WO2013183856A1 - Dispositif de diagnostic portatif - Google Patents

Dispositif de diagnostic portatif Download PDF

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Publication number
WO2013183856A1
WO2013183856A1 PCT/KR2013/003066 KR2013003066W WO2013183856A1 WO 2013183856 A1 WO2013183856 A1 WO 2013183856A1 KR 2013003066 W KR2013003066 W KR 2013003066W WO 2013183856 A1 WO2013183856 A1 WO 2013183856A1
Authority
WO
WIPO (PCT)
Prior art keywords
measurement strip
strip
heater
heating
heat
Prior art date
Application number
PCT/KR2013/003066
Other languages
English (en)
Korean (ko)
Inventor
이중진
Original Assignee
(주)미코바이오메드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by (주)미코바이오메드 filed Critical (주)미코바이오메드
Publication of WO2013183856A1 publication Critical patent/WO2013183856A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N37/00—Details not covered by any other group of this subclass
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/8483—Investigating reagent band
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48785—Electrical and electronic details of measuring devices for physical analysis of liquid biological material not specific to a particular test method, e.g. user interface or power supply
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements

Definitions

  • the present invention relates to a portable diagnostic device, and more particularly, to a portable diagnostic device for diagnosing liver disease using a measurement strip.
  • the portable diagnostic device is a device for diagnosing a disease by analyzing a sample such as blood.
  • the portable diagnostic device diagnoses a disease by using a measurement strip.
  • the measurement strip includes a reaction zone containing a reactive enzyme that can react with a sample to diagnose a disease, and each functional unit of the device body detects and analyzes a disease result by detecting and analyzing a reaction result in the reaction zone of the measurement strip. Diagnose whether or not.
  • the portable diagnostic device may be used to diagnose liver disease among the diseases.
  • GOT / GPT / GGT a diagnostic factor for liver disease, reacts rapidly at temperatures higher than room temperature on the reaction mechanism. Since the reaction rate is related to the diagnosis time, it is necessary to maintain the optimum temperature of the reaction 37 ° C. in order to shorten the diagnosis time. Therefore, the configuration of the heater for temperature control is important in the diagnostic device for diagnosing the liver disease.
  • Handheld diagnostic devices are small in size and affected by the environment. Therefore, it is difficult to control the temperature of the portable diagnostic apparatus using a heater.
  • the present invention provides a portable diagnostic device for maintaining a precise temperature for a certain time during the diagnosis.
  • the portable diagnostic device has a space for accommodating a measurement strip, a main body portion for optically measuring a sample included in the measurement strip, and a cover portion connected to the main body portion and opening and closing the space. And a first heating part provided in the main body, the first heating part for heating the measuring strip at the lower part of the space, and a second heating part provided in the cover part and for heating the measuring strip at the upper part of the space. can do.
  • the first heating unit is disposed on the first heater and the first heater that generates heat for heating the measurement strip and the heat of the first heater to the measurement strip And a first heat transfer plate for transmitting, wherein the second heating unit is disposed under the second heater and the second heater to generate heat for heating the measurement strip, and transfers the heat of the second heater to the measurement strip. It may include a second heat transfer plate for transferring.
  • the second heat transfer plate may have a protrusion protruding to correspond to the reaction hole of the measurement strip to directly transfer heat to the reaction hole of the measurement strip.
  • the portable diagnostic device may be configured to measure the temperature of the measurement strip heated by the first heating unit and the second heating unit.
  • the sensor unit may further include a sensor unit provided at a position having the same temperature as the temperature.
  • the portable diagnostic apparatus is provided to be connected to the first heating unit in the main body unit, the power supply unit for supplying power to the first heating unit and the second heating unit in the cover unit It is provided to be connected to the unit, and when the cover is closed may further include a connecting portion electrically connected to the power supply.
  • the portable diagnostic device heats up and down the measuring strip.
  • the measuring strip can be heated quickly and the heat loss of the measuring strip can be minimized.
  • the temperature of the measurement strip can be precisely controlled, and the measurement strip can be maintained at a constant temperature for a long time.
