WO2014051037A1 - Tube body, blood collection tube, and method for manufacturing tube body - Google Patents

Tube body, blood collection tube, and method for manufacturing tube body Download PDF

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Publication number
WO2014051037A1
WO2014051037A1 PCT/JP2013/076225 JP2013076225W WO2014051037A1 WO 2014051037 A1 WO2014051037 A1 WO 2014051037A1 JP 2013076225 W JP2013076225 W JP 2013076225W WO 2014051037 A1 WO2014051037 A1 WO 2014051037A1
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WO
WIPO (PCT)
Prior art keywords
tube
blood collection
outer diameter
tubular body
plug
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Application number
PCT/JP2013/076225
Other languages
French (fr)
Japanese (ja)
Inventor
雅敏 丹生谷
隆介 岡本
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積水メディカル株式会社
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Priority to JP2014538623A priority Critical patent/JPWO2014051037A1/en
Publication of WO2014051037A1 publication Critical patent/WO2014051037A1/en

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150351—Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150732—Needle holders, for instance for holding the needle by the hub, used for example with double-ended needle and pre-evacuated tube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/15003—Source of blood for venous or arterial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150259—Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150473—Double-ended needles, e.g. used with pre-evacuated sampling tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150572—Pierceable protectors, e.g. shields, caps, sleeves or films, e.g. for hygienic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A61B5/154—Devices using pre-evacuated means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0858—Side walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se

Definitions

  • the present invention relates to a body for a body fluid collection tube, a blood collection tube, and a method for manufacturing the body, and more particularly, a body fluid collection tube having an opening sealed and used by being inserted into a cylindrical blood collection holder.
  • the present invention relates to a blood collection tube and a method for manufacturing a tubular body.
  • a blood collection tube or the like is used to collect body fluid such as blood.
  • a general blood collection tube has a cylindrical tube body having one end opened and the other end bottomed. The open end of the tube is closed by a plug such as a rubber plug.
  • a plug used for the blood collection tube a plug having a cover portion that covers the outer peripheral surface of the opening end portion of the tubular body as well as a portion press-fitted into the opening of the tubular body has been used.
  • the cover portion is sheathed in the vicinity of the opening end of the tube body. Therefore, the maximum outer diameter of the blood collection tube increases at the portion where the cover portion is located.
  • the inner diameter of the part into which the blood collection tube of the blood collection holder is inserted is determined by the standard. If the diameter of the tube of the blood collection tube is increased in order to secure a large volume of body fluid, the maximum outer diameter portion of the blood collection tube becomes too large. In particular, when a highly safe stopper with a cover is attached to a tube, the maximum outer diameter portion of the blood collection tube becomes considerably large. For this reason, the maximum outer diameter of the blood collection tube becomes too larger than the inner diameter of the blood collection holder, and cannot be inserted into such a blood collection holder.
  • the conventional blood collection tube has a problem that when it is placed in a low temperature environment such as when the sample is stored frozen, the strength is lowered and the sample is easily damaged.
  • a cylindrical tube with a bottom that has an open end closed with a stopper and is inserted into a holder and used for collecting body fluid.
  • one end is an open end and the other end is a closed bottom.
  • the outer diameter of the opening end side portion connected to the opening end is a small diameter portion that is smaller than the outer diameter of the remaining portion.
  • the remaining portion is a large diameter portion having a relatively large outer diameter.
  • the tubular body of the present invention is a molded body obtained by injection blow molding of synthetic resin.
  • the length of the small-diameter portion is longer than the length of the portion of the plug body that is sheathed around the tubular body.
  • at least a part of the thickness of the portion of the plug body that is sheathed on the tube body can be absorbed by the difference in outer diameter between the large diameter portion and the small diameter portion. Therefore, the size of the maximum outer diameter portion can be reduced.
  • a blood collection tube according to the present invention is a blood collection tube that is inserted into a holder and used for collecting body fluid, and is a tube configured according to the present invention, inserted into the open end of the tube, and the tube A plug body having a portion that is sheathed on the small-diameter portion.
  • the length of the small diameter portion is longer than the length of the exterior portion of the plug.
  • the tube manufacturing method according to the present invention is a tube manufacturing method configured in accordance with the present invention, wherein a synthetic resin is injection-molded, one end is an open end, and the other end is closed
  • a step of obtaining a cylindrical preform, and the preform is mounted on a mold to which an opening end side portion is fixed, and the preform is injected into the preform from the opening end side while injecting gas into the preform.
  • the outer diameter of the opening end side portion is a small-diameter portion made smaller than the outer diameter of the remaining portion, and the remaining portion is formed by injection blow molding of synthetic resin. Since it is a large-diameter portion having a relatively large outer diameter, even if a plug body with a thick wall portion is attached to the opening end of the pipe body, The outer diameter of the maximum outer diameter portion of the attached blood collection tube can be reduced. Therefore, even when the diameter of the large-diameter portion is increased to increase the volume of blood or body fluid to be collected, the tube is closed using a thick plug body with an excellent exterior portion. Can be made. Therefore, it is possible to achieve both improvement in safety and increase in the sample capacity.
  • FIGS. 3A and 3B are a front view and a front sectional view for explaining a step of inserting the blood collection tube of the embodiment of the present invention into the blood collection holder.
  • FIGS. 1A and 1B are a front sectional view and a front view of a tubular body according to an embodiment of the present invention.
  • the tube 1 is an open end 1a having an opening at one end.
  • the other end is closed as a hemispherical bottom. And the whole is a substantially cylindrical shape.
  • the small-diameter portion 1b having a relatively small outer diameter and the large-diameter portion 1c having a relatively large outer diameter are connected to the open end 1a in the vicinity of the open end 1a.
