WO2014026396A1 - 具有增效作用的杀菌组合物 - Google Patents

具有增效作用的杀菌组合物 Download PDF

Info

Publication number
WO2014026396A1
WO2014026396A1 PCT/CN2012/080379 CN2012080379W WO2014026396A1 WO 2014026396 A1 WO2014026396 A1 WO 2014026396A1 CN 2012080379 W CN2012080379 W CN 2012080379W WO 2014026396 A1 WO2014026396 A1 WO 2014026396A1
Authority
WO
WIPO (PCT)
Prior art keywords
thiazolone
composition
composition according
active component
epoxiconazole
Prior art date
Application number
PCT/CN2012/080379
Other languages
English (en)
French (fr)
Inventor
仲汉根
Original Assignee
江苏辉丰农化股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 江苏辉丰农化股份有限公司 filed Critical 江苏辉丰农化股份有限公司
Priority to AU2012387919A priority Critical patent/AU2012387919B2/en
Priority to PL17162712T priority patent/PL3210470T3/pl
Priority to PL17162732T priority patent/PL3210471T3/pl
Priority to EA201590368A priority patent/EA025481B1/ru
Priority to EP17162712.8A priority patent/EP3210470B1/en
Priority to DK12883005.6T priority patent/DK2885971T3/en
Priority to CA2881512A priority patent/CA2881512C/en
Priority to ES12883005.6T priority patent/ES2654314T3/es
Priority to US14/421,125 priority patent/US9282744B2/en
Priority to PL12883005T priority patent/PL2885971T3/pl
Priority to EP17162742.5A priority patent/EP3210472B1/en
Priority to EP12883005.6A priority patent/EP2885971B1/en
Priority to LTEP12883005.6T priority patent/LT2885971T/lt
Priority to EP17162732.6A priority patent/EP3210471B1/en
Publication of WO2014026396A1 publication Critical patent/WO2014026396A1/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/38Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/24Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
    • A01N43/32Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms six-membered rings
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647Triazoles; Hydrogenated triazoles
    • A01N43/6531,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/84Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4

Definitions

  • the present invention is in the field of agricultural plant protection, and more particularly to a bactericidal composition having improved properties, and more particularly to a bactericidal composition contained therein.
  • Benzothiazolinone is a fungicide. It is a new, broad-spectrum fungicide that has a preventive and therapeutic effect on fungal diseases. During the sterilization process, the nuclear structure of the pathogen is destroyed, causing it to lose its heart and die, causing the metabolism of the cells to interfere with the physiological disorder and eventually leading to death. Kill the germs completely and achieve the desired effect of eradicating the disease. It is mainly used to control cucumber downy mildew, pear black spot disease, apple acne, citrus anthracnose, grape black pox, etc., and has special effects on various bacterial and fungal diseases.
  • Dimethomorph is a broad-spectrum bactericide of morpholine, which has a unique action on the fungi of the genus Aspergillus and the genus Phytophthora, mainly causing the decomposition of the sporangia wall, thus making the fungus# 3 ⁇ 4 dead.
  • Dimethomorph is a fungicide of the genus Oomycetes, which is characterized by the destruction of the formation of HI mo, which has a role in all stages of the life history of the oocysts, and is particularly sensitive in the formation of spore vines and oospores. It is inhibited at very low concentrations ( ⁇ 0.25 g/ml) and is not resistant to phenyl hydrazine M agents.
  • Dithianon is a protective fungicide for many leaf diseases of many pome fruit and stone fruit, with multiple mechanisms of action.
  • a series of fungal enzymes are inhibited by reacting with sulfur-containing groups and interfering with cellular respiration, which ultimately leads to disease death. It has a good protective activity and also has a certain therapeutic activity.
  • Suitable cropping fruit trees include pome fruits and fruit such as apples, pears, peaches, apricots, cherries, citrus, coffee, grapes, strawberries, hops, and the like.
  • the control object can control almost all fruit tree diseases such as black spot disease, mildew disease, leaf spot disease, rust, anthracnose, scab, downy mildew, brown rot and so on.
  • Iprodione is a highly effective broad-spectrum, contact-killing fungicide with a certain therapeutic and protective effect. It can also be absorbed by the roots. Can effectively prevent and treat benzopyrene-type systemic fungicides Resistant fungi. Suitable for controlling early defoliation, gray mold, early blight of various fruit trees, vegetables, melons and other crops
  • Epoxiconazol is a systemic triazole fungicide. Its mechanism of action is to inhibit the synthesis of ergosterol, which hinders the formation of cell walls. It not only has good protection, treatment and eradication activity, but also has systemic and better residual active epoxiconazole, which can increase the activity of the vegetal enzyme of the crop, leading to the contraction of the fungal squirt and inhibiting the invasion of the bacteria. This is the fluorine ring. Frustrated in all three frustrations. It has good control effect on leaf spot, powdery mildew, rust, anthracnose and white rot on grapes, such as banana, onion, celery, kidney bean, melon, asparagus, peanut and sugar beet.
  • the technical problem to be solved by the invention is: for the anti-f and soil residue problems of the bactericide in practical application, the bactericides of two different sterilization principles are screened to compound, so as to improve the control effect of the bactericide and delay the generation of resistance, Reduce the amount of application, control costs.
  • the present invention provides a bactericidal composition
  • a bactericidal composition comprising two active ingredients A and B, the active component A is thiazolone, and the active component B is selected from the group consisting of dicyandiquinone and olefin.
  • One of acymorpholine, iprodione or epoxiconazole One of acymorpholine, iprodione or epoxiconazole.
  • the compounds containing component A and component B have different structural types and different mechanisms of action. The combination of the two can bind to the broad spectrum of bactericidal spectrum, and can delay the generation and development of pathogenic bacteria resistance on a certain number, and the components There is no cross-resistance between A and component B.
  • Another object of the present invention is to provide a preparation method comprising the two active ingredients A and B bactericidal compositions and 30 ⁇ 30: 1.
  • the bactericidal composition of the present invention is composed of 6 to 92% by weight of the living component and 94 to 8% by weight of the pesticide adjuvant.
  • the present invention provides a bactericidal composition
  • a bactericidal composition comprising component A (thiazolone) and component B (one selected from the group consisting of dicyandione, enoylmorpholine, iprodiurea or epoxiconazole) for controlling plant diseases Use in.
  • compositions further comprise a carrier, an adjuvant and/or a surfactant.
  • a carrier an adjuvant and/or a surfactant.
  • Common auxiliaries can be mixed during the application.
  • the auxiliaries can be solid or liquid, they are usually used in the processing of dosage forms, such as natural or recycled minerals, solvents, dispersants, wetting agents, adhesives, thickeners, adhesives. .
  • the applicator of the composition of the invention the brain comprises the composition of the invention for use in aerial parts of plants, in particular leaves or foliage.
  • the frequency of administration and the amount administered will depend on the biological and climatic conditions of the pathogen.
  • the plant growth site such as rice fields, may be wetted with a liquid formulation of the composition, or the composition may be applied to the soil in solid form, such as in the form of granules (soil application), the composition may be passed from the soil to the plant through the roots of the plant. In vivo (systemic action).
  • compositions may be applied only with the active ingredient, or may be mixed with the additives, so that the composition of the present invention can be prepared into various dosage forms such as wettable powders, suspending agents, oil suspensions, water-dispersible granules, Water emulsion, microemulsion.
  • the compositions may be applied by spraying, misting, dusting, spreading or splashing, and the like.
  • composition of the present invention can be prepared into various dosage forms by a known method, and the active ingredient and the auxiliary agent, such as I", a solid carrier, if necessary, can be uniformly mixed with the surfactant, ground, and prepared as needed. Formulation.
  • the above solvent may be selected from aromatic hydrocarbons, and the crane contains 8-12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, and aliphatic hydrocarbons.
  • phthalates such as dibutyl phthalate or dicaprylic acid
  • aliphatic hydrocarbons such as cyclists or paraffin, alcohols and glycols and their ethers and esters, such as ethanol, ethylene glycol, ethylene glycol monomethyl; ketones, such as cyclohexanone, strong polar solvents, such as N-methyl -2-pyrrolidone, dimethyl sulfoxide or dimethylformamidine, and vegetable or vegetable oils such as soybean oil.
  • the above solid carriers are usually natural mineral fillers such as talc, kaolin. Earth, montmorillonite or activated clay.
  • a highly dispersible silicic acid or a highly dispersible adsorbent polymer carrier such as a particulate adsorbent carrier or a non-adsorbing carrier.
  • Suitable particulate adsorbent carriers are porous, such as pumice and bentonite.
  • non-adsorbing carriers such as calcite or sand.
  • a large amount of pre-granulated materials of inorganic or organic nature can be used as a carrier, in particular dolomite.
  • suitable surfactants are lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, alkaline earth metal salt, salt, salt, arylsulfonate, hospital Base sulphur ship, sulphur-based sulphur ship, sulphuric acid sulphur M3 ⁇ 4, sulphuric acid and sulphated fatty alcohol glycol ether, condensate of sulfonated naphthalene and naphthalene derivatives with formaldehyde, naphthalene or naphthalene sulfonic acid Condensate with phenol and formaldehyde, polyoxyethylene octyl phenyl ether, ethoxylated isooctyl phenol, octyl phenol, nonyl phenol, aryl aryl glycol ether, tributyl glycol Et
  • the two effective pours in the compositions of the present invention are synergistic, the activity of the composition is more pronounced than the expected sum of the living compounds of the shed, and the insect activity of the individual compounds.
  • the synergistic effect is manifested by allowing a wider application of the fungicidal control profile, quicker effect, longer lasting control effect, comforting one or a few applications for better control of plant harmful fungi, and widening the possible application interval .
  • This temple is particularly needed in the practice of plant fungus control.
  • the composition of the present invention is particularly directed to the following crop diseases: yellow mold pathogen, cucumber gray mold disease, banana leaf spot disease, grape downy mildew or lychee Phytophthora.
  • the other characteristics exhibited by the bactericidal composition of the present invention are mainly as follows: 1.
  • the compounding of the composition of the present invention has obvious synergistic effect; 2. Since the chemical composition of the two single agents of the composition is greatly different, the effect The mechanism is completely different, there is no cross-resistance, and the problem of resistance caused by the separate use of the two single agents can be delayed; 3.
  • the composition of the invention has good safety and control effect on crops. It has been verified by i that the fungicidal composition of the present invention has stable chemical properties, remarkable synergistic effect, and exhibits obvious synergistic effect and complementary effect on the control object.
  • Example 1 620/0 thiaminone ⁇ dicyandiquinone dispersible granules
  • Example 2 65% thiazolone - dicyandiquinone dispersible granules
  • Thiazolone 63. /. enoylmorpholine 2. /. , sodium lignosulfonate 6. /. , 12 yards of base sulfonate 3 . /. , xanthan gum 1%, carboxymethyl lake f3 1%, attapulgite to 100%.
  • Example 5 620/0 thiazolone ⁇ Isobacteria water dispersible granules
  • Example 6 75% thiazolone ⁇ Isobacteria water dispersible granules
  • Example 7 62% thiazolone ⁇ epoxiconazole water dispersible granules
  • Example 8 62% thiazolone ⁇ epoxiconazole water dispersible granules
  • a ratio of the active ingredient of thiazolone to one of dicyandione, dimethomorph, iprodione or epoxiconazole, and components such as dispersant, wetting agent, thickener and water After mixing evenly, after sanding and/or high-speed shearing, a semi-finished product is obtained. After analysis, water is added and uniformly filtered to obtain a finished product.
  • Thiazolone 40 / 0 , enoylmorpholine 2. / 0 , the month of the fatty alcohol polyoxyethylene ether phosphate 7. / 0 , white carbon black 3. / 0 , glycerol 6. / 0 , 2% in benzamidine, 7 to 100%.
  • Example 12 32% thiazolone ⁇ enoylmorpholine suspension
  • Example 14 42% thiazolone ⁇ different bacteria leg float
  • Example 15 55% thiazolone-epoxiconazole suspension
  • Example 16 55% thiazolone ⁇ epoxiconazole suspension
  • Example 17 90% thiazolone ⁇ dicyandione wettable powder
  • Example 19 55% thiazolone ⁇ dicyandione wettable powder
  • Example 24 50% thiazolone ⁇ iprodione wettable powder
  • Example 25 85% thiazolone ⁇ iprodione wettable powder
  • Example 26 88% thiazolone ⁇ epoxiconazole wettable powder
  • Example 27 86% thiazolone ⁇ epoxiconazole wettable powder
  • Example 28 50% thiazolone ⁇ epoxiconazole wettable powder
  • One of the active ingredient, thiazolone A, and the active ingredient B dicyandione, dimethomorph, iprodione or epoxiconazole After completely dissolving in the solvent, stir, add emulsifier, synergist and antifreeze. After the above system is mixed, add water slowly to the above mixture, and mix well to prepare different A microemulsion in the amount.
  • Example 29 18% thiazolone - dicyandione microemulsion
  • Example 30 30% thiazolone ⁇ dicyandione microemulsion
  • Example 31 15% thiazolone ⁇ enoylmorpholine microemulsion
  • Example 32 15% thiazolone ⁇ enoylmorpholine microemulsion
  • Example 33 18% thiazolone ⁇ Isobacteria microemulsion
  • Example 34 21% thiazolone ⁇ Isobacteria microemulsion
  • Tefmosone 20% Iprodione 1%, Moon fatty acid polyoxyethylene ester and phenethyl phenol polyoxyethylene ether 4%, glycerol 2%, methanol 11%, azone 1%, 7 complement to 100%.
  • Example 35 12% thiazolone ⁇ Fluorine ring microemulsion
  • thiazolone 10% of epoxiconazole, 1% of propylene glycol, 1% of phenylsulfonyl sulfonate, and phthalic acid, M3 ⁇ 4 13%, 1% of ethyl ketone, and 11% of ethyl acetate.
  • Example 36 15% thiazolone ⁇ Fluorine ring microemulsion
  • the active ingredient, thiazolone A, and one of the B active ingredients dicyandione, dimethomorph, iprodione or epoxiconazole are uniformly mixed with a solvent and an auxiliary agent under mechanical stirring, and then The emulsifier and the stabilizer are added to be evenly stirred. Finally, water is added and stirred at 100-12000 rpm for 10-30 minutes to make it a homogeneous milky product.
  • Example 37 42% thiazolone ⁇ dicyandione emulsion
  • Example 38 44% thiazolone ⁇ dicyandiquinone emulsion
  • Example 39 22% thiazolone ⁇ enoylmorpholine emulsion
  • Example 40 22% thiazolone ⁇ enoylmorpholine emulsion
  • Example 41 30% thiazolone-isobacteria aqueous emulsion
  • Example 42 420/0 thiazolone ⁇ Isobacteria aqueous emulsion
  • Example 43 21% thiazolone flucyclazole water emulsion Tefmosone 20%, epoxiconazole 1%, propylene glycol 1%, xanthan gum 1%, polyisosuccinic anhydride-polyethylene glycol copolymer 2%, polyoxyethylene block copolymer 2%, silicone elimination
  • the foaming agent is 1.5%, and the water is made up to 100%.
  • thiazolone 40% of epoxiconazole, 2% of castor oil polyoxyethylene ether, 1% of N-tweldium-based pyrrolidone, 2% of glycerol, 1.1% of polyvinyl alcohol, 2 of benzamidine %, isooctyl alcohol 1%, made up to 100%.
  • Formulating one of the active ingredient, thiazolone A, and one of the active ingredients of diacetyl cyanide, dimethomorph, iprodiurea or epoxiconazole with a dispersing agent, a stabilizer, an antifoaming agent and a solvent The proportions are mixed, put into a sanding kettle and ground, and then fed into a homomixer to mix and obtain the finished product.
  • Example 45 42% thiazolone ⁇ dicyandione oil suspension
  • Example 46 55% thiazolone ⁇ dicyandione oil suspension
  • Example 47 30% of thiazolone enoylmorpholine Suspending agent
  • Example 48 42% thiazolone ⁇ Dimethomorph oil suspension
  • Example 49 18% thiazolone ⁇ Iprobiotic oil suspension
  • Example 50 Thiafenone ⁇ Isobacteria oil suspension
  • Example 51 30% thiazolone-epoxiconazole oil suspension
  • Test subject Huangsu hearing bacteria
  • the incidence of cucumber leaves was investigated, and the disease index and control effect were calculated.
  • the control effect is converted into the probability value (y)
  • the liquid height (g/ml) is converted into a logarithmic value (x)
  • the virulence equation is calculated by the least squares method and the medium concentration EC50 is suppressed
  • the virulence of the drug is calculated according to the method of Sun Yunpei.
  • Measured virulence index (ATI) (standard drug EC50/test drug EC50)*100
  • Theoretical virulence index (TTI) ⁇ toxic virulence index * ⁇ of the + + + B Pharmacotoxicity Index * The amount of B in the mixture
  • the ratio of thiazolone dicyandione 1 10:1 1.58 205.69 96.37 213.438
  • the ratio of thiazolone: dicyandifine 1:1 2.08 156.25 80.05 195.191 ratio of thiazolone: dicyandiamide 1:10 2.26 143.81 63.73 225.655
  • Proportional thiabendazole different bacteria 1 2.07 203.38 86.170 236.02
  • Test method In the early stage of the disease, immediately spray the first time, and after 7 days, apply the second time, each treatment
  • Level 0 no lesions
  • Grade 1 The number of leaf lesions is less than 5, and the length is less than lcm
  • Grade 3 6-10 leaf lesions, some lesions are longer than lcm;
  • Grade 5 11-25 leaf lesions, some lesions are connected into pieces, the lesion area accounts for 10-25% of the leaf area; Grade 7: More than 26 leaf lesions, the lesions are connected into pieces, and the lesion area accounts for 26-50% of the leaf area; Grade 9: The lesions are connected into pieces, and the area of the lesions accounts for more than 50% of the leaf area or the whole leaves die.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

