WO2014017724A1

WO2014017724A1 - Compound for keeping teeth whitened for preventing tooth discoloration and staining

Info

Publication number: WO2014017724A1
Application number: PCT/KR2013/002346
Authority: WO
Inventors: 최다미; 신승화; 정용일; 송주동; 엄태관; 최규옥
Original assignee: 오스템임플란트 주식회사
Priority date: 2012-07-25
Filing date: 2013-03-21
Publication date: 2014-01-30
Also published as: KR101423230B1; KR20140015814A

Abstract

The present invention relates to a compound for keeping teeth whitened having glycerol monooleate as a base for ensuring proper liquidity, which is easily applied to the teeth during use and is not easily diluted or lost after applying same to the teeth due to improved adhesion to the tooth surface resulting from increased viscosity caused by the inflow of saliva. Accordingly, when the compound for keeping teeth whitened is applied in conjunction with professional whitening or self-administered whitening, and with care being taken to avoid foods causing staining and discoloration, the present invention can prevent the teeth from returning to the original tooth color thereof while protecting same from staining and discoloration circumstances caused by internal and external factors such that the whitening retention period can be lengthened.

Description

【Specification】

[Name of invention]

Teeth whitening agent to prevent discoloration and pigmentation of teeth

Technical Field

<1> The present invention protects the teeth from the environment of pigmentation and discoloration caused by endogenous and extrinsic factors to prolong the whitening duration, and also to pay attention to the food affecting the pigmentation and discoloration during professional whitening and self-whitening procedures. The present invention relates to a tooth whitening agent that can prevent or delay the phenomenon of returning to the color of the original tooth by applying anti-pigmentation agent in parallel.

Background Art

<2> With the development of society and the rising standard of living of modern people, interpersonal relations have become an important era. Accordingly, the focus of dental treatment is shifting from the function-oriented treatment to the aesthetic-oriented treatment in recent years.

<3> The effects of tooth aesthetics include the arrangement, size, color, texture and light transmission of teeth. Among these, tooth color is the most sensitive and important factor. In addition to aesthetic problems, it can also cause psychological problems such as passive interpersonal relationships or lack of confidence.

<4> The causes of tooth discoloration are classified into endogenous and exogenous factors. Endogenous factors mean that a substance having a double bond chromophore in food is deposited in an enamel layer outside the tooth. Means tartar or soft deposits attached to the tooth surface resulting in discoloration of the tooth

<5> Dental whitening, which restores discolored teeth that have lost their original color due to these factors, is called whitening. Currently, in the clinical practice for whitening teeth, professional whitening (off ice bleaching) and self-whitening ( Home bleaching is used together. ,

<6> Expert whitening is getting more attention recently because professional dentists can achieve a clear effect in a short time by using 25-35% high concentration of hydrogen peroxide. In addition, self-whitening uses less than 3% hydrogen peroxide, which itself can not be expected to be as effective as professional whitening, but when combined with expert whitening can maximize the whitening effect.

Although there is a difference in concentration, most of the tooth whitening agents contain hydrogen peroxide, so the safety issue for the human body needs to be dealt with carefully. Such a furnace As part of its power, a safer whitening agent is prepared by combining a compound that generates hydrogen peroxide in hydrogen peroxide and / or aqueous solution with a dicarboxylic anhydride that reacts with the compound to produce organic peracids, as disclosed in Korean Patent Publication No. 2009-0123876. It has been proposed.

On the other hand, even after successful teeth whitening, the surface of the tooth is continuously placed in an environment where it may become recolored or discolored while eating foods containing coloring ingredients in daily life. In order to delay recoloring or discoloration, periodical whitening care is recommended with attention to the intake of foods that can cause recoloring after tooth whitening.

However, when the tooth color is returned to the state before the whitening due to the recoloring and discoloration over time after the whitening, it may lower the aesthetic satisfaction of the procedure and in the past, may cause complaints about the whitening procedure. In addition, there is a discomfort to always pay attention to the gargling and food after whitening, and the situation to increase the burden on the patient economically and timely, such as the burden of treatment costs and side effects caused by the periodic whitening care. In addition, repeated tooth whitening may cause hypersensitivity reactions, tooth whiskers, and periodontal inflammation in sensitive teeth.

