WO2013126484A1 - Ensembles sonde optique et sondes pour tomographie en cohérence optique - Google Patents

Ensembles sonde optique et sondes pour tomographie en cohérence optique Download PDF

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Publication number
WO2013126484A1
WO2013126484A1 PCT/US2013/026986 US2013026986W WO2013126484A1 WO 2013126484 A1 WO2013126484 A1 WO 2013126484A1 US 2013026986 W US2013026986 W US 2013026986W WO 2013126484 A1 WO2013126484 A1 WO 2013126484A1
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WO
WIPO (PCT)
Prior art keywords
optical
probe
lens
stub
light
Prior art date
Application number
PCT/US2013/026986
Other languages
English (en)
Inventor
Venkata Adiseshaiah BHAGAVATULA
John Himmelreich
Original Assignee
Corning Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/403,465 external-priority patent/US8967885B2/en
Priority claimed from US13/403,485 external-priority patent/US8861900B2/en
Priority claimed from US13/403,446 external-priority patent/US8857220B2/en
Application filed by Corning Incorporated filed Critical Corning Incorporated
Publication of WO2013126484A1 publication Critical patent/WO2013126484A1/fr

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Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/26—Optical coupling means
    • G02B6/262—Optical details of coupling light into, or out of, or between fibre ends, e.g. special fibre end shapes or associated optical elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0066—Optical coherence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6852—Catheters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/02049—Interferometers characterised by particular mechanical design details
    • G01B9/0205—Interferometers characterised by particular mechanical design details of probe head
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/0209—Low-coherence interferometers
    • G01B9/02091—Tomographic interferometers, e.g. based on optical coherence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00

Definitions

  • the present invention relates to optical coherence tomography, and in pa rticular to probe optica l assemblies and probes for optical coherence tomography.
  • OCT optical coherence tomogra phy
  • the core of an OCT system is a Michelson interferometer, wherein a first optical fibe r is used as a reference arm and a second optical fiber is used as a sample arm.
  • the sample arm includes the sa mple to be a nalyzed as well as a probe that includes optical components.
  • An upstream light source provides the imaging light.
  • a photodetector is arranged in the optica l path downstrea m of the sample a nd reference a rms.
  • Optical interference of light from the sample arm and the reference a rm is detected by the photodetector only when the optica l path difference between the two arms is within the coherence length of the light from the light source.
  • Depth information from the sam ple is acquired by axially va rying the optical path length of the reference arm and detecting the interference between light from the reference arm and scattered light from the sample arm that originates from within the sample.
  • a three-dimensional image is obtained by transversely scanning in two dimensions the optical path in the sample arm. The axial resolution of the process is determined by the coherence length.
  • the probe typically needs to meet a number of specific requirements, which can include: single-mode operation at a wavelength that can penetrate to a required depth in the sample; a sufficiently small image spot size; a working distance that allows the light beam from the probe to be focused on and within the sample; a depth of focus sufficient to obtain good images from within the sample; a high signal-to-noise ratio (SNR); and a folded optical path that directs the light in the sample arm to the sample.
  • SNR signal-to-noise ratio
  • the probe needs to fit within a catheter, which is then snaked through blood vessels, intestinal tracks, esophageal tubes, and like body cavities and channels.
  • the probe needs to be as small as possible while still providing robust optical performance.
  • the probe operating parameters spot size, working distance, etc. will substantially differ depending on the type of sample to be measured and the type of measurement to be made.
  • An aspect of the disclosure is a probe optica l assembly for a probe for an OCT system, wherein the assembly includes in order along an axis an optical fiber having an end that defines an object plane, and a stub lens element.
  • the stub lens element has stub section with a proximal end that resides adjacent the optical fiber end.
  • the stub section is formed integral with a lens and has a proximal end that includes a lens surface.
  • the assembly also has a light-deflecting member arranged adjacent and spaced apart from the lens surface of the stub lens element.
  • the light-deflecting element has an axis that defines a working distance WD to an image plane.
  • the optical fiber end, the stub lens element and the light-deflecting member are arranged in a cooperative optical relationship to define an optical path between the object and image planes that is folded by the light-deflecting member.
  • the disclosure also includes a probe for an optical coherence tomography system, wherein the probe includes a transparent jacket that contains the probe optical assembly and through which the optical path passes.
  • a probe optical assembly that defines an optical path and that is suitable for use in forming an OCT probe.
  • the probe optical assembly includes a stub lens sub-assembly that operably supports i) an optical fiber having a first end and a second end, and ii) a stub lens element having a central axis, a lens with a lens surface that defines a distal end, and a stub section integrally formed with the lens and having a proximal end, the stub lens sub-assembly being configured so that the optical fiber end is in optical communication with the stub lens proxima l end over the optical path.
  • the probe optica l assembly also has a support member configured to operably support the stub lens sub-assembly so that the lens of the stub lens element resides within the interior.
  • the probe optica l assembly also has a light-deflecting member having a second axis and operably supported by the support member so that the first and second axes are generally coaxial. A portion of the second axis is folded to define a fold in the optical path.
