WO2014053111A3 - Verfahren und vorrichtung zur bearbeitung histologischer gewebeproben - Google Patents

Verfahren und vorrichtung zur bearbeitung histologischer gewebeproben Download PDF

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Publication number
WO2014053111A3
WO2014053111A3 PCT/DE2013/000547 DE2013000547W WO2014053111A3 WO 2014053111 A3 WO2014053111 A3 WO 2014053111A3 DE 2013000547 W DE2013000547 W DE 2013000547W WO 2014053111 A3 WO2014053111 A3 WO 2014053111A3
Authority
WO
WIPO (PCT)
Prior art keywords
specimen slide
tissue samples
tissue
sample
processing
Prior art date
Application number
PCT/DE2013/000547
Other languages
English (en)
French (fr)
Other versions
WO2014053111A2 (de
Inventor
Michael Ott
Michaela OTT
Original Assignee
Medite Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medite Gmbh filed Critical Medite Gmbh
Priority to GB1505265.7A priority Critical patent/GB2521561A/en
Priority to CN201380051825.XA priority patent/CN104838247B/zh
Priority to US14/433,607 priority patent/US20150260619A1/en
Publication of WO2014053111A2 publication Critical patent/WO2014053111A2/de
Publication of WO2014053111A3 publication Critical patent/WO2014053111A3/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G01N2001/2833—Collecting samples on a sticky, tacky, adhesive surface
    • G01N2001/284—Collecting samples on a sticky, tacky, adhesive surface using local activation of adhesive, i.e. Laser Capture Microdissection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G01N2001/2873—Cutting or cleaving
    • G01N2001/2886—Laser cutting, e.g. tissue catapult
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00138—Slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00168—Manufacturing or preparing test elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0441—Rotary sample carriers, i.e. carousels for samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/046—General conveyor features
    • G01N2035/0465—Loading or unloading the conveyor

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Robotics (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

Bei einem Verfahren und einer Vorrichtung zur Bearbeitung histologischer Gewebeproben, bei dem in einem automatisierten Prozess Gewebeproben geschnitten werden und im weiteren Verlauf auf Objektträgern weiter bearbeitet werden, soll eine weitestgehende Automatisierung erreicht werden. Dies wird dadurch erreicht, dass die Gewebeproben in einem automatischen Verfahren von einem Verfahrensschritt zum nächsten bewegt werden und dabei zunächst ein mit automatisch lesbaren Informationen bedruckten Objektträger zugeführt wird, auf den Objektträger eine Gewebeprobe aufgelegt wird, die Gewebeprobe auf dem Objektträger geschnitten wird, das Restgewebe von dem Objektträger abgenommen wird, mindestens ein weiterer Bearbeitungsschritt der Gewebeprobe auf dem Objektträger durchgeführt wird und abschließend der Objektträger mit der bearbeiteten Probe aus denn automatischen Prozess ausgeschleust wird.
PCT/DE2013/000547 2012-10-04 2013-09-27 Verfahren und vorrichtung zur bearbeitung histologischer gewebeproben WO2014053111A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB1505265.7A GB2521561A (en) 2012-10-04 2013-09-27 Method and device for processing histological tissue samples
CN201380051825.XA CN104838247B (zh) 2012-10-04 2013-09-27 用于加工组织学的组织试样的方法和设备
US14/433,607 US20150260619A1 (en) 2012-10-04 2013-09-27 Method and Device for Processing Histological Tissue Samples

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102012019438.2 2012-10-04
DE102012019438.2A DE102012019438B4 (de) 2012-10-04 2012-10-04 Verfahren und Vorrichtung zur Bearbeitung histologischer Gewebeproben

Publications (2)

Publication Number Publication Date
WO2014053111A2 WO2014053111A2 (de) 2014-04-10
WO2014053111A3 true WO2014053111A3 (de) 2014-06-19

Family

ID=49724926

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2013/000547 WO2014053111A2 (de) 2012-10-04 2013-09-27 Verfahren und vorrichtung zur bearbeitung histologischer gewebeproben

Country Status (5)

Country Link
US (1) US20150260619A1 (de)
CN (1) CN104838247B (de)
DE (1) DE102012019438B4 (de)
GB (1) GB2521561A (de)
WO (1) WO2014053111A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6455829B2 (ja) * 2013-04-01 2019-01-23 キヤノン株式会社 画像処理装置、画像処理方法、およびプログラム
CN107615073A (zh) * 2015-05-20 2018-01-19 沃拉克有限公司 用于处理样品载体卡的方法和设备
US10571368B2 (en) 2015-06-30 2020-02-25 Clarapath, Inc. Automated system and method for advancing tape to transport cut tissue sections
US10473557B2 (en) 2015-06-30 2019-11-12 Clarapath, Inc. Method, system, and device for automating transfer of tape to microtome sections
US10724929B2 (en) 2016-05-13 2020-07-28 Clarapath, Inc. Automated tissue sectioning and storage system
CN106771288B (zh) * 2017-01-20 2018-06-01 安徽理工大学 一种结核分支杆菌自动检测设备
JP7236358B2 (ja) * 2019-09-04 2023-03-09 平田機工株式会社 標本作製装置

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2004061425A1 (de) * 2003-01-04 2004-07-22 Rowiak Gmbh Mikrotom
US20060139621A1 (en) * 2001-11-05 2006-06-29 Baer Thomas M Automated microdissection instrument
EP1985984A1 (de) * 2006-02-13 2008-10-29 Seiko Instruments Inc. Automatisches gerät zur herstellung von scheibenförmigen proben, und automatisches verfahren zur herstellung von scheibenförmigen proben

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US6387653B1 (en) * 1999-04-09 2002-05-14 Culterra, Llc Apparatus and method for automatically producing tissue slides
DE10152404C5 (de) * 2001-10-24 2017-06-08 Carl Zeiss Microscopy Gmbh Laser-Mikrodissektionssystem
DE10154843A1 (de) * 2001-11-08 2003-05-28 Microm Int Gmbh Verfahren und Vorrichtung zur Kennzeichnung von Objektträgern für mikrotomierte Gewebeproben und deren Bearbeitung
DE102005028062C5 (de) * 2005-06-16 2015-10-22 Leica Microsystems Cms Gmbh Laser-Mikrodissektionsverfahren und Vorrichtung zur Laser-Mikrodissektion
DE102005039833A1 (de) 2005-08-22 2007-03-01 Rowiak Gmbh Vorrichtung und Verfahren zur Materialtrennung mit Laserpulsen
JP4674810B2 (ja) * 2005-12-28 2011-04-20 セイコーインスツル株式会社 自動薄切片標本作製装置及び自動薄切片標本作製方法
US7657070B2 (en) 2006-01-20 2010-02-02 Sakura Finetek U.S.A., Inc. Automated system of processing biological specimens and method
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Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
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WO2004061425A1 (de) * 2003-01-04 2004-07-22 Rowiak Gmbh Mikrotom
EP1985984A1 (de) * 2006-02-13 2008-10-29 Seiko Instruments Inc. Automatisches gerät zur herstellung von scheibenförmigen proben, und automatisches verfahren zur herstellung von scheibenförmigen proben

Also Published As

Publication number Publication date
GB201505265D0 (en) 2015-05-13
CN104838247B (zh) 2017-06-20
GB2521561A (en) 2015-06-24
WO2014053111A2 (de) 2014-04-10
DE102012019438A1 (de) 2014-04-10
US20150260619A1 (en) 2015-09-17
CN104838247A (zh) 2015-08-12
DE102012019438B4 (de) 2015-05-21

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