WO2014001504A3 - Culture of bacteriophage - Google Patents
Culture of bacteriophage Download PDFInfo
- Publication number
- WO2014001504A3 WO2014001504A3 PCT/EP2013/063633 EP2013063633W WO2014001504A3 WO 2014001504 A3 WO2014001504 A3 WO 2014001504A3 EP 2013063633 W EP2013063633 W EP 2013063633W WO 2014001504 A3 WO2014001504 A3 WO 2014001504A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bacteriophage
- vessel
- culture
- harvesting
- excess
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/26—Inoculator or sampler
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/58—Reaction vessels connected in series or in parallel
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/12—Purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/00051—Methods of production or purification of viral material
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Sustainable Development (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Immunology (AREA)
- Clinical Laboratory Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Bacteriophage are produced in a continuous process comprising maintaining a culture of bacteriophage in a first vessel (16); feeding the culture with bacteria maintained in a second vessel (12a, 12b) in the stationary phase and harvesting bacteriophage from the first vessel (16), wherein the first vessel is operated at a dilution rate in excess of 1 / (bacteriophage lysis time).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1420253.5A GB2516581B (en) | 2012-06-28 | 2013-06-28 | Culture of bacteriophage |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB201211497A GB201211497D0 (en) | 2012-06-28 | 2012-06-28 | Culture of Bacteriophage |
GB1211497.1 | 2012-06-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2014001504A2 WO2014001504A2 (en) | 2014-01-03 |
WO2014001504A3 true WO2014001504A3 (en) | 2014-02-20 |
Family
ID=46704368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2013/063633 WO2014001504A2 (en) | 2012-06-28 | 2013-06-28 | Culture of bacteriophage |
Country Status (2)
Country | Link |
---|---|
GB (2) | GB201211497D0 (en) |
WO (1) | WO2014001504A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2016353541A1 (en) * | 2015-11-11 | 2018-06-21 | Elizabeth Jayne ELLIOTT | Method and apparatus of improved bacteriophage yield |
CN109609392B (en) * | 2018-12-24 | 2022-04-19 | 上海智城分析仪器制造有限公司 | Siphon catheter feeding table cultivation method for yeast |
WO2024091978A1 (en) * | 2022-10-25 | 2024-05-02 | Sug Biosciences Llc | Biocontrol compositions of bacteriophage, methods of producing and uses thereof |
CN118222516B (en) * | 2024-02-20 | 2024-08-30 | 青岛润达生物科技有限公司 | Phage RDP-SA-21030 capable of lysing salmonella at stable phase, bactericidal composition and application thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009044414A1 (en) * | 2007-10-02 | 2009-04-09 | Gima S.P.A. | Process and system for the industrial scale purification of bacteriophages intended for bacteriophage therapy |
US20110014157A1 (en) * | 2008-03-20 | 2011-01-20 | Phytoline Gmbh | Method for producing a mixture of bacteriophages and the use thereof in the therapy of antibiotic-resistant staphylococci |
US20120040329A1 (en) * | 2010-08-12 | 2012-02-16 | Phage Biocontrol Research, Llc | Process For Continuous Production Of Bacteriophage |
-
2012
- 2012-06-28 GB GB201211497A patent/GB201211497D0/en not_active Ceased
-
2013
- 2013-06-28 GB GB1420253.5A patent/GB2516581B/en active Active
- 2013-06-28 WO PCT/EP2013/063633 patent/WO2014001504A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009044414A1 (en) * | 2007-10-02 | 2009-04-09 | Gima S.P.A. | Process and system for the industrial scale purification of bacteriophages intended for bacteriophage therapy |
US20110014157A1 (en) * | 2008-03-20 | 2011-01-20 | Phytoline Gmbh | Method for producing a mixture of bacteriophages and the use thereof in the therapy of antibiotic-resistant staphylococci |
US20120040329A1 (en) * | 2010-08-12 | 2012-02-16 | Phage Biocontrol Research, Llc | Process For Continuous Production Of Bacteriophage |
Non-Patent Citations (2)
Title |
---|
LINDEMANN B F ET AL: "Evolution of bacteriophage in continuous culture: A model system to test antiviral gene therapies for the emergence of phage escape mutants", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 76, no. 11, 1 June 2002 (2002-06-01), pages 5784 - 5792, XP002570561, ISSN: 0022-538X, DOI: 10.1128/JVI.76.11.5784-5792.2002 * |
SAUVAGEAU DOMINIC ET AL: "Two-stage, self-cycling process for the production of bacteriophages", MICROBIAL CELL FACTORIES, BIOMED CENTRAL, LONDON, NL, vol. 9, no. 1, 1 November 2010 (2010-11-01), pages 81, XP021077229, ISSN: 1475-2859, DOI: 10.1186/1475-2859-9-81 * |
Also Published As
Publication number | Publication date |
---|---|
GB2516581B (en) | 2017-03-15 |
WO2014001504A2 (en) | 2014-01-03 |
GB201420253D0 (en) | 2014-12-31 |
GB201211497D0 (en) | 2012-08-08 |
GB2516581A (en) | 2015-01-28 |
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