  • FIG. 1 is a side view of a rod made of an optical material, shown with one of its ends operably arranged relative to a heat source;
  • FIG. 2 is similar to FIG. 1 and shows a stub lens element formed by heating one end of the rod to form a bulbous end portion that defines a lens having a lens surface;
  • FIG. 3A is similar to FIG. 2 and shows the stub lens element in the process of having its lens reduced in size in the lateral dimension by mechanical means;
  • FIG. 3B is similar to FIG. 3A and shows the stub lens element having its lens reduced in size in the latera l dimension via laser processing with a laser beam;
  • FIG. 4A and FIG. 4B illustrate examples of the stub lens element formed by processing the lens to reduce its lateral dimension
  • FIG. 4C is similar to FIG. 4B and shows an example where the lens surface includes an anti-reflection coating
  • FIG. 5A and FIG. 5B are similar to FIG. 4A, with FIG. 5A showing a cutting tool being used to cut the stub section to form an angled proximal end, the resulting angled proxima l end being shown in FIG. 5B;
  • FIG. 6A is a cross-sectional view of an example stub lens element shown along with a cylindrical sleeve
  • FIG. 6B is similar to FIG. 6A and shows the stub element operably engaged with the sleeve to form a stub lens sub-assembly;
  • FIG. 6C is similar to FIG. 6B and shows an example sleeve that includes a slot that leads from the sleeve outer surface to the sleeve central channel;
  • FIG. 6D is similar to FIG. 6C and shows an adhesive material disposed in the slot and that serves to secure the stub section of the stub lens element to the sleeve;
  • FIG. 7A is similar to FIG. 6B and shows the stub lens sub-assembly of FIG. 6A along with an example optical fiber ferrule;
  • FIG. 7B is a close-up view of the optical fiber ferrule of FIG. 7A;
  • FIG. 7C shows the optical fiber ferrule with an optical fiber secured therein, engaged with the central channel of the sleeve to form a stub lens assembly, and also shows a photodetector used to measure the mode field diameter of the focused light when performing alignment of the stub lens element relative to the optical fiber;
  • FIG. 8A is a cross-sectional view that shows the stub lens assembly and a light- deflecting member along with a support member in the form of an outer sleeve, in the process of fabricating a probe optical assembly to be used to form an OCT probe;
  • FIG. 8B shows the stub lens assembly, light-deflecting member and outer sleeve operably arranged to form the probe optical assembly
  • FIG. 9A is a cross-sectional view of an example OCT probe that utilizes the probe optical assembly of FIG. 8B;
  • FIG. 9B is a close-up view of the probe optical assembly contained within the interior of the jacket of probe, showing incident light and scattered light traversing the optical path in opposite directions;
  • FIG. 10 plots the object distance OD (horizontal axis) vs. the working distance WD (left vertical axis, solid-line curve) and the mode field diameter MFD (right vertical axis, dotted-line curve) in connection with designing an example stub lens element, with all dimensions being in microns;
  • FIG. 11 is a plot similar to that of FIG. 10 that plots the image MFD, M (microns) versus the working distance WD (microns) for the case of a single-mode optical fiber, but where the fiber MFD F is changed from 10 urn to 7 urn.
  • FIG. 12 is simila r to FIG. 7B and illustrates an example modification of the optical fiber by providing a lens at the optical fiber end either by re-shaping the otherwise flat optical fiber end or by adding a separate lens element;
  • FIG. 13A through FIG. 13C illustrate an example method of forming a fiber pigtail lens assembly using a fusion splicing process
  • FIG. 13D is similar to FIG. 13C and shows the fiber pigtail assembly operably engaged with the ferrule so that the lens is adjacent one of the ferrule ends;
  • FIG. 13E is similar to FI G. 13D and shows an example embodiment where the lateral dimension of the lens has been reduced in size;
  • FIG. 13F shows the fiber pigtail assembly of FIG . 13E as arranged in a ferrule, with the ferrule and fiber pigtail operably disposed on a transparent support substrate adjacent a light-deflecting member;
  • FIG . 14 is similar to FI G . 8B and illustrates an example embodiment of the probe optical assembly that employs a fiber pigtail lens assembly in place of the stub lens assembly;
  • FIG. 15 is a plots the relationship between the length L (mm) of a stub lens element and the lens diameter D2 (mm) of the stub lens element;
  • FIG. 16A is a cross-sectional view of another example embodiment of the stub lens assembly that includes the fiber pigtail lens assembly that has a first fused fiber lens element in combination with a second stub lens element;
  • FIG. 16B is similar to FI G. 16A, but with the outer sleeve replaced by a support substrate;
  • FIG . 17 is similar to FI G . 16B and illustrates another example embodiment of a fused lens assembly wherein the support substrate is made of a transparent material, and the second stub lens has an angled surface that serves as a total-internal-reflection (TI R) mirror;
  • TI R total-internal-reflection
  • FIG . 18 is similar to FI G . 17 a nd illustrates an embodiment that includes a transparent monolithic structure that includes a stub lens element portion;
  • FIG. 19 is a plot of the length L (microns) (horizontal axis) versus the image M FDIM (microns) (left-hand vertical axis) and working distance WD (microns) (right-hand vertical axis) as defined as the beam-waist location, for an example fused lens element suitable for use in the fiber pigtail lens assembly;
  • FIG. 20 is a side view of an example fused fiber pigtail lens assembly wherein the lens includes an angled surface that defines a TI R mirror that serves to fold the lens axis and direct it through a portion of the lens surface; and [0047] FIG. 21 is similar to FIG. 20 and illustrates another embodiment of the fiber pigtail assembly.
  • Cartesian coordinates are shown in certain of the Figures for the sake of reference and are not intended as limiting with respect to direction or orientation.
  • the mode field diameter MFD is a measure of the spot size or beam width of light propagating in a single mode fiber.
  • the mode field diameter MFD is a function of the source wavelength, fiber core radius r and fiber refractive index profile.
  • the mode field diameter MFD can be measured as the full width at 13.5% of the peak power for a best fit Gaussian beam, while in another example it can be measured by using the
  • the mode field diameter MFD is also referred to herein as a property of an image spot 652 formed at a working distance WD by a probe optical assembly 450 and in this instance is referred to as the image mode field diameter MFD
  • the mode field diameter MFD associated with optical fiber 320 is thus called the fiber mode field diameter MFDp, or "fiber MFD F " for short.