一种具有增效作用的杀菌组合物及其制备方法和用途。该组合物包含两种有效成分A和B,活性组分A为噻霉酮,活性组分B为选自二氰蒽醌、烯酰吗啉、异菌脲或氟环唑中的一种,两组分之间的重量比为1:50〜50:1,优选1:30〜30:1。试验结果表明,上述杀菌组合物增效明显,更重要的是施用量减少,使用成本降低。该杀菌组合物能有效防治粮食作物、蔬菜、水果等作物的某些特定的真菌病害。

Description

说明书
具有增效作用的杀菌组合物
餘领域
本发明属于农业植物保护领域,特别是涉及一种具有改进性能的杀菌组合物,具体 地说是涉及一种包含的杀菌组合物。 背景餘
噻霉酮 (benziothiazolinone)是一种杀菌剂作用特点: 该药是一种新型、广谱杀菌 剂,对真菌性病害具有预防和治疗作用。在杀菌过程中破坏病菌细胞核结构, 使其失去 心脏部位而衰竭死亡, 干扰病菌细胞的新陈代谢, 使其生理紊乱, 最终导致死亡。 将 病菌彻底杀死, 而达到铲除病害的理想效果。主要用于防治黄瓜霜霉病、梨黑星病、苹 果疮痂病、 柑橘炭疽病、 葡萄黑痘病等对多种细菌、 真菌性病害均有特效。
烯酰吗啉 (dimethomorph)是吗啉类广谱性杀菌剂,对藻状菌的霜霉科和疫霉属的 真菌有独特的作用方式, 主要是引起孢子囊壁的分解, 从而使菌#¾亡。烯酰吗啉是专 一杀卵菌纲真菌杀菌剂,其作用特点是破坏细胞 HI莫的形成,对卵菌生活史的各个阶段 都有作用, 在孢子藤更和卵孢子的形成阶段尤为敏感, 在极低浓度下 (<0.25 g/ml)即受 到抑制, 与苯基酉 M类药剂无¾¾抗性。
二氰蒽醌 (Dithianon)是用于许多仁果、核果的多种叶部病害的保护性杀菌剂, 具 有多作用机理。通过与含硫基团反应和干扰细胞呼吸而抑制一系列真菌酶,最后导致病 害死亡。具很好的保护活性的同时, 也有一定的治疗活性。适宜作物果树包括仁果和核 果如苹果、梨、桃、 杏、樱桃, 柑橘, 咖啡, 葡萄, 草莓, 啤酒花等。 防治对象除了对 白粉病无效外,几乎可以防治所有果树病害如黑星病、霉点病、叶斑病、锈病、炭疽病、 疮痂病、 霜霉病、 褐腐病等等。
异菌脲 (iprodione)是一种二甲酰亚胺类高效广谱、触杀型杀菌剂, 具有一定的治 疗和保护作用,也可通过根部吸收起内吸作用。可有效防治对苯并咪挫类内吸杀菌剂有 抗性的真菌。适用于防治多种果树、蔬菜、瓜果类等作物早期落叶病、灰霉病、早疫病
^¾害。
氟环唑(Epoxiconazol )是一种内吸性三唑类杀菌剂, 作用机理是抑制病菌麦角甾 醇的合成, 阻碍病菌细胞壁的形成。其不仅具有很好的保护、 治疗和铲除活性, 而且具 有内吸和较佳的残留活性氟环唑可提高作物的凡丁质酶活性,导致真菌吸器的收缩,抑 制病菌侵入, 这是氟环挫在所有三挫类产品中独一无二的特性。 对香蕉、 葱蒜、 芹菜、 菜豆、瓜类、芦笋、花生、甜菜等作物上的叶斑病、 白粉病、锈病以及葡萄上的炭疽病、 白腐病等病害有良好的防效。
实际的农药经验已经表明,重复且专一施用一种活性化合物来防治有害真菌在很多 情况下将导致真菌菌株的快 择性,为降低抗性真菌菌株选择性的危险 f生, 目前通常 棚不同活性化合物的混合物来防治有害真菌。通过将具有不同作用机理的活性化合物 进行组合, 可延缓抗性产生, 降低施用量, 减少防治成本。 发明内容
本发明要解决的技术问题是:针对杀菌剂在实际应用中抗 f生以及土壤残留问题, 筛 选出两种不同杀菌原理的杀菌剂进行复配, 以提高杀菌剂防治效果, 延缓抗性产生, 降 低施用量, 防治成本。
为解决上述技术问题, 本发明提供了一种杀菌组合物, 该组合物包含两种有效成分 A和 B, 活性组分 A为噻霉酮, 活性组分 B为选自二氰蒽醌、 烯酰吗啉、 异菌脲或氟环 唑中的一种。发明人 验发现,上述杀菌组合物增效明显,更重要的是施用量减少, 降低 iffl成本。含有组分 A与组分 B的化合物结构类型不同,作用机制各异,两者复配 能銜广大杀菌谱, 并且可以在一定禾號上延缓病原菌抗性的产生和发 ϋ«, 且组分 A 与组分 B之间无交互抗性。
本发明的另一个目的是提供包含两种有效成分 A和 B杀菌组合物的制备方法及在农 30〜30: 1。
本发明的杀菌组合物是由 6〜92%重量份的活 f生组分与 94〜8%重量份的农药助剂组 成。
本发明提供了包含组分 A (噻霉酮)和组分 B (选自二氰蒽醌、 烯酰吗啉、 异菌脲 或氟环唑中的一种) 的杀菌组合物在防治植物病害中的用途。
上述组合物还包含载体、 助剂和 /或表面活性剂。 在施用的过程中可以混合常用的 助剂。
的助剂可以是固体或液体, 它们通常是剂型加工过程中常用的物质, 例如天然 的或再生的矿物质, 溶剂、 分散剂、 润湿剂、 胶粘剂、 增稠剂、 粘合剂劍巴料。
本发明组合物的施用方、脑括将本发明的组合物用于植物生长的地上部分,特别是 叶部或叶面。施用的频率和施用量取决于病原体的生物学和气候生存条件。可以将植物 的生长场所, 如稻田,用组合物的液体制剂浸湿, 或者将组合物以固体形式施用于土壤 中, 如以颗粒形式(土壤施用), 组合物可以由土壤经植物根部进入植物体内(内吸作 用) 。
这些组合物可以仅仅包會活性成分进行施用, 也可以与添加剂一起混合 iffl, 因此 本发明的组合物可以制备成各种剂型, 例如可湿性粉剂、悬浮剂、油悬浮剂、水分散粒 剂、水乳剂、微乳剂。根据这些组合物的性质以及施用组合物所要达到的目的和环境障 况, 可以选择将组合物以喷雾、 弥雾、 喷粉、 撒播或泼饶等之类的方法施用。
可用已知的方法可以将本发明的组合物制备成各种剂型, 可以将有效成分与助剂, 如 I」、 固体载体, 需要时可以与表面活性剂一起均匀混合、研磨, 制备成所需要的剂 型。
上述的溶剂可选自芳香烃, 鶴含 8-12个碳原子, 如二甲苯混合物或取代的苯, 酞酸酯类, 如酞酸二丁酯或酞酸二辛酸, 月旨肪烃类, 如环已院或石蜡, 醇和乙二醇和它 们的醚和酯, 如乙醇, 乙二醇, 乙二醇单甲基; 酮类, 如环已酮, 强极性的溶剂, 如 N-甲基 -2-吡咯院酮, 二甲基亚砜或二甲基甲酉纖, 和植物油或植物油, 如大豆油。
上述的固体载体, 如用于粉剂和可分散剂的通常是天然矿物填料, 例如滑石、高岭 土, 蒙脱石或活性白土。为了管理组合物的物理性能, 也可以加入高分散性硅酸或高分 散 f生吸附聚合物载体,例如粒状吸附载体或非吸附载体,合适的粒状吸附载体是多孔型 的, 如浮石、皂土或臌闰土; 的非吸附载体如方解石或砂。另外, 可以使用大量的 无机性质或有机性质的预制成粒状的材料作为载体, 特别是白云石。
根据本发明的组合物中的有效成分的化学 f生质, 合适的表面活性剂为木质素磺酸、 萘磺酸、 苯酚磺酸、 碱土金属盐绷安盐, 院基芳基磺艦, 院基硫艦, 院基磺艦, 月旨肪醇硫 M¾,月旨肪酸和硫酸化脂肪醇乙二醇醚,还有磺化萘和萘衍生物与甲醛的缩合 物, 萘或萘磺酸与苯酚和甲醛的缩合物, 聚氧乙烯辛基苯基醚, 乙氧基化异辛基酚, 辛 基酚,壬基酚,院基芳基聚乙二醇醚,三丁基 乙二醇醚,三硬脂基苯基聚乙二醇醚, 院基芳基聚醚醇, 乙氧基化蓖麻油, 聚氧乙烯院基醚, 氧化乙烯缩合物、 乙氧基化聚氧 丙烯, 月桂酸聚乙二醇醚缩醛, 山梨醇酯, 木质素亚硫 废液和甲基纤维素。
本发明的组合物中两种有效成倾见为增效效果,该组合物的活性比棚单个化合 物的活 f生预期总和, 以及单个化合物的 虫活性更为显著。增效效果表现为允许施用量 更宽的杀真菌控制谱、见效快、更持久的防治效果、慰仅仅一次或少数几次施 用更好的控制植物有害真菌、以及加宽了可能的施用间隔时间。这 寺性是植物真菌控 制实践过程中特别需要的。本发明的组合物特别针对下述农作物病害:黄肅霉病病菌、 黄瓜灰霉病、 香蕉叶斑病、 葡萄霜霉病或荔枝疫霉病。
本发明的杀菌组合物的表现出的其它特点主要表现为: 1、 本发明的组合物混配具 有明显的增效作用; 2、 由于本组合物的两个单剂化学结构差异很大, 作用机理完全不 同, 不存在交互抗性, 可延缓两单剂单独使用所产生的抗性问题; 3、 本发明的组合物 对作物安全、 防效好。经 i验证明, 本发明杀菌剂组合物化学性质稳定, 增效显著, 对 防治对象表现出明显的增效以及互补作用。
为了使本发明的目的、技术方案及优点更加清楚明白, 以下结合实施例, 对本发明 进行进一步详细说明。应当理解, 此处所描述的具体实施例仅用以解释本发明, 并不用 于限定本发明, 凡在本发明的精神和原则之内所做的任何修改、等同替换和改进等, 均 应包含在本发明的保护范围之内。
以下实施例所有配方中百分比均为重量百分比。本发明组合物各种制剂的加工工艺 均为现有技术, 根据不同情况可以有所变化。
一、剂型制备雄例
(一)水分散粒剂的加工及实施例
将活性成分噻霉酮与二氰蒽醌、烯酰吗啉、异菌脲或氟环唑中的一种, 与助剂和填 料按配方的比例混合均匀,经气流粉碎成可湿性粉剂,再加入一定量的水混合挤压造粒, 经千燥筛分后制得水分散粒剂产品。
