KR101423230B1 - Tooth bleaching preservable material for preventing tooth from discoloring and coloring - Google Patents

Abstract

The present invention is based on the glycerol monooleate formulation and can ensure appropriate fluidity, so that it is easy to apply to the teeth at the time of use, and after the application to the teeth, the viscosity increases due to the inflow of the saliva, By diluting or not disappearing, specialist whitening, which should be careful of foodstuffs affecting coloration and discoloration, and prevention of returning to the original tooth color when applied concurrently during self-whitening period, is prevented by internal or external human factors The present invention relates to a tooth whitening preservative which can protect teeth from the environment of coloration and discoloration and prolong the duration of whitening.

Description

[0001] The present invention relates to a tooth whitening preserving material for preventing discoloration and discoloration of teeth,

The present invention relates to a method for protecting teeth from environmental staining and discoloration caused by human and external human factors, thereby prolonging the whitening duration, and also to prevent coloring and discoloration during the whitening and whitening procedures, To a tooth whitening agent which can prevent or delay the phenomenon of returning to the original tooth color.

As the society develops and the living standards of modern people become higher, interpersonal relations become an important age. Therefore, dental treatment has been shifted from function - oriented treatment to esthetic - oriented treatment.

The influence of the tooth's aesthetics is on the arrangement, size, color, texture and light transmittance of the teeth, among which the color of the tooth is the most sensitive and important factor, It can also cause psychological problems such as inducing passive interpersonal relationships or lacking self-confidence.

The cause of tooth discoloration is classified into internal human factors and external human factors. The internal human factors are the deposition of a substance having a double bond chromophore contained in food in the enamel layer outside the tooth, It means that the precipitate adheres to the surface of teeth and causes discoloration of teeth.

The dental treatment that restores discolored teeth that have lost their original color due to various factors as described above is called tooth whitening. Now, in the clinic for tooth whitening, professional bleaching (office bleaching) and home bleaching have.

Expert whitening is getting more and more popular recently because professional dentists use 25 ~ 35% high concentration of hydrogen peroxide to get clear effects in a short time. In addition, the self-whitening method uses less than 3% hydrogen peroxide. In itself, it can not be expected to be as effective as the expert whitening effect, but it can maximize the whitening effect when it is performed simultaneously with the expert whitening treatment.

Though there is a difference in concentration, most tooth whitening agents contain hydrogen peroxide, so the safety issue for the human body needs to be carefully handled. As a part of such efforts, a more safe whitening agent is proposed, which is a compound which generates hydrogen peroxide in hydrogen peroxide and / or an aqueous solution and a dicarboxylic acid anhydride which reacts with this compound to generate an organic acid and an acid, as disclosed in Korean Patent Publication No. 2009-0123876 .

On the other hand, even though tooth whitening has been successfully carried out, since the tooth surface is constantly in an environment capable of recoloring or discoloring while consuming foods containing coloring ingredients in daily life, To delay coloration or discoloration, periodic whitening management is recommended with attention to the ingestion of food that can cause recolonization after tooth whitening.

However, if the tooth color is returned to the state before the whitening due to recoloring and discoloration over time after the whitening, the aesthetic satisfaction of the procedure is lowered and the complaint about the whitening treatment in the past may be caused. In addition, there are inconveniences to be careful about brushing teeth and food after whitening, and there is a situation where the burden is imposed on the patient economically and temporally, such as the burden of the treatment cost caused by periodic whitening management and the concern about side effects. Repetitive tooth whitening may also be seen in sensitive teeth, such as hypersensitivity, dental infection, and periodontal inflammation.

Therefore, a tooth whitening maintenance agent for preventing tooth discoloration and discoloration due to internal or external human factors after tooth whitening is required, but it has not been developed to date and generally remains to sustain the whitening effect through additional whitening In fact.

Korea Patent Publication No. 2009-0123876

Accordingly, the present invention provides a method for protecting teeth from the coloring and discoloration environment caused by human and external human factors, thereby prolonging the duration of whitening, The object of the present invention is to provide a tooth whitening agent which can prevent or delay the phenomenon of returning to the original color of a tooth by applying a coloring inhibitor in parallel.

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a tooth whitening preservative composition for preventing discoloration and discoloration of teeth after tooth whitening of teeth,
Glycerol monoallides; Polyacrylic acid or carbopol or a mixture thereof, which is a polymer for controlling the physical properties of the glycerol monooleate; At least one vitamin selected from the group consisting of ascorbic acid 2-glucoside (AA-2G) derivatives of ascorbic acid, magnesium ascorbyl phosphate, sodium ascorbyl phosphate, ascorbyl glucoside and aminopropyl ascorbyl phosphate derivative; Glycerol, a humectant; And a solvent.
The glycerol monooleate is contained in the tooth whitening preservative in an amount of 30 to 90% by weight, and may further include at least one or more of an anti-inflammatory agent, a dental caries inhibitor, or a gum disease-improving agent.