  • An example range for the working distance WD (see FIG. 9A) is 5 mm ⁇ WD ⁇ 15 mm.
  • M is in the range of
  • FIG. 1 is a side view of a rod 10 made of an optical material.
  • Example optica l materials for rod 10 include PYREX ® glass, silica, VYCOR ® glass or an optical glass.
  • An example rod 10 has a cylindrical shape with any one of a number of possible cross-sectional shapes, such as circular, elliptical, polygonal, etc.
  • the rod 10 has a body 12 that defines a central axis Al, a proximal end 14, a distal end 16, and a cross-sectional dimension (e.g., a diameter) Dl.
  • An example diameter Dl for rod 10 is in the range of 250 microns and 1000 microns for a circular cross-sectional shape.
  • FIG. 1 also shows rod distal end 16 operably disposed relative to a heat source 20.
  • An example heat source 20 includes at least one heating member 21 that generates heat 22.
  • An example heating member 21 includes an electrical arc, a laser, a joule-heating element, a flame, a ring burner, etc.
  • the heat 22 is applied to a distal end portion 17 of rod 10 adjacent distal end 16 while the rod is disposed vertically, i.e., with axis Al oriented in the direction of gravity.
  • the heat 22 is sufficient to make the distal end portion 17 flow, whereupon surface tension causes the distal end portion to become bulbous, as illustrated in FIG. 2.
  • the shape can be spherical, ellipsoid, etc.
  • the now bulbous distal end portion 17 has a diameter D2, which in an example is in the range of about 300 microns to 2,500 microns.
  • a rod 10 made of silica glass and having a diameter Dl of about 500 microns and having a circular cross-sectional shape allows for diameter D2 to be about 1.5 mm.
  • the bulbous distal end portion 17 defines a lens 40 having a lens surface 42.
  • lens 40 and the shape of lens surface 42 can be controlled by controlling the rod-end melting process, e.g., by controlling at least one of: the amount of heat 22 provided by heat source 20, the feed rate of rod 10 into heat 22, the rotation of the rod about its central axis Al, and the distance over which the rod is lowered into the heat.
  • lens surface 42 can be made spherical to a high degree of accuracy using this process, though aspherical lens surface shapes can be made as well.
  • lens surface 42 is spherical, it can have a radius of curvature R2 in the range 0.15 mm ⁇ R2 ⁇ 1.5 mm (see FIG. 3A and FIG. 4A).
  • FIG. 3A is similar to FIG. 2, and illustrates an example embodiment wherein lens 40 is in the process of being reduced in size in the lateral dimension via mechanical grinding by a mechanical grinder 50.
  • FIG. 3B is similar to FIG. 3A and illustrates another example of lens 40 being reduced in size in the lateral dimension via laser processing by a laser beam LB.
  • Arrows AR in FIG. 3A and FIG. 3B show the direction of motion of mechanical grinder 50 and laser beam LB, respectively.
  • FIG. 4A and FIG. 4B illustrate examples of a resultant stub lens element 100 formed by processing lens 40 such that its lateral dimension is reduced.
  • processed lens 40 has a reduced lateral dimension D2' in the range about 600 microns to 1 mm, while in another example the reduced lateral dimension D2' is in the range 700 microns to 800 microns.
  • stub lens element 100 has an axial length L from proximate end 14 to lens surface 42 that is in the range 0.5 mm ⁇ L ⁇ 5 mm.
  • the stub lens element 100 includes stub section 110 formed by the unaffected portion of rod 10 and the reduced-size lens 40, which hereinafter is referred to as stub lens 40.
  • the stub lens 40 has a non-lens outer surface portion 44 adjacent lens surface 42.
  • the stub section 110 serves as a handle for handling stub lens element 100 and can be cut to have a length suited for its particular application.
  • the flared shape of lens 40 is employed to accommodate light 650 that diverges as it passes from proximal end 14 to distal end 16.
  • the stub lens 40 of FIG. 4A also shows a relatively short stub section 110 that can be formed by the aforementioned cutting after stub lens element 100 is formed as described above.
  • a transition portion 120 forms the connection between stub section 110 and stub lens 40.
  • lens surface 42 of stub lens 40 can be spherical or aspherical.
  • Example aspherical surfaces include bi-conic, parabolic, hyperbolic, etc.
  • the shape of lens surface 42 can be defined by controlling the above-described melt process.
  • an anti-reflection coating 46 can be applied to lens surface 42, as illustrated in FIG. 4C.
  • FIG. 5A is similar to FIG. 4A and shows a cutting tool 150 being used to cut stub section 110 of stub lens element 100 to form an angled proximal end 14 that defines an angle ⁇ relative to axis Al, as shown in FIG. 5B.
  • the angled proximal end 14 can serve to reduce back reflections when stub lens element 100 is used in an OCT probe, as described in greater detail below.
  • An example angle ⁇ is in the range from about 5° to about 12°.
  • FIG. 6A is a cross-sectional view of an example stub lens element 100 along with a cylindrical sleeve 200.
  • the cylindrical sleeve 200 has a central axis A2, first and second ends 202 and 204, an outer surface 206, and a central channel 210 that runs along the central axis and that is open at the first and second ends.
  • the central channel 210 is sized to accommodate stub section 110 of stub lens element 100.
  • the sleeve 200 can be made of any rigid material, with glass, plastic and metal being some exemplary materials.
  • An exemplary sleeve 200 comprises a section of precision capillary tubing, which can be drawn down to a select size from a much larger tube using a process similar to a redraw process used to make optical fibers. As sleeve 200 is later incorporated into another larger sleeve as is explained below, it is referred to hereinafter as inner sleeve 200.