鎌例 1: 620/0噻霉酮 ·二氰蒽醌水分散粒剂
噻霉酮 60%, 二氰蒽醌 2%, 院基萘磺酸钠 4%,十二院基磺鹏内 3%, 硫薩 3%, 轻质碳酸麪补足至應。
鎌例 2: 65%噻霉酮 -二氰蒽醌水分散粒剂
噻霉酮 2%, 二氰蒽醌 63%, 木质素磺酸钠 5%,甲基萘磺^内甲醛缩合物 7%, 十二 垸基硫酸钠 3%, 硅¾±补足至 100%。
鎌例 3: 65%噻霉酮 ·烯酰吗啉水分散粒剂
噻霉酮 63。/。, 烯酰吗啉 2。/。, 木质素磺酸钠 6。/。,十二院基磺醱内 3。/。, 黄原胶 1%, 羧甲基淀 f3 1%, 凹凸棒土卜足至 100%。
鎌例 4: 85%噻霉酮 ·烯酰吗啉水分散粒剂
噻霉酮 2%,烯酰吗啉 83%,硫酸铵 1%,海藻酸钠 2%,甲基萘磺醱内甲醛缩合物 1%, 有机硅酮 1%, 翻土补足至 100%。
鎌例 5: 620/0噻霉酮 ·异菌脲水分散粒剂
噻霉酮 60。/。, 异菌脲 2。/。, 十二院基磺酸钠 2。/。, 院基萘磺鹏内 2。/。,硫酸铵 3。/。, 轻 质碳鹏补足至應。
^例 6: 75%噻霉酮 ·异菌脲水分散粒剂
噻霉酮 2%, 异菌脲 73%, 甲基萘磺酸,内甲醛缩合物 5%, 木质素磺鹏内 4%,十二垸 基硫翻 3%, 硅¾±补足至 100%。
鎌例 7: 62%噻霉酮 ·氟环唑水分散粒剂
噻霉酮 60%, 氟环唑 2%, 羧甲基淀禾钠1%, 十二院基磺鹏内 4%, 木质素磺鹏内 4%,黄原胶 1%, 凹凸棒土补足至 100%。
鎌例 8: 62%噻霉酮 ·氟环唑水分散粒剂
噻霉酮 2%, 氟环唑 60%, 硫酸铵 1%,海藻酸钠 2%, 甲基萘磺酸钠甲醛缩合物 1%, 有机硅酮 1%, 翻土补足至 100%。
(二)悬浮剂的加工及实施例
将活性成分噻霉酮与二氰蒽醌、 烯酰吗啉、 异菌脲或氟环唑中的一种, 与分散剂、 润湿剂、 增稠剂和水等各组分按配方的比例混合均匀, 经砂磨和 /或高速剪切后, 得到 半成品, 分析后补加水混合均匀过滤即得成品。
鎌例 9: 35%噻霉酮 ·二氰蒽醌悬浮剂
噻霉酮 25°/。, 二氰蒽醌 10°/。, 木质素磺鹏内 7°/。,黄原胶 0.8°/。, §m± 3%, 硅酸铝 镁 1%, 乙二醇 4%, 7补足至 100%。
鎌例 10: 36%噻霉酮 ·二氰蒽醌悬浮剂
噻霉酮 12%,二氰蒽醌 24%, 甲基萘磺鹏内甲醛缩合物 6%,臌闰土 4%,丙三醇 5%, 补足至 100%
鎌例 11: 42%噻霉酮 ·烯酰吗啉悬浮剂
噻霉酮 40。/0, 烯酰吗啉 2。/0, 月旨肪醇聚氧乙烯醚磷酸酯 7。/0,白炭黑 3。/0, 丙三醇 6。/0, 苯甲醱内 2%, 7补足至 100%。
鎌例 12: 32%噻霉酮 ·烯酰吗啉悬浮剂
噻霉酮 5%,烯酰吗啉 27%,木质素磺鹏内 7%,白炭黑 3%, 乙二醇 6%,黄原胶 1%, 补足至 100%
鎌例 13: 55%噻霉酮 ·异菌腿浮剂
噻霉酮 50。/0, 异菌脲 5。/0, 月旨肪醇聚氧乙烯醚磷酸酯 7%,白炭黑 3。/0, 丙三醇 6。/0, 苯甲醱内 2%, 7j补足至 100%。
鎌例 14: 42%噻霉酮 ·异菌腿浮剂
噻霉酮 2。/。, 异菌脲 40%, 木质素磺酸钠 7。/。,白炭黑 3%, 乙二醇 6%, 黄原胶 1%, 补足至 100%
鎌例 15: 55%噻霉酮 -氟环唑悬浮剂
噻霉酮 50。/0, 氟环唑 5。/0, 月旨肪醇聚氧乙烯醚磷酸酯 7。/0,白炭黑 3。/0, 丙三醇 6。/0, 苯甲醱内 2%, 7补足至 100%。
鎌例 16: 55%噻霉酮 ·氟环唑悬浮剂
噻霉酮 5%, 氟环唑 50%, 木质素磺酸钠 7%,白炭黑 3%, 乙二醇 6%, 黄原胶 1%, 补足至 100%
(三)可湿'隨剂的加工及雄例
将活性成分噻霉酮 Α与 B活性成分二氰蒽醌、烯酰吗啉、异菌脲或氟环唑中的一种 与各种助剂及填料等按比例充分混合, 经超细粉碎机粉碎后制得可湿性粉剂。
鎌例 17: 90%噻霉酮 ·二氰蒽醌可湿性粉剂
噻霉酮 2%, 二氰蒽醌 88%, 木质素磺酸麪 2%,十二院基苯磺翻 1%,翻土 2%, 凹凸棒土补足至 100%。
雄例 18: 88%噻霉酮 ·二氰蒽醌可湿性粉剂
噻霉酮 86%, 二氰蒽醌 2%, 院基聚氧乙基醚磺酸盐 1。/。,拉开粉 2%Mm± 1.5%, 白炭黑 2%, 硅¾±补足至 100%。
鎌例 19: 55%噻霉酮 ·二氰蒽醌可湿性粉剂
噻霉酮 25。/。, 二氰蒽醌 30。/。, 院基磺 M¾ 6。A木质素磺醱内 6。/。,白炭黑 11。/。, 高岭 土补足至 100%。
雄例 20: 88%噻霉酮 ·烯酰吗啉可湿性粉剂
噻霉酮 86。/。,烯酰吗啉 2。/。,聚氧乙烯辛基苯基醚 2。/。,木质素磺醱内 6。/。,白炭黑 4。/0, 硅¾±补足至 100%。 錢例 21: 50%噻霉酮 ·烯酰吗啉可湿性粉剂
噻霉酮 25。/。, 烯酰吗啉 25。/。, 木质素磺鹏 70/0,白炭黑 5。/。, 十二院基苯磺鹏内 3%, 凹凸棒土补足至 100%。
雄例 22: 62%噻霉酮 ·烯酰吗啉可湿性粉剂
噻霉酮 2。/。,烯酰吗啉 60。/。,木质素磺鹏 5。/。』 闰土 4。/。,聚氧乙烯辛基苯基醚 3%, 凹凸棒土补足至 100%。
^ 23:85。/。噻霉酮 ·异菌脲可湿性粉剂
噻霉酮 83%, 异菌脲 2%, 聚氧乙烯辛基苯基醚 1%,木质素磺鹏内 2%,白炭黑 3%, 硅¾±补足至 100%。
鎌例 24: 50%噻霉酮 ·异菌脲可湿性粉剂
噻霉酮 25。/。, 异菌脲 25。/。, 十二院基苯磺鹏内 3。/。,白炭黑 5。/。, 木质素磺鹏 70/0, 凹凸棒土补足至 100%。
鎌例 25: 85%噻霉酮 ·异菌脲可湿性粉剂
噻霉酮 3。/。, 异菌脲 82。/。, 木质素磺鹏 5。/。,臌闰土 4。/。, 聚氧乙烯辛基苯基醚 3。/0, 凹凸棒土补足至 100%。
錢例 26: 88%噻霉酮 ·氟环唑可湿性粉剂
噻霉酮 2%, 氟环唑 86%, 十二院基苯磺醱内 2%,膨润土 1%, 木质素磺鹏 2%,凹 凸棒土补足至 100%。
鎌例 27: 86%噻霉酮 ·氟环唑可湿性粉剂
噻霉酮 84%, 氟环唑 2%, 拉开粉 1%,垸基聚氧乙基醚磺 M¾ 2%,膨润土 1.5%, 白 炭黑 2%, 硅¾±补足至 100%。
鎌例 28: 50%噻霉酮 ·氟环唑可湿性粉剂
噻霉酮 25%, 氟环唑 25%, 木质素磺鹏内 6%,垸基磺酸盐 6%,白炭黑 11%, 高岭土 补足至 100%。
(四)微乳剂的加:0¾鎌例
将活性成分噻霉酮 A与活性成分 B二氰蒽醌、烯酰吗啉、异菌脲或氟环唑中的一种 在溶剂中完全溶解后, 进行搅拌, 同时加入乳化剂、增效助剂和抗冻剂, 待上述体系混 匀后, 再将水慢慢加入上述混合液中, 充分搅拌后即可配成不同含量的微乳剂。
錢例 29: 18%噻霉酮 -二氰蒽醌微乳剂
噻霉酮 3%, 二氰蒽醌 15%, 丙酮 15%,复硝辦内 0.5%, 院基聚氧乙烯醚和壬基酚聚 氧乙烯醚 5%, 丙二醇 1%, 尿素 2%, 7补足至 100%。
鎌例 30: 30%噻霉酮 ·二氰蒽醌微乳剂
噻霉酮 25%, 二氰蒽醌 5%, 脂肪酸聚氧乙烯酯和苯乙基酚聚氧乙烯醚 4%, 丙三醇 2%, 甲醇 11%,氮酮 1%, 7补足至 100%。
鎌例 31: 15%噻霉酮 ·烯酰吗啉微乳剂
噻霉酮 5%, 烯酰吗啉 10%, 垸基苯磺酸盐和垸基萘磺麟 16%, 噻酮 1%, 乙酸乙 酯 16%,丙二醇 1%, 7补足至 100%。
鎌例 32: 15%噻霉酮 ·烯酰吗啉微乳剂
噻霉酮 10%, 烯酰吗啉 5%, 十二院基苯磺鹏 8%,噻酮 0.5%, 山梨酸 14%, 聚乙 二醇 3%, 补足至 100%。
鎌例 33: 18%噻霉酮 ·异菌脲微乳剂
噻霉酮 6%, 异菌脲 12%, 丙酮 15%細薩 0.5%,垸基聚氧乙烯醚和壬基酚聚氧 乙烯醚 5%, 丙二醇 1%, 尿素 2%, 补足至 100%。
鎌例 34: 21%噻霉酮 ·异菌脲微乳剂
噻霉酮 20%, 异菌脲 1%, 月旨肪酸聚氧乙烯酯和苯乙基酚聚氧乙烯醚 4%, 丙三醇 2%, 甲醇 11%,氮酮 1%, 7补足至 100%。
鎌例 35: 12%噻霉酮 ·氟环挫微乳剂
噻霉酮 2%, 氟环唑 10%, 丙二醇 1%, 院基苯磺 ^¾和院基萘磺 M¾ 13%, 噻酮 1%, 乙酸乙酯 11%冰补足至 100%。
鎌例 36: 15%噻霉酮 ·氟环挫微乳剂
噻霉酮 10%, 氟环唑 5%, 山梨酸 14%, 噻酮 1%, 十二院基苯磺酸麪 7%,聚乙二醇 2%, 补足至 100%。 (五)水乳剂的加 例
