WO2013146307A1 - Dispositif d'injection d'une solution médicamenteuse dans un corps - Google Patents

Dispositif d'injection d'une solution médicamenteuse dans un corps Download PDF

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Publication number
WO2013146307A1
WO2013146307A1 PCT/JP2013/057242 JP2013057242W WO2013146307A1 WO 2013146307 A1 WO2013146307 A1 WO 2013146307A1 JP 2013057242 W JP2013057242 W JP 2013057242W WO 2013146307 A1 WO2013146307 A1 WO 2013146307A1
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WO
WIPO (PCT)
Prior art keywords
injection member
chemical
fixing member
drug solution
discharge port
Prior art date
Application number
PCT/JP2013/057242
Other languages
English (en)
Japanese (ja)
Inventor
重義 長尾
Original Assignee
テルモ・クリニカルサプライ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by テルモ・クリニカルサプライ株式会社 filed Critical テルモ・クリニカルサプライ株式会社
Publication of WO2013146307A1 publication Critical patent/WO2013146307A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/0208—Subcutaneous access sites for injecting or removing fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/0208—Subcutaneous access sites for injecting or removing fluids
    • A61M2039/0229—Subcutaneous access sites for injecting or removing fluids having means for facilitating assembling, e.g. snap-fit housing or modular design
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
    • A61M2039/0273—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body for introducing catheters into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
    • A61M2039/0282—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body with implanted tubes connected to the port

Definitions

  • the present invention relates to a drug solution injector for injecting a drug solution into a patient's body, and more particularly to a subcutaneously implantable in-vivo drug solution injector used for treatment such as chemotherapy.
  • a chemical injection therapy is performed in which a chemical is injected into the body.
  • a drug injector has been proposed for use in such drug injection therapy.
  • the chemical solution injector include, for example, Patent Document 1 (USP 4929236, Japanese Patent Publication No. 4-10832), Patent Document 2 proposed by the applicant of the present application (Japanese Patent Application Laid-Open No. 2004-350937), Patent Document 3 (Japanese Patent No. 3137360).
  • These chemical liquid injectors include a main body, an internal space formed in the main body, a chemical liquid inlet and a chemical outflow passage communicating with the space, and a rubber plug attached to the chemical inlet.
  • a chemical solution injection port having a (septum) and a catheter in which a lumen for chemical solution injection is formed.
  • the chemical solution injector cuts the surplus portion on the proximal end side of the catheter, and after connecting the cut end to the chemical solution injection port,
  • the drug solution injection port is placed in the living body by fixing it to the subcutaneous tissue.
  • Patent Document 4 discloses a direction resetting port.
  • the reorientation port of Patent Document 4 is a housing having a base portion that is configured to be fixed to tissue in an implantable port, and a diaphragm that is pivotally attached to the base portion and formed therein.
  • the housing includes a housing configured to receive fluid and provide access to a fluid reservoir formed within the housing.
  • Patent Document 4 it is effective in that the orientation can be reset. On the other hand, in Patent Document 4, since the base portion is not fixed to the housing, the orientation changes unnecessarily after embedding. In addition, there is a possibility that the connected tube may be detached or kinked.
  • an object of the present invention is an in-vivo drug infusion device composed of a drug solution injection member and a fixing member to which the drug solution injection member can be attached, and the direction of the discharge port of the drug solution injection member is arbitrarily selected to some extent. It is possible to provide an in-vivo drug injection device that can be used and can maintain a selected state after being implanted in the selected state and can be administered with a good drug.
  • An in-vivo drug injection device comprising a drug injection member to which a catheter can be connected and a fixing member to which the drug injection member can be attached and fixed to a living body, wherein the drug injection member includes an opening and the opening An injection member main body having a drug solution inflow space communicating with a portion; a discharge port attached to the injection member main body, communicating with the drug solution inflow space and connectable to the catheter; and the opening of the injection member main body A sealing portion capable of sealing the portion and allowing a needle for injecting a chemical solution to be inserted, and the fixing member includes a chemical injection member mounting holding portion for holding the chemical injection member by fitting, and the chemical injection member mounting An extension part extending from a side part of the holding part and having an outer edge extending from another part, and the chemical solution injection member mounting holding part of the chemical solution injection member and the fixing member is disposed in front of the fixing member. Relative extension portion, the orientation form and become in vivo liquid injection device is selectable in a pre
  • FIG. 1 is a front view of an in-vivo drug solution injector of the present invention.
  • 2 is a right side view of the in-vivo drug solution injector shown in FIG.
  • FIG. 3 is a longitudinal sectional view of a chemical solution injection member of the in vivo drug solution injection device shown in FIG. 4 is a longitudinal sectional view of a fixing member of the in-vivo drug solution injector shown in FIG.
  • FIG. 5 is a side view of the in-vivo drug solution injector with the drug solution injection member shown in FIG. 2 attached to a fixing member.
  • FIG. 6 is a longitudinal sectional view of the in-vivo drug solution injector shown in FIG.
  • FIG. 7 is a front view of the in-vivo drug solution injector with the drug solution injection member shown in FIG.
  • FIG. 8 is an explanatory diagram for explaining the operation of the in-vivo drug injection device of the present invention.
  • FIG. 9 is an explanatory diagram for explaining the operation of the in-vivo drug solution injector of the present invention.
  • FIG. 10 is a longitudinal sectional view of an in-vivo drug solution injector according to another embodiment of the present invention.
  • FIG. 11 is a longitudinal sectional view of an in-vivo drug solution injector according to another embodiment of the present invention.
  • FIG. 12 is a front view of a fixing member used in an in-vivo drug solution injector according to another embodiment of the present invention.