  • FIG. 6B is similar to FIG. 6A and shows stub lens element 100 engaged with inner sleeve 200 by inserting stub section 110 into inner sleeve central channel 210 at sleeve second end 204, thereby forming a stub lens sub-assembly 250.
  • an adhesive material 222 can be used to secure stub section 110 in central channel 210.
  • the stub lens element axis Al is substantially co-axial with inner sleeve axis A2.
  • the stub lens sub-assembly 250 is thus configured to operably support optical fiber end 324 and stub lens element 100 in a cooperative optical relationship.
  • FIG. 6C is similar to FIG. 6B and shows an example wherein inner sleeve 200 includes a slot 220 formed in inner sleeve outer surface 206 that leads to central channel 210.
  • FIG. 6D is similar to FIG. 6C and shows adhesive material 222 disposed in slot 220.
  • Adhesive material 222 is introduced into slot 220 and contacts stub section 110 of stub lens element 100. This serves to secure (fix) the stub section to inner sleeve 200, and providing an alternative to adding the adhesive material to central channel 210 from one of its ends. Once adhesive material 222 hardens, it can be ground, polished or otherwise processed to make its outer surface conform to outer surface 206 of inner sleeve 200.
  • the slot 220 may be formed in inner sleeve 200 by laser beam LB or by mechanical means, e.g., cutting or grinding.
  • FIG. 7A is similar to FIG. 6B and shows stub lens sub-assembly 250 along with an optical fiber ferrule ("ferrule") 300
  • FIG. 7B is a close-up view of ferrule 300
  • the ferrule 300 has a central axis A3, first and second ends 302 and 304, an outer surface 306, and a central bore 310 that runs along the central axis and that is open at the first and second ends.
  • the central bore 310 is sized to fit into channel 210 of inner sleeve 200.
  • the ferrule 300 can be made of any rigid material, with glass, plastic and metal being some exemplary materials. I n an example, ferrule 300 comprises a section of precision capillary tubing.
  • An example diameter of central bore 310 is about 128 microns, and an example outer diameter of ferrule 300 is about 500 microns.
  • ferrule end 304 is angled at a n angle ⁇ relative to central axis A3.
  • the central bore 310 of ferrule 300 is sized to accommodate an optical fiber 320, which in an example is a single-mode optical fiber.
  • the 3ptical fiber 320 includes end 324, which resides substantially at angled ferrule end 304. In the example where ferrule end 304 is angled, optical fiber end 324 can a lso be angled at the same angle ⁇ as the ferrule end.
  • FIG. 7C shows ferrule 300, with optical fiber 320 secured therein, engaged with central channel 210 of inner sleeve 200 at inner sleeve end 202, so that axes Al, A2 and A3 are all substantially co-axial.
  • the angled ferrule end 304 and angled end 14 of stub section 110 define a gap 210G within central channel 210 between the respective angled ends.
  • gap 210G ca n be filled with the aforementioned adhesive material 222 (not shown), e.g., in the form of an index-matching epoxy, to further reduce the back reflections and reduce the sensitivity of the rotationa l alignment of opposing angled ends.
  • the combination of stub lens sub-assembly 250, ferrule 300 and optical fiber 320 form a stub lens assembly 350.
  • the stub lens assembly 350 has an object distance OD, which is defined as the axial distance between optical fiber end 324 and lens surface 42 of lens 40.
  • object distance OD is in the range 0.5 mm ⁇ OD ⁇ 5 mm, and in a more specific example is 1 mm ⁇ OD ⁇ 3 mm.
  • one of the fabrication steps includes measuring the image MFD
  • This can be accomplished using, for example, a photodetector PD in the form of a beam- scanning appa ratus or a digital camera.
  • a light source LS is optically connected to an end 323 of optica l fiber 320.
  • the photodetector PD is used to measure the size of image spot 652 as formed by light 650 emanating from optical fiber end 324 and being focused by stub lens element 100 at the a nticipated working distance WD.
  • the axial position of at least one of ferrule 300 and stub lens element 100 can be adjusted until the object distance OD that minimizes the image M DF
  • photodetector PD generates an electrical signal SI that is representative of the detected image MFD
  • ferrule 300 and stub lens element 100 are fixed in place within inner sleeve 200 using, e.g., adhesive material 222, which can be a UV-curable epoxy.
  • adhesive material 222 which can be a UV-curable epoxy.
  • stub lens element 100 is fixed relative to inner sleeve 200 prior to the image MFD
  • gap 210G can be filled with the aforementioned index-matching material, e.g., UV-curable adhesive material 222, through slot 220 (see FIGS. 7A and 7C).
  • stub lens assembly 350 is operably supported by a support member.
  • FIG. 8A is a cross-sectional view that shows stub lens assembly 350 and a light-deflecting member 500 having an axis A5 and arranged relative to a support member 398 in the form of an outer sleeve 400 in the process of forming a probe optical assembly 450, as shown in FIG. 8B.
  • the support member 398 is configured to operably support stub lens sub-assembly 350 and light-deflecting member 500 in a cooperative optical relationship that defines folded optical path OP.
  • the light-deflecting member 500 is shown and discussed hereinbelow as a prism by way of illustration.
  • light-deflecting member 500 comprises a mirror.
  • the outer sleeve 400 has a central axis A4, first and second ends 402 and 404, an outer surface 406, and an interior 410 that runs a long the central axis and that is open at the first and second ends.
  • the interior 410 is configured to accommodate at end 402 stub lens assembly 350 and at end 404 light-deflecting member 500.
  • outer sleeve 400 includes a retaining feature 412 disposed within interior 410 at end 402, with the retaining feature configured to retain inner sleeve 200 of stub lens assembly 350.
