WO2013161070A1 - Outil de protection contre la lumière pour mesurer la circulation sanguine dans la tête, et procédé de contrôle et dispositif de contrôle pour installer celui-ci - Google Patents

Outil de protection contre la lumière pour mesurer la circulation sanguine dans la tête, et procédé de contrôle et dispositif de contrôle pour installer celui-ci Download PDF

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Publication number
WO2013161070A1
WO2013161070A1 PCT/JP2012/061425 JP2012061425W WO2013161070A1 WO 2013161070 A1 WO2013161070 A1 WO 2013161070A1 JP 2012061425 W JP2012061425 W JP 2012061425W WO 2013161070 A1 WO2013161070 A1 WO 2013161070A1
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WO
WIPO (PCT)
Prior art keywords
light
head
blood flow
shading
flow measurement
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Application number
PCT/JP2012/061425
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English (en)
Japanese (ja)
Inventor
敦 牧
長谷川　清
木村　修
杉本　日出夫
Original Assignee
株式会社日立国際電気エンジニアリング
株式会社日立製作所
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Publication date
Application filed by 株式会社日立国際電気エンジニアリング, 株式会社日立製作所 filed Critical 株式会社日立国際電気エンジニアリング
Priority to PCT/JP2012/061425 priority Critical patent/WO2013161070A1/fr
Priority to JP2014512265A priority patent/JP5923598B2/ja
Publication of WO2013161070A1 publication Critical patent/WO2013161070A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/18—Shielding or protection of sensors from environmental influences, e.g. protection from mechanical damage
    • A61B2562/185—Optical shielding, e.g. baffles