  • 13 is a longitudinal sectional view of the fixing member shown in FIG. FIG.
  • FIG. 14 is an explanatory diagram for explaining the operation of the in-vivo drug solution injector of the present invention.
  • FIG. 15 is an explanatory diagram for explaining the operation of the in-vivo drug solution injector of the present invention.
  • FIG. 16 is a side view of an in-vivo drug solution injector according to another embodiment of the present invention. 17 is a longitudinal sectional view of the in-vivo drug solution injector shown in FIG.
  • FIG. 18 is a longitudinal sectional view of an in-vivo drug solution injector according to another embodiment of the present invention.
  • FIG. 19 is a plan view of a fixing member used for the in-vivo drug solution injector shown in FIG.
  • FIG. 20 is a longitudinal sectional view of an in-vivo drug solution injector according to another embodiment of the present invention.
  • FIG. 21 is a plan view of a fixing member used in the in-vivo drug solution injector shown in FIG.
  • FIG. 22 is a front view of an in-vivo drug solution injector according to another embodiment of the present invention.
  • 23 is a side view of the in-vivo drug solution injector shown in FIG. 24 is a longitudinal sectional view of the in-vivo drug solution injector shown in FIG.
  • FIG. 25 is a side view of an in-vivo drug solution injector according to another embodiment of the present invention.
  • FIG. 26 is a front view of a fixing member used in the in-vivo medical solution injector shown in FIG.
  • FIG. 27 is a front view of another example fixing member used in the in-vivo drug solution injector of the present invention.
  • FIG. 28 is a front view of another example fixing member used in the in-vivo drug solution injector of the present invention.
  • FIG. 29 is a front view of another example fixing member used in the in-vivo drug solution injector of the present invention.
  • the in-vivo drug solution injector of the present invention will be described with reference to the illustrated embodiment.
  • the in-vivo drug solution injector 1 of the present invention includes a drug solution injection member 2 to which a catheter 5 (see FIG. 14) can be connected, and a fixing member 3 to which the drug solution injection member 2 can be attached and fixed to the living body.
  • the medicinal solution injecting member 2 is attached to the injecting member main bodies 6 and 7 having the opening and the medicinal solution inflow space 63 communicating with the opening, the injecting member main bodies 6 and 7, and communicates with the medicinal solution inflow space 63.
  • the fixing member 3 includes a chemical solution injection member mounting holding portion 31 that holds the chemical solution injection member 2 by fitting, and an extending portion that extends from a side portion of the chemical solution injection member mounting holding portion 31 and has an outer edge extending from another portion. 32. Then, the chemical solution injection member mounting holding portion 31 of the chemical solution injection member 2 and the fixing member 3 has a discharge port 9 when the chemical solution injection member 2 is mounted on the fixing member with respect to the extending portion 32 of the fixing member 3.
  • the direction can be selected within a predetermined area.
  • the chemical solution injector 1 of this embodiment includes a chemical solution injection member 2 and a fixing member 3 to which the chemical solution injection member 2 can be attached.
  • the catheter 5 can be connected to the chemical
  • the catheter 5 has a tube shape that can be inserted into the body at least at the distal end, specifically, a blood vessel (vein or artery), a vessel such as a bile duct or ureter, epidural, subarachnoid, or abdominal cavity.
  • the catheter 5 used in the drug solution injector 1 of this embodiment is a tube body having a distal end side opening (one end) and an internal lumen 51. It has a diameter and the same inner diameter.
  • the catheter 5 is flexible and preferably has a certain degree of elasticity.
  • the catheter forming material include olefin-based elastomers (for example, polyethylene elastomers and polypropylene elastomers), polyesters such as polyethylene terephthalate, soft polyvinyl chloride, polyurethane and urethane-based elastomers, polyamides and amide-based elastomers (for example, polyamide elastomers).
  • a flexible polymer material such as a fluororesin elastomer, an ethylene-vinyl acetate copolymer, and silicone rubber.
  • the fixing member 3 includes a chemical solution injection member mounting holding portion 31 and an extending portion 32 extending from the side portion of the chemical liquid injection member mounting holding portion 31 and having an outer edge extending from another portion.
  • the fixing member 3 has a flange-like portion extending over the entire periphery of the chemical liquid injection member mounting holding portion 31, and the extending portion 32 is a part of the flange-like portion and a portion protruding from the other portion. It has become. Further, in the fixing member 3 of this embodiment, the flange-like portion extends concentrically with respect to the circular shape of the chemical solution injection member mounting holding portion 31, and the extending portion 32 has a portion of the flange-like portion as a chemical solution.
  • the extended portion 32 preferably has an arcuate outer edge, but may have a substantially rectangular shape or a substantially triangular shape.
  • the fixing member 3 may have a plurality of extending portions.
  • the chemical solution injection member mounting holding portion 31 is formed by an endless ring-shaped portion 34 that can hold the side surface portion of the chemical solution injection member 2. Furthermore, in the fixing member 3 of this embodiment, the chemical solution injection member mounting holding portion 31 includes a ring-shaped portion 34 and a bottom plate portion 33 provided on the bottom surface of the ring-shaped portion 34, and a chemical solution injection member 2 described later. The bottom side portion of can be fitted.
  • the chemical injection member mounting holder 31 of the fixing member 3 can be mounted with the chemical injection member 2 in a state where the catheter 5 is connected to the discharge port 9 of the chemical injection member 2 as in this embodiment. Is preferred.
  • the medicinal solution injecting member mounting holder 31 is in a state where the catheter 5 is connected to the discharge port 9 of the medicinal solution injecting member 2 and the fixing member 3 is fixed to the living body. Therefore, it is preferable that the chemical solution injection member 2 can be attached.
