WO2014095427A1 - Water-insoluble cyclodextrin polycondensate; uses as a capturing agent - Google Patents
Water-insoluble cyclodextrin polycondensate; uses as a capturing agent Download PDFInfo
- Publication number
- WO2014095427A1 WO2014095427A1 PCT/EP2013/075816 EP2013075816W WO2014095427A1 WO 2014095427 A1 WO2014095427 A1 WO 2014095427A1 EP 2013075816 W EP2013075816 W EP 2013075816W WO 2014095427 A1 WO2014095427 A1 WO 2014095427A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acid
- cyclodextrin
- polycondensate
- anhydride
- carbon atoms
- Prior art date
Links
- 229920000858 Cyclodextrin Polymers 0.000 title claims abstract description 190
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title claims abstract description 119
- 239000000203 mixture Substances 0.000 claims abstract description 98
- 239000002253 acid Substances 0.000 claims abstract description 93
- 239000000126 substance Substances 0.000 claims abstract description 68
- -1 cyclic anhydride Chemical class 0.000 claims abstract description 60
- 229920005862 polyol Polymers 0.000 claims abstract description 58
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 56
- 239000000463 material Substances 0.000 claims abstract description 49
- 229920000642 polymer Polymers 0.000 claims abstract description 47
- 150000003077 polyols Chemical class 0.000 claims abstract description 39
- 102000011782 Keratins Human genes 0.000 claims abstract description 36
- 108010076876 Keratins Proteins 0.000 claims abstract description 36
- 150000008065 acid anhydrides Chemical class 0.000 claims abstract description 25
- 230000032050 esterification Effects 0.000 claims abstract description 24
- 238000005886 esterification reaction Methods 0.000 claims abstract description 24
- 150000002148 esters Chemical class 0.000 claims abstract description 23
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 21
- 229920001169 thermoplastic Polymers 0.000 claims abstract description 18
- 239000004416 thermosoftening plastic Substances 0.000 claims abstract description 18
- 239000003054 catalyst Substances 0.000 claims abstract description 17
- 150000004820 halides Chemical class 0.000 claims abstract description 16
- 239000004615 ingredient Substances 0.000 claims abstract description 16
- HOSGXJWQVBHGLT-UHFFFAOYSA-N 6-hydroxy-3,4-dihydro-1h-quinolin-2-one Chemical group N1C(=O)CCC2=CC(O)=CC=C21 HOSGXJWQVBHGLT-UHFFFAOYSA-N 0.000 claims abstract description 14
- 125000003118 aryl group Chemical group 0.000 claims abstract description 14
- 230000009286 beneficial effect Effects 0.000 claims abstract description 14
- 238000006068 polycondensation reaction Methods 0.000 claims abstract description 12
- 238000006243 chemical reaction Methods 0.000 claims abstract description 11
- 125000004122 cyclic group Chemical group 0.000 claims abstract description 11
- 230000002542 deteriorative effect Effects 0.000 claims abstract description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 40
- 150000001875 compounds Chemical class 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 36
- 239000002537 cosmetic Substances 0.000 claims description 31
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 30
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 30
- 229960004853 betadex Drugs 0.000 claims description 27
- 239000001116 FEMA 4028 Substances 0.000 claims description 26
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 26
- 230000008569 process Effects 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 230000015572 biosynthetic process Effects 0.000 claims description 20
- 238000003786 synthesis reaction Methods 0.000 claims description 20
- 210000004243 sweat Anatomy 0.000 claims description 19
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 16
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 15
- 239000000470 constituent Substances 0.000 claims description 15
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
- KQTIIICEAUMSDG-UHFFFAOYSA-N tricarballylic acid Chemical compound OC(=O)CC(C(O)=O)CC(O)=O KQTIIICEAUMSDG-UHFFFAOYSA-N 0.000 claims description 12
- 150000007513 acids Chemical class 0.000 claims description 11
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims description 11
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 10
- 239000004480 active ingredient Substances 0.000 claims description 10
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 10
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 10
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 10
- 230000008961 swelling Effects 0.000 claims description 10
- 239000013543 active substance Substances 0.000 claims description 9
- 150000004676 glycans Chemical class 0.000 claims description 9
- 229920001282 polysaccharide Polymers 0.000 claims description 9
- 239000005017 polysaccharide Substances 0.000 claims description 9
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 8
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 8
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 8
- 239000003963 antioxidant agent Substances 0.000 claims description 7
- 239000000499 gel Substances 0.000 claims description 7
- 229930195733 hydrocarbon Natural products 0.000 claims description 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 7
- GTZCVFVGUGFEME-UHFFFAOYSA-N trans-aconitic acid Natural products OC(=O)CC(C(O)=O)=CC(O)=O GTZCVFVGUGFEME-UHFFFAOYSA-N 0.000 claims description 7
- 239000001124 (E)-prop-1-ene-1,2,3-tricarboxylic acid Substances 0.000 claims description 6
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 claims description 6
- RLHGFJMGWQXPBW-UHFFFAOYSA-N 2-hydroxy-3-(1h-imidazol-5-ylmethyl)benzamide Chemical compound NC(=O)C1=CC=CC(CC=2NC=NC=2)=C1O RLHGFJMGWQXPBW-UHFFFAOYSA-N 0.000 claims description 6
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 6
- 229940091181 aconitic acid Drugs 0.000 claims description 6
- 125000001931 aliphatic group Chemical group 0.000 claims description 6
- 229910052783 alkali metal Inorganic materials 0.000 claims description 6
- 150000002430 hydrocarbons Chemical class 0.000 claims description 6
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 6
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 6
- 235000019260 propionic acid Nutrition 0.000 claims description 6
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 6
- 229940014800 succinic anhydride Drugs 0.000 claims description 6
- 239000011975 tartaric acid Substances 0.000 claims description 6
- 235000002906 tartaric acid Nutrition 0.000 claims description 6
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 150000001805 chlorine compounds Chemical class 0.000 claims description 5
- 239000003623 enhancer Substances 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 210000002374 sebum Anatomy 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000004215 Carbon black (E152) Substances 0.000 claims description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical class OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- LGRFSURHDFAFJT-UHFFFAOYSA-N Phthalic anhydride Natural products C1=CC=C2C(=O)OC(=O)C2=C1 LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 150000001340 alkali metals Chemical class 0.000 claims description 4
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 claims description 4
- JHIWVOJDXOSYLW-UHFFFAOYSA-N butyl 2,2-difluorocyclopropane-1-carboxylate Chemical compound CCCCOC(=O)C1CC1(F)F JHIWVOJDXOSYLW-UHFFFAOYSA-N 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 4
- 125000004494 ethyl ester group Chemical group 0.000 claims description 4
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims description 4
- 229940080345 gamma-cyclodextrin Drugs 0.000 claims description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 4
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims description 4
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 4
- SRPWOOOHEPICQU-UHFFFAOYSA-N trimellitic anhydride Chemical compound OC(=O)C1=CC=C2C(=O)OC(=O)C2=C1 SRPWOOOHEPICQU-UHFFFAOYSA-N 0.000 claims description 4
- KWSLGOVYXMQPPX-UHFFFAOYSA-N 5-[3-(trifluoromethyl)phenyl]-2h-tetrazole Chemical compound FC(F)(F)C1=CC=CC(C2=NNN=N2)=C1 KWSLGOVYXMQPPX-UHFFFAOYSA-N 0.000 claims description 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 3
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- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 3
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- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 2
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- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical class [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 claims description 2
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q13/00—Formulations or additives for perfume preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/66—Polyesters containing oxygen in the form of ether groups
- C08G63/668—Polyesters containing oxygen in the form of ether groups derived from polycarboxylic acids and polyhydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/16—Cyclodextrin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
Definitions
- the subject of the present invention is a water-insoluble cyclodextrin polycondensate which can be obtained by esterification/polycondensation reaction:
- the invention also relates to the uses of these cyclodextrin polycondensates as agents for capturing a large variety of substances in many industrial fields.
- the objective of the present invention is to search for new materials which make it possible to trap, in their matrix, a very wide range of substances or of mixtures of substances, for instance those capable of polluting the environment, those capable of having a negative impact on a large diversity of consumer products in many industrial fields or else in the cosmetics field, and those capable of generating, for example, uncomfortable reactions on a keratin material, in particular a human keratin material.
