WO2013187574A1 - Composition cosmétique de blanchiment de la peau - Google Patents

Composition cosmétique de blanchiment de la peau Download PDF

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Publication number
WO2013187574A1
WO2013187574A1 PCT/KR2013/001051 KR2013001051W WO2013187574A1 WO 2013187574 A1 WO2013187574 A1 WO 2013187574A1 KR 2013001051 W KR2013001051 W KR 2013001051W WO 2013187574 A1 WO2013187574 A1 WO 2013187574A1
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WO
WIPO (PCT)
Prior art keywords
skin
whitening
cosmetic composition
dimethicone
component
Prior art date
Application number
PCT/KR2013/001051
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English (en)
Korean (ko)
Inventor
문현규
문정열
Original Assignee
㈜제이알 코스메틱
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Application filed by ㈜제이알 코스메틱 filed Critical ㈜제이알 코스메틱
Publication of WO2013187574A1 publication Critical patent/WO2013187574A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm

Definitions

  • the present invention relates to a cosmetic composition for skin whitening, specifically titanium dioxide and arbutin having a skin whitening effect as a whitening active ingredient, keratin keratin moisturizing ingredients, softening ingredients, fine wrinkles and anti-aging ingredients, vitamin components, etc. It relates to a cosmetic composition for skin whitening to be prepared.
  • hydroquinone exhibits a predetermined whitening effect, but has a problem in that skin irritation is severe and the amount of the compound is limited to a very small amount, and ascorbic acid is easily oxidized, resulting in problems such as discoloration and discoloration. There is this.
  • thiol-based compounds such as glutathione and cysteine not only have a characteristic unpleasant odor, but also have problems with transdermal absorption, and glycosides and derivatives thereof have high polarity, making it difficult to use as a cosmetic ingredient.
  • Placenta extract on the other hand, has no irritation to the skin, but lacks a whitening effect.
  • melanin may be blocked by UV protection or blackened by reducing the discolored melanin pigment, but the effect of whitening is not in sunlight, specifically UV A or UV B It is also assumed.
  • the additional UV irradiation continues the melanin blackening phenomenon, which constantly cancels the artificial whitening function. Therefore, the whitening effect is visually confirmed and can be stably maintained for a certain period of time during and immediately after the whitening component is acted upon in combination with the constant UV protection effect.
  • This is different from applying a separate sunscreen or ingredient simultaneously or sequentially with a whitening agent to give a burden while reciprocating whitening-blackening on the skin, and the whitening phenomenon appears by the function of the initially applied whitening agent is maintained. There was an advantage that the lightening state to act as the color reference of the skin.
  • Korean Patent Publication No. 2008-78371 has proposed a cosmetic raw material for skin whitening of silkworm Cordyceps mycelia culture medium using mulberry leaf extract, and Korean Patent Publication No. 2010-7061
  • the cosmetic composition for skin whitening containing the force extract as an active ingredient has been proposed, but the skin whitening effect using natural extracts is not only questionable, but also the manufacturing process is difficult and mass production is difficult. The problem remained difficult to manufacture with.
  • the present invention has been made to solve the above problems,
  • An object of the present invention is to inhibit the excessive production of melanin in the skin cells, and to enhance the skin whitening, such as blemishes, freckles, etc. It contains a high melanin production inhibitory effect and titanium dioxide which gives a whitening effect when exposed to light To provide a cosmetic composition of the cream or lotion type.
  • the present invention increases the percutaneous absorption rate of arbutin, and prevents the irradiation of additional ultraviolet rays during the whitening effect to prevent the whitening effect is canceled, and a cream having a white reflection effect of the titanium dioxide nanoparticles that are cosmetically transparent and subtle Or to provide a cosmetic composition of the lotion type.
  • the cosmetic composition for skin whitening according to the present invention is characterized by comprising arbutin and nano-sized titanium dioxide as an active ingredient of skin whitening.