Definitions

  • the present invention relates to a shading tool used in an apparatus for measuring blood flow in the head using light such as near infrared light.
  • Devices that measure information inside a living body simply and without harming the living body are used in fields such as clinical medicine and brain science.
  • the measurement method using light is an effective means.
  • the oxygen metabolism function in the living body corresponds to the concentration of a specific pigment (hemoglobin, cytochrome aa3, myoglobin, etc.) in the living body, and the concentration of these pigments can be determined from the amount of light absorbed.
  • light is easy to handle and does not harm the living body when used within the range of safety standards.
  • a biological optical measurement device that measures the inside of a living body using light with a wavelength from visible to infrared has been proposed.
  • a plurality of light irradiating units of the probe device that generates intensity-modulated light based on the light driving signal and sequentially irradiates the living body.
  • a plurality of light detection units of the probe device outputs intensity modulated light transmitted or reflected through the living body as an analog amplitude modulation signal, and obtains biological information such as blood circulation, hemodynamics, hemoglobin change, etc. from the detected light quantity. .
  • the probe support that supports the light irradiation probe main body and the light detection probe main body is a laminated structure including a light-shielding sheet to prevent external light from entering and to reflect from the scalp. It describes that the reflected light is absorbed.
  • blood flow in the head is measured outdoors using a biological light measurement device.
  • sunlight passes through the biological tissue and reaches the photodetector, resulting in noise in the measurement signal.
  • the detector is saturated. Even when measuring indoors, it is similarly affected by the strong illumination of incandescent and fluorescent lamps.
  • the biological light measurement device may be used together with a visual line detection device for detecting the visual line of the subject. Similarly, the light of a specific frequency of the visual line detection device is also transmitted through the biological tissue to the photodetector. To reach noise and saturate the detector.
  • Patent Document 2 describes that the probe support that supports the light irradiation probe main body and the light detection probe main body is a laminated structure including a light shielding sheet, and prevents external light from entering, In Patent Document 2, light that directly enters the photodetector is targeted, and light that passes through the biological tissue that is the subject and reaches the photodetector is not considered.
  • the present invention solves these problems, and provides a light-shielding device that prevents external light such as sunlight or light from a line-of-sight detection device from passing through living tissue and reaching a photodetector to become noise or the like.
  • the purpose is to provide.
  • the light-shielding tool shields an area of 20 mm or more, more preferably 25 mm or more from the photodetector of the head-mounted probe. With this configuration, it is possible to prevent external light such as sunlight and light from the visual line detection device from reaching the photodetector through the living tissue.
  • a shading tool for head blood flow measurement used together with a head-mounted probe of a biological light measuring device, wherein the shading tool is an area of 20 mm or more, more preferably 25 mm or more from a photodetector of the head-mounted probe. It is the light-shielding tool which light-shields.
  • the light-shielding device may be a light-shielding sheet, and the light-shielding sheet may have a shape that shields light from an upper part of an eye part and a side part of the eye part.
  • the light-shielding device is a light-shielding sheet, and the light-shielding sheet covers the head-side surface of the head-mounted probe from the side surface of the eye portion and the upper portion of the eye portion.
  • the shape including and covering may be sufficient.
  • the light-shielding sheet is provided with holes for a light irradiation part and a light detection part, and the light-shielding sheet is fitted in a head-mounted probe in advance. It can be installed.
  • the light-shielding tool may be a light-shielding cap provided with a shape that covers the front upper part and the frontal part of the face of the subject.
  • the light shielding cap may include a hole for the light irradiation unit and the light detection unit, and a hole corresponding to the eye part.
  • the light-shielding device is eyeglass-shaped light-shielding glasses, and the light-shielding glasses include an upper collar portion that shields an upper portion of an eye portion and a side of the eye portion. You may provide the side collar part which light-shields a part.
  • the light-shielding glasses may be of a size that can be worn over normal glasses.
  • the light-shielding glasses may include an internal collar portion that fills a gap with the forehead portion and rides on a frame of the glasses.
  • the light-shielding glasses may include a surface fastener connected to the surface fastener of the light-shielding cap.