- Another objective of the present invention is also to search for new materials which make it possible to trap at least one beneficial agent and to delay its time for release to the exterior for the purpose of (i) either protecting it, for example during its storage or during its transportation, in order to prevent it from deteriorating, for example under the influence of atmospheric agents such as heat or cold, variations in temperature, ambient moisture, atmospheric oxygen or UV radiation; (ii) or else, owing to its sensitive chemical or physical nature, isolating it and preventing or delaying its contact with one or more other ingredients of a composition or of the site on which it must be applied, with which it is incompatible;
- beneficial agents used in particular in the cosmetics or pharmaceutical industry in perfumery, in the food-processing industry or in products resulting from the textile or leather industry, in particular in textile materials or else in cleaning products, mention may more particularly be made of fragrances, fragranced essences, essential oils, bleaching agents, insecticides, colorants, lipids, silicones, waxes, flavourings, enzymes, oxidizing agents, microorganisms, phytosanitary active agents, food additives such as flavour enhancers, textile softeners, antibacterials, cooling agents, active ingredients of medicaments, and cosmetic or dermatological active agents.
- beneficial agents are generally expensive and/or volatile and/or physicochemically unstable and/or effective over periods of time which are too short. There is therefore a need to optimize their amount in order to limit costs, to improve their stability, to protect them against their environment and/or to improve their effectiveness over time.
- microencapsulation of these substances.
- this encapsulation can also make it possible to render the material easier to use by diluting it and by promoting its homogeneous distribution within the support.
- Microencapsulation groups together all the technologies for coating or trapping substances in solid, liquid or gas form within individualized particles, the size of which ranges between a few microns and a few millimetres. If these microparticles are hollow (vesicular) they are referred to as microcapsules, and if they are solid (matricial) they are referred to as microspheres. Their size ranges from 1 m to more than 1000 pm. These microparticles can be biodegradable or non-biodegradable and can contain between 5% and 90% (by weight) of encapsulated substance.
- the encapsulated substances are very varied in origin: pharmaceutical active ingredients, cosmetic active ingredients, food additives, phytosanitary products, fragranced essences, microorganisms, cells, or else chemical reaction catalysts, etc.
- the main methods of the prior art for carrying out the encapsulation of substances in microparticles are interfacial polymerization, interfacial crosslinking, emulsion followed by solvent evaporation or extraction, double emulsion solvent evaporation/extraction, spray drying, prilling, coacervation, etc.
- Microbeads consisting of hydrophobic polymeric materials which are generally prepared by phase separation techniques (coacervation or solvent extraction-evaporation) or by polymerization or polycondensation are also known.
- the phase separation techniques generally use organic solvents which have a certain number of drawbacks: elimination into the atmosphere, persistence within galenical systems, denaturation of certain microencapsulated molecules.
- the methods by polymerization or polycondensation that are known to date have the drawback of using highly reactive materials capable of reacting with the substances encapsulated within the microbeads.
- Microbeads formed from hydrophilic polymeric materials which are generally prepared by gelling or coacervation techniques are also known from the prior art. This technique which makes it possible to encapsulate molecules in liquid or solid form is based on the desolvation of macromolecules, resulting in phase separation within a solution.
- the technique of microencapsulation by thermal gelling is known. This process, known as hot melt, is based on melting the coating material. The substance to be encapsulated is dissolved or dispersed in this molten material. The mixture is emulsified in a dispersing phase, the temperature of which is kept above the melting point of the coating. The solidification of the dispersed globules is obtained by abruptly cooling the medium.
- molecular encapsulation (cyclodextrins) is also known.
- the latter constitutes an advantageous alternative to the conventional encapsulations described above.
- Cyclodextrins have in fact been increasingly used for this purpose since the 1980s since they are cage molecules which can selectively and reversibly complex a large diversity of organic molecules in the form of "host-guest" inclusion complexes. Cyclodextrin inclusion complexes are particularly useful for transporting, protecting and releasing chemically and thermally sensitive ingredients. The release of the complexed ingredients is generally brought about via water or temperature.
- Cyclodextrins are a family of natural cyclic oligosaccharides obtained by enzymatic degradation of starch. They consist of alpha-D-glucose units (6 to 12 units) linked to one another so as to form rings delimiting in their centre a frustum-shaped cavity. The most abundant are the hexamers (a-cyclodextrin), heptamers ( ⁇ - cyclodextrin) and octamers ( ⁇ -cyclodextrin) which differ in terms of the number of glucose units and consequently in terms of the size of the conical cyclic cavity which results therefrom. All the hydroxyl (OH) polar groups are located on the exterior, making the exterior hydrophilic and explaining their solubility in water.
- the interior of the cavity contains only the glycosidic oxygen atoms and the hydrogen atoms directly bonded to the carbons, said cavity is hydrophobic and considerably less polar.
- This amphiphilic nature enables cyclodextrins to include in their cavity lipophilic (hydrophobic) molecules, provided that the size and the geometric shape of the molecules lend themselves thereto, so as to form inclusion complexes which are generally water- soluble.
- Their non-toxic and biodegradable nature predisposes them to important applications in the food-processing and pharmaceutical fields.
- the encapsulation in cyclodextrins in fact makes it possible to protect fragile molecules or to provide the slow and controlled release thereof.
- cyclodextrins can be chemically modified, for example to give ethers or esters, which will modify the solubility both of the modified cyclodextrins and of the inclusion complexes. Many advantages follow from this and allow cyclodextrins to be widely used in various industrial fields.
- Cyclodextrins are also commonly used as a formulation excipient in medicaments. They make it possible in particular to convert liquid compounds into solids (powders, tablets) by inclusion complex precipitation.
- the complexation of the active ingredients makes it possible to have better control of their passage into the bloodstream or the progressivity of their diffusion. Another application is sublingual treatment.
- the complexation of photosensitive or highly reactive active ingredients often makes it possible to protect them or to stabilize them.
- the food-processing industry also commonly uses cyclodextrins as taste enhancers, allowing easy addition of taste compounds, or for fixing molecules that are too volatile and prolonging, for example, the taste duration of chewing gums.
- Cyclodextrins are also used, on the contrary, for removing certain undesirable molecules, in particular for reducing the levels of cholesterol or of bitter compounds of ready meals or else as masking agents against bad odours. Cyclodextrins are also used for stabilizing emulsions such as mayonnaise or margarines. In the cosmetics industry, they also make it possible to stabilize emulsions and odorous or active molecules.
- the inclusion will depend on the relative size of the cavity of the cyclodextrin relative to the size of the guest molecule; if said molecule is too large, it will not be able to penetrate inside the cavity of the cyclodextrin and if, on the other hand, its size is too small, it will have few interactions with the cyclodextrin.
- the steric effect therefore plays an important role in the complexation phenomenon.
- the cyclodextrin:guest molecule molar ratio of the inclusion complexes is generally 1:1 or higher; in other words, at most one molecule is transported per cyclodextrin molecule.
- ⁇ -cyclodextrin (18 g/l, i.e. 15 mmol/l, at 25°C), can constitute a limit in their use.
- the cyclodextrin derivatives of the prior art can have certain limitations, in particular with respect to the substances that may be transported, to the substance load capacity per unit weight of the cyclodextrin derivative, to their capacity to complex certain families of molecules, in particular hydrophilic molecules, to their cost, to their toxicity, and to the ease with which they can be synthesized.
- cyclodextrin polymers which have polymer- substrate complex stability constants that are often higher than those of native cyclodextrin-substrate complexes, and for which the hydrophobic and hydrophilic compounds and the supramolecules are more readily complexed and less readily released by the cyclodextrin polymers than by the native cyclodextrins.
- cyclodextrin polymers can be categorized into two types depending on whether the cyclodextrin constitutes the backbone of the polymer or else is a side substituent of a polymer chain.
- the methods for synthesizing these prior art cyclodextrin polymers, the cyclodextrin of which constitutes the backbone, are based on the use of generally bifunctional crosslinking agents, such as epichlorohydrin, dialdehydes, diacids, diesters, diisocyanates, dihalogenated derivatives, polyisocyanates, bis-epoxides, acid dihalides in an organic solvent or else phytic acid.
- a process using a bifunctional agent such as a dialdehyde, a diacid, a diester, an acid dichloride, a diepoxide, a diisocyanate or a dihalogenated derivative has been described in document US 3 472 835.
- This method envisages the activation of cyclodextrins via the action of sodium metal in liquid aqueous ammonia and then reaction with the bifunctional crosslinking agent.
- the second type of polymer is that in which the cyclodextrin is a pendent group of a polymer chain; it is produced by grafting cyclodextrin(s) or cyclodextrin derivative(s) onto a pre-existing polymer chain.
- DE19520989 describes the grafting of cyclodextrins onto polymers. Furthermore, cyclodextrins have also been functionalized with aldehyde groups and then grafted onto chitosan via a reductive amination reaction; such a reaction is described by Tomoya T. et al. in J. Polym. Sci., Part A: Polym. Chem. 36 (11), 1965-1968 (1998).