  • the outer sleeve 400 can be made of any rigid material, with glass, plastic and metal being exemplary materials.
  • outer sleeve 400 comprises a section of precision capillary tube.
  • light-deflecting member 500 includes a cylindrica lly curved front surface 502, a planar angled surface 503 that defines a total- internal-reflection (TIR) mirror 503M, and a planar bottom surface 504.
  • the light-deflecting member central axis A5 is folded by TI R mirror 503M.
  • the angle of deflection a can be in the range between 90 and 100 degrees.
  • the light-deflecting member 500 is shown along with a retaining feature 512 that serves to retain the light-deflecting member in interior 410 at end 404 of outer sleeve 400 when the light-deflecting member and the outer sleeve are operably engaged.
  • retaining feature 512 is simply adhesive material 222.
  • FIG. 8B shows stub lens assembly 350 and light-deflecting member 500 operably engaged with outer sleeve 400 at respective ends 402 and 404, thereby forming the aforementioned probe optical assembly 450.
  • the probe optical assembly 450 includes an optical path OP that begins from optical fiber end 324 and that generally follows the substantially co-axial axes Al through A5.
  • optical fiber end 324 defines an object plane OBP and working distance WD defines the distance where light-deflecting- member axis A5 intersects axis A4 to an image plane IMP where the smallest image spot 652 is formed.
  • the optical path OP thus comprises the path over which light 650 travels from object plane OBP to image pla ne I MP.
  • FIG. 9A is similar to FIG. 8B and shows an example of an OCT probe ("probe") 600 that includes a long (e.g., several meters long) transparent jacket 610 into which probe optical assembly 450 and optica l fiber 320 are inserted.
  • An example jacket 610 has a cylindrical body portion 620 that defines an interior 624.
  • jacket 610 comprises a long polymer tube having a rounded distal end 616.
  • the cylindrical body portion 620 has a cylindrically curved outer surface 626.
  • jacket 610 has a diameter D3 in the range 1 mm ⁇ D3 ⁇ 2 mm.
  • the jacket 610 is configured to contain probe optical assembly 450 in interior 624.
  • FIG. 9A also shows an example where jacket 610 includes a proximal end 614 at which an optical fiber cable 326 that ca rries optical fiber 320 is operably connected to the jacket.
  • FIG. 9B is a close-up view of the probe optical assembly 450 contained within interior 624 of jacket 610 of probe 600 and shows light 650 and scattered light traversing optical path OP in opposite directions.
  • the light 650 originates from light source LS, which is optically coupled to end 323 of optical fiber 320.
  • light 650 from light source LS has a wavelength of about 1.3 urn.
  • the use of a single-mode optical fiber provides the necessary spatial coherence for OCT applications.
  • light 650 from light source LS initially travels down optical fiber 320 as guided light.
  • This guided light 650 exits optical fiber end 324 at or near ferrule end 304 and diverges as it begins traveling over optical path OP.
  • This divergent light then passes through gap 210G and enters proximal end 14 of stub section 110 of stub lens element 100.
  • the divergent light 650 then travels through stub section 110 to lens 40, where it exits the lens at lens surface 42 and passes to light-deflecting member 500.
  • lens surface 42 has positive optical power and so acts to converge light 650.
  • the now convergent light 650 enters light-deflecting member 500 at curved surface 502, and is then totally internally reflected at TIR mirror 503M within the light-deflecting member.
  • This reflection directs convergent light 650 to continue traveling along axis A5 and to exit light-deflecting member 500 at bottom surface 504.
  • the light 650 then passes through cylindrical body portion 620 of transparent jacket 610 that resides adjacent light- deflecting member bottom surface 504 and exits probe 600.
  • optical path OP passes through transparent jacket 610.
  • cylindrical curvature of cylindrical body portion 620 of jacket 610 acts as a cylindrical lens surface a nd so has first optical power in one direction.
  • cylindrically curved front surface 502 of light-deflecting member 500 is configured to have second optical power that compensates for the first optical power.
  • this com pensation can be provided as negative optical power (i.e., a ID concave surface) on surface 502 in the same plane of curvature as cylindrical body portion 620 or as positive optical power (i.e., a ID convex surface) in the plane of curvature orthogonal to the cylindrical body portion.
  • negative optical power i.e., a ID concave surface
  • positive optical power i.e., a ID convex surface
  • Surface 502 of light-deflecting member 500 can be made curved using standard micro- polishing and micro-finishing techniques.
  • the light 650 that exits probe 600 then travels to a sample 700, which resides adjacent the probe as shown in FIG. 9A.
  • the sample 700 has a body (volume) 701 that defines a sample surface 702.
  • the convergent light 650 is substantially brought to a focus at working distance WD by virtue of lens surface 42 of stub lens element 100 having the aforementioned positive optical power.
  • the focused light 650 forms image spot 652, which has associated image M FD
  • a portion 650S of light 650 incident upon sa mple 700 is scattered back from sa mple surface 702 or volume 701 into probe optical assembly 450 through the cylindrica l body portion 620 of tra nsparent jacket 610.
  • This scattered light 650S then travels back through probe optical assem bly 450 over optical path OP but in the reverse direction to that of incident light 650.
  • the scattered light 650 is then diverted upstrea m from optical fiber 320 by a fiber coupler FC to travel in another optical fiber section 318 (FIG. 8B) to be interfered with reference light (not shown).
  • the interfered light is then detected and processed according to conventiona l OCT procedures.
  • the stub lens element 100 serves to receive light 650 emitted from optical fiber end 324 and form a high-q uality Ga ussian bea m.
  • stub lens element 100 and light-deflecting member 500 are configured to meet the requirements for the image mode- field diameter (M FD) and working distance WD for OCT applications.
