method selected from the group consisting of cold sealing, heat sealing, vacuum sealing and hermetic sealing.
  • the pack is selected from the group consisting of heat sealable pouch, tubes, sachets, pouches, vials, bottles, cans and tins.
  • said composition is in the form of gel, granules, powder, oil, solution, suspension, emulsion, paste, lotion, cream, ointment, aerosol and semisolid.
  • a preservative free herbal cosmeceutical composition comprising:
  • At least one excipient selected from the group consisting of surfactants, emulsifiers, vehicles, gelling agents, oils, waxes, emollients, perfumes, coloring agents, propellants, opacifiers, humectants, antioxidants, suspending agents, penetration enhancers, thickening agents, antifoaming agents, scrub beads and plasticizers.
  • said composition is in the form of gel, granules, powder, oil, solution, suspension, emulsion, paste, lotion, cream, ointment, aerosol and semisolid.
  • the excipient is at least one selected from the group consisting of carbomer, polyethylene glycol, cocamidopropyl betaine (CAPB), polysorbate 20, disodium EDTA, sodium hydroxide, glycerin and water.
  • carbomer polyethylene glycol
  • CAPB cocamidopropyl betaine
  • polysorbate 20 polysorbate 20
  • disodium EDTA sodium hydroxide
  • glycerin glycerin and water.
  • a pack containing preservative free herbal cosmeceutical composition Typically, the pack is selected from the group consisting of heat sealable pouch, tubes, sachets, pouches, vials, bottles, cans and tins.
  • the inventors of the present disclosure have conducted several trials and experiments and have developed a process for the preparation of herbal cosmeceutical compositions that do not involve the use of preservatives.
  • the absence of preservatives makes the preparation more tolerable and therefore more acceptable among the users.
  • the herbal composition prepared by the aforementioned process typically contains one or more bioactive ingredients or extracts of botanicals.
  • one or more substances derived from at least one botanicals selected from the group consisting of Aloe barbadensis, Rosa sinensis, Emblica officinalis, Eclipta alba, Lawsonia inermis, Curcuma longa and Cucumis sativus are mixed with one or more excipient to obtain a cosmeceutical composition.
  • the amount of the substance is in the range of 1 % to 99% with respect to the total mass of the composition.
  • the excipient includes surfactants, emulsifiers, vehicles, gelling agents, oils, waxes, emollients, perfumes, coloring agents, propellants, opacifiers, humectants, antioxidants, suspending agents, penetration enhancers, thickening agents, antifoaming agents, scrub beads and plasticizers.
  • the cosmeceutical composition is filled in a pre-sterilized packaging material under aseptic condition and subsequently the packaging material is sealed to obtain a pack containing the preservative free cosmeceutical composition.
  • a preservative free cosmeceutical composition is prepared by initially accurately weighing and sterilizing all the ingredients individually. Post-sterilization, the ingredients are admixed, in any sequence, under aseptic conditions, to obtain the preservative free cosmeceutical composition. This composition is then filled in pre-sterilized containers, under aseptic conditions, followed by sealing. Finally, the sealed containers are sterilized, and then packed, as required. Typically, the sterilization is carried out by any method selected from the group that includes but is not limited to heat sterilization, steam sterilization, radiation sterilization and gaseous sterilization.
  • sterilization is carried out by autoclaving at a temperature ranging between 1 10 °C and 130 °C for a time period ranging between 30min and 2 hrs.
  • a preservative free cosmeceutical composition is prepared by accurately weighing and admixing all the ingredients, in any sequence, to obtain the cosmeceutical composition.
  • the resultant composition is then subjected to sterilization.
  • the sterilized composition is further filled in pre-sterilized containers, under aseptic conditions, followed by sealing. Finally, the sealed containers are sterilized, and then packed.
  • a preservative free cosmeceutical composition is prepared by accurately weighing and admixing all the ingredients, in any sequence, to obtain the herbal cosmeceutical composition.
  • the resultant composition is then filled in pre-sterilized containers, followed by sealing. Finally, the sealed containers are sterilized, and then packed.
  • the sealing of the packaging material is carried out by using one or more methods selected from the group which includes cold sealing, heat sealing, vacuum sealing and hermetic sealing.