- cyclodextrin-based polymers can also be synthesized by functionalization of said cyclodextrin with polymerizable functional groups such as acryloyl or methacryloyl. This functionalization is followed by polymerization or copolymerization of these derivatives.
- Such processes have been described in document DE4009825, by Wimmer T. et al. in Minutes Int. Symp. Cyclodextrins 6th 106-109, (1992) Ed. Hedges A.R. Ed. Sante Paris, and by Harada A. et al. in Macromolecules 9(5), 701-704 (1976).
- WO0148025 Korean in the application WO0148025 (Kimberly Klarck) is a method of a preparation of a composition which consists in reacting a cyclodextrin with a polysaccharide for example cellulose fibers by crosslinking with a reactive anionic polymer in forming esters bounds between them.
- the reactive anionic polymer comprises functional anionic groups as a cyclic acid anhydride like maleic acid anhydride and may react with a catalyst in particular with sodium hypophosphite.
- the reactive anionic polymer as used in the examples is a terpolymer of maleic acid anhydride/vinylacetate/ethylacetate BELCLENE DP80® (Durable Press 80).
- the cyclodextrin polycondensate as formed has a poor capacity in the capture of malodorous compounds and has a weak encapsulation capacity of a beneficial active ingredient like a perfume.
- the objective of the present invention is to immobilize cyclodextrins in a crosslinked polymeric network having absorbent properties and functioning like a sponge.
- the subject of the present invention is therefore a water-insoluble cyclodextrin polycondensate which can be obtained by esterification/polycondensation reaction:
- Another subject of the invention consists of the use of a cyclodextrin polycondensate as defined previously as a capturing agent.
- Another subject of the invention relates in particular to the use of a cyclodextrin polycondensate as defined previously as an agent for capturing a substance or a mixture of substances capable of polluting the environment or else a substance or mixture of substances capable of having a negative impact on a consumer product.
- Another subject of the invention relates in particular to the non- therapeutic cosmetic use of a cyclodextrin polycondensate as defined previously as an agent for capturing a substance or a mixture of substances capable of generating, for example, uncomfortable reactions on a keratin material, in particular a human keratin material.
- Another subject of the invention relates in particular to the use of a cyclodextrin polycondensate as defined previously as an agent for capturing at least one beneficial active agent.
- Another subject of the invention consists of a consumer product comprising at least one cyclodextrin polycondensate as defined previously, and more particularly the consumer product is a cosmetic or dermatological composition comprising a physiologically acceptable medium.
- polycondensate is intended to mean any polymer obtained by polymerization in steps where each step is a condensation reaction which is carried out with elimination of water or of an alcohol or of a halogenated acid in the case of an esterification.
- Monomers with two or more functional groups react so as to first form dimers, then trimers and longer oligomers, then long-chain polymers.
- water-insoluble cyclodextrin polycondensate is intended to mean any cyclodextrin polycondensate which has a solubility in water at 25°C of less than 1% by weight, even less than 0.5% by weight, or even less than 0.1% by weight.
- the term "capturing agent” is intended to mean any chemical compound, in particular any polymer, capable of trapping a substance or a mixture of substances in its structure, of immobilizing it and/or of delaying its release to the exterior.
- the cyclodextrin polycondensate polymers of the invention have a porous network which combines sponge-type superabsorbent properties with the capacity to form inclusion complexes in the cavities of cyclodextrins immobilized within the polymeric network, thus making it possible to capture substances which have an affinity with said polymeric network.
- physiologically acceptable medium is intended to mean a medium that is suitable for the topical administration of a composition.
- a physiologically acceptable medium is preferably a cosmetically or dermatologically acceptable medium, that is to say a medium which is devoid of unpleasant odour or appearance and which is entirely compatible with the topical administration route.
- keratin materials is intended to mean the skin, hides, the scalp, the lips, and/or the skin appendages such as the nails and keratin fibres, such as, for example, animal furs, body hair, wool, the eyelashes, the eyebrows and the hair.
- human keratin materials is intended to mean the skin, the scalp, the lips, and/or the skin appendages such as the nails and human keratin fibres, such as, for example, body hair, the eyelashes, the eyebrows and the hair.
- the term "cosmetic composition” is intended to mean any composition which has a non-therapeutic hygiene, care, conditioning or makeup effect contributing to improving the well- being and/or to making more attractive or modifying the appearance of the human keratin material to which said composition is applied.
- consumer product is intended to mean any manufactured product intended to be used or consumed in the form in which it is sold and which is not intended for subsequent manufacture or modification.
- the consumer products according to the invention may be cosmetic products including both cosmetic formulations and application supports or articles comprising such formulations, such as patches, wipes, nonwoven supports; intimate hygiene products including care and hygiene formulations and also articles intended for this purpose, such as sanitary tampons, wipes, towels; products for oral hygiene, such as toothpastes, mouth care products, deodorants such as sprays, breath lozenges, chewing gums, sweets; cosmetic or dermatological products: creams, milks, lotions, balms, sticks, talcs; makeup products; hair products; babycare products including formulations and articles intended for this purpose, such as wipes, nappies; pharmaceutical products and also medical and paramedical articles such as dressings, patches, prostheses; products for veterinary use, such as animal litters; animal hygiene and/or care products; household products such as laundry care and/or cleaning products (laundry detergents, softeners), washing-up products, products for cleaning and/or maintaining household appliances, products for cleaning and/or maintaining floors, tiles, wood
- the term "beneficial agent” is intended to mean any chemical compound present in a consumer product which produces a beneficial effect noticed by the consumer during use thereof and/or obtained on the consumer product itself, it being possible for said beneficial effect to be a sensory improvement, in particular a visual and/or olfactory and/or gustative and/or tactile improvement, an improvement or modification of the comfort and/or ease of application, an aesthetic effect, a hygiene effect, a feeling of cleanliness, a curative and/or prophylactic effect.
- the cyclodextrin polycondensates according to the invention can be easily prepared, in a single synthesis step, and without producing waste, at low cost, in particular by carrying out the reaction in an extruder.
- cyclodextrin polycondensates according to the invention make it possible to generate a porous polymeric network which combines sponge- type superabsorbent properties with the capacity to form inclusion complexes in the cavities of cyclodextrins immobilized within the polymeric network.
- cyclodextrin polycondensates according to the invention can be obtained by esterification/polycondensation, according to methods known to those skilled in the art, of the constituents described hereinafter.
- One of the constituents required for the preparation of the cyclodextrin polycondensates according to the invention is a cyclodextrin.
- cyclodextrin is intended to mean any compound of general structure
- cyclodextrins a- cyclodextrin, ⁇ -cyclodextrin, ⁇ -cyclodextrin, and methylated derivatives thereof such as TRIMEBs (heptakis(2,3,6-trimethyl)-3-CD), DIMEBs (heptakis(2,6-dimethyl)-3-CD) or else RAMEBs (Randomly Methylated ⁇ - Cyclodextrins); hydroxyalkylated derivatives thereof such as 2- hydroxypropyl-3-cyclodextrin ( ⁇ ; Kleptose® HPB), 3-hydroxypropyl- ⁇ -cyclodextrin, 2,3-dihydroxypropyl-3-cyclodextrin, 2-hydroxyethyl-3- cyclodextrin, 2-hydroxypropyl-Y-cyclodextrin and 2-hydroxyethyl-y- cyclodextrin; sulfobutylated derivative
- the cyclodextrin is chosen from a-cyclodextrin, ⁇ -cyclodextrin, ⁇ -cyclodextrin and mixtures thereof, and even better still ⁇ -cyclodextrin.
- the cyclodextrin(s) preferably represent(s) 10% to 70% by weight, in particular 20% to 65% by weight and better still 30% to 60% by weight of the total weight used in the synthesis of the cyclodextrin polycondensate.
- polycarboxylic acids Another constituent required for the preparation of the cyclodextrin polymers according to the invention is a saturated or unsaturated or aromatic, linear or branched or cyclic polycarboxylic acid comprising at least 2 carboxylic COOH groups, preferably 2 to 4 COOH groups.
- Said polycarboxylic acid may in particular be chosen from saturated or unsaturated, or even aromatic, linear, branched and/or cyclic polycarboxylic acids containing 2 to 50 carbon atoms, especially 2 to 40, in particular 3 to 36 carbon atoms, or even 3 to 18 and even better still 4 to 12 carbon atoms, or even 4 to 10 carbon atoms; said acid comprises at least two carboxylic COOH groups and preferably from 2 to 4 COOH groups.
