Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K6/00—Preparations for dentistry
  • A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K6/00—Preparations for dentistry
  • A61K6/15—Compositions characterised by their physical properties
  • A61K6/17—Particle size
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K6/00—Preparations for dentistry
  • A61K6/30—Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
  • A61K6/35—Preparations for stabilising dentures in the mouth
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K6/00—Preparations for dentistry
  • A61K6/70—Preparations for dentistry comprising inorganic additives
  • A61K6/71—Fillers
  • A61K6/76—Fillers comprising silicon-containing compounds
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K6/00—Preparations for dentistry
  • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
  • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
  • A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K6/00—Preparations for dentistry
  • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
  • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
  • A61K6/898—Polysaccharides

Definitions

• the invention relates to a dental prosthesis adhesive preparation.
• Such an adhesive preparation for dental prostheses is known from DE 10 2005 031 771.
• the local adhesive preparation contains thick paraffin in a proportion of 25 to 35 wt .-% and / or white Vaseline in a proportion of 10 to 20 wt .-% cream-based , a carbomer (polyacrylic acid) as an adhesive in a proportion of 1 to 15 wt .-% and as an adhesive one or at least two carboxymethyl cellulose / s or an alkali metal or alkaline earth metal salt thereof in a proportion of 15 to 50 wt .-% and highly disperse silica with 0.2 to 2.0 wt .-% as a filler.
• the invention is therefore based on the object to provide an adhesive preparation for dental prostheses, which is waiving paraffin and / or Vaseline as a base or cream substance nevertheless suitable as such and in particular not only good subjective, but also objective adhesive properties and beyond has a homogeneous consistency and high temporal stability.
• the stated object is achieved by a jaw prosthesis adhesive preparation with - 35 to 50 wt .-% vegetable oil,
• the adhesive cream consists exclusively of these components.
• the sum of vegetable oil and stabilizer is below 90% by weight.
• the filler or its at least dominant main component silica is highly porous, ie, the filler and / or the silica has a density of 1.9 to 2.1 g / cm 3 .
• silicon dioxide is usually prepared as fumed or fumed silica, it is provided in a preferred embodiment that the filler contains precipitated silica from a solution.
• the particle size is in the range from 1 to 40 ⁇ m. Particle sizes here do not denote the primary particle size, which is 5-100 nm, but the size of the particles formed by agglomeration of the primary particles, or of the agglomerate particle or the size of the agglomerate.
• the average pore size is preferably> 30 nm. While preferably the surface area of the particles ranges from 5 to 100 m 2 / g, this value is most preferably ⁇ 50m 2 / g.
• vegetable oils ensure the suppleness of the preparation. With the use of vegetable oils, an anti-inflammatory effect can be achieved with appropriate irritations due to the chemical composition.
• the adhesive also contributes to suppleness.
• the filler causes the required thickening and regulates the viscosity. It has been found that as vegetable oil in addition to olive oil in particular also St. John's wort, almond, rapeseed, soybean, sunflower, grape seed and / or wheat germ oil come into question.
• CMC carboxymethyl cellulose
• sodium salt but also as other alkali metal or alkaline earth metal salt of said cellulose or
• the adhesive preparation according to the invention may also contain hydroxypropyl cellulose (HPC) or xanthan, xanthan gum as structure-forming stabilizer.
• the adhesive in the adhesive preparation according to the invention preferably comprises polyacrylic acid having the abovementioned weight fraction, the adhesive preferably being polyacrylic acid, in particular as exclusive adhesive.
• the adhesive with a dynamic viscosity equal to or greater than 30,000 mPas is preferably used.
• Suitable polyacrylic acid or carbomers are, in particular, carbomers represented by the trade names Carbopol 971P NF and Carbopol 974P NF.
• the filler is highly porous, that the filler comprises silica precipitated from a solution, that the density of the filler, preferably at least of the silicon dioxide substantially constituting it, is between 0.08-0.23 g / cm 3 , preferably between 0.19 and 0.21 g / cm 3 , and / or that the particle size is in the range of 1 to 40 ⁇ m, the average pore size preferably being> 30 nm.
• the filler can consist exclusively of silicon oxide (silica), in a preferred embodiment it has a low content of less than 0.1% by weight, but preferably at least 0.001% by weight, most preferably at least 0.01% by weight.
• compositions with the weight proportions given there ensure suitable jaw prosthesis adhesive preparations
• 40 to 50 wt .-% of the structure-forming stabilizer 40 to 50 wt .-%, the adhesive 8 bis 13 wt .-% and / or the filler 3 to 6 wt .-% make up, wherein the sum of all components is in each case 100 wt .-%.
• the invention provides an adhesive preparation having a plastic, soft consistency which is neither too stiff nor too flowable.
• the adhesive formulation also has a suitable adhesive force above a lower acceptable value of 40 Newton, without the risk of too great adhesion of more than 150, especially 180 Newton is given.
• the adhesive preparation according to the invention has a high-temporal resistance and does not decompose even with a long storage time. Further advantages and features of the invention will become apparent from the claims and from the following description, are explained in the embodiments of the adhesive composition according to the invention. 1 shows adhesion values for various
• FIG. 1 shows adhesion average values from two measurements in Newton for a large number of adhesive formulations on the market, designated A to P, and two adhesive compositions according to the invention based on olive oil on the one hand and soybean oil on the other Composition is shown in Tables 1 to 3.
• Adhesion Composition H is the composition known in practice based on olive oil and non-petroleum based base substances, such as paraffin or vaseline, which are present in all other adhesive compositions A to G, I to P.
• the filler of the Tables is all silica-based filler with 99% silica (silica) and low levels of styrene-isoprene copolymer and aluminum stearate, each less than 0.1% by weight.
• silica silica
• styrene-isoprene copolymer aluminum stearate
• the adhesion force measurements are made with the structural measuring device
• Table 1 shows in line 1 a highly preferred formulation according to the invention VE-11-hcsoja-11 with 42% by weight of soybean oil, 9% by weight of polyacrylic acid as an adhesive, as described under the name Carbopol 971P NF by Lubrizol Corporation, Wickliffe, Ohio, USA, 44%, for example, from the Dow Germany ⁇ nlagentician mbH, Schwalbach sold under the name WALOCEL carbonated ethyl cellulose as a structure-forming stabilizer and 5 wt .-% filler.
• This adhesive formulation has an optimum - soft - consistency of 4.4 to 4.5 cm with, as shown in FIG. 1, adhesive force of 92 Newton on.
• Detergent formulations according to the invention have a biocompatible, in particular mucous membrane tolerable, slightly acidic pH of more than 5.

