WO2013168965A3 - 포도상구균 감염 예방용 백신 조성물 - Google Patents

포도상구균 감염 예방용 백신 조성물 Download PDF

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Publication number
WO2013168965A3
WO2013168965A3 PCT/KR2013/003957 KR2013003957W WO2013168965A3 WO 2013168965 A3 WO2013168965 A3 WO 2013168965A3 KR 2013003957 W KR2013003957 W KR 2013003957W WO 2013168965 A3 WO2013168965 A3 WO 2013168965A3
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WO
WIPO (PCT)
Prior art keywords
staphylococcus aureus
vaccine composition
aureus infection
preventing staphylococcus
wta
Prior art date
Application number
PCT/KR2013/003957
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English (en)
French (fr)
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WO2013168965A2 (ko
Inventor
이복률
켄지쿠로카와
정동준
안장현
전유진
김나향
카주에타카하시
김은미
안동호
Original Assignee
목암생명공학연구소
부산대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 목암생명공학연구소, 부산대학교 산학협력단 filed Critical 목암생명공학연구소
Priority to US14/399,225 priority Critical patent/US20150147328A1/en
Priority to EP13788643.8A priority patent/EP2848257A4/en
Priority to KR20147032987A priority patent/KR20150024315A/ko
Publication of WO2013168965A2 publication Critical patent/WO2013168965A2/ko
Publication of WO2013168965A3 publication Critical patent/WO2013168965A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/085—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

본 발명은 N-아세틸글루코사민(GlcNAc)이 β-위치(β-configuration)로만 수식된 리비톨-인산염 또는 이의 반복 단위, 또는 상기 반복 단위를 포함하는 벽테이코산(WTA)을 유효성분으로 함유하는, 포도상구균 감염 예방용 백신 조성물에 관한 것으로서, 본 발명의 조성물은 항-WTA 항체에 대한 결합 모티프(에피토프)를 함유하므로 백신 조성물로서 또는 항-WTA 항체를 생산하여 포도상구균 감염을 예방하는 용도로서 유용하게 사용될 수 있다.
PCT/KR2013/003957 2012-05-07 2013-05-07 포도상구균 감염 예방용 백신 조성물 WO2013168965A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US14/399,225 US20150147328A1 (en) 2012-05-07 2013-05-07 Vaccine composition for preventing staphyllococcus aureus infection
EP13788643.8A EP2848257A4 (en) 2012-05-07 2013-05-07 VACCINE COMPOSITION FOR PREVENTING STAPHYLOCOCCUS AUREUS INFECTION
KR20147032987A KR20150024315A (ko) 2012-05-07 2013-05-07 포도상구균 감염 예방용 백신 조성물

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261643697P 2012-05-07 2012-05-07
US61/643,697 2012-05-07

Publications (2)

Publication Number Publication Date
WO2013168965A2 WO2013168965A2 (ko) 2013-11-14
WO2013168965A3 true WO2013168965A3 (ko) 2014-01-16

Family

ID=49551416

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2013/003957 WO2013168965A2 (ko) 2012-05-07 2013-05-07 포도상구균 감염 예방용 백신 조성물

Country Status (4)

Country Link
US (1) US20150147328A1 (ko)
EP (1) EP2848257A4 (ko)
KR (1) KR20150024315A (ko)
WO (1) WO2013168965A2 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014193722A1 (en) 2013-05-31 2014-12-04 Genentech, Inc. Anti-wall teichoic antibodies and conjugates
US9803002B2 (en) 2013-05-31 2017-10-31 Genentench, Inc. Anti-wall teichoic antibodies and conjugates
CN112430266A (zh) * 2013-05-31 2021-03-02 基因泰克公司 抗壁磷壁酸抗体和缀合物
KR20170005852A (ko) * 2014-05-29 2017-01-16 주식회사 녹십자 포도상구균 감염 질환의 예방 또는 치료용 조성물
WO2017010845A1 (ko) * 2015-07-15 2017-01-19 재단법인 목암생명과학연구소 포도상구균 감염 질환의 예방 또는 치료용 조성물
WO2017064190A1 (en) 2015-10-13 2017-04-20 Sanofi Pasteur Immunogenic compositions against s. aureus
MX2018010491A (es) 2016-03-04 2018-11-09 Genentech Inc Proceso para la preparacion de un conjugado anticuerpo-rifamicina.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010085745A (ko) * 1998-08-31 2001-09-07 추후제출 다성분 백신
US20040247605A1 (en) * 2002-12-02 2004-12-09 Kokai-Kun John Fitzgerald Wall teichoic acid as a target for anti-staphylococcal therapies and vaccines
KR20050074582A (ko) * 2002-11-12 2005-07-18 더 브리검 앤드 우먼즈 하스피털, 인크. 포도상구균 감염에 대한 다당류 백신
KR20110124060A (ko) * 2010-05-10 2011-11-16 부산대학교 산학협력단 Ｗｔａ를 유효성분으로 함유하는 백신 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450150A (en) 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
EP0130935B1 (fr) 1983-07-01 1987-04-15 Battelle Memorial Institute Polypeptide biodégradable et son utilisation pour le relargage progressif de médicaments
US5417986A (en) 1984-03-16 1995-05-23 The United States Of America As Represented By The Secretary Of The Army Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010085745A (ko) * 1998-08-31 2001-09-07 추후제출 다성분 백신
KR20050074582A (ko) * 2002-11-12 2005-07-18 더 브리검 앤드 우먼즈 하스피털, 인크. 포도상구균 감염에 대한 다당류 백신
US20040247605A1 (en) * 2002-12-02 2004-12-09 Kokai-Kun John Fitzgerald Wall teichoic acid as a target for anti-staphylococcal therapies and vaccines
KR20110124060A (ko) * 2010-05-10 2011-11-16 부산대학교 산학협력단 Ｗｔａ를 유효성분으로 함유하는 백신 조성물

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
XIA, G. ET AL.: "Glycosylation of Wall Teichoic Acid in Staphylococcus aureus by TarM", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 18, 2010, pages 13405 - 13415, XP055176733 *

Also Published As

Publication number Publication date
KR20150024315A (ko) 2015-03-06
WO2013168965A2 (ko) 2013-11-14
EP2848257A4 (en) 2015-12-02
US20150147328A1 (en) 2015-05-28
EP2848257A2 (en) 2015-03-18

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