- polycarboxylic acids that may be used, mention may be made, alone or as a mixture, of:
- - dicarboxylic acids such as oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, dodecanedioic acid, malic acid, tartaric acid, tartronic acid, citramalic acid, dioxymaleic acid, dioxymalonic acid, maleic acid, fumaric acid, glutaconic acid, itaconic acid, fatty acid (in particular C 3 6 fatty acid) dimers, such as the products sold under the names Pripol 1006, 1009, 1013 and 1017 by Uniqema, glutamic acid, aspartic acid, oxaloacetic acid, cyclopropanedicarboxylic acid, cyclohexanedicarboxylic acid, cyclobutanedicarboxylic acid, naphthalene-1 ,4-dicarboxylic acid, naphthalene-2,3-dicar
- - tricarboxylic acids such as citric acid, aconitic acid, isocitric acid, oxalosuccinic acid, 1 ,2,3-propanetricarboxylic acid, 1,2,5- pentanetricarboxylic acid, 1 ,3,5-pentanetricarboxylic acid, transaconitic acid, 3-butene-1 ,2,3-tricarboxylic acid, 3-butene-1 ,1 ,3-tricarboxylic acid, 1 ,3,5-cyclohexanetricarboxylic acid, trimellitic acid, 1,2,3- benzenetricarboxylic acid or 1 ,3,5-benzenetricarboxylic acid;
- - tetracarboxylic acids such as 1 ,2,3,4-butanetetracarboxylic acid, pyromellitic acid, oxydisuccinic acid, thiodisuccinic acid, N-[1,2- dicarboxyethyl]-L-aspartic acid, ethylenediaminetetraacetic acid, ethylenediaminetetrapropionic acid or N ,N'-ethylenedi(L-aspartic) acid.
- said polycarboxylic acid used alone or as a mixture, is aliphatic, saturated and linear and contains 2 to 36 carbon atoms, in particular 3 to 18 carbon atoms, or even 4 to 12 carbon atoms; or alternatively is aromatic and contains 8 to 12 carbon atoms. It preferably comprises 2 to 4 COOH groups.
- citric acid aconitic acid, tartaric acid, 1 ,2,3-propanetricarboxylic acid and 1 ,2,3,4-butanetetracarboxylic acid, alone or as a mixture, preferably alone, and even better still citric acid alone.
- Polycarboxylic acid esters Among the polycarboxylic acid ester derivatives, mention may be made of the C1-C4 alkyl mono-, di-, tri- or tetraesters, in particular the methyl, ethyl, isopropyl or n-butyl esters and more preferentially the methyl or ethyl esters.
- the preferred polycarboxylic acid esters are the methyl, ethyl, isopropyl or n-butyl esters and more preferentially the methyl or ethyl esters of aliphatic, saturated, linear polyacids (2 to 4 COOH groups) containing 2 to 36 carbon atoms, in particular 3 to 18 carbon atoms, or even 4 to 12 carbon atoms; or alternatively of an aromatic acid containing 8 to 12 carbon atoms.
- methyl, ethyl, isopropyl or n-butyl esters and more preferentially the ethyl or butyl esters of citric acid, of aconitic acid, of tartaric acid, of 1 ,2,3-propanetricarboxylic acid and of 1 ,2,3,4-butanetetracarboxylic acid, alone or as a mixture, and even better still the ethyl or butyl esters of citric acid, such as triethyl citrate, acetyltriethyl citrate, tributyl citrate and acetyltributyl citrate.
- Polycarboxylic acid anhydrides such as triethyl citrate, acetyltriethyl citrate, tributyl citrate and acetyltributyl citrate.
- polycarboxylic acid-derived acid anhydrides mention may be made of:
- cyclic anhydrides of polycarboxylic acids such as phthalic anhydride, trimellitic anhydride, maleic anhydride, succinic anhydride or ⁇ , ⁇ , ⁇ ', ⁇ '-ethylenediaminetetraacetic acid dianhydride.
- the polycarboxylic acid anhydride alone or as a mixture, is chosen from maleic anhydride and succinic anhydride and more preferentially is maleic anhydride alone. d) Polycarboxylic acid halides
- the acid halides derived from said polycarboxylic acids mention may be made of the acid chlorides or acid bromides of said polycarboxylic acids, preferably the polycarboxylic acid chlorides.
- the acid halides used alone or as a mixture, are the halides of aconitic acid, of tartaric acid, of 1 ,2,3-propanetricarboxylic acid and of 1 ,2,3,4-butanetetracarboxylic acid, and preferably the chlorides of these acids.
- Said polycarboxylic acid(s) and/or ester, acid anhydride or acid halide derivatives thereof, used alone or as a mixture preferably represent(s) 5% to 40% by weight, more preferentially from 7% to 35% by weight and better still 10% to 30% by weight, of the total weight used in the synthesis of the cyclodextrin polycondensate.
- thermoplastic polyol polymer Another constituent required for the preparation of the cyclodextrin polycondensates according to the invention is a thermoplastic polyol polymer.
- polyol polymer is intended to mean a polymer having an average molecular weight ranging from 1000 to 200 000 Daltons, containing at least two hydroxyl functions.
- thermoplastic polyol polymer is intended to mean a polyol polymer which fluidifies (softens) in heat at a temperature between 100 and 250°C.
- thermoplastic polyol polymers can be used according to the invention. Mention will be made of polyether-polyols, polyester- polyols, polycarbonate-polyols, polyamide-polyols, polyurethane-polyols, polyalkylene-polyols, polycaprolactone-polyols and polysaccharides.
- polyether-polyols mention will be made of polyoxyethylene glycols, polyoxypropylene glycols, block or random copolymers of ethylene oxide and of propylene oxide, block or random copolymers of ethylene oxide and/or propylene oxide with tetrahydrofuran, and more particularly polytetramethylene glycols and polypropylene glycols.
- polyester-polyols mention will in particular be made of those obtained by polycondensation of dicarboxylic or tricarboxylic acids with polyols (di-, tri- or tetraols), for instance poly(hexamethylene adipate), and also those obtained by polycondensation of hydroxy acids, such as polyhydroxyalkanoates and in particular polylactic acid, polyhydroxybutyrate (PHB) and polyhydroxybutyrate-valerate (PHBV).
- polyols di-, tri- or tetraols
- hydroxy acids such as polyhydroxyalkanoates and in particular polylactic acid, polyhydroxybutyrate (PHB) and polyhydroxybutyrate-valerate (PHBV).
- polycarbonate-polyols examples include those prepared by reacting diols (propane-1 ,3-diol, butane-1 ,4-diol, hexane-1 ,6-diol, 1,9- nonanediol, 2-methyloctane-1 ,8-diol, diethylene glycol, etc.) with diaryl carbonates, such as diphenyl carbonate, or else with phosgene.
- diols propane-1 ,3-diol, butane-1 ,4-diol, hexane-1 ,6-diol, 1,9- nonanediol, 2-methyloctane-1 ,8-diol, diethylene glycol, etc.
- diaryl carbonates such as diphenyl carbonate, or else with phosgene.
- polyamide-polyols mention will be made more particularly of those obtained by reacting a diamine and/or a polymeric diamine with a dicarboxylic or polycarboxylic acid and a hydroxy acid, such as, for example, 12-hydroxystearic acid.
- polyurethane-polyols mention will be made of those obtained by means of a polyaddition process consisting in reacting polyisocyanates, preferably diisocyanates, with diols and/or polyols.
- polycaprolactone-polyols obtained by polymerization of epsilon- caprolactone with ring opening via polyols such as ethylene glycol, 1,2- propanediol, 1 ,3-propanediol, glycerol or trimethylolpropane.
- polyvinyl alcohol modified polyvinyl alcohol having a content of ethylene units of 4 mol% to 15 mol% and polybutadiene diols.
- thermoplastic starches which are obtained by destructuring the native granule in the presence of a plasticizer under thermomechanical stresses; cellulose derivatives, such as cellulose acetate, cellulose acetobutyrate, cellulose acetopropionate, methylcellulose, ethylcellulose, hydroxypropylcellulose, hydroxyethyl cellulose, hydroxypropylmethylcellulose, hydroxyethylmethylcellulose or carboxymethylcellulose, alone or as a mixture with alginates, gums such as guar gum, starches such as tapioca starch, modified starches such as starch octenyl succinate (E.1450), oxidized starches (E.1404), crosslinked starches (E.1412 or 1413), stabilized starches (E.1420 or E.1440), crosslinked/stabilized starches such as acetylated distarch adipate (E.1422) or hydroxypropylated distarch
- the polysaccharides are particularly preferred since they have a renewable origin and are available at high tonnage and at low cost.
- polysaccharides use may be made, alone or as a mixture, of hydroxypropylcellulose and hydroxyethylcellulose, and even better still hydroxypropylcellulose alone.
- thermoplastic polyol polymer(s) preferably represent(s) 10% to 50% by weight, in particular 15% to 45% by weight and better still 17% to 40% by weight, of the total weight used in the synthesis of the cyclodextrin polycondensate.