  • M FD image mode- field diameter
  • the angled optical fiber end 324 a nd a ngled end 14 of stub section 110 serve to reduce back reflections [and thereby?] to improve the SNR.
  • gap 210G between angled ferrule end 324 a nd ferrule a nd angled end 14 of stub section 110 can be filled with an index-matching material to furthe r reduce back reflections as well as to reduce the sensitivity of the rotationa l alignment of the opposi ng angled ends that define the ga p.
  • FIG. 10 plots the object dista nce OD (horizontal axis) vs. the working distance WD (left vertica l axis, solid-line curve) and the mode field diameter M FD (right vertical axis, dotted-line curve) in connection with designing an example stub lens element 100.
  • Al l dimensions a re in microns.
  • a Gaussia n beam for light 650 was used, a long with a radius of curvature of 0.75 mm for lens surface 42, and silica as the optica l materia l.
  • the wavelength of light 650 was 1.3 microns, at which silica has a refractive index n of about 1.45.
  • the object distance OD needs to be about 2890 microns.
  • M is about 60 microns.
  • the plot of FIG. 10 can also be used to determine the tolerances needed for this design to control worki ng dista nce WD to within certain limits. As can be seen by a circle CI provided on the solid-line curve, object distance OD needs to be controlled to better tha n about 10 microns in orde r to control worki ng dista nce WD to better than 500 microns.
  • controlling object distance OD to withi n 10 microns controls mode field diameter M FD to within about 25 microns.
  • mode field diameter M FD controls mode field diameter M FD to within about 25 microns.
  • the transverse imaging resolution depends on image M FD
  • a smaller image spot 652 with the same working distance WD is th us desired to achieve higher imaging resolution.
  • FIG. 11 is simila r to FIG. 10 a nd plots the image M FD
  • the solid line a nd dashed line curves represent two different glass types for stub lens element 100, namely, PYREX and silica, which has a lower index than PYREX.
  • the dotted line indicates the results with a smaller mode field fiber.
  • the curves plotted in FIG. 11 indicate that the smaller fiber M FDF leads to a smaller image M FD
  • a smaller refractive index n for stub lens element 100 leads to a smaller image M FD
  • FIG. 12 is simila r to FIG. 7B and illustrates an exa mple modification of optical fiber 320 at optica l fiber end 324.
  • a lens 325 is formed on (e.g., via re-shaping via acid etching or melting) or is otherwise added directly to optical fiber end 324.
  • the lens 325 can have any one of a variety of surface shapes, including spherica l and aspherical.
  • Example aspherical surface shapes include parabolic shapes, hyperbolic shapes, biconic shapes, and the like.
  • the shape of lens 325 is limited only by current optica l fiber lens-forming techniques.
  • the lens 325 is configured to reduce fiber M FD F , which in turn reduces image M FDIM.
  • M , working distance WD, and the M 2 parameter for light 650 are about 80 microns, about 13.5 mm to 15 mm and less than 1.3, respectively.
  • Embodiments of probe 600 fabricated using the components, assemblies and methods as described herein can readily meet these specifications.
  • FIG. 13A through FIG. 13C illustrate an example method of forming a fiber pigtail lens assembly 800 that can serve as a more compact version of the previously described stub lens assembly 350.
  • optical fiber 320 is spliced at optical fiber end 324 to end 14 of rod 10.
  • the optical fiber 320 has a core 322, which in an example is comprised of silica or doped silica.
  • rod 10 is made of silica so that optical fiber core 322 and the rod are substantially index matched.
  • Splicing optical fiber 320 to rod 10 forms a contiguous fiber pigtail structure 348 that is further processed to form fiber pigtail lens assembly 800.
  • the genera l process for forming this monolithic fiber pigtail structure 348 is described in U.S. Patents Nos. 7228033 B2, 7258495 Bl and 6904197 B2, which are incorporated by reference herein.
  • rod distal end portion 17 is processed to have a tapered shape and so that rod 10 has a select length to within about +/- 20 microns.
  • the subsequent lens 40 can be made to have a select configuration.
  • the resulting fiber pigtail lens assembly 800 includes a stub lens element 100 that includes stub section 110 spliced at end 14 to optical fiber 320.
  • the object distance OD is now essentially the axial distance or length L of the newly formed stub lens element 100, wherein L is the distance from proxima l end 14 of stub section 110 to the apex of lens surface 42 of lens 40.
  • length L is in the range 0.5 mm to 5.0 mm.
  • FIG. 13D is similar to FIG. 13C and shows the fiber pigtail assembly 800 operably engaged with ferrule 300 so that lens 40 is adjacent ferrule end 304.
  • Adhesive material 222 is included within central bore 310 and is used to fix stub section 110 and the spliced-end portion of optical fiber 320 within the ferrule channel.
  • FIG. 13E is similar to FIG. 13D and shows an example embodiment where lens 40 has been reduced in size by polishing, turning, grinding or like manner.
  • the fiber pigtail assembly 800 and ferrule 300 are shown operably supported by support member 398 in the form of a transparent support substrate 820 having an upper surface 828.
  • support substrate 820 supports an example light-deflecting member 500 in the form of a prism atop upper surface 828 adjacent one end of the substrate.
  • the support substrate 820 also supports fiber pigtail assembly 800 and ferrule 300 on surface 828 near the other end of the support substrate.
  • support substrate 820 has a thickness of about 190 microns.
  • light-deflecting member 500 now has a planar light- deflecting member front surface 502, along with the aforementioned angled surface 503 that defines a TIR mirror 503M, and bottom surface 504, which now resides adjacent the substrate upper surface 828.