  • FIG. 1 is a perspective view for explaining a portable diagnostic device according to an embodiment of the present invention.
  • FIG. 2 is a perspective view illustrating a state in which a measurement strip is mounted on the portable diagnostic apparatus illustrated in FIG. 1.
  • FIG. 3 is a block diagram illustrating the portable diagnostic apparatus shown in FIG. 1.
  • first and second may be used to describe various components, but the components should not be limited by the terms. The terms are used only for the purpose of distinguishing one component from another.
  • the first component may be referred to as the second component, and similarly, the second component may also be referred to as the first component.
  • FIG. 1 is a perspective view illustrating a portable diagnostic apparatus according to an embodiment of the present invention
  • FIG. 2 is a perspective view illustrating a state in which a measurement strip is mounted on the portable diagnostic apparatus illustrated in FIG. 1
  • FIG. It is a block diagram for explaining the portable diagnostic apparatus shown in FIG.
  • the portable diagnostic device 100 is a device for diagnosing a disease by receiving a measurement strip 10 and analyzing a sample such as blood.
  • the portable diagnostic device 100 may diagnose the liver disease.
  • the portable diagnostic apparatus 100 may include a main body 110, a cover 120, a first heating unit 130, a second heating unit 140, a sensor unit 150, a power supply unit 160, and a connection unit 170. And a temperature controller 180.
  • the main body 110 has a space 112 for accommodating the measurement strip 10 on one side of the upper surface.
  • the space 112 may be provided with a slot guide for mounting the measuring strip 10.
  • the measuring strip 10 may be inserted into the slot guide rearward along the horizontal direction from the front of the body portion 110.
  • the measurement strip 10 contains a sample such as blood.
  • the measuring strip 10 has reaction holes 12 above and below. A sample is injected into the measurement strip 10 through the upper reaction hole 12, and light for optically measuring the sample passes through the lower reaction hole 12.
  • the main body 110 has an optical portion 114 at the bottom of the space.
  • the optical unit 114 optically measures a sample of the measuring strip 10 to diagnose whether a disease, in particular liver disease, is present. Since a technique of diagnosing a disease by analyzing a sample using the optical unit 114 is common, a specific technique is omitted.
  • the main body 110 has a display unit 116 for displaying the measurement results of the optical unit 114.
  • the cover part 120 is connected to the main body part 110 and opens and closes the space 112 in which the measurement strip 10 is accommodated.
  • the cover part 120 may be hinged to the main body part 110 to open and close the space 112.
  • the cover 120 may open and close the space 112 in a sliding manner.
  • the first heating unit 130 is provided in the main body 110 and heats the measurement strip 10 in the lower portion of the space 112.
  • the first heating unit 130 includes a first heater 132 and a first heat transfer plate 134.
  • the first heater 132 is provided inside the main body 110 under the space 112 and generates heat for heating the measurement strip 10.
  • the first heater 132 may be a spiral hot wire or a printed circuit board having a spiral wire.
  • the first heat transfer plate 134 is disposed above the first heater 132, and transfers heat from the first heater 132 to the measurement strip 10.
  • the first heat transfer plate 134 may be made of a metal material having excellent thermal conductivity. Since the first heat transfer plate 134 has a flat plate shape, heat of the first heater 132 may be uniformly transferred to the measurement strip 10.
  • the first heater 132 and the first heat transfer plate 134 are provided to expose the optical unit 114 so that the optical unit 114 can measure the measurement strip.
  • the second heating unit 140 is provided in the cover 120 and heats the measurement strip 10 in the upper portion of the space 112.
  • the second heating unit 140 includes a second heater 142 and a second heat transfer plate 144.
  • the second heater 142 is provided inside the cover 120 and generates heat for heating the measurement strip 10.
  • the second heater 142 may be a spiral wire or a printed circuit board having a spiral wire.
  • the spiral shape of the second heater 142 and the spiral shape of the first heater 132 may be the same to provide heat uniformly to the measurement strip 10. However, in some cases, the spiral shape of the second heater 142 and the spiral shape of the first heater 132 may be different from each other.
  • the second heat transfer plate 144 is disposed under the second heater 142, and transfers heat from the second heater 142 to the measurement strip 10.