- At least one polycarboxylic acid cyclic anhydride chosen so as to be other than the first polycarboxylic acid anhydride previously mentioned is also used for the preparation of the cyclodextrin polycondensates according to the invention.
- the additional polycarboxylic acid cyclic anhydride may in particular correspond to one of the following formulae:
- a and B taken together, form a saturated or unsaturated, or even aromatic, ring containing in total 5 to 7 and in particular 6 carbon atoms.
- a and B represent a hydrogen atom or together form an aromatic ring containing in total 6 carbon atoms.
- polycarboxylic acid cyclic anhydrides which may be used, mention may be made of, alone or as a mixture, phthalic anhydride, trimellitic anhydride, maleic anhydride and succinic anhydride. Preferably, use may be made of maleic anhydride and succinic anhydride alone or as a mixture, and even better still maleic anhydride alone.
- polycarboxylic acid cyclic anhydride When said polycarboxylic acid cyclic anhydride is present among the ingredients used, it preferably represents 0.1% to 10% by weight, in particular 0.5% to 5% by weight, or even 0.7% to 4% by weight, relative to the total weight used in the synthesis of the cyclodextrin polycondensate.
- esterification catalyst will be used for the preparation of the cyclodextrin polycondensates according to the invention.
- the esterification catalyst may in particular be chosen from dihydrogen phosphates, hydrogen phosphates, phosphates, hypophosphites and phosphites of alkali metals, alkali metal salts of polyphosphoric acids, alkali metal or alkaline-earth metal carbonates, bicarbonates, acetates, borates and hydroxides, aliphatic amines and aqueous ammonia, optionally combined with an inorganic solid support such as alumina, silica gels, Al silicates, zeolites, titanium oxides or zirconium oxides.
- the esterification catalyst may also be chosen from sulfonic acids or titanates.
- Use may preferably be made of sodium hydrogen phosphate, sodium dihydrogen phosphate and sodium hypophosphite and even better still sodium dihydrogen phosphate.
- esterification catalyst When said esterification catalyst is present among the ingredients used, it preferably represents 0.1% to 5% by weight, in particular 0.5% to 4% by weight, or even 0.5% to 3% by weight, relative to the total weight used in the synthesis of the cyclodextrin polycondensate.
- At least one non- polymeric polyol comprising 3 to 6 hydroxyl groups will also be used for the preparation of the cyclodextrin polycondensates according to the invention.
- a mixture of such polyols may obviously be used.
- Said polyol may in particular be a linear, branched and/or cyclic, saturated or unsaturated carbon-based and in particular hydrocarbon-based compound containing 3 to 18 carbon atoms, in particular 3 to 12 or even 4 to 10 carbon atoms, and 3 to 6 hydroxyl (OH) groups, and also possibly comprising one or more oxygen atoms inserted in the chain (ether function).
- Said polyol is preferably a linear or branched saturated hydrocarbon- based compound containing 3 to 18 carbon atoms, in particular 3 to 12 or even 4 to 10 carbon atoms, and 3 to 6 hydroxyl (OH) groups. It may be chosen, alone or as a mixture, from:
- triols such as 1 ,2,4-butanetriol, 1 ,2,6-hexanetriol, trimethylolethane, trimethylolpropane or glycerol;
- - tetraols such as pentaerythritol (tetramethylolmethane), erythritol, diglycerol or ditrimethylolpropane;
- - hexols such as sorbitol and mannitol; or alternatively dipentaerythritol or triglycerol.
- the polyol is chosen from glycerol, pentaerythritol, diglycerol and sorbitol, and mixtures thereof; and even better still the polyol is glycerol alone.
- said polyol comprising 3 to 6 hydroxyl groups is present among the ingredients used, it preferably represents 1% to 30% by weight, in particular 2% to 25% by weight, or even 10% to 20% by weight, relative to the total weight used in the synthesis of the cyclodextrin polycondensate .
- the ratio between the number of moles of polycarboxylic acid and the number of moles of the cyclodextrin preferably ranges from 0.5 to 5, especially from 0.6 to 4 and in particular from 0.7 to 3. It has been noted that these proportions make it possible to obtain a cyclodextrin polycondensate which is advantageously water-insoluble and which, moreover, has at the same time an appropriate capacity for both capturing and impregnating various ingredients.
- the cyclodextrin polycondensate according to the invention has an acid number, expressed in mg of potassium hydroxide per g of polycondensate, greater than or equal to 20, in particular ranging from 20 to 250 and even better still ranging from 40 to 180.
- This acid number may be readily determined by those skilled in the art via the conventional analytical methods.
- the amount of -COOH groups present is evaluated according to the number of milligrams of potassium hydroxide required to neutralize 1 g of cyclodextrin polycondensate, the dispersion being carried out in a mixture of solvents (1 part of water and 1 part of absolute ethanol).
- the cyclodextrin polycondensate according to the invention exhibits a degree of swelling in water, measured at 20°C, greater than or equal to 100%, in particular ranging from 100% to 1000% and even better still ranging from 300% to 900%. This degree of swelling is measured in the manner described hereinafter.
- the polycondensate according to the invention may be prepared via the esterification/polycondensation processes usually used by those skilled in the art.
- a general preparation process consists:
- cyclodextrins in mixing together one or more cyclodextrins, a polycarboxylic acid and/or a derivative thereof (esters, acid anhydrides or acid halides), at least one thermoplastic polyol polymer and optionally at least one polycarboxylic acid cyclic anhydride chosen so as to be other than the previous polycarboxylic acid anhydride and/or at least one esterification catalyst and/or at least one non-polymeric polyol comprising 3 to 6 hydroxyl groups,
- Said preparation process may also comprise a step of adding at least one antioxidant to the reaction medium, in particular in a weight concentration preferably ranging from 0.01% and 2% relative to the total weight used in the synthesis of the cyclodextrin polycondensate, so as to limit the possible degradation associated with prolonged heating.
- the antioxidant may be chosen from hindered phenols, aromatic secondary amines, organophosphorus compounds, sulfur compounds, lactones and bisphenols, and mixtures thereof.
- antioxidants that are particularly preferred, mention may in particular be made of BHT, BHA, TBHQ, 1 ,3,5-trimethyl-2,4,6,tris(3,5-di- (tert-butyl)-4-hydroxybenzyl)benzene, octadecyl 3,5,di-(tert-butyl)-4- hydroxycinnamate, tetrakis[methylene-3-(3,5-di-(tert-butyl)-4- hydroxyphenyl)propion ate] methane, octadecyl 3-(3,5-di-(tert-butyl)-4- hydroxyphenyl)propionate, 2,5-di-(tert-butyl)hydroquinone, 2,2- methylenebis(4-methyl-6-(tert-butyl)phenol), 2,2-methylenebis(4-ethyl-6- (tert-butyl)phenol), 4,4-butylidenebis(6
- One particularly preferred mode of preparation of the cyclodextrin polycondensates of the present invention consists in mixing at least one cyclodextrin, at least one polycarboxylic acid and/or an ester, acid anhydride or acid halide derivative thereof, at least one thermoplastic polyol polymer and optionally at least one polycarboxylic acid cyclic anhydride chosen to be other than the previous polycarboxylic acid anhydride and/or optionally at least one esterification catalyst and/or optionally at least one non-polymeric polyol, in an apparatus which makes it possible to bring the mixture to a thermoplastic state by combining sufficient temperature and shear force conditions, thus making the various components compatible.
- an extruder for instance of the Clextral BC 21® twin-screw type or any other apparatus which can meet these criteria, which operates at a temperature ranging from 100 to 250°C and preferentially from 110 to 200°C.
- the preferred mode of preparation of the materials of the invention consists in incorporating, in a single step, all the ingredients in an extruder at a temperature ranging from 110 to 200°C, preferably ranging from 120 to 190°C and even better still from 150 to 180°C.
- the residence time in an extruder preferably ranges from 1 to 10 minutes and even better still from 1 to 5 minutes.
- said polycondensate may subsequently be ground if required.
- Another subject of the invention consists of the use of a cyclodextrin polycondensate as defined previously as an agent for capturing a substance or a mixture of substances capable of polluting the environment, such as gaseous pollutants (volatile organic compounds), metal cations, oils and fats, polluting substances in drinking water, industrial water and aqueous effluents and also in soils and surrounding volatile odorous molecules.
- gaseous pollutants volatile organic compounds
- metal cations volatile organic compounds
- oils and fats oils and fats
- VOCs gaseous pollutants
- chlorinated compounds for instance chlorobenzene, carbon tetrachloride and monovinyl chloride.
- metal cations mention may more particularly be made of lead, cadmium, mercury, iron and copper cations.
