WO2013164435A3 - Protéine de fusion de la protéine lymphopoiétine stromale thymique canine avec la région fc d'igg - Google Patents

Protéine de fusion de la protéine lymphopoiétine stromale thymique canine avec la région fc d'igg Download PDF

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Publication number
WO2013164435A3
WO2013164435A3 PCT/EP2013/059212 EP2013059212W WO2013164435A3 WO 2013164435 A3 WO2013164435 A3 WO 2013164435A3 EP 2013059212 W EP2013059212 W EP 2013059212W WO 2013164435 A3 WO2013164435 A3 WO 2013164435A3
Authority
WO
WIPO (PCT)
Prior art keywords
igg
region
protein
thymic stromal
stromal lymphopoietin
Prior art date
Application number
PCT/EP2013/059212
Other languages
English (en)
Other versions
WO2013164435A2 (fr
Inventor
Mohamad Morsey
Jeanine D. Mattson
Dan M. GORMAN
Rene De Waal Malefyt
Leonard G. Presta
Original Assignee
Intervet International B.V.
Intervet Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intervet International B.V., Intervet Inc. filed Critical Intervet International B.V.
Publication of WO2013164435A2 publication Critical patent/WO2013164435A2/fr
Publication of WO2013164435A3 publication Critical patent/WO2013164435A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention concerne des protéines de fusion de TSLP canine ou de ses fragments antigéniques, avec la région Fc d'IgG, ainsi que les acides nucléiques qui codent ces protéines de fusion. La présente invention concerne en outre des procédés de fabrication et d'utilisation de ces protéines de fusion et acides nucléiques.
PCT/EP2013/059212 2012-05-04 2013-05-03 Protéine de fusion de la protéine lymphopoiétine stromale thymique canine avec la région fc d'igg WO2013164435A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261642563P 2012-05-04 2012-05-04
US61/642,563 2012-05-04

Publications (2)

Publication Number Publication Date
WO2013164435A2 WO2013164435A2 (fr) 2013-11-07
WO2013164435A3 true WO2013164435A3 (fr) 2013-12-27

Family

ID=48325700

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2013/059212 WO2013164435A2 (fr) 2012-05-04 2013-05-03 Protéine de fusion de la protéine lymphopoiétine stromale thymique canine avec la région fc d'igg

Country Status (2)

Country Link
AR (1) AR090915A1 (fr)
WO (1) WO2013164435A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008076255A2 (fr) * 2006-12-14 2008-06-26 Schering-Plough Ltd. Lymphopoïétine stromale thymique (tslp) canine et utilisations associées
WO2008076321A1 (fr) * 2006-12-14 2008-06-26 Schering Corporation Anticorps anti-tslp technique
WO2011056772A1 (fr) * 2009-11-04 2011-05-12 Schering Corporation Anticorps anti-tslp manufacturé

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006557A2 (fr) 1997-08-01 1999-02-11 Schering Corporation Proteines de membrane cellulaire mammalienne et reactifs associes
JP4454859B2 (ja) 1998-11-13 2010-04-21 イミュネックス・コーポレーション ヒトｔｓｌｐｄｎａおよびポリペプチド
US6890734B2 (en) 2000-11-10 2005-05-10 Schering Corporation Nucleic acids encoding a cytokine receptor complex
SE532251C2 (sv) 2006-11-28 2009-11-24 Theravac Pharmaceuticals Ab Nya formuleringar av TSLP för behandling av TH2-medierade inflammatoriska sjukdomar genom vaccinering

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008076255A2 (fr) * 2006-12-14 2008-06-26 Schering-Plough Ltd. Lymphopoïétine stromale thymique (tslp) canine et utilisations associées
WO2008076321A1 (fr) * 2006-12-14 2008-06-26 Schering Corporation Anticorps anti-tslp technique
WO2011056772A1 (fr) * 2009-11-04 2011-05-12 Schering Corporation Anticorps anti-tslp manufacturé

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
KLUKOWSKA-RÖTZLER JOLANTA ET AL: "Expression of thymic stromal lymphopoietin in canine atopic dermatitis.", VETERINARY DERMATOLOGY, vol. 24, no. 1, February 2013 (2013-02-01), pages 54 - e14, XP002708782, ISSN: 1365-3164 *
LIN ET AL: "TSLP-induced placental DC activation and IL-10<+> NK cell expansion: Comparative study based on BALB/cxC57BL/6 and NOD/SCIDxC57BL/6 pregnant models", CLINICAL IMMUNOLOGY, vol. 126, no. 1, 31 October 2007 (2007-10-31), ACADEMIC PRESS, US, pages 104 - 117, XP022394221, ISSN: 1521-6616, DOI: 10.1016/J.CLIM.2007.09.006 *
LIOSSIS ET AL: "Monoclonal antibodies and fusion proteins in medicine", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 116, no. 4, 1 October 2005 (2005-10-01), ELSEVIER, AMSTERDAM, NL, pages 721 - 729, XP005094457, ISSN: 0091-6749, DOI: 10.1016/J.JACI.2005.06.035 *
MIZUE TERAI ET AL: "Human interleukin 10 receptor 1/IgG1-Fc fusion proteins: immunoadhesins for human IL-10 with therapeutic potential", CANCER IMMUNOLOGY, IMMUNOTHERAPY, vol. 58, no. 8, 14 January 2009 (2009-01-14), SPRINGER, BERLIN, DE, pages 1307 - 1317, XP019706358, ISSN: 1432-0851 *
SANDER DE KIVIT ET AL: "Apical TLR ligation of intestinal epithelial cells drives a T1-polarized regulatory or inflammatory type effector response", IMMUNOBIOLOGY, vol. 216, no. 4, 16 August 2010 (2010-08-16), URBAN UND FISCHER VERLAG, DE, pages 518 - 527, XP028169004, ISSN: 0171-2985, [retrieved on 20100821], DOI: 10.1016/J.IMBIO.2010.08.005 *
SUNG BONG HWAN ET AL: "Human soluble E-selectin immunoadhesin inhibits leukemic monocyte adhesion to endothelial cells", CELL BIOCHEMISTRY AND FUNCTION, vol. 25, no. 5, 1 September 2007 (2007-09-01), BUTTERWORTH, GUILDFORD, GB, pages 585 - 589, XP009171654, ISSN: 0263-6484, [retrieved on 20060807] *
YANLU ZHANG ET AL: "Functions of thymic stromal lymphopoietin in immunity and disease", IMMUNOLOGIC RESEARCH, vol. 52, no. 3, 25 January 2012 (2012-01-25), HUMANA PRESS INC, NEW YORK, pages 211 - 223, XP035054105, ISSN: 1559-0755, DOI: 10.1007/S12026-012-8264-Z *

Also Published As

Publication number Publication date
AR090915A1 (es) 2014-12-17
WO2013164435A2 (fr) 2013-11-07

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