  • the fixing member 3 of this embodiment accommodates the extending portion 32 and the bottom side portion of the chemical solution injection member 2 and is mounted with the chemical solution injection member 2.
  • medical solution injection member mounting holding part 31 for this is provided.
  • the fixing member 3 includes a bottom plate portion 33, a ring-shaped portion 34 projecting annularly from the bottom plate portion 33, an extending portion 32 projecting outward from a part of the ring-shaped portion 34, and the bottom plate portion 33.
  • a chemical solution injection member mounting holding portion 31 formed by the surface and the cylindrical inner surface of the ring-shaped portion 34 is provided.
  • maintenance part 31 can be fitted in the bottom part side part of the chemical
  • the chemical liquid injection member mounting holder 31 is a cylindrical concave portion that can be fitted and housed with the cylindrical bottom 61a of the chemical liquid injection member 2.
  • the chemical injection member 2 of this embodiment is a columnar body having substantially the same outer diameter except for the portion where the discharge port 9 is disposed, and the chemical injection member mounting holding portion of the fixing member 3 31 can accommodate a portion facing the bottom portion 61a and the discharge port arrangement portion of the chemical solution injection member 2.
  • the chemical injection member mounting / holding portion 31 has a lower protrusion height from the bottom surface of the chemical injection member mounting / holding portion 31 than the height of the cylindrical bottom portion 61a of the chemical injection member 2.
  • the discharge port 9 of the chemical solution injection member 2 attached to the chemical injection member attachment holding portion 31 can be positioned at an arbitrary position on the arc shape wall portion 35. For this reason, the direction (position) of the discharge port 9 in the mounting state of the chemical solution injection member 2 to the fixing member 3 is changed from the state in which the port position is obliquely above and to the left of the fixing member 3 shown in FIG. It is possible to arbitrarily select the region up to the state that is diagonally upward to the right.
  • the bottom part of the chemical solution injection member 2 and the chemical solution injection member mounting holding portion 31 of the fixing member 3 are attached to the fixing member 3 fixed to the living body when the chemical solution injection member 2 is attached to the fixing member.
  • the direction of the discharge port 9 is selectable within a predetermined area.
  • the chemical injection member mounting / holding portion 31 includes one end side wall height changing portion 36 a where the height of the wall portion is higher than one end portion of the arcuate wall portion 35, and the arcuate wall portion 35.
  • the other end side wall height changing portion 36b having a wall height higher than the end portion, and the portion between the one end side wall height changing portion 36a and the other end side wall height changing portion 36b and facing the extending portion 32, It is an arcuate wall 35 in which the discharge port 9 can be located.
  • the ratio of the arc-shaped wall portion 35 in the ring-shaped portion 34 is preferably 100 (all cylindrical protrusions are arc-shaped wall portions) to 20%, particularly preferably 40 to 25%.
  • the ring-shaped portion 34 which is a portion between the one end side wall height changing portion 36 a and the other end side wall height changing portion 36 b and is a portion on the extending portion 32 side, faces the extending portion 32.
  • the wall height gradually increases.
  • the ring-shaped part 34 is provided with the inner surface which contacts the outer surface of the chemical
  • the fixing member 3 is provided with living body sewing filler embedded portions 11 and 12.
  • the embedding parts 11 and 12 are filled with a filler that can be pierced by a suture needle, and can be sewn to a living body.
  • the whole fixing member 3 may be formed of a material that can be pierced by a suture needle, and in this case, an embedded portion may not be provided.
  • the fixing member may be a fixing member 3a as provided in the drug injection device 10 shown in FIG.
  • the fixing member 3a according to this embodiment is thicker toward the end of the extending portion 32a, and the bottom surface of the bottom plate portion 33a is an inclined surface.
  • the bottom surface is formed of a material that can be easily cut with a knife, a cutter, or the like. By doing in this way, it can be set as the shape suitable for the condition by cutting a bottom face according to a condition.
  • the extending part may extend over the entire outer periphery of the bottom surface of the cylindrical protruding part.
  • the fixing member 3b as provided in the medicine injection device 20 shown in FIG. 11 may be used.
  • the extending portion 32b extends over the entire outer periphery of the bottom surface of the cylindrical protrusion (in other words, the entire periphery of the bottom surface portion 33b). Furthermore, the extending portion 32b is thicker toward the end portion of the extending portion 32b (in other words, the outer edge of the fixing member), and the bottom surface portion 33b is thin at the center and is formed at the peripheral portion. It has a curved surface that becomes thicker toward it. And also in this type of fixing member 3b, it is preferable that the bottom surface is formed of a material that can be easily cut with a knife, a cutter, or the like. By doing in this way, it can be set as the shape suitable for the condition by cutting a bottom face according to a condition.
  • the fixing member is the inner surface of the opening (specifically, the opening end) of the chemical liquid injection member mounting holding portion 31, in other words, the ring-shaped portion, like the fixing member 3 c shown in FIGS. 12 and 13.
  • the liquid injection member holding protrusion 37 may be provided on the inner surface of the opening 34.
  • the chemical injection member holding protrusion 37 is an endless annular rib extending over the entire inner surface of the open end of the chemical injection member mounting holder 31.
  • maintenance may be a some dot shape or a linear thing.
  • a material for forming the fixing member a material having a certain degree of transparency is preferable. Hard resins such as polysulfone, polyethersulfone, epoxy resin and polyacetal, various rubbers such as silicone rubber, isoprene rubber and natural rubber, polyurethane A soft resin such as polyamide elastomer is used.