  • composition of the present disclosure is in the form that includes but is not limited to gel, granules, powder, oil, solution, suspension, emulsion, paste, lotion, cream, ointment, aerosol and semisolid.
  • a preservative free cosmeceutical composition in gel form, is prepared by dispersing carbomer in demineralized water followed by the addition of other'excipients and substances derived from botanicals, to obtain a dispersion. Further, sodium hydroxide is added to the dispersion, which converts the dispersion into gel from. The composition in the form of gel is subsequently filled into pre- sterilized containers and sealed. Finally, the sealed containers are autoclaved at a temperature ranging between 110 °C and 130 °C for a time period ranging between 30min. and 2 hrs.
  • the container includes but is not limited to sachets, pouches, vials, bottles, cans, tubes and tins.
  • the container may be a unit dose container, a unit dispensing device and the like. Aloe
  • Aloe belongs to the Asphodelaceae (Liliaceae) family and is a shrubby or arborescent, perennial, xerophytic and succulent, pea- green color plant.
  • Aloe is known to have originated in northern Africa, however, it is widely cultivated throughout the world. It is commonly found in the Arabian peninsula, North Africa (Morocco, Mauritania, Egypt) as well as Sudan and the other neighboring countries, along with the Canary, Cape Verde, and Madeira Islands. It is also found in India, Australia, Barbados, Caribbean, Nigeria, Paraguay and the United States of America.
  • Aloe vera is widely grown as an ornamental plant and its succulence allows the species to survive in areas of low rainfall. Upon cultivation in pots, the species requires well- drained sandy potting soil and bright sunny conditions.
  • Chemical constituents Acetylated mannans, aloins, polymannans, anthraquinone C-glycosides, anthrones, anthraquinones, such as emodin, and various lectins are the most common chemical constituents present in aloe.
  • the aloe plant may be used for a very diverse spectrum of applications such as a cooling and moisturizing agent, skin protection and anticancer agent, use in dental care, wound and lesion treatment, diabetes management, source of proteins, lipids, amino acids, vitamins, enzymes, inorganic and organic compounds and carbohydrates.
  • Aloe has an extremely diverse sphere of applications with respect to skin care products.
  • the mucopolysaccharides present in aloe help in binding moisture into the skin.
  • Aloe stimulates fibroblasts which produces the collagen and elastin fibers making the skin more elastic and less wrinkled. It also has cohesive effects on the superficial flaking epidermal cells by sticking them together, thereby softening the skin.
  • the amino acids also soften hardened skin cells and zinc acts as an astringent to tighten pores. Its moisturizing effects have also been studied in the treatment of dry skin which is associated with occupational exposure. Aloe vera gel gloves have shown improved skin integrity, decrease in the appearance of fine wrinkles and decrease in erythema. It has also shown anti-acne effect. Further, aloe vera gel has also been reported to have a protective effect against radiation damage to the skin. Post exposure to aloe vera gel, an antioxidant protein, metallothionein, is generated in the skin, which scavenges hydroxyl radicals and prevents suppression of superoxide dismutase and glutathione peroxidase in the skin. This reduces the production and release of skin keratinocyte-derived immunosuppressive cytokines such as interleukin-10 (IL-10) and hence prevents UV-induced suppression of delayed type hypersensitivity.
  • IL-10 interleukin-10
  • Amla is a highly nutritious plant belonging to the family Phyllanthaceae.
  • Amla is widely distributed in most of the tropical and subtropical countries such as China, India, Indonesia, the Malay Peninsula and Southeast Asia. The species is native to India and grows in Pakistan, Uzbekistan, Sri Lanka and Bangladesh.
  • Amla is cultivated as an orchard crop in India, especially in the warmer, semi- arid coastal regions in India. With orchard-type cultivation, about 200 trees can be accommodated per acre. The tree ripens in autumn and bears fruit for up to 65 to 70 years and it is a common practice to harvest the berries by hand. About 5,000 to 10,000 kg of fruit per month is exported by India to Singapore, Malaysia and Europe.
