WO2014106826A3 - Analogue d'anthracycline et utilisations associées - Google Patents

Analogue d'anthracycline et utilisations associées Download PDF

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Publication number
WO2014106826A3
WO2014106826A3 PCT/IB2014/058075 IB2014058075W WO2014106826A3 WO 2014106826 A3 WO2014106826 A3 WO 2014106826A3 IB 2014058075 W IB2014058075 W IB 2014058075W WO 2014106826 A3 WO2014106826 A3 WO 2014106826A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
compound
relates
anthracycline analogue
anthracycline
Prior art date
Application number
PCT/IB2014/058075
Other languages
English (en)
Other versions
WO2014106826A2 (fr
Inventor
Rajashri Ramakant PARAB
Rajan Mukund Panshikar
Prashant Venkatesh Shanbhag
Girish Badrinath Mahajan
Prabhu Dutt Mishra
Prafull Vasant Ranadive
Original Assignee
Piramal Enterprises Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Piramal Enterprises Limited filed Critical Piramal Enterprises Limited
Publication of WO2014106826A2 publication Critical patent/WO2014106826A2/fr
Publication of WO2014106826A3 publication Critical patent/WO2014106826A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un composé purifié de formule 1. L'invention concerne toutes les formes isomères et les formes tautomères du composé de formule 1 et leurs sels et dérivés pharmaceutiquement acceptables. La présente invention concerne en outre les procédés d'isolement et de production du composé de formule 1 par fermentation de la souche PM1029477/MTCC 5709 de Streptomycetes. L'invention concerne également les compositions pharmaceutiques contenant composé de formule 1 sous la forme d'un ingrédient actif et leur utilisation dans le traitement du cancer.
PCT/IB2014/058075 2013-01-07 2014-01-06 Analogue d'anthracycline et utilisations associées WO2014106826A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361749788P 2013-01-07 2013-01-07
US61/749,788 2013-01-07

Publications (2)

Publication Number Publication Date
WO2014106826A2 WO2014106826A2 (fr) 2014-07-10
WO2014106826A3 true WO2014106826A3 (fr) 2014-10-30

Family

ID=51062527

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2014/058075 WO2014106826A2 (fr) 2013-01-07 2014-01-06 Analogue d'anthracycline et utilisations associées

Country Status (1)

Country Link
WO (1) WO2014106826A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108210935B (zh) * 2016-12-09 2023-08-18 凯惠科技发展(上海)有限公司 抗体药物偶联物、制备方法、中间体、药物组合物及应用
KR20220080139A (ko) * 2019-10-10 2022-06-14 셀렉타 바이오사이언시스, 인코퍼레이티드 인지질-플라바글린 접합체 및 표적화된 암 치료를 위해 이를 사용하는 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0022574A1 (fr) * 1979-07-13 1981-01-21 Sanraku-Ocean Co., Ltd. Antibiotiques appartenant au groupe rhodomycine et procédé pour leur préparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0022574A1 (fr) * 1979-07-13 1981-01-21 Sanraku-Ocean Co., Ltd. Antibiotiques appartenant au groupe rhodomycine et procédé pour leur préparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YOSHIMOTO, A. ET AL.: "Structure-sensitivity relationship of anthracycline antibiotics to C7-reduction by redox enzymes", JAPANESE JOURNAL OF ANTIBIOTICS, vol. 44, no. 3, 1991, pages 287 - 295 *

Also Published As

Publication number Publication date
WO2014106826A2 (fr) 2014-07-10

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