  • the chemical liquid injection member 2 includes an injection member main body (bottom member 6, upper member 7) having an opening and a chemical liquid inflow space 63 communicating with the opening, and an injection member main body (this In the embodiment, the outlet member 9 attached to the bottom member 6 and the upper member 7), communicated with the chemical solution inflow space 63 and connectable to the catheter 5, and the opening of the injection member main body 6 are sealed and the chemical solution is used. And a seal portion 8 that can be pierced with an injection needle.
  • the chemical solution injection member 2 of this embodiment is composed of an injection member main body (bottom member 6, upper member 7) and a seal portion 8.
  • the injection member main body is provided on the bottom member 6 having a recess that forms the chemical solution inflow space 63, the ring-shaped upper member 7 attached to the upper surface side of the bottom member 6, and the side of the upper member 7.
  • a discharge port 9 that penetrates the side portions of the upper member 7 and the bottom member 6 and reaches the chemical solution inflow space 63 is provided.
  • the seal portion 8 is disposed between the bottom member 6 and the upper member 7, and the peripheral edge portion is sandwiched between the bottom member 6 and the upper member 7 to seal the space between the bottom member 6 and the upper member 7 in a liquid-tight manner. Yes.
  • the bottom side portion of the chemical solution injection member 2 extends to the bottom side from the portion where the discharge port 9 is disposed. It has a columnar bottom 61a.
  • the cylindrical bottom 61a can be fitted into the chemical solution injection member mounting holding portion 31 of the fixing member 3 described above.
  • the injection member main body is a columnar body having substantially the same outer diameter except for the portion where the discharge port 9 is disposed.
  • pouring member mounting holding part 31 of the fixing member 3 mentioned later can accommodate not only said cylindrical bottom part 61a but the site
  • the bottom member 6 of the injection member main body is from a disc-shaped bottom plate portion 61 and a position on the central portion side of the predetermined length from the periphery of the bottom plate portion 61.
  • a projecting annular wall 62 is provided.
  • the annular wall portion 62 is provided with an opening 64 into which the base end portion (mounting portion) 92 of the discharge port 9 can be inserted. Therefore, the base opening of the discharge port 9 is exposed at the annular wall 62 portion.
  • the ring-shaped upper member 7 mounted on the upper surface side of the bottom member 6 includes an opening for accommodating the seal portion in a state where the central portion of the seal portion is exposed.
  • the upper member 7 has an inner diameter that is substantially the same as the outer diameter of the annular wall portion 62 of the bottom member 6 described above.
  • the annular wall portion 62 of the bottom member 6 is accommodated in the upper member 7, and the bottom member
  • the peripheral portion of the flat plate portion 6 (the portion extending from the annular wall portion 62) is in contact with the bottom surface of the upper member 7.
  • the upper member 7 has a cylindrical projecting portion 72 having a mounting hole for penetrating the base end portion (mounting portion) 92 of the discharge port 9, and the lower surface of the cylindrical projecting portion 72 is a bottom member. 6 is fixed to the upper surface of the projecting portion 61b provided at 6.
  • the injection member main body bottom member 6, upper member 7
  • a material having a certain degree of transparency is preferable, and polysulfone, polyethersulfone, epoxy resin, polyacetal, and the like are used.
  • the seal portion 8 can be pierced with a chemical solution injection needle, and the piercing portion is sealed after the chemical solution injection needle is removed.
  • the seal portion 8 is made of an elastic material.
  • various rubbers such as silicone rubber, isoprene rubber and natural rubber, various resins such as polyurethane, polyamide elastomer, polybutadiene, and soft vinyl chloride, or combinations of two or more of these, etc.
  • silicone rubber which is inert to the living body and has relatively little change in physical properties.
  • the seal portion 8 protrudes from the main body portion, the flange portion 81 formed by the peripheral portion of the main body portion, the flange portion 81, and a protruding portion whose outer diameter is smaller than the main body portion. 82.
  • the seal portion 8 has a small-diameter portion (projecting portion) 82 at the top, and the small-diameter portion (projecting portion) 82 enters the opening of the ring-shaped upper member 7 and the surface thereof is exposed.
  • the exposed portion forms a puncturable site with a puncture needle.
  • the seal portion 8 is accommodated in a state in which the peripheral edge portion (flange portion 81) is sandwiched between the upper member 7 and the bottom member 6 described above, and the space between the upper member 7 and the bottom member 6 is liquid-tight. Sealed to state.
  • the discharge port 9 includes a flow path 91 penetrating the inside, a distal end portion 93 having an outer diameter that can be inserted into the end opening of the catheter 5, and the injection member main body 6 side (the mounting portion 92 side) from the distal end portion 93. ) And an intra-catheter insertable portion including an enlarged diameter portion 94 larger in diameter than the distal end portion 93.
  • the small-diameter distal end portion 93 is a small-diameter portion that has the same outer diameter and extends a predetermined length. By providing such a small-diameter portion, the distal end portion of the intra-catheter insertable portion can be easily entered into the catheter. .
  • the enlarged diameter portion 94 is tapered toward the injection member main body side (mounting portion 92 side), and the end portion (maximum outer diameter portion) of the enlarged diameter portion 94 is an acute angle. It is the formed annular protrusion.
  • the in-vivo drug solution injector 1 of the present invention is provided in a state where the fixing member 3 is not attached to the drug solution injection member 2. And after inserting the front-end
  • the direction of the extending portion of the fixing member 3 and the direction of the discharge port of the drug injection member to which the catheter is connected are determined.
  • the direction of the extending portion is not linear with the direction in which the catheter extends, in other words, the direction of the discharge port 9.