Therefore, a tooth whitening agent is required to prevent tooth discoloration and pigmentation by endogenous and exogenous factors after tooth whitening, but it has not been discovered until now, and in general, it is necessary to continue the effect of whitening through additional whitening. I'm staying.

[Detailed Description of the Invention]

[Technical problem]

Therefore, the present invention protects teeth from the environment of pigmentation and discoloration caused by endogenous or exogenous factors, prolongs the duration of whitening, and also affects the pigmentation and discoloration during professional whitening and self-whitening procedures. It is an object of the present invention to provide a tooth whitening agent that can prevent or delay the phenomenon of returning to the color of the original tooth by applying the anti-pigmentation agent in parallel during the attention period.

Technical Solution

The present invention relates to a composition for preventing discoloration and pigmentation of a tooth, comprising a glycerol monooleate, a polymer for controlling the physical properties of the glycerol monooleate, a tooth containing an organic inorganic compound and a solvent having a whitening effect Provide a whitening oil. Here, the glycerol monooleate may be included in the amount of 5 to 95% by weight, more preferably in the amount of 30 to 90% by weight in the tooth whitening retainer.

In addition, the polymer may be a nonionic polymer, an anionic polymer or a salt thereof, a synthetic polymer, or one or two or more kinds of polyacrylic acid or carbopol.

In addition, the organic 'inorganic compound may be a vitamin or a vitamin derivative, preferably ascorbic acid or a derivative thereof ascorbic acid glucoside (ascorbic acid 2-glucoside (AA-2G), magnesium ascorbyl phosphate, sodium At least one selected from the group consisting of ascorbyl phosphate, ascorbyl glucoside, aminopropyl ascorbyl phosphate, tocope, tocopheryl acetate, tocopheryl linoleate, tocopheryl nicotinate, tocopheryl glucoside, tocopheryl succinate It may be more than one.

Meanwhile, the tooth whitening maintenance agent of the present invention may further include at least one or more of a flavoring agent, hypersensitivity treatment agent or dental caries suppressor or gum disease improving agent. [Beneficial] effect ^'

According to the tooth whitening and maintenance agent according to the present invention, by applying the foods that affect coloration and discoloration in parallel during the professional whitening and self-whitening periods, the phenomenon of returning to the original tooth color is prevented, 치아 Protects teeth from the environment of pigmentation and discoloration caused by exogenous factors, thereby prolonging the whitening duration.

In addition, the tooth whitening maintenance agent of the present invention can ensure proper fluidity by glycerol based on the mono- rate formulation, so that it is easy to apply to the teeth at the time of use, the viscosity by the inflow of saliva after applied to the teeth Has an advantage that the adhesion to the tooth surface is enhanced so that it is not easily limated or lost.

In addition, the tooth whitening maintenance agent of the present invention can further prolong the duration of tooth whitening by more effectively blocking pigmentation and discoloration after whitening by further adding vitamins and vitamin derivatives to glycerol monoacrylate.

In addition, the present invention can improve the shortcomings of the short shelf life of vitamins while maintaining the same teeth discoloration and anti-pigmentation effect of vitamins by adding vitamin derivatives to the teeth whitening oil, especially Vitamin derivatives are whitening agents because they exist in a stable state for a long time in aqueous solution compared to conventional vitamins. In terms of sustained efficacy of the vitamin compared to the improved effect can be obtained.

[Brief Description of Drawings]

1 is a photograph showing that the viscosity of the tooth whitening retainer of the present invention is changed by the addition of water.

Figure 2 is a photograph comparing the degree of discoloration and pigmentation for the hamster teeth when applying the tooth whitening maintenance agent of the present invention compared to the unused control.

Figure 3 is a view showing the results of evaluating the shade guide value for the teeth of the hamster of FIG.

Figure 4 is a photograph showing the results of experiments evaluating the effectiveness of the tooth whitening agent of the present invention in the teeth of extracted human.

5 is a view showing the results of the experiment carried out by accelerated aging under conditions corresponding to two years of long-term preservation in order to evaluate the long-term stability and effectiveness of the vitamin derivative added in the tooth whitening maintenance.

Figure 6 is a photograph showing the results of a hamster ball bag test performed to evaluate the irritation of the whitening agent of the present invention on the mucous membrane.