在乳化釜中,将活性成分噻霉酮 A与 B活性成分二氰蒽醌、烯酰吗啉、异菌脲或氟 环唑中的一种与溶剂、助剂在机械搅拌下混合均匀,然后投入乳化剂和稳定剂搅拌均匀, 最后加入水,在 100-12000转 / 中的繊下搅拌 10-30分钟,使之成为均匀乳状的产品。
鎌例 37: 42%噻霉酮 ·二氰蒽醌水乳剂
噻霉酮 40%, 二氰蒽醌 2%, N-邻苯二甲酸二甲酯 4%,壬基酚苯氧乙烯醚 3%, 2,6- 二叔丁基 "4-甲基苯酚 2%,乙二醇 3%,聚乙烯醇 1%,苯甲酸钠 1%,有机硅消泡剂 0.8%, 补足至 100% ο
鎌例 38: 44%噻霉酮 ·二氰蒽醌水乳剂
噻霉酮 4%,二氰蒽醌 40%,丁基羟基茴香醚 4。/。,聚异丁二酸酐-聚乙二醇共聚物 3%, 丙二醇 2%, 黄原胶 3%, 聚乙烯醇 1%, 有 #1硅消泡剂 1.2%, 7补足至 100%。
錢例 39: 22%噻霉酮 ·烯酰吗啉水乳剂
噻霉酮 20%, 烯酰吗啉 2%, 聚氧乙烯嵌段共聚物 3%,丙二醇 1%, 黄原胶 2%, 聚 异丁二酸酐-聚乙二醇共聚物 3%, 有机硅消泡剂 1.2%, 7J补足至 100%o
鎌例 40: 22%噻霉酮 ·烯酰吗啉水乳剂
噻霉酮 2。/。, 烯酰吗啉 20。/。, N-十二院基吡咯院酮 2。/。,蓖麻油聚氧乙烯醚 1。/。, 丙三 醇 3%, 聚乙烯醇 1.2%, 苯甲醱内 1%, 异辛醇 2%, 7补足至 100%。
鎌例 41: 30%噻霉酮 -异菌脲水乳剂
噻霉酮 25%, 异菌脲 5%, 2,6-二叔丁基 -4-甲基苯酚 1%, 壬基酚苯氧乙烯醚 2%, 乙 二醇 3%, 苯甲醱内 1%, N-邻苯二甲酸二甲酯 2%,聚乙烯醇 1%, 有机硅消泡剂 1%, 水 补足至 100%。
鎌例 42: 420/0噻霉酮 ·异菌脲水乳剂
噻霉酮 2%, 异菌脲 40%, 丙二醇 2%, 丁基羟基茴香醚 3%,聚异丁二酸酐-聚乙二醇 共聚物 3。/。, 黄原胶 3。/。, 聚乙烯醇 1。/。, 有机硅消泡剂 1.2。/。, 7补足至 100%。
鎌例 43: 21%噻霉酮 ·氟环唑水乳剂 噻霉酮 20%, 氟环唑 1%, 丙二醇 1%, 黄原胶 1%, 聚异丁二酸酐-聚乙二醇共聚物 2%, 聚氧乙烯嵌段共聚物 2%,有机硅消泡剂 1.5%, 水补足至 100%。
鎌例 44: 42%噻霉酮 ·氟环唑水乳剂
噻霉酮 2%, 氟环唑 40%, 蓖麻油聚氧乙烯醚 2%, N-十二院基吡咯院酮 1%,丙三醇 2%, 聚乙烯醇 1.1%, 苯甲醱内 2%, 异辛醇 1%, 补足至 100%。
(四)油悬翻的加 1_¾餓例
将活性成分噻霉酮 A与 B活性成分二氰蒽醌、烯酰吗啉、异菌脲或氟环唑中的一种 与分散剂、 稳定剂、 消泡剂和溶剂等各组分按配方的比例混合, 放入砂磨釜内研磨后, 送入均质混合器内混匀即得成品。
鎌例 45: 42%噻霉酮 ·二氰蒽醌油悬浮剂
噻霉酮 2%, 二氰蒽醌 40%, 木质素磺鹏内 8%,臌闰土 4%, 黄原胶 1%, 有机硅消 泡齐 IJ 2%, 大豆油补足至 100%
鎌例 46: 55%噻霉酮 ·二氰蒽醌油悬浮剂
噻霉酮 50%,二氰蒽醌 5%,拉开粉 8%,翻土 5%,有机硅酮 2%,机油补足至 100% 鎌例 47: 30%噻霉酮 ·烯酰吗啉油悬浮剂
噻霉酮 25%, 烯酰吗啉 5%, 萘磺酸甲醛缩合物 8%,硅¾± 5%, 硅酸镁铝 2%, 二 氯乙院补足至 100%。
鎌例 48: 42%噻霉酮 ·烯酰吗啉油悬浮剂
噻霉酮 2%,烯酰吗啉 40%,木质素磺翻 11%,二氧化硅气纖 4%,硅廳美铝 2%, 蓖麻油补足至 100%。
^例 49: 18%噻霉酮 ·异菌脲油悬浮剂
噻霉酮 3%, 异菌脲 15%, 有机硅消泡剂 1%, 翻土 3%, 木质素磺翻 7%,黄原 胶 1%, 大豆油补足至 100%。
鎌例 50: 噻霉酮 ·异菌脲油悬浮剂
噻霉酮 20%,异菌脲 2%,翻土 3%,拉开粉 7%,有机硅酮 2%,机油补足至 100%。 錢例 51: 30%噻霉酮 -氟环唑油悬浮剂
噻霉酮 25%, 氟环唑 5%, 萘磺酸甲醛缩合物 8%,硅藻土 5%, 硅廳美铝 2%, 二氯 乙院补足至 100%。
雄例 52: 45%噻霉酮 ·氟环唑油悬浮剂
噻霉酮 15%, 氟环唑 30%, 木质素磺翻 11%,二氧化硅气纖 4%, 硅廳美铝 2%, 蓖麻油补足至 100%。 二、药效 微
(一)生物测定实施例
i、 噻霉酮与二氰蒽醌复酉 s寸黄 霉病病菌毒力测定 ¾t验
试验对象: 黄肅聽病菌
按照 ¾t验分级标准调查黄瓜整株叶片的发病情况, 计算病情指数和防治效果。 将防治效果换算成几率值 (y) , 药液弄高度 ( g/ml)转换成对数值(x) , 以最 小二乘法计算毒力方程和抑制中浓度 EC50, 依孙云沛法计算药剂的毒力指数级共毒系 数(CTC) 。
实测毒力指数 (ATI) = (标准药剂 EC50/供试药剂 EC50)*100
理论毒力指数(TTI) =Α药剂毒力指数 *混剂中 Α的百 量 + B药剂毒力指数 *混剂 中 B的百 量
共毒系数(CTC) =[混剂实测毒力指数 (ATI ) /混剂理论毒力指数(TTI) ]*100 CTC 80,组合物表现为拮抗作甩 80<CTC<120,组合物表现为相加作用, CTC 120, 组合物表现为增效作用。
表 1噻霉酮、 二氰蒽醌及其不同配比复配对黄肅霉病毒力测定结果分析
ECso c U
翻名称 ATI TTI 系数(CTC)
g ml)
噻霉酮 3.25 1∞.0 1 1
二 fl蒽酉昆 5.41 60.1 1 1
配比噻霉酮 二氰蒽酉 1=50:1 2.37 137.13 99.215 138.215
配比噻霉酮 二氰蒽酉 1=30:1 1.91 170.16 98.67 172.454
配比噻霉酮 二氰蒽酉 1=10:1 1.58 205.69 96.37 213.438 配比噻霉酮: 二氰細 =1:1 2.08 156.25 80.05 195.191 配比噻霉酮: 二氰蒽酉 1:10 2.26 143.81 63.73 225.655
配比噻霉酮: 二氰蒽酉 1:30 3.79 85.61 61.43 139.358
配比噻霉酮: 二氰蒽酉 1:50 4.18 77.76 60.88 127.720
结果 (表 1 ) 表明, 噻霉酮与二氰蒽醌复酉 S寸黄瓜霜霉病的防治效果显著提高, 说明二者复配对黄瓜霜霉病病菌有显著的增效作用。 尤其是噻霉酮与二氰蒽醌配比在
1:30〜30:1之间, 噻霉酮与二氰蒽醌的共毒系数均在 135以上, 增效作用明显。
2、 噻霉酮与烯酰吗啉复配对黄 霉病毒力测定 i验
表 2噻霉酮、 烯酰吗啉及其不同配比复配对黄肅霉病毒力测定结果分析
Figure imgf000014_0001
结果 (表 2 ) 表明, 噻霉酮与烯酰吗啉复酉 S寸黄瓜霜霉病的防治效果显著提高, 说明二者复配对黄瓜霜霉病具有显著的增效作用, 尤其是噻霉酮与烯酰吗啉配比在 1:30〜30:1之间, 噻霉酮与烯酰吗啉的共毒系数均在 170以上, 增效作用明显。
3、 噻霉酮与异菌脲复酉 S寸黄瓜灰霉病毒力测定 i验
表 3噻霉酮、 异菌脲及其不同配比复酉 S寸黄瓜灰霉病毒力测定结果分析 翻名称 ECso cU g ml) ATI πι 系数( c) 口麵酮 4.21 100.∞ 1 1
异菌脲 5.82 72.34 1 1
配比噻霉酮 异菌 50:1 3.32 126.81 99.458 127.50
配比噻霉酮 异菌 30:1 3.05 138.03 99.108 139.27
配比噻霉酮 异菌 0:1 2.29 183.84 97.485 188.58
配比噻霉酮 异菌 :1 2.07 203.38 86.170 236.02
配比噻霉酮 异菌 :10 2.54 165.75 74.855 221.43
配比噻霉酮 异菌 :30 4.18 100.72 73.232 137.54
配比噻霉酮 异菌 :50 4.62 91.13 72.882 125.04 结果 (表 3 )表明, 噻霉酮与异菌脲复酉 S寸黄瓜灰霉病的防治效果显著提高, 说 明二者复配对黄瓜灰霉病具有显著的增效作用, 尤其是噻霉酮与异菌脲配比在 1:30〜 30:1之间, 噻霉酮与异菌脲的共毒系数均在 135以上, 增效作用明显。
4、 噻霉酮与氟环唑复酉 S寸香蕉叶斑病毒力测定 i验
表 4噻霉酮、 氟环唑及其不同配比复酉 S寸香蕉叶斑病毒力测定结果分析
Figure imgf000015_0001
结果 (表 4)表明, 噻霉酮与氟环唑复酉 S寸香蕉叶斑病的防治效果显著提高, 说 明二者复配对香蕉叶斑病具有显著的增效作用, 尤其是噻霉酮与氟环唑配比在 1:30〜
30:1之间, 噻霉酮与氟环唑的共毒系数均在 140以上, 增效作用明显。
(二) 田间药效验证试验
试验方法: 在发病初期, 立即进行第一次喷雾, 7天后进行第二次施药, 每个处理