  • the discharge port arrangement site (specifically, the arrangement site of the cylindrical projecting portion 72 of the upper member 7) can select an arbitrary position on the arc-shaped projecting portion 35. Therefore, as shown in FIG. 15, the drug solution injection member 2 and the fixing member 3 are held in the state of FIG.
  • the chemical solution injection member 2 is attached to the fixing member 3 after the fixing member 3 is cut into the living skin and inserted into the formed pocket and fixed to the living body using a suture. May be.
  • the in-vivo drug injection device 30 of this embodiment includes a drug solution injection member 2a and a fixing member 3d for mounting and holding the drug solution injection member 2a.
  • the medicinal solution injection member 2a is the same as the medicinal solution injection member 2 described above except that the protruding height has a columnar bottom 61a slightly higher than the medicinal solution injection member 2 described above.
  • the chemical liquid injection member 2a of this embodiment has a bottom side portion of the chemical liquid injection member 2a closer to the bottom side than the portion where the discharge port 9 is disposed, as shown in FIGS. It has a columnar bottom 61a that extends.
  • the cylindrical bottom 61a can be fitted into a chemical solution injection member mounting holding portion 31 of a fixing member 3d described later.
  • the injection member main body is a cylindrical body having substantially the same outer diameter except for the portion where the discharge port 9 is disposed.
  • maintenance part 31 of the fixing member 3d mentioned later can accommodate not only the said cylindrical bottom part 61a but the site
  • the fixing member 3d includes a chemical solution injection member mounting holding portion 31 and an extending portion 32 extending eccentrically with respect to the circular shape of the chemical solution injection member mounting holding portion 31.
  • the chemical solution injection member mounting holding portion 31 is formed by an endless or ring-shaped portion 34 having a slit having a predetermined width that can hold the side surface portion of the chemical solution injection member 2a.
  • the chemical injection member mounting / holding portion 31 does not have a bottom surface portion and is formed only by the ring-shaped portion 34, and the bottom portion of the chemical injection member 2a described above is fitted. It is possible.
  • the chemical injection member 2a can be mounted in a state where the catheter 5 is connected to the discharge port 9 of the chemical injection member 2a, and the chemical injection member mounting holder 31, the catheter 5 is connected to the discharge port 9 of the chemical solution injection member 2a, and the chemical solution injection member 2a can be mounted in a state where the fixing member 3d is fixed to the living body.
  • the chemical liquid injection member mounting / holding portion 31 is a cylindrical space portion in which the cylindrical bottom portion 61a of the chemical liquid injection member 2a can be fitted and housed.
  • the chemical solution injection member 2a of this embodiment is a cylindrical body having substantially the same outer diameter except for the portion where the discharge port 9 is disposed, and the chemical solution injection member mounting holding portion of the fixing member 3d. 31 can accommodate a portion facing the bottom portion 61a and the discharge port arrangement portion of the chemical liquid injection member 2a.
  • the chemical solution injection member mounting holding portion 31 (in other words, the ring-shaped portion 34) has an arc shape whose projecting height is lower than the height of the cylindrical bottom portion 61a of the chemical solution injection member 2a.
  • the discharge port 9 of the chemical solution injection member 2a attached to the chemical solution injection member attachment holding portion 31 can be positioned at an arbitrary position on the arcuate wall portion 35.
  • the direction (position) of the discharge port 9 in the mounting state of the chemical injection member 2a to the fixing member 3d is the same as the in-vivo chemical injection device 1 described above, and the port position is the fixing member 3d shown in FIG. It is possible to arbitrarily select a region from a state that is diagonally upper left to a state that is diagonally upper right shown in FIG.
  • the chemical liquid injection member mounting holding portion 31 includes the one end side wall height changing portion 36 a where the height of the wall portion is higher than one end portion of the arcuate wall portion 35, and the arcuate wall portion 35.
  • the other end side wall height changing portion 36b having a wall height higher than the end portion, and the portion between the one end side wall height changing portion 36a and the other end side wall height changing portion 36b and facing the extending portion 32, It is an arcuate wall 35 in which the discharge port 9 can be located.
  • the ratio of the arc-shaped wall portion 35 in the ring-shaped portion 34 is preferably 100 (all cylindrical protrusions are arc-shaped wall portions) to 20%, particularly preferably 40 to 25%.
  • the ring-shaped portion 34 that is the portion between the one end side wall height changing portion 36a and the other end side wall height changing portion 36b and that is the extending portion 32 side portion gradually moves toward the extending portion 32.
  • the wall height is high.
  • the ring-shaped part 34 is provided with the inner surface which contacts the outer surface of the chemical
  • the fixing member 3d also includes two living body filling filler embedded portions 11 and 12. Also in the fixing member 3d of this embodiment, as in the fixing member 3c shown in FIGS.
  • the inner surface of the opening end of the ring-shaped portion 34 of the chemical injection member mounting holder 31 in other words, The medicinal solution injecting member holding protrusion 37 may be provided on the inner surface of the opening of the ring-shaped portion 34.
  • the in-vivo drug solution injector 40 of this embodiment includes a drug solution injection member 2 and a fixing member 3e for mounting and holding the drug solution injection member 2.
  • the chemical injection member 2 is the same as described above.
  • the fixing member 3e includes a chemical liquid injection member mounting holding portion 31 and an extending portion 32 extending eccentrically with respect to the circular shape of the chemical liquid injection member mounting holding portion 31.
  • the chemical liquid injection member mounting holding portion 31 is formed by a ring-shaped portion 34 that can hold the side surface portion of the chemical liquid injection member 2.
  • the ring-shaped portion 34 has a notch 39 that extends from the upper end to the lower end and has a predetermined width into which the cylindrical protrusion 72 provided with the discharge port 9 of the chemical solution injection member 2 can enter. .