- oils and fats are of mineral, animal, vegetable, marine or synthetic origin.
- the cyclodextrin polycondensates of the invention by virtue of their chemical nature and their superabsorbent polymeric network, have in particular a strong capacity to absorb fatty substances such as vegetable oils, mineral oils, for instance hydrocarbons such as isohexadecane, paraffin oil, terpenes, squalene, isoparaffins, ceresin, petroleum jelly, hydrogenated oils, silicone oils, saturated or unsaturated fatty acids (such as oleic acid), fatty acid esters, fatty alcohols (such as myristyl alcohol, cetyl alcohol, stearyl alcohol, myricyl alcohol), butters, ester waxes, or a mixture thereof.
- fatty substances such as vegetable oils, mineral oils, for instance hydrocarbons such as isohexadecane, paraffin oil, terpenes, squalene, isoparaffins, ceresin, petroleum jelly, hydrogenated oils, silicone oils, saturated or unsaturated fatty acids (such as oleic
- the cyclodextrin polycondensates make it possible in particular to capture fats, dirt, fatty waste which may be produced during the manufacturer or consumption of numerous consumer products, in particular food- processing industry products, household products, for instance laundry detergents, detergent products for textiles, for instance stain removers, products for cleaning and/or maintaining floors, cosmetic cleansing products, for instance makeup removers.
- Another subject of the invention consists of the use of a cyclodextrin polycondensate as defined previously as an agent for capturing and protecting a substance or a mixture of substances which may deteriorate under the influence of atmospheric agents (moisture, heat, oxygen, light, etc.) or upon contact with one or more ingredients in a composition.
- a cyclodextrin polycondensate as defined previously as an agent for capturing and protecting a substance or a mixture of substances which may deteriorate under the influence of atmospheric agents (moisture, heat, oxygen, light, etc.) or upon contact with one or more ingredients in a composition.
- these substances termed particularly sensitive, fragile or unstable mention may in particular be made of fragrances (perfumery ingredients) and flavourings, vitamins, hormones and dyes.
- Another subject of the invention consists of the non-therapeutic cosmetic use of a cyclodextrin polycondensate as defined previously as an agent for capturing a substance or a mixture of substances capable of generating, for example, uncomfortable reactions on a keratin material and in particular a human keratin material.
- the substances capable of generating uncomfortable reactions on a keratin material are chosen in particular from:
- malodorous molecules and in particular malodorous bodily molecules produced by sweat and the bacteria which grow therein during its development mention may be made of malodorous molecules and in particular malodorous bodily molecules produced by sweat and the bacteria which grow therein during its development.
- malodorous bodily molecules mention may be made of:
- R-i represents i) a linear or branched (C1-C2 0 ) alkyl group which is optionally substituted, preferably with at least one hydroxyl group, ii) a linear or branched (C 2 -C 2 o)alkenyl group which is optionally substituted, preferably with at least one hydroxyl group; in particular, the alkyl or alkenyl group contains from 2 to 14 carbon atoms.
- acetic acid 2-propenoic acid, propanoic acid, propionic acid, 2- methylpropanoic acid, 2-methylpropenoic acid, 2-butenoic acid, 2-methyl- 2-butenoic acid, 3-methyl-2-butenoic acid, butanoic acid, 2-methylbutanoic acid, 3-methylbutanoic acid, 3-hydroxybutanoic acid, 3-hydroxy-3- methylbutanoic acid, 2-methylbutyric acid, isovaleric acid, 2-pentenoic acid, 2-methyl-2-pentenoic acid, 3-methyl-2-pentenoic acid, pentanoic acid, 2-methylpentanoic acid, 3-methylpentanoic acid, 3-hydroxypentanoic acid, 3-hydroxy-3-methylpentanoic acid, 3-methylhexanoic acid, 3- hydroxy-3-methylhexanoic acid, hexanoic acid, (E)-3-methyl-2-hexenoic
- the odorous fatty acids are chosen from propionic acid, 3- methyl-2-hexenoic acid, isovaleric acid, 2-methylbutyric acid, hexanoic acid, octanoic acid, nonanoic acid, decanoic acid and dodecanoic acid; b) Mercaptoalkanols such as those of formula (2) below:
- HS-R 2 -OH (2) in which R 2 represents a linear or branched (C 1 -C 10 ) and preferably (Ci- C 6 ) alkylene group.
- the mercaptoalkanol odorous molecules are chosen from 3- methyl-3-sulfanylhexan-1 -ol, 3-sulfanylhexan-1 -ol, 2-methyl-3- sulfanylbutan-1 -ol, 3-sulfanylpentan-1 -ol, 3-sulfanylbutan-1 -ol, 3-methyl-3- sulfanylpentan-1 -ol and 3-methyl-3-sulfanylbutan-1 -ol; c) steroids such as those chosen from androst-16-ene steroids, in particular 5a-androst-16-en-3-one and 5a-androst-16-en-3a-ol, androst-2- en-17-one, androsta-4,16-dien-3-one,
- the odorous sulfoconjugated steroid compounds are preferentially chosen from the sulfates derived from dehydroepiandrosterone (DHEA), from androsterone and from testosterone, 5a-androst-16-en-3a-sulfate, androsta-5,16-dien-33-sulfate, dehydroepiandrosterone sulfate, testosterone sulfate, 5a- dehydrotestosterone sulfate and 5a-androstan-17-on-3a-sulfate; e) odorous-molecule precursors chosen from conjugated fatty amino acids, such as the conjugated product of glutamine with (E)-3-methyl-2-hexenoic acid (a) and the conjugated product of glutamine with 3-hydroxy-3- methylhexanoic acid (b).
- DHEA dehydroepiandrosterone
- a conjugated product of glutamine with (E)-3-methyl-2-hexenoic acid
- Ri is as defined previously;
- R'i represents i) a linear or branched (Ci-C 2 o)alkyl group which is optionally substituted, preferably with at least one hydroxyl group, ii) a linear or branched (C 2 -C 2 o)alkenyl group which is optionally substituted, preferably with at least one hydroxyl group.
- R contains from 1 to 14 carbon atoms, and more particularly R'- ⁇ represents a linear or branched (Ci-C 6 )alkyl group such as methyl.
- linear or branched (Ci-C 6 ) alkyl esters and in particular the methyl ester of 3-hydroxy-3-methylhexanoic acid, 3-hydroxy-4-methyloctanoic acid, (E)-3-methyl-2-hexenoic acid, 3- hydroxyhexanoic acid and 3-hydroxyoctanoic acid.
- Mention may also be made of the linear or branched (Ci-C 6 ) alkyl esters and in particular the methyl esters of the following acids:
- acetic acid 2-propenoic acid, propanoic acid, 2-methylpropanoic acid, 2- methylpropenoic acid, 2-butenoic acid, 2-methyl-2-butenoic acid, 3- methyl-2-butenoic acid, butanoic acid, 2-methylbutanoic acid, 3- methylbutanoic acid, 3-hydroxybutanoic acid, 3-hydroxy-3-methylbutanoic acid, 2-pentenoic acid, 2-methyl-2-pentenoic acid, 3-methyl-2-pentenoic acid, pentanoic acid, 2-methylpentanoic acid, 3-methylpentanoic acid, 3- hydroxypentanoic acid, 3-hydroxy-3-methylpentanoic acid, 2-heptenoic acid, 2-methyl-2-heptenoic acid, 3-methyl-2-heptenoic acid, heptanoic acid, 2-methylheptanoic acid, 3-methylheptanoic acid, 3-hydroxyheptanoic acid, 3-hydroxy-3-methylheptanoic acid
- R 4 and R' 4 which may be identical or different, represent a hydrogen atom, a linear or branched (Ci-C 8 )alkyl or linear or branched (C 2 - C 8 )alkenyl group, such as methyl, optionally substituted with a hydroxyl group; preferably, R 4 represents a hydrogen atom and R' 4 represents a (Ci-C 6 )alkyl group optionally substituted with a hydroxyl group;
- ALK and ALK' which may be identical or different, represent a linear or branched (Ci-C 8 )alkylene group optionally substituted with a group -X 2 -R 4 , with R 4 ;
- the odorous compounds of this class are chosen from the following compounds:
- the odorous molecules capable of being efficiently captured by the cyclodextrin polycondensates of the invention are chosen from 3-methyl-2-hexenoic acid, octanoic acid, nonanoic acid, decanoic acid, 6, 10-dimethyl-5,9-undecadien-2-one, tridecanone, isopentanol and 1 -decanol.
- sweat eccrine or apocrine
- Sweat contains mainly water. It also contains minerals, in addition to lactate which is an ionized form of lactic acid, and urea.