4个小区, 小区 20平米。 于药前和第二次药后 10天调查统计发病情况, 小区
5点随机取样, 每点调查 5株作物, 调查整株上每叶片的病斑面积占叶片面积的百分率 并分级, 计算病情指数和防治效果。
∑ (各级叶片发病数 X该级代表值 )
病情指数 = χ ΐ οο
调查总叶片数 X最高级代表值 药前对照病情指数 X药后处理病情指数
防治效果 (1 - ) X 100
药后对照病情指数 X药前处理病情指数
预期防效 (%) =Χ+Υ-ΧΥ/100 (其中, X, Υ为单剂防效)
分级标准:
0级: 无病斑; 1级: 叶片病斑少于 5个, 长度小于 lcm ;
3级: 叶片病斑 6-10个, 部分病斑长度大于 lcm ;
5级: 叶片病斑 11-25个, 部分病斑连成片, 病斑面积占叶面积的 10-25%; 7级: 叶片病斑 26个以上, 病斑连成片, 病斑面积占叶面积的 26-50%; 9级: 病斑连成片, 病斑面积占叶面积的 50%以上或全叶枯死。
( 1) «酮与二氰蒽醌混配对葡萄霜霉病的田间药效试验
表 5 噻霉酮与二氰蒽醌混配对葡萄霜霉病防治效果
用量 第二次药后 11天
药前病
序号 处理药剂 (a.i.g/ha
情指数 病情指数 防效 (%)
)
15%噻霉酮水乳剂 125.8 2.79 6.46 85.8
50%二氰蒽醌悬浮剂 4.2 3.21 50.51 3.5
实施例 1 两者混合后预期防效 86.3
62%噻霉酮 ·二氰蒽醌水分散粒剂
130.0 3.02 3.05 93.8
(噻霉酮:二氰蒽醌 =60:2 )
15%噻霉酮水乳剂 4 2.81 40.00 12.7
50%二氰蒽醌悬浮剂 126 2.9 11.25 76.2 实施例 2 两者混合后预期防效 79.2
65%噻霉酮 ·二氰蒽醌水分散粒剂
130.0 2.88 4.60 90.2
(噻霉酮:二氰蒽醌 =2:63 )
15%噻霉酮水乳剂 92.8 2.69 10.75 75.5 实施例 9 50%二氰蒽醌悬浮剂 37.2 2.79 39.26 13.7
两者混合后预期防效 78.9
35%噻霉酮 ·二氰蒽醌悬浮剂
130.0 2.72 2.35 94.7
(噻霉酮:二氰蒽醌 =25:10)
15%噻霉酮水乳剂 43.4 2.85 23.56 49.3
50%二氰蒽醌悬浮剂 86.6 2.98 30.37 37.5 实施例 10 两者混合后预期防效 68.3
36%噻霉酮 ·二氰蒽醌悬浮剂
130.0 2.83 2.17 95.3
(噻霉酮:二氰蒽醌 =12:24)
15%噻霉酮水乳剂 2.9 2.76 40.87 9.2
50%二氰蒽醌悬浮剂 127.1 3.04 11.15 77.5 实施例 17 两者混合后预期防效 79.6
90%噻霉酮 ·二氰蒽醌可湿性粉剂
130.0 2.93 5.83 87.8
(噻霉酮:二氰蒽醌 =2:88 )
15%噻霉酮水乳剂 127 3 6.75 86.2
50%二氰蒽醌悬浮剂 3 2.87 45.35 3.1
实施例 18
两者混合后预期防效 86.6
88%噻霉酮 ·二氰蒽醌可湿性粉剂 130.0 2.91 4.65 90.2 (噻霉酮:二氰蒽醌 =86:2 )
15%噻霉酮水乳剂 59 2.79 20.15 55.7
50%二氰蒽醌悬浮剂 71 2.85 31.46 32.3 实施例 19 两者混合后预期防效 70.0
55%噻霉酮 ·二氰蒽醌可湿性粉剂
130.0 3.02 4.19 91.5
(噻霉酮:二氰蒽醌 =25:30)
15%噻霉酮水乳剂 21.6 2.68 28.63 34.5
50%二氰蒽醌悬浮剂 108.4 2.89 22.01 53.3 实施例 29 两者混合后预期防效 69.4
18%噻霉酮 ·二氰蒽醌微乳剂
130.0 2.75 3.36 92.5
(噻霉酮:二氰蒽醌 =3:15 )
15%噻霉酮水乳剂 108.4 2.87 10.06 78.5
50%二氰蒽醌悬浮剂 21.6 2.93 43.62 8.7 实施例 30 两者混合后预期防效 80.37
30%噻霉酮 ·二氰蒽醌微乳剂
130.0 2.85 3.63 92.2
(噻霉酮:二氰蒽醌 =25:5 )
15%噻霉酮水乳剂 123.8 2.68 6.86 84.3
50%二氰蒽醌悬浮剂 6.2 2.89 45.15 4.2 实施例 37 两者混合后预期防效 84.96
42%噻霉酮 ·二氰蒽醌水乳剂
130.0 2.75 3.86 91.4
(噻霉酮:二氰蒽醌 =40: 2 )
15%噻霉酮水乳剂 11.8 2.76 34.34 23.7
50%二氰蒽醌悬浮剂 118.2 2.85 16.03 65.5 实施例 38 两者混合后预期防效 73.7
44%噻霉酮 ·二氰蒽醌水乳剂
130.0 3.11 3.14 93.8
(噻霉酮:二氰蒽醌 =4:40)
15%噻霉酮水乳剂 6.2 2.9 39.11 17.3
50%二氰蒽醌悬浮剂 123.8 2.85 14.36 69.1 实施例 45 两者混合后预期防效 74.4
42%噻霉酮 ·二氰蒽醌油悬浮剂
130 2.79 4.32 90.5
(噻霉酮:二氰蒽醌 =2:40)
15%噻霉酮水乳剂 118.2 3.05 9.05 81.8
50%二氰蒽醌悬浮剂 11.8 3.25 49.23 7.1 实施例 46 两者混合后预期防效 83.1
55%噻霉酮 ·二氰蒽醌油悬浮剂
130 2.99 3.17 93.5
(噻霉酮:二氰蒽醌 =50:5 )
清水对照
2.93 46.93
(CK)
测定结果(表 5 )表明, 噻霉酮与二氰蒽醌复酉 S寸防治葡萄霜霉病的防效明显提 高, 说明二者复酉 S寸葡萄霜霉病有显著的增效作用。
(2) «酮与烯酰吗啉混配对荔枝疫霉病的田间药效试验 用量 第二次药后 11天 药前病
序号 处理药剂 (a.i.g/ha
情指数 病情指数 防效 (%)
)
15%噻霉酮水乳剂 145.4 2.51 5.95 81.2
50%烯酰吗啉可湿性粉剂 19.6 2.63 30.89 6.8 实施例 3 两者混合后预期防效 82.5
65%噻霉酮 ·烯酰吗啉水分散粒剂
150.0 2.52 3.52 88.9 (噻霉酮: 烯酰吗啉 =63:2 )
15%噻霉酮水乳剂 3.5 2.32 28.50 2.5
50%烯酰吗啉可湿性粉剂 146.5 2.29 6.95 75.9 实施例 4 两者混合后预期防效 76.5
85%噻霉酮 ·烯酰吗啉水分散粒剂
150 2.52 4.51 85.8 (噻霉酮: 烯酰吗啉 =2:83 )
15%噻霉酮水乳剂 142.9 2.45 6.14 80.1
50%烯酰吗啉可湿性粉剂 7.1 2.38 28.40 5.3 实施例 11 两者混合后预期防效 81.2
42%噻霉酮 ·烯酰吗啉悬浮剂
150.0 2.53 4.50 85.9 (噻霉酮: 烯酰吗啉 =40:2 )
15%噻霉酮水乳剂 23.4 2.26 21.47 24.6
50%烯酰吗啉可湿性粉剂 126.6 2.64 12.81 61.5 实施例 12 两者混合后预期防效 71.0
32%噻霉酮 ·烯酰吗啉悬浮剂
150 2.65 4.37 86.9 (噻霉酮: 烯酰吗啉 =5:27 )
15%噻霉酮水乳剂 146.6 2.54 5.60 82.5
50%烯酰吗啉可湿性粉剂 3.4 2.52 30.90 2.7 实施例 20 两者混合后预期防效 83.0
88%噻霉酮 ·烯酰吗啉可湿性粉剂
150.0 2.51 4.36 86.2 (噻霉酮: 烯酰吗啉 =86:2 )
15%噻霉酮水乳剂 75.0 2.72 14.29 58.3
50%烯酰吗啉可湿性粉剂 75.0 2.81 23.79 32.8 实施例 21 两者混合后预期防效 72.0
50%噻霉酮 ·烯酰吗啉可湿性粉剂
150.0 2.41 3.49 88.5 (噻霉酮: 烯酰吗啉 =25:25 )
15%噻霉酮水乳剂 4.8 2.36 28.58 3.9
50%烯酰吗啉可湿性粉剂 145.2 2.32 7.54 74.2 实施例 22 两者混合后预期防效 75.2
62%噻霉酮 ·烯酰吗啉可湿性粉剂
150.0 2.55 4.88 84.8 (噻霉酮: 烯酰吗啉 =2:60)
15%噻霉酮水乳剂 50.0 2.82 21.07 40.7 实施例 50%烯酰吗啉可湿性粉剂 100.0 2.53 16.74 47.5
31: 两者混合后预期防效 68.9
15%噻霉酮 ·烯酰吗啉微乳剂 150.0 2.63 3.48 89.5 (噻霉酮: 烯酰吗啉 =5:10)
15%噻霉酮水乳剂 100.0 2.66 10.66 68.2
50%烯酰吗啉可湿性粉剂 50.0 2.39 22.86 24.1 实施例 32 两者混合后预期防效 75.9
15%噻霉酮 ·烯酰吗啉微乳剂
150.0 2.35 3.58 87.9
(噻霉酮: 烯酰吗啉 =10:5 )