  • the direction (position) of the discharge port 9 when the chemical injection member 2 is attached to the fixing member 3e is a region from one end of the notch 39 to the other end, as in the in-vivo chemical injection device 1 described above.
  • the interval can be arbitrarily selected.
  • the ratio of the part where the notch 39 is formed in the ring-shaped part 34 is preferably 40 to 20%.
  • a connection part (non-notch part) 38 is provided at the lower part of the notch part 39. In this part, the ring-like part 34 has a complete ring-like form.
  • the fixing member 3e of this embodiment also has the chemical solution injection member mounting holding portion 31 having no bottom portion and is formed only by the ring-shaped portion 34, and the cylindrical protruding portion 72 provided with the discharge port 9 is provided. In the protruding state, the entire side surface of the above-described chemical liquid injection member 2 can be fitted. And also in the fixing member 3e of this embodiment, the chemical injection member 2 can be mounted in a state where the catheter 5 is connected to the discharge port 9 of the chemical injection member 2, and further, the chemical injection member mounting holding portion 31, the catheter 5 is connected to the discharge port 9 of the drug solution injection member 2, and the drug solution injection member 2 can be mounted in a state where the fixing member 3e is fixed to the living body.
  • the fixing member 3e of this embodiment may also have a bottom plate portion like the fixing member 3 described above. Further, like the fixing member 3c shown in FIG. 12 and FIG. 13 described above, a chemical liquid injection member holding protrusion 37 is provided on the inner surface of the open end of the ring-shaped portion 34 of the chemical liquid injection member mounting holder 31. Also good.
  • the in-vivo drug solution injector 50 of this embodiment includes a drug solution injection member 2 and a fixing member 3f for mounting and holding the drug solution injection member 2.
  • the chemical injection member 2 is the same as described above.
  • the fixing member 3 f includes a chemical liquid injection member mounting holding portion 31 and an extending portion 32 that extends eccentrically with respect to the circular shape of the chemical liquid injection member mounting holding portion 31.
  • the chemical solution injection member mounting holding portion 31 is formed by a ring-shaped portion 34 that can hold the side surface portion of the chemical solution injection member 2.
  • the ring-shaped portion 34 has a slit 39a that extends from the upper end to the lower end and has a predetermined width into which the cylindrical protrusion 72 provided with the discharge port 9 of the chemical liquid injection member 2 can enter.
  • the direction (position) of the discharge port 9 in the mounting state of the chemical liquid injection member 2 to the fixing member 3f is similar to the in-vivo chemical liquid injection tool 40 described above between the regions from one end to the other end of the slit 39a.
  • the ratio of the portion where the slit 39a is formed in the ring-shaped portion 34 is preferably 40 to 20%.
  • the fixing member 3f of this embodiment also has the chemical injection member mounting / holding portion 31 having no bottom portion and is formed only by the ring-shaped portion 34, and the cylindrical protruding portion 72 provided with the discharge port 9 is provided. In the protruding state, the entire side surface of the above-described chemical liquid injection member 2 can be fitted. And also in the fixing member 3f of this embodiment, the chemical injection member 2 can be mounted in a state where the catheter 5 is connected to the discharge port 9 of the chemical injection member 2, and further, the chemical injection member mounting holding portion 31, the catheter 5 is connected to the discharge port 9 of the drug solution injection member 2, and the drug solution injection member 2 can be mounted in a state where the fixing member 3f is fixed to the living body.
  • the in-vivo drug solution injector 60 of this embodiment includes a drug solution injection member 2b and a fixing member 3g for mounting and holding the drug solution injection member 2b.
  • the chemical liquid injection member 2b is the same as the chemical liquid injection member 2 described above except that it does not have a cylindrical bottom.
  • part of the discharge port 9 is a cylindrical body of substantially the same outer diameter.
  • pouring member mounting holding part 31 of the fixing member 3g mentioned later can accommodate the cylindrical upper part of the chemical
  • the fixing member 3g includes a chemical solution injection member mounting holding portion 31 and an extending portion 32 extending eccentrically with respect to the circular shape of the chemical solution injection member mounting holding portion 31.
  • the chemical solution injection member mounting holding portion 31 is formed by an endless ring-shaped portion 34 that can hold the side surface portion of the chemical solution injection member 2b.
  • the chemical injection member mounting / holding portion 31 has no bottom portion and is formed only by the ring-shaped portion 34, and the upper portion of the chemical injection member 2b described above is fitted. It is possible.
  • the chemical injection member 2b can be mounted in a state where the catheter 5 is connected to the discharge port 9 of the chemical injection member 2b, and further, the chemical injection member mounting holder 31, the catheter 5 is connected to the discharge port 9 of the drug solution injection member 2b, and the drug solution injection member 2b can be mounted in a state where the fixing member 3g is fixed to the living body.
  • the chemical solution injection member mounting holding portion 31 is a cylindrical space portion in which the cylindrical bottom portion 61a of the chemical solution injection member 2b can be fitted and housed.
  • the chemical injection member 2b is a columnar body having substantially the same outer diameter except for the portion where the discharge port 9 is disposed, and the fixing member 3g is attached and held with the chemical injection member.
  • the part 31 can accommodate the upper part of the chemical solution injection member 2b and the part facing the discharge port arrangement part.
  • the chemical injection member mounting holding portion 31 (in other words, the ring-shaped portion 34) has an arc-shaped wall whose width is narrower than the height of the upper cylindrical portion of the chemical injection member 2b.