  • the check method for wearing a shading tool is a check method for wearing a shading tool for head blood flow measurement that is used together with a head-mounted probe of a biological light measurement device.
  • the method includes a step of measuring and displaying a frequency spectrum, and a step of determining that the shading device is not completely installed when the spectrum of the gaze detection light from the gaze detection device is detected.
  • the check device for wearing a shading tool is a check device for wearing a shading tool for head blood flow measurement that is used together with a head-mounted probe of a biological light measurement device.
  • a frequency spectrum measurement unit that measures the frequency spectrum
  • a line-of-sight detection light spectrum detection unit that detects the presence or absence of the spectrum of the line-of-sight detection light of the line-of-sight detection device, and the spectrum of the line-of-sight detection light are detected from the measured frequency spectrum
  • a warning signal output unit that outputs a warning signal.
  • the shading tool of the present invention it is possible to prevent external light such as sunlight and light from a line-of-sight detection device from passing through the living tissue and reaching the photodetector, and noise and saturation of the detector can be prevented.
  • a highly accurate biological light measurement signal can be obtained.
  • the method and apparatus for checking shading device mounting of the present invention it is possible to surely check whether the shading device is properly mounted, forgetting to mount the shading device, or an incomplete mounting state. It is possible to prevent the measurement from being performed.
  • FIG. 8 shows a schematic cross-sectional view of blood flow measurement of the head.
  • Light such as near infrared light emitted from the light irradiator 12 is incident on the scalp from the scalp and propagates in all directions in the tissue to be measured.
  • the light that has passed through the measurement target region of the head is received by the photodetector 14 that is disposed in the vicinity of the light irradiator 12.
  • the distance (SD distance) between the light irradiator 12 and the photodetector 14 is, for example, 30 mm.
  • FIG. 8 shows one light irradiator 12 and two light detectors 14, a plurality of light irradiators and a plurality of lights are used in order to expand the measurement region and simultaneously perform multi-channel measurement. Use a measuring probe with alternating detectors.
  • FIG. 9 shows an example of a measurement probe.
  • FIG. 9 is a front view of the head-mounted probe. This head-mounted probe is mounted on a subject's head and measures brain activity in the frontal region.
  • the light source that is the light irradiation unit 12 and the light receiving unit that is the light detection unit 14 are alternately arranged in two rows and eight rows.
  • FIG. 10 is a diagram showing a state where the head-mounted probe of FIG. 9 is mounted on the frontal portion of the subject.
  • FIG. 10A is a diagram showing a state where the head-mounted probe 10 is mounted
  • FIG. 10B is a diagram showing a state where the head-mounted probe is mounted and covered with a light-shielding cap 30 from above. It is.
  • FIG. 11 shows a schematic diagram in which the gaze detection device 150 is used in combination with the biological light measurement device 100.
  • a head mounted probe 110 of a biological light measuring device is mounted on the frontal portion of the subject.
  • the head-mounted probe is connected to the head-mounted probe control box 120 with an electric wire, and the control box 120 is mounted, for example, on the waist of the subject.
  • the control box 120 is controlled by wireless LAN communication from the biological light measuring device control personal computer 130.
  • the line-of-sight detection device 150 irradiates the subject's eyes with near-infrared light from the near-infrared LED 160 and detects the reflected light from the retina of the eye with the near-infrared camera 170.
  • the processing device 180 By processing the obtained imaging signal by the processing device 180, the position of the subject's line of sight, for example, whether or not the subject is looking at the image on the display 140, which is a stimulus presentation device, is detected.
  • an image is displayed on the display 140, and the state of blood flow in the head of the subject at that time is measured by the biological light measurement device 100.
  • the line-of-sight detection device 150 detects the line-of-sight position of the subject, and also detects, for example, whether or not the subject has reacted by looking at the image on the display.
  • the inventor of the present invention can detect light emitted from other devices such as external light such as sunlight and a line-of-sight detection device from the exposed skin surface. It has been discovered that scattered light that has penetrated through the living body reaches the photodetector and causes noise and, in some cases, saturation of the detector. If it demonstrates with sectional drawing of FIG. 8, light from the outside, such as sunlight and room illumination light, will permeate
  • Fig. 3 consider the light detection intensity when a light shielding range is set around the photodetector. As shown in FIG. 3A, the inside of a circle (filled area) having a radius R from the photodetector is a light shielding range, and the infinity from the periphery is outside the light shielding range.