  • Ascorbic acid vitamin C
  • ellagitannins such as emblicanin A (37%), emblicanin B (33%), punigluconin (12%) and pedunculagin (14%)
  • punicafolin phyllanemblinin A, B, C, D, E and F
  • polyphenols such as flavonoids, kaempferol, ellagic acid and gallic acid are the common chemical constituents of Amla.
  • Amla is highly nutritious and is an important dietary source of minerals, amino acids and vitamins such as Vitamin C, thiamine, riboflavin and niacin.
  • the fruit is useful as an astringent, cardiotonic, diuretic, laxative, liver tonic, refrigerant, stomachic, restorative, antipyretic, anti-inflammatory and hair tonic. Promotes longevity and prevents maladies of old age. Further, it helps to attain a state of enhanced well-being such as improving the memory and intellect. Even further, amla hastens recovery from disease. Haridra
  • Haridra is a perennial herb with pulpy, orange, tuberous roots belonging to the family Zingiberaceae.
  • GeoRraphical origin It is native to tropical South Asia. India, China, Pakistan Bangladesh and other Asian countries are the places where turmeric trees are commonly found.
  • Turmeric or haridra needs temperatures between 20 °C and 30 °C (68 °F and 86 °F) and a considerable amount of annual rainfall to grow and propagate.
  • the rhizomes are gathered annually and used for a wide spectrum of applications. These rhizomes are in turn used for further propagation in the following season.
  • Curcumin demethoxycurcumin, bisdemethoxycurcumin, turmerin, wenyujinlactone A, neolitamone A, zedoarondiol, isozedoarondiol, aerugidiol, curcumol, curdione, (lR,10R)-epoxy-(-)-l, 10- dihydrocurdine3 and parviflorene F4 are the common chemical constituents of haridra.
  • It has analgesic, anti-inflammatory, anti-blood clotting, antibacterial, expectorant and antioxidant activities. It is used for the treatment of diseases such as arthritis, gastrointestinal distress, dyspepsia, cognitive function disorders, gallstone, various types of inflammation, irritable bowel syndrome, osteoarthritis and viral infection.
  • diseases such as arthritis, gastrointestinal distress, dyspepsia, cognitive function disorders, gallstone, various types of inflammation, irritable bowel syndrome, osteoarthritis and viral infection.
  • Hibiscus is a bushy, evergreen shrub or small tree belonging to the family Malvaceae and has glossy leaves and solitary, brilliant red flowers that flower in summer and autumn.
  • the 5-petalled flowers have characteristic orange-tipped red anthers.
  • Hibiscus contains anthocyanins, flavonoids, cyanidin-3,5-diglucoside, cyanidin-3-sophoroside-5-glucoside, quercetin-3,7-diglucoside, quercetin-3-diglucoside, a cyclopeptide alkaloid, cyanidin chloride, quercetin, hentriacontane, and vitamins such as riboflavin, ascorbic acid and thiamine.
  • the plant has a very diverse spectrum of activities that include diuretic, demulcent, antidiarrheal, aphrodisiac, abortifacient and antitussive. It is also used for the management of conditions such as gonorrhea, irregular menstruation, flu & cough, stomach pain, eye problems, cough, fever and in labor. The leaves and flowers show exceptional hair growth and anti-greying properties.
  • Maka is a small branched annual herbaceous plant belonging to the family Asteraceae.
  • Maka is a plant native to the U.S.A and the tropical areas worldwide. It is commonly found in India, China, Thailand, and Brazil.
  • Cultivation This plant is quite prolific and can grow on land or directly in water. It grows commonly, as a weed, in moist places, in warm temperate to tropical areas in the world. It is a plant fostering throughout the year, however, is more commonly observed at the end of the rainy season and during winters. It prefers a clayey soil with abundant moisture. The germination percentage of seeds is 62% in diffused sunlight, whereas that in continuous light with pre-treatment of seeds with mud is higher.
  • Eclipta alba contains a wide variety of active principles which includes coumestans, alkaloids, flavonoids, glycosides, polyacetylenes, triterpenoids.
  • the leaves contain stigmasterol, a-terthienylmethanol, wedelolactone, demethylwedelolactone and demethylwedelolactone-7-glucoside.
