WO2013164512A3 - Composición para su uso en el tratamiento y/o prevención de la inflamación, el estrés oxidativo y la neovascularización ocular - Google Patents
Composición para su uso en el tratamiento y/o prevención de la inflamación, el estrés oxidativo y la neovascularización ocular Download PDFInfo
- Publication number
- WO2013164512A3 WO2013164512A3 PCT/ES2013/070279 ES2013070279W WO2013164512A3 WO 2013164512 A3 WO2013164512 A3 WO 2013164512A3 ES 2013070279 W ES2013070279 W ES 2013070279W WO 2013164512 A3 WO2013164512 A3 WO 2013164512A3
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- WO
- WIPO (PCT)
- Prior art keywords
- composition
- prevention
- treatment
- oxidative stress
- neovascularization
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/22—Organic compounds
- C11D7/26—Organic compounds containing oxygen
- C11D7/261—Alcohols; Phenols
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/22—Organic compounds
- C11D7/26—Organic compounds containing oxygen
- C11D7/267—Heterocyclic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere al uso de la quercetina (QCT) o de una composición que comprende QCT y al menos otro compuesto polifenólico, preferiblemente resveratrol (RES), para el tratamiento y/o prevención de lesiones o enfermedades que cursan con inflamación, estrés oxidativo y/o neovascularización ocular, preferiblemente del segmento anterior, más preferiblemente de la superficie ocular y aun más preferiblemente del epitelio corneal. La invención también se refiere al uso de la QCT y de dicha composición como agente antimicrobiano, antioxidante y antiinflamatorio en soluciones de limpieza y mantenimiento de lentes de contacto.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ESP201230664 | 2012-05-04 | ||
ES201230664A ES2428665B1 (es) | 2012-05-04 | 2012-05-04 | Composición para su uso en el tratamiento y/o prevención de la inflamación, el estrés oxidativo y la neovascularización ocular |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2013164512A2 WO2013164512A2 (es) | 2013-11-07 |
WO2013164512A3 true WO2013164512A3 (es) | 2014-03-20 |
Family
ID=48700616
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/ES2013/070279 WO2013164512A2 (es) | 2012-05-04 | 2013-05-06 | Composición para su uso en el tratamiento y/o prevención de la inflamación, el estrés oxidativo y la neovascularización ocular |
Country Status (2)
Country | Link |
---|---|
ES (1) | ES2428665B1 (es) |
WO (1) | WO2013164512A2 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2729862T3 (es) | 2014-03-28 | 2019-11-06 | Hortus Novus Srl | Composiciones basadas en azafrán para la prevención y/o el tratamiento de trastornos oculares degenerativos |
US10092585B2 (en) | 2014-09-19 | 2018-10-09 | Hortus Novus Srl | Compositions based on saffron for the prevention and/or treatment of corneal dystrophies |
IT202200002108A1 (it) | 2022-02-07 | 2023-08-07 | Indena Spa | Composizioni a base di quercetina per il trattamento e la prevenzione di affezioni oculari |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002057473A1 (en) * | 2001-01-17 | 2002-07-25 | Young-Mee Park | Method for inhibiting vegf and epo gene expression by quercetin |
US20030133945A1 (en) * | 2002-01-11 | 2003-07-17 | Farley Michael Donald | Natural food supplement |
WO2004062683A1 (en) * | 2003-01-09 | 2004-07-29 | Michael Donald Farley | Improvements in or relating to immune functions |
US20050163873A1 (en) * | 2004-01-14 | 2005-07-28 | Robert Ritch | Methods and formulations for treating glaucoma |
US20050220907A1 (en) * | 2004-03-30 | 2005-10-06 | Theoharides Theoharis C | Implanted medical devices with anti-inflammatory coatings |
US20060111318A1 (en) * | 2003-04-18 | 2006-05-25 | Advanced Medicine Research Institute | Agent for treating eye diseases |
US20060127505A1 (en) * | 2002-01-16 | 2006-06-15 | David Haines | Anti-inflammatory formulations |
EP1844784A1 (en) * | 2006-03-28 | 2007-10-17 | Epitech Group S.r.l. | A pharmaceutical composition for the treatment of pathologies caused by the general response of the immune system |
WO2008016095A1 (fr) * | 2006-08-02 | 2008-02-07 | Santen Pharmaceutical Co., Ltd. | REMÈDE PRÉVENTIF OU CURATIF POUR LES KÉRATOCONJONCTIVITES CONTENANT UN ACTIVATEUR DE Nrf2 EN TANT QUE MATIÈRE ACTIVE |
WO2008061536A1 (en) * | 2006-11-22 | 2008-05-29 | Ocumedic Aps | Compositions and methods of using same for treatment of a disease or disorder of the eye and/or the adnexa of the eye |