- the strong water-absorbing capacity of the cyclodextrin polycondensates of the invention makes it possible to efficiently capture the constituents of sweat when said polycondensates are applied to keratin materials.
- a subject of the invention therefore consists of a process for cosmetic treatment of human perspiration and/or of body odours, consisting in applying, to the surface of a human keratin material, a composition comprising, in a physiologically acceptable medium, at least one cyclodextrin polycondensate as defined previously.
- Human sebum generally comprises in its composition lipids comprising squalene (approximately 15%), ester waxes (approximately 25%), cholesterol esters (approximately 2%), triglycerides (approximately 57%) and cholesterol (approximately 1%).
- the strong lipid-adsorbing capacity of the cyclodextrin polycondensates of the invention makes it possible to efficiently capture the excess sebum when said polycondensates are applied to the surface of the skin, the hair or the scalp, and to treat greasy skin and greasy hair against seborrhoea and the appearance of oily dandruff and to prevent skin or hair disorders resulting therefrom.
- Another subject of the invention therefore consists of a non-therapeutic cosmetic process for caring for and/or cleansing a human keratin material which is greasy or prone to be greasy, comprising at least one step of topical application, to said keratin material, of a composition comprising, in a physiologically acceptable medium, at least one cyclodextrin polycondensate as defined previously.
- the cyclodextrin polycondensates according to the invention can also be used for trapping at least one beneficial agent, as described previously.
- beneficial agents are chosen from: a) Fatty substances
- Fatty substances are commonly used in the formulation of pharmaceutical, cosmetic and/or food-processing compositions. They may be chosen from the group comprising:
- natural oils of vegetable, animal or marine origin such as olive oil, sesame oil, argan oil, palm oil, soya bean oil, woad oil, babassu oil, aloe vera, avocado oil, allantoin, bisabol, grapeseed oil, apricot oil, wheat germ oil, almond oil, groundnut oil, macadamia nut oil, buckthorn oil, evening primrose oil, borage oil, ginger oil, geraniol, jujube oil, mink oil or lanolin,
- mineral oils such as isohexadecane, para-isoparaffin, ceresin or petroleum jelly,
- silicone oils (v) silicone oils, (vi) hydrocarbon-based compounds, such as paraffin oil,
- fatty alcohols such as myristyl alcohol, cetyl alcohol, stearyl alcohol or myricyl alcohol,
- butters such as shea butter or cocoa butter
- One of the possible applications according to the invention is the conveying of fatty substances for cosmetic use or for food use or for dietary cosmetic use, such as nutritive supplements.
- fatty substances for cosmetic use or for food use or for dietary cosmetic use such as nutritive supplements.
- One of the possible applications according to the invention is the conveying of flavouring substances and/or of taste enhancers for food use or for dietary cosmetic use, such as nutritive supplements.
- flavouring substances mention may be made of those chosen:
- flavour enhancers The European Union defines flavour enhancers in the list of food additives via an E number. They are numbered from E620 (glutamic acid) to E641 (L-leucine).
- flavour enhancers mention may be made of
- glutamates such as glutamic acid (E620), monosodium glutamate (E621), monopotassium glutamate (E622), calcium diglutamate
- guanylates such as guanylic acid or guanisine monophosphate
- inosinates such as inosinic acid (E630), disodium inosinate (E631), dipotassium inosinate (E632) or calcium inosinate (E633). Mention may also be made of calcium 5'-ribonucleotide (E634), disodium 5'-ribonucleotide (E635), maltol (E636), ethylmaltol (E637), glycine (E640) and L-leucine (E641 ).
- lactic acid (acidifier) (E270), sweeteners such as acesulfame- K (E950), aspartame (E951), thaumatin (E957), neohesperidin dihydrochalcone (E959), neotame (E961) or erythritol (E968).
- sweeteners such as acesulfame- K (E950), aspartame (E951), thaumatin (E957), neohesperidin dihydrochalcone (E959), neotame (E961) or erythritol (E968).
- fragmenting substance is intended to mean any fragrance or aroma capable of giving off a pleasant odour.
- Fragrances are compositions in particular containing the starting materials described in S. Arctander, Perfume and Flavor Chemicals (Montclair, N.J., 1969), in S. Arctander, Perfume and Flavor Materials of Natural Origin (Elizabeth, N.J., 1960) and in Flavor and Fragrance Materials - 1991, Allured Publishing Co., Wheaton, III.
- an essential oil is an odorous product generally of complex composition, obtained from a botanically defined plant starting material, either by steam distillation, or by dry distillation, or via an appropriate mechanical method without heating (cold pressing).
- the essential oil is generally separated from the aqueous phase by a physical method which does not result in any significant change in the composition.
- Abietaceae or Pinaceae conifers; Amaryllidaceae; Anacardaceae; Anonaceae: ylang ylang; Apiaceae (for example Umbelliferae): dill, angelica, coriander, sea fennel, carrot, parsley; Araceae; Aristolochiaceae; Asteraceae: yarrow, artemisia, camomile, helichrysum; Betulaceae; Brassicaceae; Burseraceae: frankincense; Carophyllaceae; Canellaceae; Cesalpiniaceae: copaifera (copaiba balsam); Chenopodaceae; Cistaceae: rock rose; Cyperaceae; Dipterocarpaceae; Ericaceae: gaultheria (wintergreen); Euphorbiaceae; Fabaceae; Geraniaceae: geranium; Guttiferae; Hamamelidaceae; Her
- fragrancing substances are in particular: geraniol, geranyl acetate, farnesol, borneol, bornyl acetate, linolool, linalyl acetate, linalyl propionate, linalyl butyrate, tetrahydrolinolool, citronellol, citronellyl acetate, citronellyl formate, citronellyl propionate, dihydromyrcenol, dihydromyrcenyl acetate, tetrahydromyrcenol, terpineol, terpinyl acetate, nopol, nopyl acetate, nerol, neryl acetate, 2-phenylethanol, 2-phenylethyl acetate, benzyl alcohol, benzyl acetate, benzyl salicylate, styrallyl acetate, benzyl benzoate, amyl
- Another of the possible applications is, for example, the conveying of fragrancing substances for the manufacture of perfumery products (fragrances, eaux de toilette, eaux de perfume, aftershave lotions), cosmetic products for caring for and/or cleansing keratin materials, in particular human keratin materials, makeup products, laundry cleaning and/or care products, household products, in the manufacture of clothing, shoes, soles and products for the maintenance thereof, in products intended for animal hygiene, such as litters, in inks, products resulting from the paper industry, in products intended for babycare (wipes, nappies), in products intended for intimate hygiene (tampons, wipes, towels), in products for sanitary use, and in food-processing products and products resulting from agriculture.
- Pharmaceutical active ingredients for example, the conveying of fragrancing substances for the manufacture of perfumery products (fragrances, eaux de toilette, eaux de perfume, aftershave lotions), cosmetic products for caring for and/or cleansing keratin materials, in particular human keratin materials, makeup products, laundry cleaning and/
- pharmaceutical active ingredient is intended to mean a molecule which has a curative and/or prophylactic therapeutic effect.
- NSAIDs non-steroidal anti-inflammatory drugs
- abortifacients alpha-blockers, alpha2-agonists, aminosides, analgesics, anaesthetics, local anaesthetics, anorexigenics, 5HT3 antagonists, calcium antagonists, anti-angina agents, antiarrhythmics, antibiotics, anticholinergics, anticholinesterases, antidiabetics, anti-diarrhoea agents, antidepressants, antihistamines, antihypertensives, antimycotics, antimalarials, antiparasitics, antipsychotics, antipyretics, antiretrovirals, antiseptics, antispasmodics, antivirals, antiemetics, antiepileptics, anxiolytics, barbiturates, benzodiazepines, broncho
- NSAIDs non-steroidal anti-inflammatory drugs
- abortifacients alpha-blockers, alpha2-
- cosmetic active agent is intended to mean any molecule which has a hygiene, care, makeup or dyeing effect contributing to improving the well-being and/or to making more attractive the appearance of the human keratin material to which said composition is applied.
- the cosmetic active agents can therefore be chosen from any of the substances which meet this definition and which are present in products such as
- hygiene products makeup-removing products, toothpastes, deodorants, antiperspirants, shower gels, bath preparations (bubble bath, bath oil, bath salts), intimate cleansing gels, soaps, shampoos,
- care products antiwrinkle cream, day cream, night cream, moisturizing cream, floral water, scrubbing product, milk, beauty mask, lip balm, tonic,
- hair care and/or treatment products such as styling products, dyeing products, permanent-waving products, conditioning products: conditioner, hair relaxing product, hair straightening product; gel, oil, lacquer, mask,
- makeup products concealer, eyeliner, face powder, foundation, khol, mascara, powder, skin whitening product, lipstick, nail varnish,
- fragrances eau de Cologne, eau de toilette, perfume
- suntan products self-tanning products, aftersun and suntan creams, milks, oils, sticks or solutions,
- shaving products and hair removal products aftershave, hair removal cream, shaving foam and gels.