15%噻霉酮水乳剂 136.4 2.56 6.90 78.6
50%烯酰吗啉可湿性粉剂 13.6 2.25 26.91 5.1 实施例 39 两者混合后预期防效 79.7
22%噻霉酮 ·烯酰吗啉水乳剂
150.0 3.01 5.20 86.3
(噻霉酮: 烯酰吗啉 =20:2 )
15%噻霉酮水乳剂 13.6 2.51 27.14 14.2
50%烯酰吗啉可湿性粉剂 136.4 2.62 10.63 67.8 实施例 40 两者混合后预期防效 72.4
22%噻霉酮 ·烯酰吗啉水乳剂
150.0 2.51 3.83 87.9
(噻霉酮: 烯酰吗啉 =2:20)
15%噻霉酮水乳剂 125.0 2.52 8.35 73.7
50%烯酰吗啉可湿性粉剂 25.0 2.35 26.77 9.6 实施例 47 两者混合后预期防效 76.2
30%噻霉酮 ·烯酰吗啉油悬浮剂
150.0 2.69 4.91 85.5
(噻霉酮: 烯酰吗啉 =25:5)
15%噻霉酮水乳剂 7.1 2.55 29.95 6.8
50%烯酰吗啉可湿性粉剂 142.9 2.21 8.02 71.2 实施例 48 两者混合后预期防效 73.2
42%噻霉酮 ·烯酰吗啉油悬浮剂
150.0 2.36 4.10 86.2
(噻霉酮: 酰吗啉 =2:40)
清水对照
2.58 32.51
( CK)
测定结果(表 6 )表明, 噻霉酮与烯酰吗啉复酉 S寸防治荔枝疫霉病的防效明显提 高, 说明二者复酉纖枝疫霉病有显著的增效作用。
(3) «酮与异菌脲混配对荔 的田间药效试验
表 7 噻霉酮与异菌脲混酉 S寸辣椒灰霉病的防治效果
第二次药后 11天 药前病
序号 处理药剂
情指数 病情指数 防效 (%)
15%噻霉酮水乳剂 174.2 3.32 9.60 75.8
50%异菌脲悬浮剂 5.8 3.11 35.98 3.2 实施例 5 两者混合后预期防效 76.6
62%噻霉酮 ·异菌脲水分散粒剂
180.0 3.52 6.77 83.9
(噻霉酮: 异菌脲 =60:2 )
¾«| 6 15%噻霉酮水乳剂 4.8 3.32 35.91 9.5 50%异菌脲悬浮剂 175.2 3.89 14.09 69.7 两者混合后预期防效 72.6
75%嶋酮 ·异菌胁分散翻
180.0 3.51 7.26 82.7 (噻霉酮: 异菌脲 =2:73)
15%噻霉酮水乳剂 163.6 2.85 10.01 70.6
50%异菌脲悬浮剂 16.4 2.98 32.30 9.3
¾»J l3 两者混合后预期防效 73.3
55%嶋酮 ·异菌騰翔
180.0 3.11 5.91 84.1 (噻霉酮: 异菌脲 =50:5)
15%噻霉酮水乳剂 8.6 3.21 32.30 15.8
50%异菌脲悬浮剂 171.4 3.14 13.81 63.2
¾»!| 14 两者混合后预期防效 69.0
42%嶋酮 ·异菌騰翔
180.0 3.15 6.55 82.6 (噻霉酮: 异菌脲 =2:40)
15%噻霉酮水乳剂 175.8 2.84 8.11 76.1
50%异菌脲悬浮剂 4.2 2.92 33.88 2.9 两者混合后预期防效 76.8
85%嶋酮 ·异菌脲可湿性粉剂
180.0 2.82 5.59 83.4 (噻霉酮: 异菌脲 =83:2)
15%噻霉酮水乳剂 90.0 3.76 23.68 47.3
50%异菌脲悬浮剂 90.0 3.24 26.60 31.3
¾»J 24 两者混合后预期防效 63.8
50%嶋酮 -异菌脲可湿性粉剂
180.0 3.35 4.88 87.8 (噻霉酮: 异菌脲 =25:25)
15%噻霉酮水乳剂 4.2 3.31 35.68 9.8
50%异菌脲悬浮剂 175.8 3.22 13.70 64.4
¾»J 25 两者混合后预期防效 67.9
85%嶋酮 ·异菌脲可湿性粉剂
180.0 3.45 7.38 82.1 (噻霉酮: 异菌脲 =2:83)
15%噻霉酮水乳剂 60.0 3.72 30.90 30.5
50%异菌脲悬浮剂 120.0 3.13 18.25 51.2 两者混合后预期防效 66.1
18%嶋酮 ·异菌脲微?
180.0 3.42 4.82 88.2 (噻霉酮: 异菌脲 =6:12)
15%噻霉酮水乳剂 171.4 3.26 10.05 74.2
50%异菌脲悬浮剂 8.6 3.11 35.20 5.3 两者混合后预期防效 75.6
21%嶋酮 ·异菌脲微?
180.0 3.32 6.55 83.5 (噻霉酮: 异菌脲 =20:1)
¾»J 41 15%噻霉酮水乳剂 150.0 3.56 15.91 62.6
50%异菌脲悬浮剂 30.0 3.25 31.19 19.7 两者混合后预期防效 70.0 30%嶋酮 ·异菌胁
180.0 3.41 5.34 86.9
(噻霉酮: 异菌脲 =25:5)
15%噻霉酮水乳剂 8.6 3.51 35.44 15.5
50%异菌脲悬浮剂 171.4 3.12 14.43 61.3
¾»J 42 两者混合后预期防效 67.3
42%嶋酮 ·异菌胁
180.0 3.11 6.28 83.1
(噻霉酮: 异菌脲 =2:40)
15%噻霉酮水乳剂 30.0 3.22 30.48 20.8
50%异菌脲悬浮剂 150.0 2.96 13.69 61.3 两者混合后预期防效 69.3
18%嶋酮 ·异菌脲油悬浮剂
180.0 2.90 3.99 88.5
(噻霉酮: 异菌脲 =3:15)
15%噻霉酮水乳剂 163.6 2.86 10.36 69.7
50%异菌脲悬浮剂 16.4 2.91 31.44 9.6
¾»J 50 两者混合后预期防效 72.6
22%嶋酮 ·异菌脲油悬浮剂
180.0 3.19 6.33 83.4
(噻霉酮: 异菌脲 =20:2)
清水对照
3.21 38.36
( CK)
测定结果(表 7 )表明,噻霉酮与异菌脲复酉 S寸防治辣椒灰霉病的防效明显提高, 说明二者复酉 S寸辣椒灰霉病有显著的增效作用。
(4) «酮与氟环唑混配对香蕉叶斑病的田间药效试验
表 8 噻霉酮与氟环唑混配对香蕉叶斑病防治效果
Figure imgf000021_0001
55%鶴酮 -解嶋翻
100.0 3.71 7.10 85.7 (嶋酮: 解 50:5)
15%噻霉酮水乳剂 9.1 3.55 38.52 18.9
50%氟环唑悬浮剂 90.9 3.88 20.40 60.7
¾»J l6 两者混合后预期防效 68.1
55%鶴酮 -解嶋翻
100.0 3.83 7.28 85.8 (嶋酮: 解 5:50)
15%噻霉酮水乳剂 2.3 3.56 44.82 5.9
50%氟环唑悬浮剂 97.7 3.34 14.39 67.8
¾»!| 26 两者混合后预期防效 69.7
88%鶴酮 ·解唑可湿性粉剂
100.0 3.63 8.21 83.1 (嶋酮: 解 2:86)
15%噻霉酮水乳剂 97.3 3.55 11.16 76.5
50%氟环唑悬浮剂 2.3 3.87 49.76 3.9
¾»J 27 两者混合后预期防效 77.4
86%嶋酮 ·解唑可湿性粉剂
100.0 3.93 9.04 82.8 (嶋酮: 解 84:2)
15%噻霉酮水乳剂 50.0 3.59 25.22 47.5
50%氟环唑悬浮剂 50.0 3.55 30.97 34.8
¾»J 28: 两者混合后预期防效 65.8
50%嶋酮 -解唑可湿性粉剂
100.0 3.42 6.96 84.8 (嶋酮: 解 25:25)
15%噻霉酮水乳剂 16.7 3.83 37.00 27.8
50%氟环唑悬浮剂 83.3 3.89 24.72 52.5
¾»J 35 两者混合后预期防效 65.7
12%嶋酮 · m m
100.0 3.65 6.40 86.9
(嶋酮: 解 2:10)
15%噻霉酮水乳剂 66.7 3.87 25.73 50.3
50%氟环唑悬浮剂 33.3 3.93 41.28 21.5 两者混合后预期防效 61.0
15%嶋酮 · m m
100.0 365 800.92 83.6
(嶋酮: 解 10:5)
15%噻霉酮水乳剂 95.2 3.68 12.41 74.8
50%氟环唑悬浮剂 4.8 3.89 49.34 5.2 两者混合后预期防效 76.1
21%嶋酮 · ^ 9
100.0 2.75 5.78 84.3
(嶋酮: 解 20:1)
15%噻霉酮水乳剂 4.8 3.76 45.38 9.8
50%氟环唑悬浮剂 95.2 3.55 15.86 66.6 雄例 44: 两者混合后预期防效 69.9
42%嶋酮 · ^ 9
100.0 3.31 6.60 85.1 (嶋酮:
Figure imgf000022_0001
Figure imgf000023_0001
提高, 说明二者复酉 寸香蕉叶斑病有显著的增效作用。