  • FIG. 3B is a diagram showing an example of the spectrum of actually measured incandescent lamps and fluorescent lamps.
  • the broken line shows the Planck distribution spectrum that is in good agreement with the incandescent lamp, and the solid line shows the fluorescent lamp spectrum.
  • the plank distribution has a greater power in the near infrared region.
  • the detector is provided with a visible light cut filter (transmittance of less than 700 nm is 0.1%, transmittance of 700 nm or more is 90%), and circular light shielding is performed.
  • the light shielding radius is set to 10-30 mm in 5 mm increments under the conditions, the current value after photoelectric conversion of disturbance light (incandescent light and fluorescent light) mixed in the detector is expressed as an approximate solution of the diffusion equation. Utilized and obtained by calculation with reference to the absorption spectrum of hemoglobin.
  • the amount of light that reaches 4.0 mW of irradiation light was obtained and compared with the calculated disturbance light intensity.
  • Table 1 shows the calculation results.
  • the total light intensity of the two wavelengths used for the measurement is about 23.0E-10 [A], and the disturbance light is desirably 10% or less of the intensity.
  • the disturbance light is less than 10% of the total light intensity of two wavelengths at the light receiving level, it is shown in bold.
  • the light-shielding range in which ambient light contamination is less than or equal to this amount of light was 25 mm or more for incandescent lamps and 20 mm or more under fluorescent lamps, regardless of illuminance.
  • FIG. 1 shows a light shielding tool comprising a light shielding sheet of Example 1 of the present invention.
  • This light shielding sheet is used together with a head mounted probe mounted on the frontal head.
  • FIG. 1A shows a plan view of the light shielding sheet 20 as viewed from the front
  • FIG. 1B shows a side view of the head mounted probe 10 and the light shielding sheet 20 mounted on the subject.
  • the light-shielding sheet of this example is shaped to cover the subject's forehead and the side of the eye so as not to cover the eyes.
  • the width of the light shielding sheet needs to have a width that shields light from the photodetector by 20 mm or more, preferably 25 mm or more.
  • the light-shielding sheet is preferably in close contact with the skin of the subject.
  • the light-shielding sheet is provided with adhesiveness, for example, a gel-like adhesive substance is formed on the surface on the skin side and adhered to the skin. Or you may make it closely_contact
  • FIG. 2A shows a state where the head-mounted probe 10 is mounted after the adhesive light-shielding sheet 20 is attached.
  • FIG. 2B shows a state where the head-mounted probe 10 is further covered with a light shielding cap 30.
  • a light shielding sheet having a width that covers 20 mm or more from the photodetector by using a light shielding sheet having a width that covers 20 mm or more from the photodetector, it is possible to prevent the incidence of light from the outside and perform measurement with reduced noise.
  • FIG. 4 shows a light shielding tool comprising the light shielding sheet of Example 2 of the present invention.
  • the light shielding sheet 40 has a shape that covers from the upper part of the eye to the rear part of the head-mounted probe including the head-side surface of the head-mounted probe 10.
  • FIG. 4A shows a plan view seen from the front of the light shielding sheet 40
  • FIG. 4B shows a side view of the head mounted probe 10 and the light shielding sheet 40 attached to the subject.
  • the light shielding sheet includes holes 45 for passing the light irradiation unit and the light detector corresponding to the positions of the light irradiation unit and the light detector of the head-mounted probe.
  • the shape which covers the side part of an eye part is provided similarly to the light shielding sheet of Example 1.
  • FIG. As a material for the light shielding sheet, a material having elasticity and a light shielding effect may be used. For example, wet suit material (with single-sided or double-sided fabric).
  • the distance d from the photodetector to the upper edge of the eye of the light shielding sheet or the distance d ′ from the photodetector to the rear edge of the light shielding sheet is 20 mm or more, preferably 25 mm. It is necessary to have the above width.
  • the attachment of the light-shielding sheet of this embodiment can be easily performed by fitting the light-shielding sheet in advance to the contact pad of the head-mounted probe.
  • the means for attaching the light shielding sheet to the skin is not necessarily required.
  • the skin surface side of the light shielding sheet has adhesiveness. May be allowed.
  • FIG. 5 shows a light shielding tool including a light shielding cap according to a third embodiment of the present invention.
  • the light-shielding cap 50 has a shape covering the front upper part and the frontal part of the face, and has a hole 53 at a position corresponding to the eye part.
  • a hole 55 for passing the light irradiation unit and the light detector is provided corresponding to the positions of the light irradiation unit and the light detector of the head-mounted probe.
  • FIG. 6 shows a light shielding tool including the light shielding glasses of Example 4 of the present invention.
  • the light-shielding glasses are used to shield light from outside by wearing the head-mounted probe in the same manner as the eyeglasses. It is good also as a size which can be used from normal spectacles.