  • the direction connecting the open end 1a and the bottom is the length direction.
  • the tube 1 can be manufactured by injection blow molding of synthetic resin.
  • the injection blow molding of the present invention includes a preform process and a blow molding process described below as essential processes. As an example, each process of injection blow molding will be described.
  • Preform A cylindrical injection-molded preform is molded by injection molding of synthetic resin.
  • This preform has a cylindrical shape in which one end is an open end and the other end is closed. That is, the outer diameter of the cylindrical portion is constant.
  • the plastic preform obtained in the previous step is mounted on a mold and molded while injecting air from the mouth. More specifically, a mold capable of fixing the opening end and the vicinity of the opening end of the preform so that the diameter does not change is prepared as a mold. A preform is set in this mold, a gas such as air is injected from the opening end, and the shape is changed so as to increase the diameter of the large diameter portion. That is, the shape of the preform is changed so as to spread radially outward from the central axis of the tube, and the tube 1 shown in FIGS. 1A and 1B can be obtained.
  • the ratio C2 / C1 between the outer diameter C2 of the large diameter portion 1c and the outer diameter C1 of the small diameter portion 1b shown in FIG. 1 (a) is preferably 1.1 to 1.5. In order for this ratio to exceed 1.5, it is necessary to relatively increase the outer diameter of the large diameter portion, but it becomes difficult to insert a widely used automatic analyzer into the tube rack. Further, if this ratio is smaller than 1.1, the thickness of the portion of the plug body that is sheathed on the tube body cannot be increased so much, and it is desirable that the ratio is 1.1 to 1.5.
  • the outer diameter C1 of the small diameter portion is 11 to 14 mm
  • the outer diameter C2 of the large diameter portion is 14 to 17 mm
  • the tube length is 95 to 105 mm.
  • the average thickness of a pipe body be an average value of the thickness obtained by measuring 10 places at intervals of 8 mm from the position which went down from the opening part of the pipe body to 20 mm.
  • the tube average thickness of the tube of the present invention is preferably 0.5 to 1.5 mm. If the thickness is less than 0.5 mm, there is a problem that sufficient strength cannot be secured. If the thickness is more than 1.5 mm, it is difficult to secure a sufficient amount of sample collection because the internal volume is reduced, so 0.5 to 1 .5mm is desirable.
  • the length C5 of the small diameter portion 1b is preferably 5 to 20 mm, and the length C6 of the large diameter portion 1c is preferably 80 to 95 mm.
  • FIGS. 2A and 2B show an example of such a plug.
  • the plug body 11 has a plug body 12 made of rubber, elastomer or the like.
  • the lower end portion of the plug body 12 is a portion that is press-fitted into the open end of the tube body.
  • a cover member 13 is attached to the outside of the plug body 12.
  • the cover member 13 has an annular flange portion 13a having a through hole in the center and a cover portion 13b extending downward from the outer peripheral edge of the annular flange portion 13a, which is located on the upper surface of the plug body 12.
  • the cover portion 13 b is a portion that is externally attached to the small diameter portion 1 b of the tube body 1 when the plug body 11 is attached to the tube body 1. Since the cover portion 13b is provided, even when blood is about to scatter when the cover portion 13b is detached from the tube body 1, it is regulated by the cover portion 13b. Therefore, the safety of the inspection worker can be improved.
  • the maximum outer diameter of the blood collection tube is increased by the thickness of the cover portion 13b.
  • the outer diameter of the small diameter portion 1b is made smaller than that of the large diameter portion 1c. Therefore, at least a part of the thickness of the cover portion 13b can be absorbed by the difference in the outer diameter.
  • the plug body provided with such a cover is an overcap type plug body.
  • An overcap type plug body has a greater effect of preventing blood scattering at the time of opening than when a rubber plug type or film plug type plug body is used.
  • a blood collection tube safer for the handler can be provided.
  • the blood collection tube of the present embodiment has a structure in which the plug 11 is attached to the tube 1 as shown in FIGS. 3 (a) and 3 (b).
  • the exterior portion of the plug body 11, that is, the cover portion 13 b is located outside the outer peripheral surface of the small diameter portion 1 b of the tube body 1.
  • the blood collection tube is inserted from the opening below the blood collection holder 21.
  • the blood collection holder that can use the blood collection tube of the present invention, but a blood collection holder having an inner diameter of 17 mm to 18 mm can be particularly preferably used. Since the internal diameter of blood collection holders widely used in Japan is 17 mm, the tube of the present invention can be used in many holders used in Japan.
  • the tubular body of the present invention manufactured by blow molding so as to have the above-described structure has a characteristic that the impact strength at ⁇ 20 ° C. is higher than that of the tubular body manufactured by injection molding. Can be handled safely with little damage.
  • Example 1 An injection molded preform having a tube body outer diameter of 13 mm was prepared using PET resin as a raw material. The obtained preform is heated and blow-molded, the tube small diameter part outer diameter C1 is 13 mm, the large diameter part maximum outer diameter C2 is 16 mm, the tube length is 100 mm, and the tube average wall thickness is 0.8 mm. Body 1 was obtained. The ratio C2 / C1 between the maximum outer diameter and the outer diameter of the small diameter portion of the obtained tube 1 was 1.2.
  • Comparative Example 2 A PET resin was used as a raw material, and one end was opened as in Comparative Example 1 by injection molding to obtain a cylindrical tube with a bottom.
  • the outer diameter of the tube was 16 mm, the tube length was 100 mm, and the tube average thickness was 1 mm.
  • overcap type plug can be fitted
  • An overcap type plug body having a maximum outer diameter of the cover portion of 16.6 mm and a cover portion made of PE resin was fitted.