Claims

权利要求书
1、 具有增效作用的杀菌剂组合物, 其特征在于所述的组合物包含 A和 B两种 活 f生组分, 其中活性组分 A为噻霉酮, 活 f生组分 B为选自二氰蒽醌、烯酰吗啉、 异 菌脲或氟环唑中的一种, 两组分之间的重量比为 1 : 50-50: 1,优选 1 : 30〜30: 1。
2、根据权利要求 1所述的组合物, 其特征在于所述的组合物是由 6〜92%重量 份的活性组分与 94〜8%重量份的农药助剂组成。
3、 根据权利要求 1所述组合物, 其特征在于活性组分噻霉酮与活性组分二氰 蒽醌的重量比为 1 : 30〜30: 1。
4、 根据权利要求 1所述组合物, 其特征在于活性组分噻霉酮与活性组分烯酰 吗啉的重量比为 1 : 30〜30: 1。
5、 根据权利要求 1所述组合物, 其特征在于活性组分噻霉酮与活性组分异菌 脲的重量比为 1: 30〜30: 1。
6、 根据权利要求 1所述组合物, 其特征在于活性组分噻霉酮与活性组分氟环 唑的重量比为 1: 30〜30: 1。
7、 根据权利要求 1所述的组合物, 其特征在于所述的组合物的剂型为农业上 允许的任意一种剂型。
8、 根据权利要求 5所述的组合物, 其特征在于所述的组合物的剂型为可湿性 粉剂、 悬浮剂、 漏孚剂、 水分散粒剂、 水乳剂、 微乳剂。
9、 根据权利要求 1所述的组合物, 其特征在于所述的组合物在农业领域防治 农作物病害的应用。
10、 根据权利要求 9所述的组合物, 所述农作物病害选自黄 «霉病病菌、 黄 瓜灰霉病、 香蕉叶斑病、 葡萄霜霉病或荔枝疫霉病。
PCT/CN2012/080379 2012-08-13 2012-08-20 具有增效作用的杀菌组合物 WO2014026396A1 (zh)

Priority Applications (14)

Application Number Priority Date Filing Date Title
AU2012387919A AU2012387919B2 (en) 2012-08-13 2012-08-20 Synergistic fungicide composition
PL17162712T PL3210470T3 (pl) 2012-08-13 2012-08-20 Synergistyczna kompozycja fungicydu
PL17162732T PL3210471T3 (pl) 2012-08-13 2012-08-20 Synergistyczna kompozycja fungicydu
EA201590368A EA025481B1 (ru) 2012-08-13 2012-08-20 Синергетическая фунгицидная композиция
EP17162712.8A EP3210470B1 (en) 2012-08-13 2012-08-20 Synergistic fungicide composition
DK12883005.6T DK2885971T3 (en) 2012-08-13 2012-08-20 SYNERGISTIC FUNGICIDE COMPOSITION
CA2881512A CA2881512C (en) 2012-08-13 2012-08-20 Synergistic fungicide composition comprising benzisothiazolinone
ES12883005.6T ES2654314T3 (es) 2012-08-13 2012-08-20 Composición fungicida sinérgica
US14/421,125 US9282744B2 (en) 2012-08-13 2012-08-20 Synergistic fungicide composition
PL12883005T PL2885971T3 (pl) 2012-08-13 2012-08-20 Synergistyczna kompozycja fungicydu
EP17162742.5A EP3210472B1 (en) 2012-08-13 2012-08-20 Synergistic fungicide composition
EP12883005.6A EP2885971B1 (en) 2012-08-13 2012-08-20 Synergistic fungicide composition
LTEP12883005.6T LT2885971T (lt) 2012-08-13 2012-08-20 Sinergetinė fungicidų kompozicija
EP17162732.6A EP3210471B1 (en) 2012-08-13 2012-08-20 Synergistic fungicide composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201210287687.2 2012-08-13
CN201210287687.2A CN102763657B (zh) 2012-08-13 2012-08-13 具有增效作用的杀菌组合物

Publications (1)

Publication Number Publication Date
WO2014026396A1 true WO2014026396A1 (zh) 2014-02-20

Family

ID=47091422

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2012/080379 WO2014026396A1 (zh) 2012-08-13 2012-08-20 具有增效作用的杀菌组合物

Country Status (13)

Country Link
US (1) US9282744B2 (zh)
EP (4) EP2885971B1 (zh)
CN (1) CN102763657B (zh)
AU (4) AU2012387919B2 (zh)
CA (4) CA2941028C (zh)
DK (2) DK2885971T3 (zh)
EA (1) EA025481B1 (zh)
ES (3) ES2730205T3 (zh)
HU (4) HUE045173T2 (zh)
LT (3) LT3210472T (zh)
PL (3) PL2885971T3 (zh)
PT (3) PT3210470T (zh)
WO (1) WO2014026396A1 (zh)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105613517A (zh) * 2016-02-29 2016-06-01 陕西西大华特科技实业有限公司 噻霉酮在防治马铃薯疮痂病上的应用及防治马铃薯疮痂病方法
CN105613518A (zh) * 2016-02-29 2016-06-01 陕西西大华特科技实业有限公司 噻霉酮在防治马铃薯黑痣病上的应用及防治马铃薯黑痣病方法
WO2018000528A1 (zh) * 2016-06-26 2018-01-04 江苏辉丰农化股份有限公司 一种杀菌剂组合物
WO2022198049A1 (en) * 2021-03-19 2022-09-22 Arxada, LLC Biocidal composition and method