  • the cosmetic composition for skin whitening according to the present invention is a keratin keratin moisturizing component which is formed by mixing any one or more of butylene glycol, sodium hyaluronate, glycerin, sodium chondroitin sulfate, betaine, mannan, ceramide 3; Wheat germ oil, camellia oil, cetylethylhexanoate, ceresin, lecithin, olive oil, squalene, phytosterol, shea butter, a flexible component formed by mixing; Skin whitening composition comprising any one or more of titanium dioxide, arbutin, magnesium ascorbyl phosphate, mulberry root extract, lettuce extract, dipotassium glycyriate; Skin regeneration component comprising any one or more of hydrolyzed pea protein and human oligopeptide 1; Fine lines and anti-aging ingredients composed of adenosine; Plant extract components which are formed by mixing any one or more of aloe vera leaf juice, ginkgo
  • the cosmetic composition for skin whitening comprises a skin adhesion component composed of a copolymer of sodium acrylate and sodium acryloyl dimethyl taurate or a copolymer of dimethicone and vinyl dimethicone; A suspension component composed of polysorbate 80, cetelyl phi, and sebum 10,1-dimethicone; And a surface treatment component composed of dimethicone, cetyl dimethicone, cyclopentasiloxane, cyclohexasiloxane, and stearyl dimethicone.
  • a skin adhesion component composed of a copolymer of sodium acrylate and sodium acryloyl dimethyl taurate or a copolymer of dimethicone and vinyl dimethicone
  • a suspension component composed of polysorbate 80, cetelyl phi, and sebum 10,1-dimethicone
  • a surface treatment component composed of dimethicone, cetyl dimethicone
  • the skin is kept in a moist moisturizing state to hydrate the epidermal keratin stratum corneum to enlarge the pores between keratin, and the arbutin as a hydrophilic component effectively black melanin.
  • Keraton keratin moisturizing component to reach and absorb up to the basal layer where the epidermis and blood vessels present, and similar composition to the intercellular lipids of the keratin layer effectively keep keratin keratin moisturizing components from being lost and absorption of active ingredients Characterized by a flexible component having a composition similar to the sebum or cell membrane to promote.
  • glycerin, butylene glycol, betaine, mannan, ceramide 3 and the like are adopted as keratin keratin moisturizing ingredients, and flexible ingredients having components similar to sebum or cell membranes are lecithin and squalane.
  • Phytosterol and shea butter are adopted.
  • titanium dioxide which is one of the core elements of the present invention, was pretreated in the form of fine particles (nano), and was dispersed in an emulsion composition of a cream or lotion type.
  • titanium dioxide in the form of nanoparticles are mixed with the suspension component so as not to be exclusively mixed with the skin surface environment composed of sweat, sebum, and intercellular lipids, and to ensure that the cosmetic composition according to the present invention adheres well to the skin.
  • a surface treatment component composed of a silicone oil component such as dimethicone, setting dimethicone, stearyl dimethicone, etc. was added.
  • the dispersion stability in the formulation is excellent, and the surface lipid of the skin In addition to good compatibility with (sebum, components derived from intercellular lipids), adhesion stability to skin was also relatively good.
  • arbutin which is one of the active ingredients included in the application to the facial skin, inhibits the excessive production of melanin in the skin cells, thereby improving the appearance of blemishes, freckles, and imparting a skin whitening effect.
  • Titanium dioxide which gives a whitening effect when exposed to light, is included as an active ingredient, and therefore, there is an advantage in that it can give a skin whitening and whitening effect, especially outdoors.
  • the cosmetic composition according to the present invention provides instant moisture to the texture of the soft and light whipped cream to provide sufficient moisturizing effect and improve dark and dull skin, fine wrinkles and thick wrinkles even when only a small amount is used. There are other benefits to protecting and making your skin look fresh and beautiful.
  • the present invention increases the percutaneous absorption rate of arbutin, and prevents the whitening effect is canceled out by preventing the irradiation of additional ultraviolet rays during the whitening effect, and can enjoy the white reflection effect of the titanium dioxide nanoparticles that are cosmetically transparent and subtle. There is another advantage.