  • the fiber pigtail assembly 800 is disposed on upper surface 828 and in an example is secured thereto, e.g., with adhesive material 222.
  • the fiber pigtail assembly 800 is a rranged so that lens surface 42 of lens 40 confronts planar light-deflecting- member surface 502.
  • the light-deflecting member TIR mirror 503M serves to fold axis Al so that optical path OP passes through support substrate 820 at the location adjacent light- deflecting member bottom surface 504.
  • light-deflecting member 500 can be formed by providing a blank (also called a preform) having a triangular cross-section and that can include a
  • the blank is then drawn into rods using standard glass drawing techniques, wherein the rods have the same cross-sectional shape as the blank.
  • This light-deflecting member fabrication method requires shaping one blank from which hundreds of meters of light-deflecting-member rods can then be drawn. Centimeter lengths of the light-deflecting-member rods can be mounted on support substrate 820 and then diced into individual light-deflecting members and substrates such as shown in FIG. 13F
  • the bla nk is formed so that light-deflecting-member surface 502 has the appropriate curvature.
  • light-deflecting-member surface 502 ca n have an amount of ti lt relative to light-deflecting member axis A5 that is ca pable of reducing back reflections.
  • a tilt of about 2 degrees is sufficient for reducing back reflections to as low as -50 dB to -60 dB.
  • FIG. 14 is simila r to FIG. 8B and illustrates an example embodiment of probe optical assembly 450 that employs fiber pigtail lens assembly 800 in place of the aforementioned stub lens assembly 350.
  • the fiber pigtail lens assembly 800 is shown being held in place within outer sleeve 400 by retaining feature 412.
  • the use of fiber pigtail lens assembly 800 simplifies the design a nd assembly of probe optica l assembly 450 and also eliminates ga p 210G, which was present in stub lens assembly 350 described a bove.
  • the configu ration of fusion-spliced fiber pigtail lens assembly 800 reduces the amount of back reflection to an acceptable level without the need for angled facets.
  • FIG. 14 also shows a n example of light-deflecting member 500 opera bly engaged at end 404 of outer sleeve 400.
  • light-deflecting member 500 ca n be molded or embossed to sleeve 400 using polymers or UV curable epoxies.
  • the fiber pigtail lens assembly 800 is relatively tolerant to process variations.
  • a n exam ple lens radius R2 for lens 40 of fiber pigtail lens assembly 800 is in the range about 750 microns to about 800 microns.
  • rod 10 from which lens 40 is formed has a diameter Dl in the range of about 350 microns to a bout 500 microns.
  • FIG. 15 plots the relationship between the stub lens element length L (mm) and the diameter D2 (mm) of lens 40 of stub lens e lement 100.
  • the total va riation in length L is ostensibly determined by the accuracy of the mechanism used to feed rod 10 into heat source 20 during the lens formation process (see FIG. 1).
  • Even with a change in length AL of 50 microns, the corresponding change in the lens diameter AD2 is only a bout 2.5 microns.
  • This a mou nt of change in the diameter D2 of lens 40 does not lead to a significa nt cha nge i n the focusing characteristics of the lens, so the working distance WD and image M FD
  • FIG. 16A is a cross-sectiona l view of another example embodiment of stub lens assem bly 350 that includes fiber pigtail lens assembly 800, wherein its fused stub lens element is denoted as 100A (with lens 40A, lens surface 42A, etc.), as used in combination with a second stub lens element, which is denoted as 100B (with lens 40B, lens surface 42B, etc.).
  • the support member 398 in the form of inner sleeve 200 operably supports ferrule 300 at first end 202 and operably supports stub lens element 100B at second end 204.
  • This configuration of stub lens assembly 350 now has two optica l surfaces with optical power, namely stub lens surfaces 42A a nd 42B.
  • the stub lens surfaces 42A and 42B are a rra nged in stub lens assembly 350 so that they are confronting.
  • the fiber M FD F associated with fiber pigtail lens assembly 800 in this exam ple can be made relatively sma ll.
  • optica l fiber 320 to be a conventional optica l fiber, such as SM F-28 ® optical fi ber, which is avai lable from Corning, Inc., Corning, NY, and which has a core diameter of nominally 10 microns.
  • Another advantage is that the amount of back scattering of light 650 is relatively low by virtue of the pigtail configuration of fiber pigtail lens assem bly 800. Also, the two lenses 40A and 40B can be configu red so that light 650 is substantially collimated as it travels from lens surface 42A to lens surface 42B, as illustrated in FIG. 16A. This ca n serve to reduce a ny beam distortions and also to reduce the diameter requirements for lens 40B of stub lens element 100B.
  • FIG. 16B is simila r to FIG. 16A and illustrates an example embodiment of stub lens assembly 350 wherein outer sleeve 200 is replaced with support substrate 820.
  • the support substrate 820 ca n be made of a rigid material such as glass, plastic, metal a nd the like.
  • FIG. 17 is simila r to FIG. 16B and illustrates another example embodiment of stub lens assembly 350 wherein support substrate 820 is made of a transparent material.
  • support substrate 820 is formed as a unitary molded piece that includes first and second ends 824 a nd 826, and a recess 830 formed in upper surface 828.
  • the ferrule 300 with fiber pigtail lens assembly 800 engaged therewith is disposed on upper surface 828 of support substrate 820 adjace nt end 824.
  • stub lens element 100B is disposed on upper surface 828 of support substrate 820 adjacent end 826, with the stub lens surface 42B in opposition to stub lens surface 42A.
  • Stub lens element 100B has an angled distal end 14B that defines a TI R mirror 14BM .