  • the second heat transfer plate 144 may be made of a metal material having excellent thermal conductivity. Since the second heat transfer plate 144 has a flat plate shape, heat of the second heater 142 may be uniformly transferred to the measurement strip 10.
  • the second heat transfer plate 144 has a protrusion 145.
  • the protrusion 145 protrudes downward to correspond to the reaction hole of the measurement strip 10 accommodated in the space 112.
  • the second heat transfer plate 144 may directly transfer heat to the reaction hole 12 of the measurement strip 10 through the protrusion 145.
  • the measuring strip 10 can be heated more quickly.
  • the first heating unit 130 and the second heating unit 140 are heated to surround the measuring strip 10 at the upper and lower portions of the measuring strip 10.
  • the temperature of the measuring strip 10 may vary depending on the type of disease to be diagnosed. If the disease is liver disease, the measurement strip 10 may be heated to about 37 ° C.
  • the portable diagnostic device 100 can heat the measurement strip 10 uniformly and quickly.
  • the first heating unit 130 and the second heating unit 140 are positioned above and below the measurement strip 10, heat loss of the measurement strip 10 may be minimized. Therefore, since the temperature change of the measuring strip 10 can be minimized, the temperature of the measuring strip 10 can be kept constant for a long time.
  • first heating unit 130 and the second heating unit 140 have been described as including the first heat transfer plate 134 and the second heat transfer plate 144, respectively, the first heating unit 130 is described above.
  • the second heater 140 may include only the first heater 132 and the second heater 142, respectively.
  • the sensor unit 150 is provided in the main body 110 or the cover 120 and measures the temperature of the measurement strip 10 heated by the first heating unit 130 and the second heating unit 140.
  • the sensor unit 150 may be provided in the space 112 of the main body 110 on which the measuring strip 10 is mounted to accurately measure the temperature of the measuring strip 10. However, since the space 112 is mounted on the measurement strip 10, the sensor unit 150 may not be mounted. Therefore, after calculating the temperature distribution of the portable diagnostic apparatus 100 while heating the first heating unit 130 and the second heating unit 140, the temperature of the space 112 on which the measurement strip 10 is mounted.
  • the sensor unit 150 may be provided at a position having the same temperature as that of the sensor unit 150. The position can be the top, bottom or side of the space 112 in which the measuring strip 10 is mounted. In addition, when the position is plural, the sensor unit 150 may be provided in plural.
  • the sensor unit 150 may be additionally provided at various positions in addition to the position having the same temperature as the temperature of the space 112 in which the measurement strip 10 is mounted. Therefore, the temperature of the measurement strip 10 can be more accurately confirmed using the sensor unit 150.
  • the power supply unit 160 is provided to be connected to the first heating unit 130 in the main body unit 110, and supplies power to the first heating unit 130.
  • the power supply unit 160 protrudes from the space 112 of the main body unit 110.
  • connection part 170 is provided to be connected to the second heating part 140 in the cover part 120.
  • the connection unit 170 is electrically connected to the power supply unit 160 when the cover unit 120 is closed.
  • the connection part 170 contacts the protruding portion of the power supply part 160. Therefore, when the cover unit 120 is closed, the power of the power supply unit 160 is transmitted to the second heating unit 140 through the connection unit 170.
  • the temperature controller 180 may be provided in the main body 110 or the cover 120, and may be connected to the first heating unit 130, the second heating unit 140, and the sensor unit 150.
  • the temperature controller 180 adjusts whether the first heating unit 130 and the second heating unit 140 are heated according to the temperature of the measurement strip 10 measured by the sensor unit 150.
  • the temperature controller 180 may individually control the first heating unit 130 and the second heating unit 140.
  • the temperature controller 180 may be connected to the power supply unit 160 to control the first heating unit 130 and the second heating unit 140 by turning on and off the power supply unit 160. Therefore, the temperature controller 180 can maintain the measurement strip 10 at a constant temperature for a long time accurately.
  • the portable diagnostic apparatus can quickly heat the measuring strip to a constant temperature, and keep the measuring strip at a constant temperature for a long time. Therefore, it is possible to accurately diagnose the disease by using the portable diagnostic device. Therefore, the reliability of the portable diagnostic apparatus can be improved.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Human Computer Interaction (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)