  • the discharge port 9 of the chemical solution injection member 2b attached to the chemical solution injection member attachment holding portion 31 can be positioned at an arbitrary position below the arcuate wall portion. For this reason, the direction (position) of the discharge port 9 in the state in which the chemical solution injection member 2b is attached to the fixing member 3g is the same as the in-vivo drug injection device 1 described above, and the port position is the fixing member 3g shown in FIG.
  • the chemical solution injection member mounting holding portion 31 includes an end wall width changing portion in which the width of the wall portion is larger than one end portion of the lower surface of the arc-shaped wall portion of the ring-shaped member 34, and an arc-shaped wall.
  • the other end side wall width changing part where the width of the wall part becomes larger than the other end part of the part, and the part facing the extension part 32 between the one end side wall width changing part and the other end side wall width changing part is discharged. It is an arcuate wall where the port 9 can be located.
  • the ratio of the arc-shaped wall portion in the ring-shaped portion 34 is preferably 100 (all cylindrical protrusions are arc-shaped wall portions) to 20%, and particularly preferably 40 to 25%.
  • the ring-shaped portion 34 that is the portion between the one end side wall height changing portion and the other end side wall height changing portion and becomes the extending portion 32 side portion gradually becomes a wall toward the extending portion 32.
  • the width is wide.
  • the ring-shaped part 34 is provided with the inner surface which contacts the outer surface of the chemical
  • the fixing member 3g also includes two living body sewing filler embedded portions 11 and 12.
  • the opening (specifically, the opening end) of the chemical liquid injection member mounting / holding portion 31 is also provided.
  • the inner surface of the opening of the ring-shaped portion 34 may be provided with a protrusion 37 for holding a chemical solution injection member.
  • the in-vivo drug solution injector 70 of this embodiment includes a drug solution injection member 2a and a fixing member 3h for mounting and holding the drug solution injection member 2a.
  • the chemical liquid injection member 2a is the same as that shown in FIGS. 15 and 16 and described above, and has a cylindrical bottom portion 61a slightly higher than the chemical liquid injection member 2.
  • the fixing member 3 h includes a chemical liquid injection member mounting holding portion 31 and an extending portion 32 that extends slightly eccentrically with respect to the circular shape of the chemical liquid injection member mounting holding portion 31.
  • the chemical solution injection member mounting holding portion 31 is formed by an endless flat ring-shaped portion 34 that can hold the side surface portion of the chemical solution injection member 2a.
  • the chemical injection member mounting holding portion 31 does not have a bottom portion and is formed only by the ring-shaped portion 34, and the bottom portion of the chemical injection member 2a described above is fitted. It is possible.
  • the chemical injection member 2a can be mounted in a state where the catheter 5 is connected to the discharge port 9 of the chemical injection member 2a, and the chemical injection member mounting holder 31, the catheter 5 is connected to the discharge port 9 of the chemical solution injection member 2a, and the chemical solution injection member 2a can be mounted in a state where the fixing member 3h is fixed to the living body.
  • the chemical liquid injection member mounting / holding portion 31 is a short cylindrical space portion in which the cylindrical bottom portion 61a of the chemical liquid injection member 2a can be fitted and housed.
  • the fixing member 3h also includes two living body filling filler embedded portions 11 and 12.
  • the opening (specifically, the opening end) of the chemical injection member mounting / holding portion 31 is provided.
  • the inner surface, in other words, the inner surface of the opening of the ring-shaped portion 34 may be provided with a protrusion for holding a chemical solution injection member.
  • a fixing member 3i shown in FIG. 27 may be used as an outer edge form of the fixing member.
  • the basic configuration of the fixing member 3i is the same as that of the fixing member 3 described above, and the only difference is the outer edge form.
  • the chemical solution injection member mounting / holding portion 31 is provided not at the center of the fixing member 3i but at a position diagonally above and to the right of the center.
  • a fixing member 3j shown in FIG. 28 may be used as an outer edge form of the fixing member.
  • the basic configuration of the fixing member 3j is the same as that of the fixing member 3 described above, and the only difference is the outer edge form.
  • the chemical solution injection member mounting holding portion 31 is provided not at the center portion of the fixing member 3j but at a position diagonally above and to the left of the center portion.
  • the fixing member 3i and the fixing member 3j also include the chemical solution injection member mounting holder 31 and an extending portion 32 that extends eccentrically with respect to the circular shape of the chemical solution injection member mounting holder 31.
  • the chemical solution injection member mounting holding portion 31 is formed by an endless ring-shaped portion 34 that can hold the side surface portion of the chemical solution injection member 2.
  • the chemical solution injection member mounting holding portion 31 includes a ring-shaped portion 34 and a bottom plate portion 33 provided on the bottom surface of the ring-shaped portion 34, and the chemical solution injection member The bottom part of 2 can be fitted.
  • the form of the chemical injection member mounting holder is not limited to the above-described form, and the forms of the chemical injection member mounting holders of all the embodiments described above can be used.
  • the fixing member may be a fixing member 3k shown in FIG.
  • the fixing member 3k includes two chemical solution injection member mounting holders 31a and 31b. And as a form of chemical
  • a protrusion for holding a chemical solution injection member may be provided on the inner surface.
  • the in-vivo drug solution injector of the present invention is as follows.