  • the obtained tube was subjected to an impact test using a 3 kg weight in a low temperature environment of ⁇ 20 ° C. in accordance with JIS K7211-1 “Plastic-Hard Plastic Puncture Impact Test Method”. Among these, the impact strength at which 50% of the pipes to be measured were destroyed was defined as 50% fracture energy, and the value was measured. Based on the obtained value, the case where the 50% fracture energy exceeded 10 J was evaluated as “Good”, and the case where it did not exceed was evaluated as “Poor”.
  • the tube of the present invention manufactured by blow molding had a characteristic that the impact strength at ⁇ 20 ° C. was higher than that of the tube manufactured by injection molding.

Abstract

Provided is a tube body that enables the volume of the collected sample to be increased, can be applied to a plug body having a cover part having a large wall thickness, and has a higher impact resistance at low temperatures. A tube body (1) used through being inserted into a blood collection holder, wherein one end is an opening end (1a), the other end is a closed bottom part, and the outer diameter of a small-diameter part continuous from the opening end (1a) is formed so as to be smaller than the outer diameter of a large diameter part (1c) which is the remaining portion, the tube body (1) comprising a molded article obtained by performing injection blow molding on a synthetic resin.

Description

管体、採血管及び管体の製造方法Tubular body, blood collection tube, and method of manufacturing the tubular body
　本発明は、体液採取チューブ用の管体、採血管及び管体の製造方法に関し、より詳細には、筒状の採血ホルダーに挿入して用いる、開口部が密栓された体液採取用の管体、採血管及び管体の製造方法に関する。 The present invention relates to a body for a body fluid collection tube, a blood collection tube, and a method for manufacturing the body, and more particularly, a body fluid collection tube having an opening sealed and used by being inserted into a cylindrical blood collection holder. The present invention relates to a blood collection tube and a method for manufacturing a tubular body.
　血液などの体液を採取するために、採血管等が用いられている。一般的な採血管は、一端が開口されておりかつ他端が有底の円筒状の管体を有する。この管体の開口端がゴム栓などの栓体により閉じられている。 A blood collection tube or the like is used to collect body fluid such as blood. A general blood collection tube has a cylindrical tube body having one end opened and the other end bottomed. The open end of the tube is closed by a plug such as a rubber plug.
　下記の特許文献１～２に示すように、従来、上記管体として円筒状の有底の管体が広く用いられている。 As shown in Patent Documents 1 and 2 below, a cylindrical bottomed tubular body has been widely used as the tubular body.
特許第４１９８３０９号公報Japanese Patent No. 4198309 特開平６－１６５７７２号公報Japanese Patent Laid-Open No. 6-165572
　昨今の検査項目数の増加等の要因によって、医療現場ではより大容量の体液を採取できるような管体のニーズが高まっている。 Due to factors such as the recent increase in the number of examination items, there is an increasing need for a tube that can collect a larger volume of body fluid in the medical field.
　ところで、採血等においては、検査従事者の安全性を確保する必要がある。そのため、上記採血管に用いられる栓体として、管体の開口部に圧入される部分だけでなく、管体の開口端部分の外周面を被覆するカバー部を有する栓体が用いられてきている。このような栓体では、カバー部が管体の開口端近傍部分に外装されることになる。そのため、カバー部が位置している部分において、採血管の最大外径が大きくなる。 By the way, in the blood collection, it is necessary to ensure the safety of the laboratory staff. Therefore, as a plug used for the blood collection tube, a plug having a cover portion that covers the outer peripheral surface of the opening end portion of the tubular body as well as a portion press-fitted into the opening of the tubular body has been used. . In such a plug body, the cover portion is sheathed in the vicinity of the opening end of the tube body. Therefore, the maximum outer diameter of the blood collection tube increases at the portion where the cover portion is located.
　他方、採血ホルダーの採血管が挿入される部分の内径は、規格により定まっている。大容量の体液を確保するために、採血管の管体の径を太くすると、採血管の最大外径部分が大きくなりすぎる。特に、上記カバー部付きの安全性に優れた栓体を管体に装着すると、採血管の最大外径部分はかなり大きくなる。そのため、採血ホルダーの内径よりも採血管の最大外径が大きくなりすぎ、このような採血ホルダーに挿入することができなくなる。 On the other hand, the inner diameter of the part into which the blood collection tube of the blood collection holder is inserted is determined by the standard. If the diameter of the tube of the blood collection tube is increased in order to secure a large volume of body fluid, the maximum outer diameter portion of the blood collection tube becomes too large. In particular, when a highly safe stopper with a cover is attached to a tube, the maximum outer diameter portion of the blood collection tube becomes considerably large. For this reason, the maximum outer diameter of the blood collection tube becomes too larger than the inner diameter of the blood collection holder, and cannot be inserted into such a blood collection holder.
　そのため、従来、安全性に優れたカバー部付きの栓体ではなく、最大外径部分の増大を招かないゴム栓やフィルム状の栓が管体の開口端を閉じるために用いられてきている。しかしながら、これらの栓体では、開封時に体液や血液が飛散しやすいという問題がある。 Therefore, conventionally, a rubber plug or a film-like plug that does not cause an increase in the maximum outer diameter portion has been used to close the open end of the tube, instead of a plug with a cover portion excellent in safety. However, these plugs have a problem that body fluid and blood are likely to scatter when opened.
　上記のとおり、従来、検査者の安全性の確保と、血液や体液の採取量の大容量化との両立を果たすことは困難であった。 As described above, conventionally, it has been difficult to ensure both the safety of the examiner and the increase in the volume of collected blood and body fluid.
　また、従来の採血管では、サンプルを凍結保存する場合などのような低温環境下に置かれると、強度が低下し、取扱い等により破損しやすいという問題もあった。 In addition, the conventional blood collection tube has a problem that when it is placed in a low temperature environment such as when the sample is stored frozen, the strength is lowered and the sample is easily damaged.