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According to the tooth whitening preservative according to the present invention, it is possible to prevent the phenomenon of returning to the original color of the teeth by applying the whitening agent during the whitening period and the whitening period, It is possible to protect teeth from the environment of coloration and discoloration caused by factors and prolong the duration of whitening.

In addition, since the tooth whitening agent of the present invention is based on the glycerol monooleate formulation, it is easy to apply to the teeth at the time of use because it can ensure appropriate fluidity, and after application to the teeth, the viscosity increases due to the inflow of saliva, It has an advantage that adhesion with the surface is improved so that it is not easily diluted or lost.

In addition, the tooth whitening preservative of the present invention can further increase the duration of tooth whitening by more effectively blocking coloration and discoloration after whitening by further adding vitamins and vitamin derivatives to glycerol monooleate.

In addition, by adding the vitamin derivative to the tooth whitening preservative, the present invention can improve the disadvantage that the vitality preservation effect is short while maintaining the same effect of preventing the discoloration and discoloration of the teeth of vitamins. In particular, Of the present invention is in a stable state for a long period of time in an aqueous solution state as compared with the vitamin of the present invention.

FIG. 1 is a photograph showing that the tooth whitening agent of the present invention changes viscosity by the addition of water. FIG.
FIG. 2 is a photograph of the degree of discoloration and discoloration of a tooth of a hamster when the tooth whitening agent of the present invention is applied to the unused control group.
FIG. 3 is a view showing a result of evaluation of a shade guide value with respect to a tooth of the hamster of FIG. 2; FIG.
FIG. 4 is a photograph showing the results of an experiment evaluating the effectiveness of the tooth whitening agent of the present invention on teeth of an extracted human. FIG.
FIG. 5 is a graph showing the results of an experiment in which accelerated aging was conducted under conditions corresponding to two years of long-term preservation in order to evaluate the long-term stability and efficacy of vitamin derivatives added into tooth whitening preservatives.
FIG. 6 is a photograph showing a test result of a hamster ball pocket performed to evaluate the irritation on the mucous membrane of the tooth whitening preservative of the present invention. FIG.

Hereinafter, preferred embodiments of the tooth whitening agent of the present invention will be described in detail.

The present invention relates to a teeth whitening and retention agent for tooth discoloration and discoloration inhibiting or retarding the formation of a kind of protective film on a tooth so that a substance having a double bond chromophore contained in the food is deposited on the enamel layer outside the teeth, And has a function of preventing (re-) discoloring or coloring of teeth on a tooth surface for a predetermined period of time.

Here, the tooth whitening preservative of the present invention is formed into a liquid phase which is easy to apply first to the teeth in order to improve the applicability. However, after the tooth whitening agent is actually applied to the teeth, And a formulation capable of improving the adhesion with the tooth surface and thus effectively protecting the teeth from the food that affects the coloring.

As described above, the formulation of the tooth whitening preservative of the present invention, in which the viscosity is increased by the addition of water so as to realize both the excellent application and the adhesion with the tooth surface, increases the stickiness by using the intermolecular bonding of the hydrophilic polymer Glycerol monooleate, polymers and solvents to enable attachment to the teeth.

Glycerol monooleate forms liquid crystals according to the temperature and moisture content, and thus has properties that are different in shape and physical properties corresponding to the surrounding environment. That is, the phase change of glycerol monooleate has a fluidity on a lamellar phase, a reversed phase micell phase, or a reversed phase hexagonal phase, so that it can be easily applied or applied to a tooth surface, As the content of water increases, the structure changes into a cubic state, and solidifies and the fluidity is lost. The present invention uses such a change in physical properties of the liquid crystal as a formulation to be utilized as a tooth whitening preservative.

In particular, the tooth whitening agent of the present invention using glycerol monooleate as a basic agent has a good fluidity when applied to a tooth and is comfortable to apply to teeth. However, after being applied to a tooth, viscosity of the tooth whitening agent And it is not easily diluted or lost in the oral condition by being present in a form which is easy to adhere to the teeth.

Such glycerol monooleate may be added in an amount of about 5 to 95% by weight in the tooth whitening preservative, and is preferably added in an amount of 30 to 90% by weight in order to take the form of a formulation.