  • the roots contain hentriacontanol and heptacosanol and polyacetylene substituted thiophenes.
  • the aerial part is reported to contain a phytosterol, P-amyrin in the n-hexane extract and luteolin-7-glucoside, P-glucoside of phytosterol, a glucoside of a triterpenic acid and wedelolactone in polar solvent extract.
  • the polypeptides isolated from the plant yield cystine, glutamic acid, phenyl alanine, tyrosine and methionine.
  • Maka is a powerful liver tonic, a rejuvenator and is especially good for the hair. It is effective when used on the scalp to manage hair loss. It is used for management of conditions such as athlete's foot, eczema and dermatitis. Roots of Eclipta prostrata are emetic and purgative. Black dye obtained from Eclipta prostrata is used for dyeing hair and tattooing and also as anti-venom against snake bite.
  • Henna is a flowering plant and a sole species in the genus in the family Lythraceae.
  • Henna is native to tropical and subtropical regions of Africa, southern Asia, and northern Australia, mostly in the semi-arid zones. It is commonly found in countries such as China, Amsterdam, Iran, Tunisia, Islam, Saudi Arabia, Egypt, India, Iraq, Iran, Pakistan, Bangladesh, Pakistan, Turkey, Somalia and Sudan.
  • Henna grows best in latitudes ranging between 15° and 25° N and S from Africa to the Western Pacific. It produces the highest dye content when cultivated in temperatures between 35 °C and 45 °C. The plant grows rapidly by putting out new shoots during the onset of precipitation intervals, after which the growth slows. Gradually, the leaves yellow and fall during prolonged dry or cool intervals. Henna does not thrive below 11 °C and a temperature below 5°C will kill the plant.
  • Carbohydrates, glycosides, tannins, phenolic compounds, gums and mucilage are the main chemical constituents of Henna. It further contains lawsone, apigenin, luteolin, 2-methoxy-3-methyl- 1 ,4-naphthoquinone, cosmosiin and apiin.
  • Henna has been found to exhibit antibacterial, antifungal and dermatological properties and is popularly used for coloring skin, scalp and nails.
  • the flowers are intellect promoting and useful in cephalagia, burning sensation, insomnia and fever.
  • the leaves form an extremely important herbal remedy for the management of a diverse spectrum of diseases including wounds, ulcers, cough, bronchitis, lumbago, hemi crania, leucoderma, scabies, boil, hepatopathy, spleenopathy, ophthalmic conditions and jaundice.
  • Cucumber is a widely cultivated plant in the gourd family Cucurbitaceae, which bears cylindrical edible fruits when ripe. Slicing, pickling and burpless are the three main varieties of cucumber.
  • Cultivation A few varieties of cucumber are such that the blossoms create seedless fruits without pollination. Pollination for these parthenocarpic varieties degrades the quality.
  • the parthenocarpic varieties are usually grown in greenhouses in the United States, where bees are excluded. In Europe, they are grown outdoors in certain regions where bees are excluded.
  • most cucumber varieties are seeded and require pollination. Therefore thousands of hives of honey bees are annually carried to cucumber fields just before bloom. China, Iran and Turkey are the top producers of cucumber for the year 2010 according to the Food and Agriculture Organization of the United Nations.
  • Chemical constituents Phosphorus, potassium, silicon, erepsin, vitamin E, beta-carotene, and folic acid.
  • the fruit of cucumber contains 96.4% moisture, 0.4% protein, 2.8% carbohydrates, 0.01% calcium along with iron, vitamin B and C.
  • Cucumber is very useful for skin treatment and natural beautification purposes. It has fat bursting and wrinkle releasing properties. It is extremely effective for treatment of sunburns. Further, cucumber is used to regulate cholesterol levels as well as blood pressure. Even further, it is used for the management of constipation. Cucumber has excellent effects on the skin and even for the eyes. It is called a cool fruit whose effect is believed to bring relief to the eyes in summer.
  • a preservative free herbal cosmeceutical composition comprising one or more substances derived from at least one botanical which includes Aloe barbadensis, Rosa sinensis, Emblica officinalis, Eclipta alba, Lawsonia inermis, Curcuma longa and Cucumis sativus and least one excipient.