　本発明の目的は、管体に外装される部分の肉厚が厚い栓体を用いた場合であっても、採血ホルダーに挿入することが可能であり、検体の大容量化及び安全性の両立を図り得る管体、採血管及び該管体の製造方法を提供することにある。また、本発明の他の目的は、低温下における耐衝撃性が高められた管体、該管体を有する採血管及び管体の製造方法を提供することにある。 The object of the present invention is to be able to be inserted into a blood collection holder even when a plug body with a thick portion of the outer portion of the tube is used, and it is possible to achieve both large capacity and safety of the specimen. It is an object to provide a tube body, a blood collection tube, and a method for manufacturing the tube body. Another object of the present invention is to provide a tubular body with improved impact resistance at low temperatures, a blood collection tube having the tubular body, and a method for producing the tubular body.
　本発明のある広い局面によれば、開口端が栓体で閉じられ、かつホルダーに挿入されて体液の採取に用いられる、有底の円筒状の管体が提供される。本発明の管体では、一端が開口端であって、他端が閉じられた底部である。開口端に連なる開口端側部分の外径が残りの部分の外径よりも小さくされている小径部とされている。残りの部分が、相対的に外径の大きな大径部とされている。本発明の管体は、合成樹脂の射出ブロー成型により得られた成型体からなる。 According to a wide aspect of the present invention, there is provided a cylindrical tube with a bottom that has an open end closed with a stopper and is inserted into a holder and used for collecting body fluid. In the tubular body of the present invention, one end is an open end and the other end is a closed bottom. The outer diameter of the opening end side portion connected to the opening end is a small diameter portion that is smaller than the outer diameter of the remaining portion. The remaining portion is a large diameter portion having a relatively large outer diameter. The tubular body of the present invention is a molded body obtained by injection blow molding of synthetic resin.
　本発明に係る管体のある特定の局面では、前記小径部の長さが、前記栓体の前記管体の周囲に外装されている部分の長さよりも長い。この場合には、栓体の管体へ外装される部分の肉厚の少なくとも一部が、上記大径部と小径部との外径の差により吸収され得る。従って、最大外径部分の大きさを小さくすることができる。 In a specific aspect of the tubular body according to the present invention, the length of the small-diameter portion is longer than the length of the portion of the plug body that is sheathed around the tubular body. In this case, at least a part of the thickness of the portion of the plug body that is sheathed on the tube body can be absorbed by the difference in outer diameter between the large diameter portion and the small diameter portion. Therefore, the size of the maximum outer diameter portion can be reduced.
　本発明に係る採血管は、ホルダーに挿入され、体液の採取に用いられる採血管であって、本発明に従って構成された管体と、前記管体の前記開口端に挿入され、かつ前記管体の前記小径部分に外装されている部分を有する栓体とを備える。 A blood collection tube according to the present invention is a blood collection tube that is inserted into a holder and used for collecting body fluid, and is a tube configured according to the present invention, inserted into the open end of the tube, and the tube A plug body having a portion that is sheathed on the small-diameter portion.
　本発明に係る採血管のある特定の局面では、前記小径部の長さが、前記栓体の前記外装部分の長さよりも長い。 In a specific aspect of the blood collection tube according to the present invention, the length of the small diameter portion is longer than the length of the exterior portion of the plug.
　本発明に係る管体の製造方法では、本発明に従って構成された管体の製造方法であって、合成樹脂を射出成型し、一端が開口端とされており、他端が閉じられた有底部とされている円筒状のプリフォームを得る工程と、前記プリフォームを開口端側部分が固定される金型に装着し、開口端側からプリフォーム内部にガスを注入しつつ、プリフォームを上記開口端側部分を除く部分において長さ方向中心軸部分を中心として径方向外側に膨らませ、大径部分を形成する工程とを備える射出ブロー成型からなる。 The tube manufacturing method according to the present invention is a tube manufacturing method configured in accordance with the present invention, wherein a synthetic resin is injection-molded, one end is an open end, and the other end is closed A step of obtaining a cylindrical preform, and the preform is mounted on a mold to which an opening end side portion is fixed, and the preform is injected into the preform from the opening end side while injecting gas into the preform. And a step of inflating radially outward with a central axis portion in the length direction as a center in a portion excluding the opening end side portion to form a large diameter portion.
　本発明に係る管体によれば、合成樹脂の射出ブロー成型からなり、開口端側部分の外径が残りの部分の外径よりも小さくされている小径部とされており、残りの部分が相対的に外径の大きな大径部とされているため、管体の開口端に装着される栓体として管体に外装される部分の肉厚が厚い栓体を用いたとしても、栓体付きの採血管の最大外径部分の外径を小さくすることができる。従って、大径部分の径を大きくし、採取する血液や体液の大容量化を図った場合であっても、安全性に優れた外装部分の肉厚の厚い栓体を用いて管体を閉成することができる。よって、安全性の向上と、試料の大容量化の両立を図ることが可能となる。 According to the tubular body according to the present invention, the outer diameter of the opening end side portion is a small-diameter portion made smaller than the outer diameter of the remaining portion, and the remaining portion is formed by injection blow molding of synthetic resin. Since it is a large-diameter portion having a relatively large outer diameter, even if a plug body with a thick wall portion is attached to the opening end of the pipe body, The outer diameter of the maximum outer diameter portion of the attached blood collection tube can be reduced. Therefore, even when the diameter of the large-diameter portion is increased to increase the volume of blood or body fluid to be collected, the tube is closed using a thick plug body with an excellent exterior portion. Can be made. Therefore, it is possible to achieve both improvement in safety and increase in the sample capacity.