In order to control the physical properties of glycerol monooleate, a basic drug, a polymer compound, that is, a polymer is added. For example, the physical properties of the formulation can be changed by adding a polymer having excellent tooth adhesion or by adding a polymer exhibiting a different behavior according to a change in temperature.

Examples of the polymer that can be used in the tooth whitening agent of the present invention include a polymer made of a nonionic polymer, an anionic polymer or a salt thereof, a synthetic polymer such as polyacrylic acid or carbopol, And mixtures thereof.

These polymers may be added in an amount of about 50% by weight or less in the tooth whitening preservative as a mixture of one kind or two or more kinds, and preferably, in order to improve the adhesion through the viscosity enhancement of the basic formulations and form the formulations, To 30% by weight.

FIG. 1 shows that the tooth whitening agent of the present invention made from the above-described formulation changes viscosity by the addition of water. 1 is an initial state of the tooth whitening preservative of the present invention, which is in a liquid form and flowable before the introduction of water, so that it is in a ready-to-apply form. On the right side, As a result of simulating the environment, as visually confirmed, the viscosity increased and the adhesion was greatly improved. As described above, the tooth whitening preservative of the present invention is not easily diluted or lost in the oral environment due to the improvement of the adhesiveness as the viscosity increases.

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Representative compounds that may be added include vitamins and vitamin derivatives as compounds. Examples of vitamins and vitamin derivatives include ascorbic acid and derivatives thereof such as ascorbic acid 2-glucoside (AA-2G), magnesium ascorbyl phosphate, sodium ascorbyl phosphate, ascorbyl glucoside, aminopropyl ascorbyl phosphate, Or more.

In addition, the tooth whitening preservative according to the present invention can be used as a tooth whitening preservative according to the present invention, in addition to the above-mentioned ingredients, by adding an incense, a hypersensitizer or a dental caries inhibitor or a gum disease improving agent, May be improved.

Hereinafter, an experimental example of the effect of the tooth whitening agent of the present invention will be described.

Prior to describing each experimental example, three kinds of tooth whitening preservatives used in the experiment, that is, a tooth whitening preservative and three kinds of tooth whitening preservatives added with vitamins or vitamin derivatives to the tooth whitening preservative The contents of each composition are shown in Table 1 below.

In the following table, 'Glycerol' is a wetting agent, 'Poloxamer' is a nonionic polymer, 'Water is a solvent,' Peppermint Oil 'is a flavor,' Sodium Fluoride 'is a hypersensitivity agent,' Polyacrylic Acid ' Absorbic Acid 'is a vitamin for improving the effectiveness of tooth whitening agent, and' Absorbic Acid 2-Glucoside 'is a vitamin derivative for improving tooth whitening agent.

As a basic formulation, the tooth whitening agent and the tooth whitening agent were added with vitamin and vitamin derivatives, respectively. Whitening agent Content (% by weight) Whitening agent +
AA Content (% by weight) Whitening agent +
AA-2G Content (% by weight) Glycerol Monooleate 60 Glycerol Monooleate 60 Glycerol Monooleate 60 Glycerol 15 Glycerol 15 Glycerol 13 Poloxamer 10 Poloxamer 10 Poloxamer 10 Water 2 Water 2 Water 2 Peppermint Oil 2.5 Peppermint Oil 2.5 Peppermint Oil 2.5 Sodium Fluoride 0.5 Sodium Fluoride 0.5 Sodium Fluoride 0.5 Polyacrylic Acid 10 Polyacrylic Acid 5 Polyacrylic Acid 5 - - Absorbic Acid 5 Absorbic Acid 2-Glucoside 7

※ whitening agent; Tooth whitening preservatives, AA; ascorbic acid, AA-2G; asorbic aid 2-gucoside

[Experimental Example 1]

FIGS. 2 and 3 show the results of a comparison between the use group of the tooth whitening preservative of the present invention and the unused control group after tooth whitening treatment.

FIG. 2 is a photograph of the degree of discoloration and discoloration of the hamster tooth when the tooth whitening agent of the present invention is applied to the tooth of a hamster (5 weeks old, male) in comparison with the unused control group.

The tooth whitening agent was applied to the tooth of the hamster immediately after the whitening was completed, and then freely ingested the drinking water and food. As a result of observing tooth discoloration degree of each individual at 2 weeks and 4 weeks, the degree of discoloration of the tooth whitening agent was returned to the original tooth color before the whitening treatment (control group) I was able to confirm the delay. Therefore, it can be confirmed that the tooth whitening preservative of the present invention effectively protects the teeth from the environment causing coloring, and can maintain the whitening more favorably.