  • Figure 1 shows the dispersion stability according to the size of titanium dioxide compared to the skin of Asians.
  • Keraton keratin moisturizing ingredients were selected by mixing butylene glycol, sodium hyaluronate, glycerin, sodium chondroitin sulfate, betaine, mannan, ceramide 3.
  • wheat germ oil As a flexible component, wheat germ oil, camellia oil, cetylethylhexanoate, ceresin, lecithin, olive oil, squalane, phytosterol and shea butter were selected.
  • titanium dioxide 10-20 nm size
  • arbutin As skin whitening ingredients, titanium dioxide of 10-20 nm size, arbutin, magnesium ascorbyl phosphate, mulberry root extract, cedar extract, and dipotassium glycylizate were selected.
  • Adenosine was adopted as fine wrinkles and anti-aging ingredients.
  • hydrolyzed pea protein vegetable stem cell extract
  • human oligopeptide 1 human oligopeptide 1
  • Plant extracts were selected by mixing aloe vera leaf juice, ginkgo leaf extract and centella asiatica extract.
  • tocopheryl acetate and panthenol were used in combination.
  • disodium IDT was used, and as a fragrance component, a combination of natural aroma essences was used.
  • Comparative Example 1 was prepared after excluding the butyl and nano-sized titanium dioxide in the cosmetic composition of the cream form of Example 1.
  • Example 1 The whitening effect of Example 1 and Comparative Example 1 on humans was evaluated by the sensory test.
  • Example 1 20 people were selected for healthy women and men in their 40s and 50s, who suffered from melanin on their skin, and their faces were divided into two vertically, and the left cheek had a cosmetic composition according to the present invention of Example 1
  • the control of Comparative Example 1 was applied twice a day for morning and evening, and applied for 2 months. Determination of the whitening effect was to evaluate the degree of whitening effect through the following evaluation score as a subjective evaluation of the individual after using the composition of the present invention. The results are shown in Table 1 below.
  • whitening effect is 25% or less than the control group.
  • composition of the present invention is used as a cosmetic composition of the cream, as shown in the above experimental results, the cosmetic composition of Example 1 containing arbutin and titanium dioxide is whitening compared to the cosmetic composition of Comparative Example 1 It was confirmed that the effect is excellent.
  • Figure 1 shows the dispersion stability according to the size of the titanium dioxeo compared to the skin of Asians.
  • nano-sized titanium dioxides used as skin whitening ingredients particles of a certain nano size should be used, but the particles settle if the mixture of dimethicone, cetyl dimethicone, cyclopentasiloxane / cyclohexasiloxane, and stearyldimethicone is not added. , Agglomeration, solidification, and so on, resulting in phase separation due to color change, viscosity change, and composition ratio change, so that the whitening effect and UV blocking effect cannot be properly seen.
  • the particle size should be limited at 10-25 nm, maintain the electrical repulsive force between the titanium dioxide particles and titanium dioxide In order for the resin on the surface to cause the steric hindrance of the absorption amount, it was confirmed that it is preferable to add the surface treatment component of the silicone oil series.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne une composition cosmétique de blanchiment de la peau, et, plus précisément, une composition cosmétique de blanchiment de la peau préparée en incluant du dioxyde de titane de dimension nanométrique et de l'arbutine, ayant des effets de blanchiment de la peau, comme principes actifs de blanchiment. Lorsque la composition cosmétique de la présente invention est étalée sur la peau du visage, l'arbutine, qui est l'un des principes actifs contenus dans la composition, réduit la génération de mélanine en excès dans les cellules cutanées, permettant ainsi d'atténuer les taches de vieillesse, les taches de rousseur et autres et apportant des effets de blanchiment de la peau. De plus, étant donné que le dioxyde de titane, qui fournit des effets de blanchiment, est contenu comme principe actif, la composition peut fournir des effets de blanchiment de la peau lorsqu'elle est exposée à la lumière, en particulier à l'extérieur.
PCT/KR2013/001051 2012-06-12 2013-02-08 Composition cosmétique de blanchiment de la peau WO2013187574A1 (fr)