　加えて、上記小径部と大径部が連ねられた構造を有するため、低温下における耐衝撃性を高めることも可能となる。 In addition, since the small-diameter portion and the large-diameter portion are connected to each other, it is possible to improve impact resistance at low temperatures.
図１（ａ）及び（ｂ）は、本発明の一実施形態に係る管体の正面断面図及び正面図である。1A and 1B are a front sectional view and a front view of a tubular body according to an embodiment of the present invention. 図２（ａ）及び（ｂ）は、本発明の一実施形態で用いられる栓体の正面図及び正面断面図である。2 (a) and 2 (b) are a front view and a front sectional view of a plug used in one embodiment of the present invention. 図３（ａ）及び（ｂ）は、本発明の一実施形態の採血管を採血ホルダーに挿入する工程を説明するための正面図及び正面断面図である。FIGS. 3A and 3B are a front view and a front sectional view for explaining a step of inserting the blood collection tube of the embodiment of the present invention into the blood collection holder.
　以下、図面を参照しつつ、本発明の具体的な実施形態を説明することにより、本発明を明らかにする。 Hereinafter, the present invention will be clarified by describing specific embodiments of the present invention with reference to the drawings.
　図１（ａ）及び（ｂ）は、本発明の一実施形態に係る管体の正面断面図及び正面図である。 FIGS. 1A and 1B are a front sectional view and a front view of a tubular body according to an embodiment of the present invention.
　管体１は、一端が開口を有する開口端１ａである。他端が半球状の底部として閉じられている。そして、全体が略円筒状である。もっとも、開口端１ａ近傍の開口端１ａに連なり、外径が相対的に小さい小径部１ｂと、相対的に外径の大きな大径部１ｃとが連ねられている。開口端１ａと底部とを結ぶ方向を長さ方向とする。 The tube 1 is an open end 1a having an opening at one end. The other end is closed as a hemispherical bottom. And the whole is a substantially cylindrical shape. However, the small-diameter portion 1b having a relatively small outer diameter and the large-diameter portion 1c having a relatively large outer diameter are connected to the open end 1a in the vicinity of the open end 1a. The direction connecting the open end 1a and the bottom is the length direction.
　上記管体１は、合成樹脂の射出ブロー成型により製造することができる。本発明の射出ブロー成型は、以下に述べるプリフォーム工程と、ブロー成型工程とを必須の工程として備える。一例として、射出ブロー成型の各工程を説明する。 The tube 1 can be manufactured by injection blow molding of synthetic resin. The injection blow molding of the present invention includes a preform process and a blow molding process described below as essential processes. As an example, each process of injection blow molding will be described.
　（１）プリフォーム
　合成樹脂の射出成型により、円筒状の射出成型プリフォームを成型する。このプリフォームは、一端が開口端であり、他端が閉じられている円筒状の形状を有する。すなわち、円筒状の部分の外径は一定とされている。 (1) Preform A cylindrical injection-molded preform is molded by injection molding of synthetic resin. This preform has a cylindrical shape in which one end is an open end and the other end is closed. That is, the outer diameter of the cylindrical portion is constant.
　（２）プリフォーム加熱
　前工程で生産されたプリフォームを加熱し、可塑性を増す。 (2) Preform heating The preform produced in the previous step is heated to increase plasticity.
　（３）ブロー成型
　前工程で得られた可塑性を有するプリフォームを金型に装着し、口部より空気を注入しつつ成型する。より具体的には、金型として、プリフォームの開口端及び開口端近傍部分を径が変化しないように固定し得る金型を用意する。この金型にプリフォームをセットし、開口端から空気などのガスを注入し、大径部の径が大きくなるように形状を変化させ、成型する。すなわち、管体の中心軸から径方向外側に広がるようにプリフォームの形状を変化させ、図１（ａ）及び（ｂ）に示した管体１を得ることができる。 (3) Blow molding The plastic preform obtained in the previous step is mounted on a mold and molded while injecting air from the mouth. More specifically, a mold capable of fixing the opening end and the vicinity of the opening end of the preform so that the diameter does not change is prepared as a mold. A preform is set in this mold, a gas such as air is injected from the opening end, and the shape is changed so as to increase the diameter of the large diameter portion. That is, the shape of the preform is changed so as to spread radially outward from the central axis of the tube, and the tube 1 shown in FIGS. 1A and 1B can be obtained.
　（４）排出
　金型から成型された管体１を外し、冷却する。 (4) Discharge The tube 1 molded from the mold is removed and cooled.
　図１（ａ）に示す大径部１ｃの外径Ｃ２と、小径部１ｂの外径Ｃ１との比Ｃ２／Ｃ１は、１．１～１．５であることが望ましい。この比が１．５を超えるには、相対的に大径部の外径を大きくする必要があるが、広く用いられている自動分析装置の管体ラックへの挿入が難しくなる。また、この比を１．１より小さくすると、栓体の管体へ外装される部分の肉厚をあまり厚くできないため、１．１～１．５である事が望ましい。 The ratio C2 / C1 between the outer diameter C2 of the large diameter portion 1c and the outer diameter C1 of the small diameter portion 1b shown in FIG. 1 (a) is preferably 1.1 to 1.5. In order for this ratio to exceed 1.5, it is necessary to relatively increase the outer diameter of the large diameter portion, but it becomes difficult to insert a widely used automatic analyzer into the tube rack. Further, if this ratio is smaller than 1.1, the thickness of the portion of the plug body that is sheathed on the tube body cannot be increased so much, and it is desirable that the ratio is 1.1 to 1.5.