- active agents for caring for human keratin materials such as the skin, the lips, the scalp, the hair, the eyelashes or the nails
- active agents for caring for human keratin materials such as the skin, the lips, the scalp, the hair, the eyelashes or the nails
- examples that may be mentioned include:
- cyclodextrin polycondensates according to the invention can be used very advantageously in a cosmetic or dermatological composition which comprises, moreover, a physiologically acceptable medium.
- the amount of cyclodextrin polycondensate present in the compositions obviously depends on the type of composition and on the desired properties and may vary within a very wide range, generally ranging from 0.1% to 100% by weight, preferably from 0.5% to 95% by weight, in particular from 1% to 70% by weight, or even from 1.5% to 50% by weight and better still from 2% to 20% by weight, relative to the total weight of the composition.
- composition may thus comprise, depending on the intended application, constituents that are common for this type of composition.
- composition according to the invention may advantageously comprise at least one fatty phase which may comprise at least one compound chosen from volatile or non-volatile carbon-based, hydrocarbon-based, fluoro and/or silicone oils, waxes and/or solvents of mineral, animal, plant or synthetic origin, alone or as a mixture, provided that they form a stable, homogeneous mixture and are compatible with the intended use.
- fatty phase which may comprise at least one compound chosen from volatile or non-volatile carbon-based, hydrocarbon-based, fluoro and/or silicone oils, waxes and/or solvents of mineral, animal, plant or synthetic origin, alone or as a mixture, provided that they form a stable, homogeneous mixture and are compatible with the intended use.
- volatile is intended to mean any compound that is capable of evaporating on contact with keratin materials in less than one hour, at ambient temperature (25°C) and atmospheric pressure (1 atm).
- this volatile compound has a non-zero vapour pressure, at ambient temperature and atmospheric pressure, ranging from 0.13 Pa to 40 000 Pa (10 "3 to 300 mmHg), in particular ranging from 1.3 Pa to 13 000 Pa (0.01 to 100 mmHg), and more particularly ranging from 1.3 Pa to 1300 Pa (0.01 to 10 mmHg).
- non-volatile is intended to mean a compound that remains on human keratin materials at ambient temperature and atmospheric pressure for at least one hour and that in particular has a vapour pressure of less than 10 "3 mmHg (0.13 Pa).
- the fatty phase may represent from 1% to 99% by weight of the composition, especially from 5% to 95% by weight, in particular from 10% to 90% by weight, or even from 20% to 85% by weight, of the total weight of the composition.
- the composition may also comprise other ingredients commonly used in cosmetic compositions.
- Such ingredients may be chosen from antioxidants, fragrances, essential oils, preservatives, cosmetic active agents, moisturizers, vitamins, ceramides, sunscreens, surfactants, spreading agents, wetting agents, dispersants, antifoams, neutralizing agents, stabilizers, polymers and in particular liposoluble film-forming polymers, and mixtures thereof.
- antioxidants fragrances, essential oils, preservatives, cosmetic active agents, moisturizers, vitamins, ceramides, sunscreens, surfactants, spreading agents, wetting agents, dispersants, antifoams, neutralizing agents, stabilizers, polymers and in particular liposoluble film-forming polymers, and mixtures thereof.
- compositions according to the invention may be in any common acceptable form for a cosmetic or dermatological composition.
- Example 1a The ⁇ -cyclodextrin polycondensate 1a was obtained after extrusion of the ⁇ -cyclodextrin (CD) in the presence of hydroxypropylcellulose (HPC), citric acid and sodium dihydrogen phosphate (DHPS). The proportions of each constituent are indicated as percentages by weight below:
- the polycondensate 1 a was obtained in the form of a cream-coloured powder with an average particle size of 10 ⁇ .
- the cyclodextrin polycondensate 1 a has an acid number of 150 mg of potassium hydroxide per g of polycondensate and a degree of swelling in water of 805%.
- the solid obtained was detached from the crystallizing dish and then finely milled using a knife mill of coffee mill type. It was analyzed by 2D DOSY NMR which made it possible to demonstrate the covalent grafting of the citric acid onto the ⁇ -cyclodextrin so as to form an oligomer, the diffusion coefficient of which is 173 ⁇ 2 /8, which corresponds to a molecular weight estimated at approximately 3800 g/mol. Its acid number is 195 mg of potassium hydroxide per g of polycondensate and its degree of swelling in water is 0% since it is entirely soluble at ambient temperature (solubility greater than 30%).
- Test protocol 500 ⁇ of sweat were placed in a 6-ml Headspace® flask and 2, 5, 10 or 25 mg of cyclodextrin polycondensate to be evaluated were added.
- the flask was crimped (with Al/Si septum) and was placed in an oven at 37°C for 24 hours and then acidified by adding 50 ⁇ of 1 N HCI.
- a control sweat was used: same protocol but without the addition of cyclodextrin polycondensate.
- SPME solid-phase microextraction
- mapping of the odorous molecules produced by the developing sweat was evaluated by mass spectography respectively on the control sweat and on the sweat incubated in the presence of cyclodextrin polycondensate 1 a.
- Example 1 a It was observed that the ⁇ -cyclodextrin polycondensate of Example 1 a according to the invention exhibits a level of fragrance encapsulation which is 3.7 times greater than that of ⁇ -cyclodextrin, than that of the comparative ⁇ -cyclodextrin polycondensate A and than that of the comparative ⁇ -cyclodextrin polycondensate B.
- Example 1 Deodorant and antiperspirant formulation
- the encapsulation properties of the ⁇ -cyclodextrin polymer 1 c were measured and compared to the ⁇ -cyclodextrin polycondensate 3a as described above, and
- Example 1 c ⁇ -cyclodextrin polycondensate of Example 1 c according to the invention exhibited a level of fragrance encapsulation which was 3.4 times greater than that of the comparative ⁇ -cyclodextrin polycondensate 3a.
- a pool of sweat is extracted from a panel of 6 male volunteers having a more or less pronounced malodour degree.
- the samples were evaluated after incubation and compared to two sweat controls on the same time : a positive sweat control containing 0.1 % by weight of Aluminium Chlorhydrate and a negative sweat control with sweat alone.
- cyclodextrin polycondensate 1 c had a good deodorant efficacy which can reach the level of an aluminum salt contrarily to the comparative cyclodextrin polycondensate 3a which had a low efficacy.
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Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2015129060A RU2662778C2 (en) | 2012-12-20 | 2013-12-06 | Water-insoluble cyclodextrine polycondensate: application as a capturing agent |
EP13802608.3A EP2935340A1 (en) | 2012-12-20 | 2013-12-06 | Water-insoluble cyclodextrin polycondensate; uses as a capturing agent |
CN201380073487.XA CN105008403B (en) | 2012-12-20 | 2013-12-06 | Water-insoluble cyclodextrin condensation polymer;Purposes as capturing agent |
CA2897853A CA2897853A1 (en) | 2012-12-20 | 2013-12-06 | Water-insoluble cyclodextrin polycondensate; uses as a capturing agent |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261740134P | 2012-12-20 | 2012-12-20 | |
FR1262394A FR3000080B1 (en) | 2012-12-20 | 2012-12-20 | WATER INSOLUBLE CYCLODEXTRIN POLYCONDENSATE; USES AS CAPTURE AGENT |
FR1262394 | 2012-12-20 | ||
US61/740,134 | 2012-12-20 |
Publications (1)
Publication Number | Publication Date |
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WO2014095427A1 true WO2014095427A1 (en) | 2014-06-26 |
Family
ID=47882290
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PCT/EP2013/075816 WO2014095427A1 (en) | 2012-12-20 | 2013-12-06 | Water-insoluble cyclodextrin polycondensate; uses as a capturing agent |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP2935340A1 (en) |
CN (1) | CN105008403B (en) |
CA (1) | CA2897853A1 (en) |
FR (1) | FR3000080B1 (en) |
RU (1) | RU2662778C2 (en) |
WO (1) | WO2014095427A1 (en) |
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Also Published As
Publication number | Publication date |
---|---|
RU2015129060A (en) | 2017-01-25 |
EP2935340A1 (en) | 2015-10-28 |
CN105008403B (en) | 2019-03-19 |
CA2897853A1 (en) | 2014-06-24 |
RU2662778C2 (en) | 2018-07-30 |
FR3000080A1 (en) | 2014-06-27 |
CN105008403A (en) | 2015-10-28 |
FR3000080B1 (en) | 2015-01-30 |
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