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103120167A (zh) * 2013-01-15 2013-05-29 中国农业科学院植物保护研究所 烯酰吗啉可分散油悬浮剂
CN104094950B (zh) * 2013-06-09 2016-06-01 江苏辉丰农化股份有限公司 具有增效作用的杀菌组合物
CN104542630B (zh) * 2014-12-27 2019-08-02 江西中迅农化有限公司 一种含有噻唑锌和噻霉酮的杀菌组合物
EP3282852A1 (en) * 2015-04-16 2018-02-21 Basf Se Attenuation of phytotoxicity of multisite fungicides by high-molecular-weight dispersants
CN105685060A (zh) * 2015-10-19 2016-06-22 陕西西大华特科技实业有限公司 杀菌组合物的制备及应用
CN106818723A (zh) * 2015-12-04 2017-06-13 陕西西大华特科技实业有限公司 含噻霉酮的组合物及其制备方法
CN106259384B (zh) * 2016-05-30 2019-06-21 江苏辉丰农化股份有限公司 一种杀菌剂组合物
CN106538549A (zh) * 2016-10-31 2017-03-29 广东中迅农科股份有限公司 一种含有噻霉酮和氟吗啉的杀菌组合物
CN107306972A (zh) * 2017-06-13 2017-11-03 中国农业科学院植物保护研究所 百里香酚及其组合物
CN107787988A (zh) * 2017-09-28 2018-03-13 江苏明德立达作物科技有限公司 一种壳寡糖和噻霉酮油悬浮剂及其制备方法
CN107529402A (zh) * 2017-10-10 2018-01-02 陕西西大华特科技实业有限公司 一种含噻霉酮和咯菌腈的杀菌组合物
CN108812684A (zh) * 2018-09-28 2018-11-16 陕西西大华特科技实业有限公司 一种含噻霉酮和丁吡吗啉的组合杀菌物
CN110537548A (zh) * 2018-12-13 2019-12-06 北京宇悦生物科技有限公司 农药组合物及其应用
CN114208827B (zh) * 2021-12-27 2023-02-28 四川科宏达集团有限责任公司 一种高电解质农药微乳助剂

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101796955A (zh) * 2009-12-31 2010-08-11 青岛星牌作物科学有限公司 一种复配杀菌组合物及应用
CN101984809A (zh) * 2010-07-22 2011-03-16 福建诺德生物科技有限责任公司 一种以松脂基植物油为载体的油悬制剂及其制备方法
CN102823602A (zh) * 2012-05-29 2012-12-19 陕西西大华特科技实业有限公司 一种含有噻霉酮和氟环唑的杀菌组合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003095828A (ja) * 2001-09-27 2003-04-03 Shinto Fine Co Ltd 工業用抗菌組成物及び抗菌方法
DK2197278T3 (da) * 2007-09-07 2013-08-26 Basf Se Co-krystaller af pyrimethanil og dithianon
CN101595889A (zh) * 2009-05-07 2009-12-09 深圳诺普信农化股份有限公司 一种含有异菌脲的杀菌组合物
EP2453739B2 (en) * 2009-07-14 2023-03-01 Basf Se A process for preparing an aqueous suspension of an organic pesticide compound
CN101695297B (zh) * 2009-11-04 2012-10-03 陕西西大华特科技实业有限公司 噻霉酮水悬浮剂及其制备方法
CN101999372B (zh) * 2010-12-14 2015-11-25 陕西西大华特科技实业有限公司 含有噻霉酮和苯醚甲环唑的杀菌组合物
EP2667720B1 (en) * 2011-01-28 2021-01-20 Deepak Pranjivandas Shah Pesticidal composition comprising sulphur, a fungicide and an agrochemical excipient
CN102100233B (zh) * 2011-03-01 2016-06-08 陕西西大华特科技实业有限公司 一种含噻霉酮与己唑醇的杀菌组合物
CN102258037B (zh) * 2011-05-25 2016-04-20 陕西西大华特科技实业有限公司 含噻霉酮和戊唑醇的杀菌组合物
CN102239860B (zh) * 2011-07-28 2015-07-15 陕西西大华特科技实业有限公司 一种含噻霉酮和三环唑的增效杀菌组合物
CN102578131A (zh) * 2012-02-03 2012-07-18 上海韬鸿化工科技有限公司 杀菌灭藻剂及其应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101796955A (zh) * 2009-12-31 2010-08-11 青岛星牌作物科学有限公司 一种复配杀菌组合物及应用
CN101984809A (zh) * 2010-07-22 2011-03-16 福建诺德生物科技有限责任公司 一种以松脂基植物油为载体的油悬制剂及其制备方法
CN102823602A (zh) * 2012-05-29 2012-12-19 陕西西大华特科技实业有限公司 一种含有噻霉酮和氟环唑的杀菌组合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2885971A4 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105613517A (zh) * 2016-02-29 2016-06-01 陕西西大华特科技实业有限公司 噻霉酮在防治马铃薯疮痂病上的应用及防治马铃薯疮痂病方法
CN105613518A (zh) * 2016-02-29 2016-06-01 陕西西大华特科技实业有限公司 噻霉酮在防治马铃薯黑痣病上的应用及防治马铃薯黑痣病方法
WO2018000528A1 (zh) * 2016-06-26 2018-01-04 江苏辉丰农化股份有限公司 一种杀菌剂组合物
US20190254279A1 (en) * 2016-06-26 2019-08-22 Jiangsu Huifeng Bio Agriculture Co., Ltd. Fungicidal composition
AU2016413017B2 (en) * 2016-06-26 2020-01-23 Adama Huifeng (Jiangsu) Ltd. Bactericide composition
AU2016413017C1 (en) * 2016-06-26 2020-04-30 Adama Huifeng (Jiangsu) Ltd. Bactericide composition
US11219213B2 (en) 2016-06-26 2022-01-11 Adama Huifeng (Jiangsu), Ltd. Fungicidal composition
WO2022198049A1 (en) * 2021-03-19 2022-09-22 Arxada, LLC Biocidal composition and method

Also Published As

Publication number Publication date
LT3210470T (lt) 2019-06-25
PL3210470T3 (pl) 2020-01-31
PL2885971T3 (pl) 2018-05-30
AU2016202646B2 (en) 2016-09-29
ES2725104T3 (es) 2019-09-19
ES2654314T3 (es) 2018-02-13
LT3210472T (lt) 2019-03-25
AU2016202647A1 (en) 2016-05-19
CN102763657B (zh) 2014-09-17
AU2016202646A1 (en) 2016-05-19
CA2881512C (en) 2017-07-25
EP2885971A4 (en) 2016-03-16
LT2885971T (lt) 2018-01-25
PT3210471T (pt) 2019-05-29
EA025481B1 (ru) 2016-12-30
HUE044013T2 (hu) 2019-09-30
CA2941027A1 (en) 2014-02-20
AU2016202645B2 (en) 2016-09-29
PL3210471T3 (pl) 2019-09-30
EP3210471A1 (en) 2017-08-30
CA2881512A1 (en) 2014-02-20
HUE045173T2 (hu) 2019-12-30
CN102763657A (zh) 2012-11-07
US20150208659A1 (en) 2015-07-30
AU2016202645A1 (en) 2016-05-19
HUE043968T2 (hu) 2019-09-30
EP3210470B1 (en) 2019-03-13
AU2012387919B2 (en) 2016-05-19
CA2941028C (en) 2016-12-13
DK3210470T3 (da) 2019-06-17
EP2885971B1 (en) 2017-10-04
CA2940957A1 (en) 2014-02-20
CA2940957C (en) 2018-02-27
US9282744B2 (en) 2016-03-15
DK2885971T3 (en) 2018-01-02
CA2941027C (en) 2018-02-27
EP3210471B1 (en) 2019-02-06
EP2885971A1 (en) 2015-06-24
EP3210472A1 (en) 2017-08-30
PT3210470T (pt) 2019-06-18
CA2941028A1 (en) 2014-02-20
EP3210470A1 (en) 2017-08-30
EA201590368A1 (ru) 2015-05-29
PT2885971T (pt) 2018-01-03
HUE038086T2 (hu) 2018-09-28
AU2012387919A1 (en) 2015-03-05
AU2016202647B2 (en) 2016-09-29
ES2730205T3 (es) 2019-11-08
EP3210472B1 (en) 2019-02-06

Similar Documents

Publication Publication Date Title
WO2014026396A1 (zh) 具有增效作用的杀菌组合物
WO2017121019A1 (zh) 一种杀菌剂组合物
WO2018086633A1 (zh) 一种包含苯并异噻唑啉酮类和乙蒜素的杀菌剂组合物
WO2014180020A1 (zh) 具有增效作用的杀菌组合物
WO2018040775A1 (zh) 一种杀菌剂组合物
WO2018059606A1 (zh) 含有苯并异噻唑啉酮类和双炔酰菌胺的杀菌组合物
WO2018157649A1 (zh) 一种包含大黄素衍生物与苯并异噻唑啉酮的杀菌剂组合物
WO2017185559A1 (zh) 一种杀菌剂组合物
WO2018126878A1 (zh) 一种包含苯并异噻唑啉酮类和四氟醚唑的杀菌剂组合物
WO2018068773A2 (zh) 含苯并异噻唑啉酮类和极细链格孢激活蛋白的杀菌组合物
WO2018024067A1 (zh) 一种杀菌剂组合物
WO2018001152A1 (zh) 一种杀菌剂组合物
WO2018006462A1 (zh) 一种杀菌剂组合物
WO2018040788A1 (zh) 一种杀菌剂组合物
WO2018054396A1 (zh) 一种杀菌剂组合物
WO2018068772A1 (zh) 包含苯并异噻唑啉酮类和唑嘧菌胺的杀菌组合物
WO2018006463A1 (zh) 一种杀菌剂组合物
CN103300018B (zh) 具有噻霉酮与烯酰吗啉的增效杀菌组合物
WO2018036302A1 (zh) 一种杀菌剂组合物
CN105230635B (zh) 杀菌组合物及其应用
CN109287640B (zh) 含有噻霉酮和异噻菌胺的杀菌剂组合物
WO2018000526A1 (zh) 一种杀菌剂组合物
WO2017206328A1 (zh) 一种杀菌剂组合物
CN103314969B (zh) 具有噻霉酮与二氰蒽醌的增效杀菌组合物

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12883005

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2881512

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 14421125

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2012387919

Country of ref document: AU

Date of ref document: 20120820

Kind code of ref document: A

REEP Request for entry into the european phase

Ref document number: 2012883005

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2012883005

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 201590368

Country of ref document: EA