　具体的な数値としては、小径部の外径Ｃ１は１１～１４ｍｍ、大径部の外径Ｃ２は１４～１７ｍｍ、管長は９５～１０５ｍｍがそれぞれ望ましい。この範囲内の値にすることにより、広く用いられている自動分析装置の搬送装置に適用することが可能となり、従来の管体と同様の検査用途に使用することができる。 Specifically, it is desirable that the outer diameter C1 of the small diameter portion is 11 to 14 mm, the outer diameter C2 of the large diameter portion is 14 to 17 mm, and the tube length is 95 to 105 mm. By setting the value within this range, it can be applied to a widely used transport device of an automatic analyzer, and can be used for inspection purposes similar to a conventional tube.
　なお、管体の平均肉厚は、管体開口部より２０ｍｍ底部へ下がった位置より８ｍｍ間隔で１０箇所で測定して得られた肉厚の平均値とする。 In addition, let the average thickness of a pipe body be an average value of the thickness obtained by measuring 10 places at intervals of 8 mm from the position which went down from the opening part of the pipe body to 20 mm.
　本発明の管体の管体平均肉厚は０．５～１．５ｍｍであることが望ましい。０．５ｍｍより薄くすると、充分な強度を確保できない問題があり、１．５ｍｍより厚くすると、内容積が少なくなることで充分な検体採取量を確保することが難しくなるため、０．５～１．５ｍｍであることが望ましい。 The tube average thickness of the tube of the present invention is preferably 0.5 to 1.5 mm. If the thickness is less than 0.5 mm, there is a problem that sufficient strength cannot be secured. If the thickness is more than 1.5 mm, it is difficult to secure a sufficient amount of sample collection because the internal volume is reduced, so 0.5 to 1 .5mm is desirable.
　小径部１ｂの長さＣ５は５～２０ｍｍ、大径部１ｃの長さＣ６は８０～９５ｍｍであることがそれぞれ好ましい。ただし、広く用いられている自動分析装置において搬送装置に適用させるためには、Ｃ５＋Ｃ６＝１００±５ｍｍの式が成立する必要がある。また、小径部１ｂの長さＣ５が長すぎると、大径部１ｃを短くしなければならない。従って、内容積が少なくなり、充分な検体採取量を確保することが難しくなる。 The length C5 of the small diameter portion 1b is preferably 5 to 20 mm, and the length C6 of the large diameter portion 1c is preferably 80 to 95 mm. However, in order to apply it to a transport apparatus in a widely used automatic analyzer, the formula of C5 + C6 = 100 ± 5 mm needs to be established. If the length C5 of the small diameter portion 1b is too long, the large diameter portion 1c must be shortened. Accordingly, the internal volume is reduced, and it is difficult to secure a sufficient amount of sample collection.
　本発明の管体に使用できる栓体としては特に制限はないが、一体化された上部フランジを有する環状キャップ部と、キャップ部外面に被さるカバー部から構成された、いわゆるオーバーキャップタイプの栓体がより好適に使用できる。図２（ａ）及び（ｂ）に、このような栓体の一例を示す。 Although there is no restriction | limiting in particular as a plug body which can be used for the pipe body of this invention, The so-called overcap type plug body comprised from the cyclic | annular cap part which has an integrated upper flange, and the cover part which covers a cap part outer surface. Can be used more suitably. FIGS. 2A and 2B show an example of such a plug.
　図２（ａ）及び（ｂ）に示すように、栓体１１は、ゴムやエラストマーなどからなる栓本体１２を有する。栓本体１２の下端部分は、管体の開口端に圧入される部分である。 2 (a) and 2 (b), the plug body 11 has a plug body 12 made of rubber, elastomer or the like. The lower end portion of the plug body 12 is a portion that is press-fitted into the open end of the tube body.
　栓本体１２の外側に、カバー部材１３が装着されている。カバー部材１３は、栓本体１２の上面に位置している、中央に貫通孔を有する円環状のフランジ部１３ａと、円環状のフランジ部１３ａの外周縁から下方に延びるカバー部１３ｂを有する。カバー部１３ｂは、栓体１１が管体１に装着された際に、管体１の小径部１ｂに外装される部分である。このカバー部１３ｂが設けられているため、管体１から取り外した際に、血液が飛び散ろうとしたとしても、カバー部１３ｂにより規制される。そのため、検査従事者の安全性を高めることができる。 A cover member 13 is attached to the outside of the plug body 12. The cover member 13 has an annular flange portion 13a having a through hole in the center and a cover portion 13b extending downward from the outer peripheral edge of the annular flange portion 13a, which is located on the upper surface of the plug body 12. The cover portion 13 b is a portion that is externally attached to the small diameter portion 1 b of the tube body 1 when the plug body 11 is attached to the tube body 1. Since the cover portion 13b is provided, even when blood is about to scatter when the cover portion 13b is detached from the tube body 1, it is regulated by the cover portion 13b. Therefore, the safety of the inspection worker can be improved.
　上記栓体１１では、カバー部１３ｂが設けられているため、カバー部１３ｂの肉厚分だけ、採血管の最大外径が大きくなる。 In the plug body 11, since the cover portion 13b is provided, the maximum outer diameter of the blood collection tube is increased by the thickness of the cover portion 13b.
　しかしながら、本実施形態では、上記小径部１ｂの外径が大径部１ｃよりも小さくされている。従って、上記カバー部１３ｂの肉厚の少なくとも一部を、上記外径の差により吸収することができる。 However, in the present embodiment, the outer diameter of the small diameter portion 1b is made smaller than that of the large diameter portion 1c. Therefore, at least a part of the thickness of the cover portion 13b can be absorbed by the difference in the outer diameter.