FIG. 3 is a graph showing the results of shade guide evaluation of the tooth through the "VITA bleachedguide 3D-master" for the experimental group treated with tooth whitening agent immediately after the whitening of the hamster tooth and the untreated control group .

As a result of evaluating the whitening agent immediately after the whitening treatment and the untreated control group at 28 days after the whitening, the untreated control group without the tooth whitening agent showed an average shade guide value of 4.5 to 5.0 M2 And the shade guide value of 2.5 ~ 3.0 M2 in the experimental group treated with tooth whitening agent immediately after the whitening. Therefore, it can be concluded that the experimental group with teeth whitening agent maintains a shade guide value that is about 5 times brighter than the untreated control group numerically.

[Experimental Example 2]

FIG. 4 is a result of an experiment evaluating the effectiveness of the tooth whitening agent of the present invention on teeth of an extracted person.

Tooth whitening was performed by selecting teeth that were similar to shade guides in the extracted teeth, and classified into the experimental group with the tooth whitening agent applied and the untreated experimental group. The control group included an experimental group in which neither tooth whitening nor tooth whitening agent was applied.

In the experimental method, the teeth corresponding to each experimental group were added to the carbonated cola and incubated at 37 ° C.

FIG. 4 is a photograph showing the degree of discoloration observed by the above experimental method for each test group. In the teeth whitening test group, the brightest shade guide value was shown in the test group to which the tooth whitening agent was applied.

In the case of the tooth whitening treatment, the shade guide value was darker than the initial tooth color within 48 hours after immersion in the staining solution, It was difficult to maintain a post-shade guide. Therefore, it can be confirmed that the tooth whitening preservative of the present invention effectively protects the teeth from the coloring environment and can maintain the whitening effect.

[Experimental Example 3]

FIG. 5 is a graph showing experimental results of accelerated aging under conditions corresponding to two years of long-term preservation in order to evaluate the long-term stability and efficacy of vitamin derivatives added into tooth whitening preservatives.

Tooth whitening preservatives, vitamins (AA-1) and vitamins (Vitamin A), including vitamins, including teeth-whitening preservatives in Experimental Examples 1 and 2 were whitened with the same shade guide (2.5 M2) 2G) were immersed in the carbonated cola, and the shade guide was observed over time.

Experimental results showed that the whitening effect was the most effective in the experimental group with the vitamin derivative, and the tooth brightness was maintained at an average of 2 levels in comparison with the tooth whitening agent containing the vitamin and the vitamin.

Therefore, it can be confirmed that a tooth whitening agent containing a vitamin derivative is more advantageous for long-term preservation.

[Experimental Example 4]

The tooth whitening agent of the present invention is directly applied to teeth in oral cavity and is inevitably exposed to gingiva and oral mucosa. Therefore, a hamster ball bag test (ISO 10993-10, stimulus and hypersensitivity test) was conducted to evaluate the stimulation on the mucosa when the tooth whitening preservative of the present invention was repeatedly exposed to several mucous membranes.

FIG. 6 is a photograph showing the result of repeatedly applying a tooth whitening agent to the hamster ball pocket in a ball pocket on the right side by 0.1 cc each time, and comparing with the untreated control group on the left side. As a result of the experiment, there was no remarkable difference in the right ball pocket applied with tooth whitening preservatives, and no noticeable erythema, skin irritation and sensation were observed.

Therefore, it can be confirmed that the tooth whitening agent of the present invention is safe even if it is directly exposed to gingiva and oral cavity.

Claims (7)

WHAT IS CLAIMED IS: 1. A tooth whitening preservative composition for preventing discoloration and discoloration of teeth after tooth whitening,
Glycerol monoallides;
Polyacrylic acid or carbopol or a mixture thereof, which is a polymer for controlling the physical properties of the glycerol monooleate;
At least one vitamin selected from the group consisting of ascorbic acid 2-glucoside (AA-2G) derivatives of ascorbic acid, magnesium ascorbyl phosphate, sodium ascorbyl phosphate, ascorbyl glucoside and aminopropyl ascorbyl phosphate derivative;
Glycerol, a humectant; And
A tooth whitening preservative comprising a solvent. delete The method according to claim 1,
Wherein the glycerol monooleate is contained in an amount of 30 to 90% by weight in the tooth whitening preservative. delete delete delete The method according to claim 1 or 3,
A tooth whitening agent, an antiperspirant agent, an antiperspirant agent, a dental caries inhibitor, or a gum disease improving agent.

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