  • the preservative free cosmeceutical composition is prepared by the process disclosed in the first aspect of the present disclosure.
  • the substance used in preparing composition of the present disclosure is derived from various parts of botanicals such as leaves, flowers, fruits, seeds, stem, twigs, branches, bark, stolons, tubers, roots, rhizomes and combinations thereof. Further, the substance is in the form selected from the group that includes but is not limited to extracts, granules, powders, semisolids, isolated fractions, dispersions and oils. In one embodiment, the substance is in the form of an extract. Typically, the extract is selected from the group that include but are not limited to alcoholic, hydro-alcoholic and aqueous extract. Further, the extract is prepared by using techniques selected from the group that includes but is not limited to Soxhlet extraction, percolation, decoction, maceration and supercritical fluid extraction.
  • the excipient includes surfactants, emulsifiers, vehicles, gelling agents, oils, waxes, emollients, perfumes, coloring agents, propellants, opacifiers, humectants, antioxidants, suspending agents, penetration enhancers, thickening agents, antifoaming agents, scrub beads and plasticizers.
  • the surfactant used in preparing the composition of the present disclosure is at least one selected from the group that includes but is not limited to triethanolamine, alkyl polyethylene oxide, alkylphenol polyethylene oxide, sodium laureth sulphate, sodium dodecyl sulphate, alkyl alcohol, sodium lauryl sulfate, polyoxyethylene/polyoxypropylene block polymers (poloxamers), glycerols, polyglycerols, fatty acids, polyethylene glycol hydroxy stearate, polyalkyl glucosides, ceramides, polyethylene glycol/alkyl glycol copolymers, and polyethylene glycol/polyalkylene glycol ether di-block or tri-block copolymers, diacetylated monoglycerides, diethylene glycol monostearate, ethylene glycol monostearate, glyceryl monooleate, propylene glycol monostearate, macrogol esters, macrogol stearate, polyoxyethylene
  • the oil is at least one selected from the group that includes but is not limited to isopropyl myristate, myristyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2- octyldodecyl palmitate, oleyl oleate, ethylhexyl cocoate, dicaprylyl carbonate, cetearyl isononanoate, oleyl erucate, erucyl oleate, erucyl o
  • the wax used in the preparing composition of the present disclosure is at least one selected from the group that includes but is not limited to candelilla wax, carnauba wax, bees wax, esparto grass wax, cork wax, guaruma wax, rice germ oil wax, sugarcane wax, berry wax, ouricury wax, montan wax, jojoba wax, shea butter, beeswax, shellac wax, spermaceti, lanolin (wool wax), uropygial grease, ceresin, ozocerite (earth wax), paraffin waxes, sunflower wax, lemon wax, grape fruit wax and laurel wax.
  • candelilla wax carnauba wax, bees wax, esparto grass wax, cork wax, guaruma wax, rice germ oil wax, sugarcane wax, berry wax, ouricury wax, montan wax, jojoba wax, shea butter, beeswax, shellac wax, spermace
  • the thickening agent is at least one selected from the group that includes but is not limited to hydroxypropyl methylcellulose, hydroxypropyl cellulose, sodium carboxy methyl cellulose, hydroxyethyl cellulose, carbopol polyethylene glycol, acrylates, methacrylates, gelatin, alginates, pectins, tragacanth, karaya gum, xanthan gum, carrageenin, agar, alginate, chitosan and acacia.
  • the emollient is at least one selected from the group that includes but is not limited to stearic acid, caprylic acid, oleic acid, palmitic acid, lauric acid, cetyl alcohol, lauryl alcohol, stearyl alcohol, cetearyl alcohol, oleyl alcohol, octyl palmitate, octyl stearate, glyceryl stearate, propylene glycol, dicaprate, dicaprylate and cetyl palmitate.
  • the humectant is at least one selected from the group that includes but is not limited to glycerin, sorbitol, propylene glycol, hexylene glycol, butylene glycol, MP Diol, Urea & alpha-hydroxy acids (AHA's), sodium-2-pyrrolidone-5- carboxylate (Sodium PCA), glucose, fructose, proteins, amino acids, short chain ethers, vitamins, erythritol, capryl glycol and phytantriol.