  • FIG. 6 (a) and 6 (b) are perspective views of the light-shielding glasses
  • FIG. 6 (c) is a front view of the light-shielding glasses
  • FIG. The side view of the mounted state is shown.
  • the light-shielding glasses 60 include an upper light-shielding collar portion 62, and are configured such that the upper light-shielding collar portion 62 overlaps the light-shielding cap 30 when the light-shielding glasses are mounted from above the light shielding cap 30.
  • Near-infrared irradiation from below by the line-of-sight detection device and the necessary field of view of the subject are secured, and both sides and the upper part of the field of view are shielded from light.
  • the opening of the eye is made as small as possible, and the side and the lower part of the outer corner of the eye are shielded as much as possible by the light shielding collar 64 on the side.
  • the inner collar 66 is provided inside the light shielding glasses.
  • the internal brim portion fills a gap with the forehead portion that enables the use of the glasses, blocks intrusion light from below, and prevents slipping by riding on the frame of the glasses 68. be able to. Further, by allowing the light-shielding glasses 60 and the light-shielding cap 30 to be connected with a hook-and-loop fastener, it is possible to further prevent slipping.
  • FIG. 7 (a) shows a state in which the head mounted probe of the biological light measuring device is mounted, the light blocking cap 30 is mounted thereon, and the light blocking glasses 60 of the present embodiment are mounted.
  • FIG. 7B shows a state in which normal glasses 68 are used and the light-shielding glasses 60 of the present embodiment are mounted thereon.
  • Example 5 prior to the measurement of blood flow of the head using the biological light measurement device, whether or not the subject wears the light-shielding device of Examples 1 to 4 or the like, and whether the light-shielding device is sufficient.
  • the present invention relates to a check method and a check device.
  • the subject is irradiated with light of a specific frequency from the near-infrared LED 160, and the reflection from the retina of the eye is photographed by the near-infrared camera 170, thereby determining the position of the subject's line of sight. Detected. Therefore, if the light from the line-of-sight detection device is detected by the photodetector of the head-mounted probe, it appears as noise of a specific frequency, so even if the intensity of the light is simply measured on the time axis, the light from the line-of-sight detection device It is difficult to detect whether the light is shielded by the light shielding tool.
  • FIG. 12 (a) and 12 (b) show the detection intensity of light by the photodetector on the time axis t and the frequency axis f, respectively.
  • FIG. 12 (a) it is not clear whether the light from the line-of-sight detection device is mixed even if the intensity of the light is seen on the time axis, but it is displayed as a frequency spectrum as shown in FIG. 12 (b). Then, a spectrum peak appears in the light frequency of the line-of-sight detection device. By checking whether or not this spectral peak appears, it can be detected that light from the line-of-sight detection device is mixed, and the user can forget to wear the shading tool or check for poor mounting.
  • FIG. 13 is a diagram showing a check flow for checking whether or not a light shield is mounted.
  • the check is started (S1301), first, the light intensity is measured based on the signal intensity from the photodetector (S1302). In the case of illumination light such as sunlight or a fluorescent lamp, if the intensity of the detection light is greater than the reference value (S1303), it is determined that the shading tool is not mounted or that the mounting is incomplete. A warning such as “external light is affecting” is displayed (S1304). If the intensity of the detected light is smaller than the reference value in S1303, the spectrum of the detection signal from the photodetector is measured and displayed (S1305).
  • illumination light such as sunlight or a fluorescent lamp
  • FIG. 14 shows a schematic block diagram of a check device equipped with a light shield.
  • the shading tool wearing check device 200 includes a frequency spectrum measurement unit 202, a line-of-sight detection light spectrum detection unit 204, and a warning signal output unit 208.
  • the photodetection signal from the photodetector is input to the frequency spectrum measurement unit 202, and the frequency spectrum is measured.
  • the line-of-sight detection light spectrum detection unit 204 detects the presence or absence of the spectrum of the line-of-sight detection light of the line-of-sight detection device from the measured frequency spectrum.
  • a warning signal is output from the warning signal output unit 206. Based on the warning signal, a warning of a light shielding defect is issued. For example, a warning such as “External light is affecting” is displayed on the display unit 208. As a warning, as another method, a lamp may be blinked or an alarm may be given.
  • the check method for wearing the light shield shown in FIG. 13 or the check device for wearing the light shield shown in FIG. 14 it is possible to check whether the light shield is forgotten to be worn or defective.
  • the biological light measurement can be performed in a state where the tool is securely attached.