　このようなカバー部が設けられている栓体をオーバーキャップタイプの栓体というものとする。オーバーキャップタイプの栓体では、ゴム栓タイプやフィルム栓タイプの栓体を用いた場合よりも開封時の血液の飛散を防止する効果が大きい。取扱者にとってより安全な採血管を提供することができる。 Suppose that the plug body provided with such a cover is an overcap type plug body. An overcap type plug body has a greater effect of preventing blood scattering at the time of opening than when a rubber plug type or film plug type plug body is used. A blood collection tube safer for the handler can be provided.
　本実施形態の採血管は、図３（ａ）及び（ｂ）に示すように、上記管体１に上記栓体１１が装着されている構造を有する。ここでは、栓体１１の外装部分、すなわちカバー部１３ｂが、管体１の小径部１ｂの外周面の外側に位置していることになる。 The blood collection tube of the present embodiment has a structure in which the plug 11 is attached to the tube 1 as shown in FIGS. 3 (a) and 3 (b). Here, the exterior portion of the plug body 11, that is, the cover portion 13 b is located outside the outer peripheral surface of the small diameter portion 1 b of the tube body 1.
　図３（ａ）及び（ｂ）に示すように、使用に際しては、採血ホルダー２１の下方の開口から上記採血管を挿入する。 As shown in FIGS. 3A and 3B, in use, the blood collection tube is inserted from the opening below the blood collection holder 21.
　本発明の採血管を使用できる採血ホルダーに特に制限はないが、内径が１７ｍｍ～１８ｍｍの採血ホルダーが特に好適に使用できる。国内で広く用いられている採血ホルダーの内径は１７ｍｍのものが多いため、本発明の管体は日本国内で用いられるホルダーの多くに用いることができる。 There is no particular limitation on the blood collection holder that can use the blood collection tube of the present invention, but a blood collection holder having an inner diameter of 17 mm to 18 mm can be particularly preferably used. Since the internal diameter of blood collection holders widely used in Japan is 17 mm, the tube of the present invention can be used in many holders used in Japan.
　また、上記構成を具備するようにブロー成形で製造した本発明の管体は、射出成形で製造した管体に対して－２０℃での衝撃強度が高いという特性を有しており、取り扱い時の破損が少なく安全に取り扱いすることができる。 In addition, the tubular body of the present invention manufactured by blow molding so as to have the above-described structure has a characteristic that the impact strength at −20 ° C. is higher than that of the tubular body manufactured by injection molding. Can be handled safely with little damage.
　以下実施例において本発明を説明するが、本発明はこの態様に限定されるものではない。 Hereinafter, the present invention will be described in Examples, but the present invention is not limited to this embodiment.
　（実施例１）
　ＰＥＴ樹脂を原料とし、管体最大外径１３ｍｍの射出成型プリフォームを作成した。得られたプリフォームを加熱、ブロー成型し、管体小径部外径Ｃ１は１３ｍｍ、大径部の最大外径Ｃ２は１６ｍｍ、管長は１００ｍｍ、管体平均肉厚は０．８ｍｍである、管体１を得た。得られた管体１の最大外径と小径部外径との比Ｃ２／Ｃ１は１．２であった。 (Example 1)
An injection molded preform having a tube body outer diameter of 13 mm was prepared using PET resin as a raw material. The obtained preform is heated and blow-molded, the tube small diameter part outer diameter C1 is 13 mm, the large diameter part maximum outer diameter C2 is 16 mm, the tube length is 100 mm, and the tube average wall thickness is 0.8 mm. Body 1 was obtained. The ratio C2 / C1 between the maximum outer diameter and the outer diameter of the small diameter portion of the obtained tube 1 was 1.2.
　（比較例１）
　ＰＥＴ樹脂を原料とし、射出成型により、一端が開口されて円筒状の有底の管体を得た。円筒部分の外径は１３ｍｍであり、管長は１００ｍｍ、管体平均肉厚は１ｍｍとした。 (Comparative Example 1)
Using PET resin as a raw material, one end was opened by injection molding to obtain a cylindrical bottomed tube. The outer diameter of the cylindrical portion was 13 mm, the tube length was 100 mm, and the average tube thickness was 1 mm.
　（比較例２）
　ＰＥＴ樹脂を原料とし、射出成型により、比較例１と同様に一端が開口されており、有底の円筒状の管体を得た。管体の外径は１６ｍｍ、管長は１００ｍｍ、管体平均肉厚は１ｍｍとした。 (Comparative Example 2)
A PET resin was used as a raw material, and one end was opened as in Comparative Example 1 by injection molding to obtain a cylindrical tube with a bottom. The outer diameter of the tube was 16 mm, the tube length was 100 mm, and the tube average thickness was 1 mm.
　（実施例及び比較例の評価）
　得られた管体について以下の方法で評価した。評価の結果は表１に記す。 (Evaluation of Examples and Comparative Examples)
The obtained tubular body was evaluated by the following method. The evaluation results are shown in Table 1.
　（オーバーキャップタイプ栓体の嵌合可否）
　カバー部の最大外径が１６．６ｍｍで、カバー部の材質がＰＥ樹脂からなるオーバーキャップタイプの栓体を嵌合し、嵌合可能ならば○、嵌合不可能ならば×で評価した。 (Overcap type plug can be fitted)
An overcap type plug body having a maximum outer diameter of the cover portion of 16.6 mm and a cover portion made of PE resin was fitted.