  • An in-vivo medicinal solution injecting device comprising a medicinal solution injecting member to which a catheter can be connected and a fixing member to which the medicinal solution injecting member can be attached and fixed to a living body, wherein the medicinal solution injecting member includes an opening An injection member main body having a chemical liquid inflow space communicating with the opening; a discharge port attached to the injection member main body, communicating with the chemical liquid inflow space and connectable to the catheter; and the injection member main body A sealing portion that can pierce a needle for injecting a chemical solution, and the fixing member includes a chemical injection member mounting holding portion that holds the chemical injection member by fitting, and the chemical solution An extension part extending from a side part of the injection member mounting holding part and an outer edge extending from the other part, and the chemical injection member mounting holding part of the chemical injection member and the fixing member is the fixing part
  • An in-vivo drug injection device that has a configuration in which a direction of the discharge port can be selected within
  • the direction of the discharge port of the drug solution injection member with respect to the fixing member can be arbitrarily selected to a certain extent, and after being embedded in the selected state, the selected state can be maintained. Continued good drug administration is possible.
  • the in-vivo drug solution according to (1) wherein the drug solution injection member mounting holding portion of the fixing member is an endless or ring-shaped portion having a slit having a predetermined width capable of holding a side surface portion of the drug solution injection member. Infusion tool.
  • the chemical liquid injection member mounting holding portion of the fixing member includes the ring-shaped portion and a bottom plate portion provided on the bottom surface of the ring-shaped portion, and a bottom side portion of the chemical liquid injection member can be fitted.
  • the in-vivo drug injection device according to (2) which is a drug solution injection member mounting holder.
  • the chemical liquid injection member mounting holding portion of the fixing member can be mounted with the chemical liquid injection member in a state where the catheter is connected to a discharge port of the chemical liquid injection member.
  • the in-vivo drug solution injector according to any one of the above.
  • the medicinal solution injection member mounting holding portion of the fixing member is mounted with the medicinal solution injection member in a state where the catheter is connected to the discharge port of the medicinal solution injection member and the fixing member is fixed to the living body.
  • the in-vivo drug solution injector according to any one of (1) to (3), which is possible.
  • the bottom side portion of the chemical liquid injection member has a columnar bottom that extends to the bottom side from the discharge port arrangement site, and the chemical liquid injection member mounting holding portion of the fixing member is a part of the chemical liquid injection member.
  • the in-vivo drug solution injector according to any one of the above (1) to (5) which is a cylindrical concave portion into which a cylindrical bottom portion can be fitted.
  • the chemical injection member is a cylindrical body having substantially the same outer diameter except for the discharge port arrangement portion, and the chemical injection member mounting holding portion of the fixing member is the discharge of the chemical injection member.
  • the in-vivo drug solution injection device according to any one of the above (1) to (6), which holds a portion facing a port arrangement portion and a bottom side portion or an upper side portion.
  • the chemical injection member mounting holder of the fixing member has an arcuate wall portion whose protruding height from the bottom surface of the chemical injection member mounting holder is lower than the height of the columnar bottom of the chemical injection member.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Un dispositif pour injecter une solution médicamenteuse dans le corps (1) comprend un organe d'injection de solution médicamenteuse (2) et un organe de fixation (3) auquel peut être ajusté l'organe d'injection de solution médicamenteuse. L'organe d'injection de solution médicamenteuse est muni : d'un corps d'organe d'injection (6) doté d'un espace d'entrée de solution médicamenteuse (63) ; d'un orifice de décharge (9) qui communique avec l'espace d'entrée de solution médicamenteuse et permet de raccorder un cathéter ; et d'une partie d'étanchéité (8) qui permet le perçage d'une aiguille d'injection de solution médicamenteuse. L'organe de fixation (3) est pourvu : d'une partie d'ajustement et de retenue de l'organe d'injection de solution médicamenteuse (31) qui maintient l'organe d'injection de solution médicamenteuse (2) grâce à l'insertion de l'organe d'injection de solution médicamenteuse (2) ; et d'une parte d'extension (32) qui s'étend depuis la partie d'ajustement et de retenue de l'organe d'injection de solution médicamenteuse (31). L'organe d'injection de solution médicamenteuse et la partie d'ajustement et de retenue (31) de l'organe de fixation ont des formes permettant de sélectionner l'orientation de l'orifice de décharge (9) dans une plage prescrite lorsqu'il est ajusté à la partie d'extension de l'organe de fixation.
PCT/JP2013/057242 2012-03-29 2013-03-14 Dispositif d'injection d'une solution médicamenteuse dans un corps WO2013146307A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012077422 2012-03-29
JP2012-077422 2012-03-29

Publications (1)

Publication Number Publication Date
WO2013146307A1 true WO2013146307A1 (fr) 2013-10-03

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020180854A1 (fr) 2019-03-03 2020-09-10 Tal Michael Gabriel Orifice d'accès vasculaire pouvant être changé par voie sous-cutanée

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004329871A (ja) * 2002-10-25 2004-11-25 B Braun Medical Sas 薬剤を投与するために皮下にインプラントするためのチャンバ
WO2011053499A1 (fr) * 2009-10-27 2011-05-05 Medical Components, Inc. Ensemble à orifices multiples
JP2012045139A (ja) * 2010-08-26 2012-03-08 Nihon Covidien Kk 皮下埋込ポート及びその製造方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004329871A (ja) * 2002-10-25 2004-11-25 B Braun Medical Sas 薬剤を投与するために皮下にインプラントするためのチャンバ
WO2011053499A1 (fr) * 2009-10-27 2011-05-05 Medical Components, Inc. Ensemble à orifices multiples
JP2012045139A (ja) * 2010-08-26 2012-03-08 Nihon Covidien Kk 皮下埋込ポート及びその製造方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020180854A1 (fr) 2019-03-03 2020-09-10 Tal Michael Gabriel Orifice d'accès vasculaire pouvant être changé par voie sous-cutanée
EP3934733A4 (fr) * 2019-03-03 2022-11-16 Portal Access, Inc. Orifice d'accès vasculaire pouvant être changé par voie sous-cutanée

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