Landscapes

• Health & Medical Sciences (AREA)
• Oral & Maxillofacial Surgery (AREA)
• Animal Behavior & Ethology (AREA)
• Epidemiology (AREA)
• Life Sciences & Earth Sciences (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Plastic & Reconstructive Surgery (AREA)
• Inorganic Chemistry (AREA)
• Chemical & Material Sciences (AREA)
• Adhesives Or Adhesive Processes (AREA)
• Dental Preparations (AREA)
• Medicinal Preparation (AREA)

Priority Applications (12)

Applications Claiming Priority (2)

Publications (1)

Family

ID=49162109

Family Applications (1)

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Cited By (1)

Citations (4)

Family Cites Families (29)

• 2013
  • 2013-07-04 DK DK13759979.1T patent/DK2763647T3/da active
  • 2013-07-04 ES ES13759979T patent/ES2777206T3/es active Active
  • 2013-07-04 JP JP2015551130A patent/JP6188818B2/ja not_active Expired - Fee Related
  • 2013-07-04 WO PCT/EP2013/002573 patent/WO2014106516A1/de not_active Ceased
  • 2013-07-04 PT PT137599791T patent/PT2763647T/pt unknown
  • 2013-07-04 CA CA2896173A patent/CA2896173C/en active Active
  • 2013-07-04 BR BR112015012101A patent/BR112015012101B1/pt not_active IP Right Cessation
  • 2013-07-04 US US14/654,957 patent/US9662277B2/en not_active Expired - Fee Related

Patent Citations (4)

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