　（５０％破壊エネルギー）
　得られた管体に対し、－２０℃の低温環境においてＪＩＳ　Ｋ７２１１－１「プラスチック－硬質プラスチックのパンクチャー衝撃試験方法」に則り、衝撃試験を３ｋｇの錘を用いて行った。このうち、測定対象のうち５０％の管体が破壊される衝撃強度を５０％破壊エネルギーと定義し、その値を測定した。得られた値を元に、５０％破壊エネルギーが１０Ｊを超えるものに関しては○で、超えないものに関しては×で評価した。 (50% destruction energy)
The obtained tube was subjected to an impact test using a 3 kg weight in a low temperature environment of −20 ° C. in accordance with JIS K7211-1 “Plastic-Hard Plastic Puncture Impact Test Method”. Among these, the impact strength at which 50% of the pipes to be measured were destroyed was defined as 50% fracture energy, and the value was measured. Based on the obtained value, the case where the 50% fracture energy exceeded 10 J was evaluated as “Good”, and the case where it did not exceed was evaluated as “Poor”.
　ブロー成形で製造した本発明の管体は、射出成形で製造した管体に対して－２０℃での衝撃強度が高いという特性を有していた。 The tube of the present invention manufactured by blow molding had a characteristic that the impact strength at −20 ° C. was higher than that of the tube manufactured by injection molding.
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000001
　１…管体
　１ａ…開口端
　１ｂ…小径部
　１ｃ…大径部
　１１…栓体
　１２…栓本体
　１３…カバー部材
　１３ａ…フランジ部
　１３ｂ…カバー部
　２１…採血ホルダー DESCRIPTION OF SYMBOLS 1 ... Tube 1a ... Open end 1b ... Small diameter part 1c ... Large diameter part 11 ... Plug body 12 ... Plug body 13 ... Cover member 13a ... Flange part 13b ... Cover part 21 ... Blood collection holder

Claims (5)

  1. 　開口端が栓体で閉じられ、かつホルダーに挿入されて体液の採取に用いられる有底の円筒状の管体であって、
    　一端が開口端であって、他端が閉じられた底部であり、開口端に連なる開口端側部分の外径が残りの部分の外径よりも小さくされている小径部とされており、残りの部分が相対的に外径の大きな大径部とされており、合成樹脂の射出ブロー成型により得られた成型体からなる、管体。     A cylindrical tube with a bottom that is closed with a stopper and is inserted into a holder and used to collect body fluid,
    One end is an open end, the other end is a closed bottom, and the outer diameter of the open end side portion connected to the open end is a small diameter portion that is smaller than the outer diameter of the remaining portion, and the rest Is a large-diameter portion having a relatively large outer diameter, and is a tubular body made of a molded body obtained by injection blow molding of synthetic resin.
  2. 　前記小径部の長さが、前記栓体の前記管体の周囲に外装されている部分の長さよりも長い、請求項１に記載の管体。 The tubular body according to claim 1, wherein a length of the small diameter portion is longer than a length of a portion of the plug body that is sheathed around the tubular body.
  3. 　ホルダーに挿入され、体液の採取に用いられる採血管であって、
    　請求項１または２に記載の管体と、
    　前記管体の前記開口端に挿入され、かつ前記管体の前記小径部分に外装されている部分を有する栓体とを備える、採血管。     A blood collection tube that is inserted into a holder and used to collect body fluid,
    The tubular body according to claim 1 or 2,
    A blood collection tube comprising: a plug inserted into the opening end of the tubular body and having a portion sheathed on the small diameter portion of the tubular body.
  4. 　前記小径部の長さが、前記栓体の前記外装部分の長さよりも長い、請求項３に記載の採血管。 The blood collection tube according to claim 3, wherein a length of the small diameter portion is longer than a length of the exterior portion of the plug.
  5. 　請求項１または２に記載の管体の製造方法であって、
    　合成樹脂を射出成型し、一端が開口端とされており、他端が閉じられた有底部とされている円筒状のプリフォームを得る工程と、
    　前記プリフォームを開口端側部分が固定される金型に装着し、開口端側からプリフォーム内部にガスを注入しつつ、プリフォームを前記開口端側部分を除く部分において長さ方向中心軸部分を中心として径方向外側に膨らませ、大径部分を形成する工程とを備える、管体の製造方法。     It is a manufacturing method of the pipe object according to claim 1 or 2,
    A step of injection molding synthetic resin, obtaining a cylindrical preform having one end as an open end and the other end closed as a bottomed portion;
    The preform is mounted on a mold to which the opening end side portion is fixed, and a gas is injected into the preform from the opening end side while the preform is removed from the opening end side portion in the lengthwise central axis portion. And a step of forming a large-diameter portion by inflating radially outward from the center.
PCT/JP2013/076225 2012-09-28 2013-09-27 Tube body, blood collection tube, and method for manufacturing tube body WO2014051037A1 (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109507178A (en) * 2018-12-25 2019-03-22 菏泽学院 A kind of environment-friendly microbial indole test instrument
WO2020106225A3 (en) * 2018-11-19 2020-06-25 Turajane Thana Round-bottom tube with a triple-lock stopper
EP3573759A4 (en) * 2017-01-25 2020-07-29 Yantai AusBio Laboratories Co., Ltd. Equipment and methods for automated sample processing for diagnostic purposes

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JP2011073762A (en) * 2009-09-30 2011-04-14 Kyoraku Co Ltd Container formed of resin and method for manufacturing the same

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3573759A4 (en) * 2017-01-25 2020-07-29 Yantai AusBio Laboratories Co., Ltd. Equipment and methods for automated sample processing for diagnostic purposes
US11883817B2 (en) 2017-01-25 2024-01-30 Yantai Ausbio Laboratories Co., Ltd. Equipment and methods for automated sample processing for diagnostic purposes
WO2020106225A3 (en) * 2018-11-19 2020-06-25 Turajane Thana Round-bottom tube with a triple-lock stopper
CN109507178A (en) * 2018-12-25 2019-03-22 菏泽学院 A kind of environment-friendly microbial indole test instrument
CN109507178B (en) * 2018-12-25 2021-03-19 菏泽学院 Environment-friendly microbial indole tester

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