  • the stub lens elements 100A and 100B are a capitad (i.e., thei r respective axes A1A and A1B are made co-linea r) usi ng for exa mple the aforementioned method of monitoring of the image M FD
  • the fiber pigtail lens assembly 800 can be axially adjusted within ferrule 300 prior to being fixed in place.
  • FIG. 18 is simila r to FIG. 17 a nd illustrates an embodiment wherein the support mem ber 398 com prises a transparent monolithic structure 850 that includes ends 854 and 856, and a planar upper surface portion 858 adjacent end 854.
  • the monolithic structure 850 a lso includes stub lens element portion 100B adjacent end 856, with the stub lens element portion including a ngled end 14B and TIR mirror 14BM .
  • planar upper surface portion 858 includes at least one alignment feature 860 that facilitates alignment of ferrule 300 and fiber pigtail lens assembly 800 supported thereby with the stub lens element portion 100B.
  • An example alignment feature 860 is a groove (e.g., a V- groove) that accom modates a corresponding (e.g., complimenta ry) alignment feature 360 of ferrule 300.
  • the monolithic structure 850 can be formed, for exa mple, by molding a polymer material, thereby providing for low-cost mass production that can em ploy reusable molds.
  • the configu rations of stub lens assembly 350 of FIG. 18 has the advantage that the bea m dimension of light 650 is substa ntia lly la rger compared to the single mode fiber mode-field diameter before it is incident on lens surface 42B. This substantially reduces the light intensity on the lens surfaces so that they can tolerate much higher power levels without degradation, especially when monolithic structure 850 comprises a polymer material.
  • FIG. 19 is a plot of the length L (microns) (horizontal axis) versus the image M FDIM (microns)(left-hand vertical axis) and working distance WD (microns)(right-hand vertical axis) as defined as the beam-waist location, for an example stub lens element 100 suitable for use in fused fiber pigtail lens assembly 800.
  • the curve with the circles corresponds to image M FD
  • the plot shows that fiber pigtail lens assembly 800 can have an image M FD
  • FIG. 20 is a side view of an example fiber pigtail lens assembly 800 wherein lens 40 includes an angled surface (facet) 43 that defines a TIR mirror 43M that serves to fold axis Al and direct it through a portion of lens surface 42.
  • the facet 43 can also include a curvature to compensate for the defocusing effect of curved outer surface 626 of jacket 610.
  • FIG. 21 is another embodiment of the fiber pigtail assembly 800 assembly similar to that shown in FIG. 20, but where optica l fiber 320 is not fusion spliced to lens 40. Rather, optical fiber end 324 is spaced apart from lens 40 and is in optical communication therewith through index-matching material 222, e.g., UV epoxy.
  • the optical fiber 320 is shown being supported in ferrule 300, which in turn is supported in inner sleeve 200.
  • lens 40 of FIG. 21 performs both the beam bending at lens surface 42 and the internal reflection at angled surface (facet) 43.
  • FIG. 20 shows that performs both the beam bending at lens surface 42 and the internal reflection at angled surface (facet) 43.
  • lens 40 is formed as a single element fabricated from a hemispherical or biconic ball lens made of a glass or a polymer material. With polymer materials, the fabrication of biconic lens or shaped stub lens is generally easier and can be more readily mass produced, e.g., via a molding process.

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Abstract

L'invention concerne des ensembles sonde optiques et des sondes conçues pour des applications de tomographie en cohérence optique (OCT). L'ensemble sonde comprend une fibre optique, une lentille à taille réduite et un élément déflecteur de lumière disposés selon une relation optique de coopération pour définir un trajet optique entre la fibre optique et un plan-image plié par l'élément déflecteur de lumière. La sonde optique comprend une enveloppe transparente qui renferme l'ensemble sonde optique.
PCT/US2013/026986 2012-02-23 2013-02-21 Ensembles sonde optique et sondes pour tomographie en cohérence optique WO2013126484A1 (fr)

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US13/403,465 2012-02-23
US13/403,446 2012-02-23
US13/403,465 US8967885B2 (en) 2012-02-23 2012-02-23 Stub lens assemblies for use in optical coherence tomography systems
US13/403,485 2012-02-23
US13/403,485 US8861900B2 (en) 2012-02-23 2012-02-23 Probe optical assemblies and probes for optical coherence tomography
US13/403,446 US8857220B2 (en) 2012-02-23 2012-02-23 Methods of making a stub lens element and assemblies using same for optical coherence tomography applications

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PCT/US2013/026986 WO2013126484A1 (fr) 2012-02-23 2013-02-21 Ensembles sonde optique et sondes pour tomographie en cohérence optique
PCT/US2013/026989 WO2013126487A1 (fr) 2012-02-23 2013-02-21 Ensembles lentille à taille réduite conçus pour être utilisés dans des systèmes de tomographie en cohérence optique

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JPH1156786A (ja) * 1997-08-28 1999-03-02 Olympus Optical Co Ltd 光走査プローブ装置
US6445939B1 (en) * 1999-08-09 2002-09-03 Lightlab Imaging, Llc Ultra-small optical probes, imaging optics, and methods for using same
US7228033B2 (en) 2000-03-17 2007-06-05 Corning Incorporated Optical waveguide lens and method of fabrication
US6904197B2 (en) 2002-03-04 2005-06-07 Corning Incorporated Beam bending apparatus and method of manufacture
US20060067620A1 (en) * 2004-09-29 2006-03-30 The General Hospital Corporation System and method for optical coherence imaging
US7258495B1 (en) 2005-06-24 2007-08-21 Corning Incorporated Lensed fiber stub assemblies optical and optoelectronic packages including them
US20090244545A1 (en) * 2008-03-26 2009-10-01 Fujifilm Corporation Optical rotary adaptor and optical tomographic imaging apparatus using the same

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