[Form for implementation of invention]

Hereinafter, a preferred embodiment of the tooth whitening retainer of the present invention will be described in detail. <28> The present invention is a tooth whitening agent for preventing or discoloring teeth and delaying, by forming a kind of protective film on the teeth material having a double bond chromophore contained in the food is deposited on the enamel layer outside the teeth or tartar Soft precipitates have a function of preventing the adhesion of (re) discoloration or pigmentation of the teeth to the surface of the teeth for a period of time.

In order to improve applicability, the tooth whitening retainer of the present invention is first formed in a liquid phase which is easy to apply to a tooth, but after being actually applied to the tooth, the tooth whitening oil is gradually contacted with water such as saliva in the oral cavity. As the viscosity increases, adhesion to the tooth surface is improved, and thus, it is characterized in that it is composed of a formulation that can effectively protect the teeth from food affecting pigmentation.

As described above, the formulation of the tooth whitening agent of the present invention, in which the viscosity is increased by the addition of moisture to realize both effects of excellent applicability and adhesion to the tooth surface, is adhesive by using intermolecular bonds of a hydrophilic polymer. Glycerol contains monooleates, polymers, and solvents to increase their adhesion and allow adhesion to teeth.

Glycerol monooleate forms liquid crystals depending on temperature and water content. Therefore, it has the characteristics of different forms and physical properties due to the surrounding environment. In other words, the phase change of glycerol monoacrylate is in the form of lamellar, inverted micellar (i cell) or inverted hexagon (hexagonal) phase is fluid and easy to apply or apply to the surface of the tooth, As the moisture content increases, the structure changes to a cubic phase, thereby solidifying and thus losing fluidity. The present invention is to develop such a change in the physical properties of the liquid crystal is utilized as a tooth whitening maintenance agent.

In particular, the tooth whitening and maintaining agent of the present invention, which is based on glycerol monoacrylate, is suitable for applying to the teeth because of its fluidity when applied to the teeth, but after being applied to the teeth, contact with moisture and saliva in the oral cavity is applied. As a result, the viscosity is increased, and it is easily changed in the form of adhesion to the tooth so that it is not easily diluted or lost in oral conditions.

This glycerol monoacrylate can be added in the amount of about 5 to 95% by weight in the tooth whitening retainer, preferably in an amount of 30 to 90% by weight in order to form the formulation.

In order to control the physical properties of the basic glycerol monooleate, a polymer compound, ie, a polymer, is added. For example, it is possible to change the physical properties of the formulation by adding a polymer having excellent tooth adhesion, or by adding a polymer exhibiting different behavior according to the change of temperature.

<35> The polymer that can be used in the tooth whitening and keeping agent of the present invention is a nonionic polymer, an anionic polymer or a salt thereof, or a polyacrylic acid as a synthetic polymer.

It may contain one or more combinations, such as polyacrylic acid or carbopol.

These polymers may be used as one or two or more combinations in the tooth whitening retention agent.

It may be added in an amount of less than 50% by weight, preferably in an amount of 5 to 30% by weight in order to improve the adhesion through the viscosity of the base formulation and form the formulation.

Figure 1 shows that the tooth whitening retainer of the present invention made with the above formulation changes in viscosity due to the addition of water. The left picture of Figure 1 is the initial state of the tooth whitening maintenance agent of the present invention before the water flows into the liquid form in the form of easy to apply, the formulation is easy to apply, the right picture is exposed to a certain level of moisture It is the result of simulating my environment, but as you can see with the naked eye, the viscosity increases The castle was greatly improved. As such, the tooth whitening retainer of the present invention is not easily diluted or lost in the oral environment according to the improvement of adhesion due to the increase in viscosity.

In addition, the tooth whitening maintenance agent according to the present invention may be added with an organic and inorganic compound that is effective in whitening in order to prevent discoloration and delay recoloring.

Representative compounds that may be added include vitamins and vitamin derivatives as compounds. Ascorbic acid and its derivatives, ascorbic acid 2-glucoside (AA-2G), magnesium ascorbyl phosphate, sodium ascorbyl phosphate, ascorbyl glucoside, aminopropyl ascorbyl phosphate Tomate, tocofe, tocopheryl acetate, tocopheryl linoleate, tocopheryl nicotinate, tocopheryl glucoside, tocopheryl succinate or to a combination of two or more thereof.