  • group that includes but is not limited to glycerin, sorbitol, propylene glycol, hexylene glycol, butylene glycol, MP Diol, Urea & alpha-hydroxy acids (AHA's), sodium-2-pyrrolidone-5- carboxylate (Sodium PCA), glucose, fructose, proteins, amino acids, short chain ethers, vitamins, erythritol, capryl glycol and phytantriol.
  • AHA's U
  • the antifoaming agent is at least one selected from the group that includes but is not limited to silicone emulsion, polyethylene oxide-poly propylene oxide (peo-ppo) block copolymer, phenethyl disiloxane, tetramethyl decynediol, polysilicone-7, phenyl trimethicone, bisphenyl-hexamethicone, simethicone, dimethicone, dimethiconol, hexamethyl-disiloxane, silica dimethyl silylate, silica silylate, hexyl alcohol, isopropyl alcohol, octyl alcohol, propyl alcohol and petroleum distillates.
  • silicone emulsion polyethylene oxide-poly propylene oxide (peo-ppo) block copolymer
  • peo-ppo polyethylene oxide-poly propylene oxide
  • trimethicone bisphenyl-hexamethicone
  • the perfume is at least one selected from the group that includes but is not limited to citrus musk, floral woody, citrus musk woody, fresh bouquet, musk, floral musk, lavender oil, jasmine oil, rose oil, cedarwood oil, sandalwood oil, orange oil and lemon oil.
  • the composition includes at least one excipient selected from the group comprising carbomer, polyethylene glycol, CAPB, polysorbate 20, disodium EDTA, sodium hydroxide and glycerin.
  • the pack is selected from the group consisting of heat sealable pouch, tubes, sachets, pouches, vials, bottles, cans, tubes and tins.
  • the gel was then filled and subsequently sealed in pre-sterilized heat sealable pouches aseptically.
  • the sealed pouches were then autoclaved at a temperature of 121°C, for a time period of 30 minutes to obtain a preservative free herbal cosmeceutical composition in the form of gel.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Chemical & Material Sciences (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Informatics (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention concerne un procédé de préparation d'une composition cosmétique à base d'herbes sans conservateurs. La composition contient une ou plusieurs substances dérivées d'au moins une plante choisie dans le groupe constitué de Aloe barbadensis, Rosa sinensis, Emblica officinalis, Eclipta alba, Lawsonia inermis, Curcuma longa etCucumis sativus. Selon le procédé de la présente invention, la composition cosmétique à base d'herbes est remplie dans un matériau d'emballage pré-stérilisé dans des conditions d'asepsie, puis le matériau d'emballage est scellé afin d'obtenir un emballage contenant une composition cosmétique à base d'herbes sans conservateurs.
PCT/IN2014/000014 2013-01-14 2014-01-07 Procédé pour la préparation de compositions cosmétiques à base d'herbes sans conservateurs WO2014108917A1 (fr)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105738546A (zh) * 2014-12-12 2016-07-06 桂林八加一药物研究股份有限公司 毛郁金药材指纹图谱的建立方法及其指纹图谱

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Publication number Priority date Publication date Assignee Title
WO2010086717A2 (fr) * 2009-01-30 2010-08-05 Himalaya Global Holdings Limited Compositions nettoyantes à base de plantes et leur procédés de préparation
WO2012013736A1 (fr) * 2010-07-28 2012-02-02 Horus Pharma Composition a usage topique sans conservateur comprenant de l'acide hyaluronique

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WO2010086717A2 (fr) * 2009-01-30 2010-08-05 Himalaya Global Holdings Limited Compositions nettoyantes à base de plantes et leur procédés de préparation
WO2012013736A1 (fr) * 2010-07-28 2012-02-02 Horus Pharma Composition a usage topique sans conservateur comprenant de l'acide hyaluronique

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105738546A (zh) * 2014-12-12 2016-07-06 桂林八加一药物研究股份有限公司 毛郁金药材指纹图谱的建立方法及其指纹图谱

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