Abstract

L'invention concerne un dispositif de diagnostic portatif qui comprend : un corps principal qui a un espace permettant de loger une bandelette de mesure, et qui mesure optiquement un échantillon contenu dans la bandelette de mesure ; un couvercle qui est connecté au corps principal et qui ouvre et ferme l'espace ; une première unité chauffante qui est disposée dans le corps principal et qui chauffe la bandelette de mesure sur la partie inférieure de l'espace ; et une seconde unité chauffante qui est disposée dans le couvercle et qui chauffe la bandelette de mesure sur la partie supérieure de l'espace. Ainsi, puisque le dispositif de diagnostic portatif chauffe la bandelette de mesure depuis le haut et le bas, la bandelette de mesure peut être chauffée rapidement et uniformément et peut être maintenue à une température uniforme pour de longues périodes.
PCT/KR2013/003066 2012-06-07 2013-04-12 Dispositif de diagnostic portatif WO2013183856A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2012-0060946 2012-06-07
KR1020120060946A KR20130137387A (ko) 2012-06-07 2012-06-07 휴대용 진단 장치

Publications (1)

Publication Number Publication Date
WO2013183856A1 true WO2013183856A1 (fr) 2013-12-12

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ID=49712217

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Application Number Title Priority Date Filing Date
PCT/KR2013/003066 WO2013183856A1 (fr) 2012-06-07 2013-04-12 Dispositif de diagnostic portatif

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KR (1) KR20130137387A (fr)
WO (1) WO2013183856A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160090927A (ko) * 2015-01-22 2016-08-02 (주)미코바이오메드 휴대용 실시간 dna 분석 장치
KR102577994B1 (ko) * 2015-11-03 2023-09-13 프리시젼바이오 주식회사 유체 시료 검사기기

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4934817A (en) * 1987-12-09 1990-06-19 Lre Relais+Elektronik Gmbh Device with detachable test strip holder for optically evaluating a test strip
EP0449525A1 (fr) * 1990-03-26 1991-10-02 Cascade Medical, Inc. Appareil médical de diagnostic
US5591403A (en) * 1994-10-21 1997-01-07 International Technidyne Corporation Portable prothrombin time test apparatus and associated method of performing a prothrombin time test
US6201607B1 (en) * 1998-04-13 2001-03-13 Mit Development Corporation Blood fluid characteristics analysis instrument
KR20100032364A (ko) * 2007-04-29 2010-03-25 아크레이 가부시키가이샤 분석 장치

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4934817A (en) * 1987-12-09 1990-06-19 Lre Relais+Elektronik Gmbh Device with detachable test strip holder for optically evaluating a test strip
EP0449525A1 (fr) * 1990-03-26 1991-10-02 Cascade Medical, Inc. Appareil médical de diagnostic
US5591403A (en) * 1994-10-21 1997-01-07 International Technidyne Corporation Portable prothrombin time test apparatus and associated method of performing a prothrombin time test
US6201607B1 (en) * 1998-04-13 2001-03-13 Mit Development Corporation Blood fluid characteristics analysis instrument
KR20100032364A (ko) * 2007-04-29 2010-03-25 아크레이 가부시키가이샤 분석 장치

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