In addition, the tooth whitening maintenance agent according to the present invention does not change the shape retention and stability of the formulation by adding a flavoring agent, hypersensitivity treatment agent or dental caries suppressor or gum disease improving agent in addition to the aforementioned components. It can also improve oral experience.

<41>

Hereinafter, an experimental example of the effect of the tooth whitening retainer of the present invention will be described.

Before explaining each experimental example, three kinds of tooth whitening agents used in the experiments, namely, three types of vitamins or vitamin derivatives respectively added to the tooth whitening oil and the tooth whitening oil To specify the content of each tooth whitening agent composition is shown in Table 1 below.

<44>

<45> In the following composition table, 'Glycerol' is a humectant, 'Poloxamer' is a nonionic polymer, water is a solvent, 'Peppermint Oil' is a flavoring agent, 'Sodium Fluoride' is a hypersensitivity treatment agent, and 'Polyacrylic Acid' is an ionic Polymer, 'Absorbic Acid' is a vitamin for improving the effect of teeth whitening and 'Absorbic Acid 2-Glucoside' is a vitamin derivative for improving the effect of teeth whitening.

<46> [Table 1]

<47> Content of Compositions of Three Types of Teeth Whitening Retaining Agents Added Vitamin and Vitamin Derivatives to the Teeth Whitening Retaining Agent and Tooth Whitening Retaining Agent

Whitening and keeping agents; Tooth whitening agents, AA; ascorbic acid, AA-2G; asorbic aid

2-gucos i de

<49>

<50> [Experimental Example 1]

2 and 3 are the results of comparing the use group and the unused control group of the tooth whitening maintenance agent of the present invention after the tooth whitening procedure.

FIG. 2 is a photograph of hamsters (5 weeks old, male) in contrast to the unused control group for discoloration and coloration of hamster teeth when the tooth whitening agent of the present invention is applied to the teeth. .

The tooth whitening agent was applied to the hamster's teeth immediately after the tooth whitening was completed, and then freely consumed drinking water and food. Observation of the discoloration of the teeth at 2 and 4 weeks, respectively, showed that the experimental group treated with the tooth whitening agent returned to the original tooth color before the whitening procedure compared to the untreated experimental group (control). It was confirmed that the delay. Therefore, it can be seen that the tooth whitening agent of the present invention can effectively protect the teeth from the environment causing the coloring to maintain the whitening better.

3 is a result of evaluating the shade guide value of the teeth through the "VITA bleachedguide 3D-master" for the experimental group and the untreated control group treated with teeth whitening agent immediately after the whitening procedure of the hamster teeth Is shown in the graph.

<55> Immediately after whitening, the control group treated with the whitening maintenance agent and the untreated control group As a result of evaluation after 28 days, the untreated control group showed an average shade guide value of 4.5 5.0 M2, and the experimental group treated with tooth whitening agent immediately after whitening averaged 2.5 3.0 M2. Shade guide figures. Therefore, it can be seen that the experimental group treated with the tooth whitening agent maintains the shade guide value about 5 levels brighter than the control group which was not treated.

<56>

Experimental Example 2

4 is an experimental result of evaluating the effectiveness of the tooth whitening maintenance agent of the present invention in the teeth of extracted human.

Among teeth extracted, tooth whitening with similar shade guide was selected, and teeth whitening was performed, and classified into experimental group and non-applied experimental group to which tooth whitening maintenance agent was applied. In addition, the control group included an experimental group that did not perform both tooth whitening and tooth whitening agents.

In the experimental method, the teeth corresponding to each experimental group were placed in the coke with the carbonic acid removed, and cultured at 37 ^° C., and the degree of color change was observed from the immersion solution for each immersion time.

FIG. 4 is a photograph in which the degree of coloring observed through the above experimental method was prepared for each experimental group, and showed the brightest shade guide value in the experimental group to which the tooth whitening maintenance agent was applied in the experimental group of the teeth whitening test.

In addition, in the experimental group that performed the tooth whitening but did not apply the tooth whitening emulsion, the tooth whitening agent was applied as the shade guide value was darker than the color of the initial tooth within 48 hours after immersion in the coloring solution. It was found to be more difficult to maintain the shade guide after whitening than the experimental group applied. Therefore, it can be seen that the tooth whitening agent of the present invention can effectively protect the teeth from the coloring environment to maintain the effect of whitening.