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Abstract

La présente invention concerne un outil de protection contre la lumière qui empêche la lumière extérieure telle que la lumière du soleil et la lumière provenant d'un dispositif de détection de ligne de visée et similaire d'être transmise à travers un tissu d'un organisme, d'atteindre un détecteur de lumière, et de devenir du bruit, par exemple. Un outil de protection contre la lumière pour mesurer la circulation sanguine dans la tête est utilisé conjointement avec une sonde installée sur la tête d'un dispositif de mesure de lumière d'organisme, et l'outil de protection contre la lumière protège une région de 20 mm ou plus contre un détecteur de lumière de la sonde montée sur la tête contre la lumière. Une forme de l'outil de protection contre la lumière est une plaque de protection contre la lumière pour protéger une partie au-dessus des yeux et des parties à côté des yeux contre la lumière. De plus, une autre forme de l'outil de protection contre la lumière est constituée de lunettes de protection contre la lumière et est pourvue d'une partie de bord supérieur pour protéger la partie au-dessus des yeux contre la lumière et une partie de bord latéral pour protéger les parties à côté des yeux contre la lumière.
PCT/JP2012/061425 2012-04-27 2012-04-27 Outil de protection contre la lumière pour mesurer la circulation sanguine dans la tête, et procédé de contrôle et dispositif de contrôle pour installer celui-ci WO2013161070A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/JP2012/061425 WO2013161070A1 (fr) 2012-04-27 2012-04-27 Outil de protection contre la lumière pour mesurer la circulation sanguine dans la tête, et procédé de contrôle et dispositif de contrôle pour installer celui-ci
JP2014512265A JP5923598B2 (ja) 2012-04-27 2012-04-27 頭部血流計測用遮光具の装着のチェック方法およびチェック装置

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PCT/JP2012/061425 WO2013161070A1 (fr) 2012-04-27 2012-04-27 Outil de protection contre la lumière pour mesurer la circulation sanguine dans la tête, et procédé de contrôle et dispositif de contrôle pour installer celui-ci

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Cited By (5)

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Publication number Priority date Publication date Assignee Title
JP2018029778A (ja) * 2016-08-24 2018-03-01 株式会社島津製作所 脳機能計測装置
EP3513726A4 (fr) * 2016-09-14 2020-01-29 Dynamic Brain Lab, LLC. Dispositif de mesure d'informations biologiques
WO2021192829A1 (fr) * 2020-03-26 2021-09-30 株式会社島津製作所 Dispositif de mesure optique et procédé de maintien de sonde
WO2022254883A1 (fr) * 2021-06-02 2022-12-08 浜松ホトニクス株式会社 Unité de sonde
EP4278968A1 (fr) * 2022-05-19 2023-11-22 Universität Zürich Couvercle de protection contre la lumière et système de capteur pourvu de couvercle de protection contre la lumière

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JP2010115252A (ja) * 2008-11-11 2010-05-27 Shimadzu Corp ホルダー

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018029778A (ja) * 2016-08-24 2018-03-01 株式会社島津製作所 脳機能計測装置
EP3513726A4 (fr) * 2016-09-14 2020-01-29 Dynamic Brain Lab, LLC. Dispositif de mesure d'informations biologiques
WO2021192829A1 (fr) * 2020-03-26 2021-09-30 株式会社島津製作所 Dispositif de mesure optique et procédé de maintien de sonde
JPWO2021192829A1 (fr) * 2020-03-26 2021-09-30
JP7409479B2 (ja) 2020-03-26 2024-01-09 株式会社島津製作所 光計測装置およびプローブホルダセット
WO2022254883A1 (fr) * 2021-06-02 2022-12-08 浜松ホトニクス株式会社 Unité de sonde
EP4278968A1 (fr) * 2022-05-19 2023-11-22 Universität Zürich Couvercle de protection contre la lumière et système de capteur pourvu de couvercle de protection contre la lumière

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