WO2011057183A1 (en) * | 2009-11-06 | 2011-05-12 | Alcon Research, Ltd. | Nutritional supplements for relief of dry eye |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005099721A2 (en) * | 2004-04-15 | 2005-10-27 | The Regents Of The University Of California | Compositions comprising plant-derived polyphenolic compounds and inhibitors of reactive oxygen species and methods of using thereof |
US20070212395A1 (en) * | 2006-03-08 | 2007-09-13 | Allergan, Inc. | Ocular therapy using sirtuin-activating agents |
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2012
- 2012-05-04 ES ES201230664A patent/ES2428665B1/es active Active
-
2013
- 2013-05-06 WO PCT/ES2013/070279 patent/WO2013164512A2/es active Application Filing
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002057473A1 (en) * | 2001-01-17 | 2002-07-25 | Young-Mee Park | Method for inhibiting vegf and epo gene expression by quercetin |
US20030133945A1 (en) * | 2002-01-11 | 2003-07-17 | Farley Michael Donald | Natural food supplement |
US20060127505A1 (en) * | 2002-01-16 | 2006-06-15 | David Haines | Anti-inflammatory formulations |
WO2004062683A1 (en) * | 2003-01-09 | 2004-07-29 | Michael Donald Farley | Improvements in or relating to immune functions |
US20060111318A1 (en) * | 2003-04-18 | 2006-05-25 | Advanced Medicine Research Institute | Agent for treating eye diseases |
US20050163873A1 (en) * | 2004-01-14 | 2005-07-28 | Robert Ritch | Methods and formulations for treating glaucoma |
US20050220907A1 (en) * | 2004-03-30 | 2005-10-06 | Theoharides Theoharis C | Implanted medical devices with anti-inflammatory coatings |
EP1844784A1 (en) * | 2006-03-28 | 2007-10-17 | Epitech Group S.r.l. | A pharmaceutical composition for the treatment of pathologies caused by the general response of the immune system |
WO2008016095A1 (fr) * | 2006-08-02 | 2008-02-07 | Santen Pharmaceutical Co., Ltd. | REMÈDE PRÉVENTIF OU CURATIF POUR LES KÉRATOCONJONCTIVITES CONTENANT UN ACTIVATEUR DE Nrf2 EN TANT QUE MATIÈRE ACTIVE |
WO2008061536A1 (en) * | 2006-11-22 | 2008-05-29 | Ocumedic Aps | Compositions and methods of using same for treatment of a disease or disorder of the eye and/or the adnexa of the eye |
WO2011057183A1 (en) * | 2009-11-06 | 2011-05-12 | Alcon Research, Ltd. | Nutritional supplements for relief of dry eye |
Non-Patent Citations (8)
Title |
---|
CAO X ET AL: "The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice", EXPERIMENTAL EYE RESEARCH, ACADEMIC PRESS LTD, LONDON, vol. 91, no. 1, 1 July 2010 (2010-07-01), pages 15 - 25, XP027063939, ISSN: 0014-4835, [retrieved on 20100528], DOI: 10.1016/J.EXER.2010.03.016 * |
HAYNES W L ET AL: "EFFECT OF INHIBITORS OF ARACHIDONIC ACID METABOLISM ON CORNEAL NEOVASCULARIZATION IN THE RAT", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE - IOVS, ASSOCIATION FOR RESEARCH IN VISION AND OPHTHALMOLOGY, US, vol. 30, no. 7, 1 July 1989 (1989-07-01), pages 1588 - 1593, XP009052446, ISSN: 0146-0404 * |
JIN SOOK YOON ET AL: "Quercetin Inhibits IL-1[beta]-Induced Inflammation, Hyaluronan Production and Adipogenesis in Orbital Fibroblasts from Graves' Orbitopathy", PLOS ONE, vol. 6, no. 10, 19 October 2011 (2011-10-19), pages e26261, XP055077146, DOI: 10.1371/journal.pone.0026261 * |
KELLY G S: "Quercetin", ALTERNATIVE MEDICINE REVIEW, THORNE RESEARCH INC., SANDPOINT, US, vol. 16, no. 2, 1 June 2011 (2011-06-01), pages 172 - 194, XP008164453, ISSN: 1089-5159 * |
MILAN STEFEK ET AL: "Eye Lens in Aging and Diabetes: Effect of Quercetin", REJUVENATION RESEARCH, vol. 14, no. 5, 1 October 2011 (2011-10-01), pages 525 - 534, XP055077137, ISSN: 1549-1684, DOI: 10.1089/rej.2011.1170 * |
NIINA M M SAVIRANTA ET AL: "Plant flavonol quercetin and isoflavone biochanin A differentially induce protection against oxidative stress and inflammation in ARPE-19 cells", FOOD RESEARCH INTERNATIONAL, ELSEVIER APPLIED SCIENCE, BARKING, GB, vol. 44, no. 1, 31 October 2010 (2010-10-31), pages 109 - 113, XP028134769, ISSN: 0963-9969, [retrieved on 20101104], DOI: 10.1016/J.FOODRES.2010.10.056 * |
ROMERO J ET AL: "Pharmacologic modulation of acute ocular inflammation with quercetin", OPHTHALMIC RESEARCH, S. KARSER AG. BASEL, CH, vol. 21, 1 January 1989 (1989-01-01), pages 112 - 117, XP002113010, ISSN: 0030-3747 * |
SOUMYAJIT MAJUMDAR ET AL: "Potential of the bioflavonoids in the prevention/treatment of ocular disorders", JOURNAL OF PHARMACY AND PHARMACOLOGY, 1 January 2010 (2010-01-01), pages 951 - 965, XP055077194, Retrieved from the Internet <URL:http://onlinelibrary.wiley.com/doi/10.1211/jpp.62.08.0001/pdf> [retrieved on 20130830], DOI: 10.1211/jpp.62.08.0001 * |
Also Published As
Publication number | Publication date |
---|---|
ES2428665A1 (es) | 2013-11-08 |
WO2013164512A2 (es) | 2013-11-07 |
ES2428665B1 (es) | 2014-10-01 |
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