<63>

<64> [Experimental Example 3]

5 is a graph showing the results of experiments carried out by accelerated aging under conditions corresponding to two years of long-term preservation in order to evaluate the long-term stability and effectiveness of the vitamin derivative added in the tooth whitening and maintaining agent.

<66> After tooth whitening from the lower mandible of pigs with the same shade guide (2.5 M2), the tooth whitening fat and vitamin derivative added with vitamins, including the control group to which the tooth whitening oil of Experimental Examples 1 and 2 was applied A shade guide was observed for each time by immersing in the coke removed with carbonic acid for the experimental group each coated with (AA-2G) added tooth whitening maintenance agent.

As a result of the experiment, the whitening maintenance effect was most effective in the experimental group to which the vitamin derivative was added, and the average two-level tooth brightness was maintained compared to the control group and the whitening agent to which the vitamin was added.

Therefore, it can be seen that the tooth whitening oil containing the vitamin derivative is more advantageous for long-term preservation.

<70>

Experimental Example 4

The tooth whitening maintenance agent of the present invention is directly applied to the teeth in the oral cavity and is exposed to the gingiva and the oral mucosa. Therefore, the hamster ball bag test (ISO 10993-10, irritation and hypersensitivity test) was performed to evaluate the irritation on the mucosa when the tooth whitening maintenance agent of the present invention was repeatedly exposed to the mucosa several times.

6 is a photograph showing the results of comparing the teeth whitening agent to the ball bag on the right by applying O. lcc to the ball bag on the right side compared to the untreated control on the left. As a result of the experiment, no special features were observed in the cheek pocket on the right side of the tooth whitening agent applied.

Therefore, it can be confirmed that the tooth whitening maintenance agent of the present invention is a safe formulation even when directly exposed to the gingiva and the oral cavity.

[Industrial Applicability] ^"

The present invention protects the teeth from the environment of pigmentation and discoloration caused by endogenous and extrinsic factors to prolong the duration of whitening, and also to pay attention to the food affecting the pigmentation and discoloration during professional whitening and self-whitening procedures. Application of anti-pigmentation agents in parallel provides industrial applicability, as it provides a tooth whitening agent that can prevent or retard the phenomenon of returning to the original tooth color.

Claims

[Range of request]

[Claim 1]

As a composition for preventing discoloration and pigmentation of teeth,

Glycerol with monooleate;

A polymer for controlling the physical properties of the glycerol monooleate;

Organic and inorganic compounds having a whitening effect; And

Tooth whitening retainer comprising a solvent.

[Claim 2]

The method of claim 1,

The glycerol monooleate is a tooth whitening oil, characterized in that contained in the amount of 5 to 95% by weight in the tooth whitening oil.

[Claim 3]

The method of claim 2,

The glycerol monooleate is in the amount of 30 90 weight ¾, tooth whitening retainer, characterized in that contained in the tooth whitening retainer.

[Claim 4]

In U,

The polymer is a tooth whitening and maintenance agent, characterized in that the polymer is a nonionic polymer, an anionic polymer or a salt thereof, a synthetic polymer of one or two or more of polyacrylic acid or carbopol. .

[Claim 5]

In accordance with any one of claims U to 4,

The organic 'inorganic compound is a teeth whitening agent, characterized in that the vitamin or vitamin derivative.

[Claim 6]

The method of claim 5,

The vitamin or vitamin derivative may be ascorbic acid or a derivative thereof ascorbic glucoside (ascorbic acid 2-glucoside (AA-2G), magnesium ascorbyl phosphate, sodium ascorbyl phosphate, ascorbyl glucoside, aminopropyl ascorbyl phosphate Tooth whitening agent, characterized in that at least one selected from the group consisting of paint, tocope, tocopheryl acetate, tocopheryl linoleate, tocopheryl nicotinate, tocopheryl glucoside, tocopheryl succinate . [Claim 7]

The method according to any one of claims 1 to 4,

Tooth whitening agent, characterized in that it further comprises at least one of a flavoring agent, hypersensitivity treatment agent, dental caries suppressor or gum disease improver 제