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KR10-2012-0062844 2012-06-12
KR20120062844 2012-06-12

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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110893169A (zh) * 2019-12-23 2020-03-20 广州微肽生物科技有限公司 一种美白补水面膜及其制备方法
CN111514061A (zh) * 2020-06-16 2020-08-11 雷菁 一种抗衰老美白除皱面膜及其生产方法
CN111700811A (zh) * 2020-06-22 2020-09-25 浙江英树生物科技有限公司 一种美白防晒双功能防晒喷雾及其制备方法
CN112120948A (zh) * 2020-10-22 2020-12-25 广州源美药业科技有限公司 一种具有美白淡斑功效的组合物
CN112137933A (zh) * 2020-10-22 2020-12-29 广州源美药业科技有限公司 一种具有美白补水修复功效的组合物
CN112472622A (zh) * 2021-01-11 2021-03-12 广州葆雀化妆品有限公司 一种青春亮颜娇嫩日霜
CN112494344A (zh) * 2020-12-11 2021-03-16 广州市拉凯尔干细胞研究所 一种即效美白基质及其在化妆品中的应用
CN113041174A (zh) * 2021-02-20 2021-06-29 仲恺农业工程学院 一种含水解植物蛋白的油茶籽油精华液及其制备方法与应用
CN113057902A (zh) * 2021-02-20 2021-07-02 仲恺农业工程学院 一种含水解植物蛋白的油茶籽油面霜及其制备方法
CN113057901A (zh) * 2021-02-20 2021-07-02 仲恺农业工程学院 一种含水解植物蛋白的油茶籽油护肤组合物及其制备方法与应用
CN115770196A (zh) * 2022-11-30 2023-03-10 广州市婷采化妆品有限公司 一种多效美白祛斑护肤品及其制备方法及其应用
WO2023050493A1 (fr) * 2021-09-28 2023-04-06 蔻蔻琪生物科技(杭州)有限公司 Composition anti-glycation nanométrique, son procédé de préparation et son application
CN118415940A (zh) * 2024-05-09 2024-08-02 美蔻生物药业(广州)有限公司 一种紧致美白的组合物及其制备方法

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KR101629368B1 (ko) * 2014-08-13 2016-06-10 (주)클레어스코리아 미백 화장품 및 그 제조 방법
CN105878109A (zh) * 2016-05-03 2016-08-24 福建春伦茶业集团有限公司 一种含茉莉精油的美白祛斑精华液
KR20230069589A (ko) 2021-11-12 2023-05-19 이민지 측백나무 추출물을 유효성분으로 함유하는 미백용 화장료 조성물 및 이를 포함하는 제품

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Cited By (17)

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Publication number Priority date Publication date Assignee Title
CN110893169B (zh) * 2019-12-23 2023-05-02 广州微肽生物科技有限公司 一种美白补水面膜及其制备方法
CN110893169A (zh) * 2019-12-23 2020-03-20 广州微肽生物科技有限公司 一种美白补水面膜及其制备方法
CN111514061A (zh) * 2020-06-16 2020-08-11 雷菁 一种抗衰老美白除皱面膜及其生产方法
CN111700811B (zh) * 2020-06-22 2022-04-12 浙江英树生物科技有限公司 一种美白防晒双功能防晒喷雾及其制备方法
CN111700811A (zh) * 2020-06-22 2020-09-25 浙江英树生物科技有限公司 一种美白防晒双功能防晒喷雾及其制备方法
CN112120948A (zh) * 2020-10-22 2020-12-25 广州源美药业科技有限公司 一种具有美白淡斑功效的组合物
CN112137933A (zh) * 2020-10-22 2020-12-29 广州源美药业科技有限公司 一种具有美白补水修复功效的组合物
CN112494344A (zh) * 2020-12-11 2021-03-16 广州市拉凯尔干细胞研究所 一种即效美白基质及其在化妆品中的应用
CN112472622A (zh) * 2021-01-11 2021-03-12 广州葆雀化妆品有限公司 一种青春亮颜娇嫩日霜
CN113057902A (zh) * 2021-02-20 2021-07-02 仲恺农业工程学院 一种含水解植物蛋白的油茶籽油面霜及其制备方法
CN113057901A (zh) * 2021-02-20 2021-07-02 仲恺农业工程学院 一种含水解植物蛋白的油茶籽油护肤组合物及其制备方法与应用
CN113041174A (zh) * 2021-02-20 2021-06-29 仲恺农业工程学院 一种含水解植物蛋白的油茶籽油精华液及其制备方法与应用
CN113057901B (zh) * 2021-02-20 2023-10-03 仲恺农业工程学院 一种含水解植物蛋白的油茶籽油护肤组合物及其制备方法与应用
WO2023050493A1 (fr) * 2021-09-28 2023-04-06 蔻蔻琪生物科技(杭州)有限公司 Composition anti-glycation nanométrique, son procédé de préparation et son application
CN115770196A (zh) * 2022-11-30 2023-03-10 广州市婷采化妆品有限公司 一种多效美白祛斑护肤品及其制备方法及其应用
CN115770196B (zh) * 2022-11-30 2023-11-21 广州市婷采化妆品有限公司 一种多效美白祛斑护肤品及其制备方法及其应用
CN118415940A (zh) * 2024-05-09 2024-08-02 美蔻生物药业(广州)有限公司 一种紧致美白的组合物及其制备方法

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KR101391834B1 (ko) 2014-05-07

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