WO2013108587A1

WO2013108587A1 - Medical fluid transfusion method and medical fluid transfusion device

Info

Publication number: WO2013108587A1
Application number: PCT/JP2013/000016
Authority: WO
Inventors: 結輝竹中; 中村　徹; 晃庸奥田; 東條　剛史; 章博太田; 朗 ▲樋▼口
Original assignee: パナソニック株式会社
Priority date: 2012-01-17
Filing date: 2013-01-08
Publication date: 2013-07-25
Also published as: JP5444509B2; JPWO2013108587A1

Abstract

Provided is a medical fluid transfusion device or method, comprising: a first retaining part (21) which retains a container (24); a second retaining part (22) which retains a syringe (26) to which a needle (25) is attached; a first moving part (23) which moves the first retaining part (21) up and down in the plumb direction; and a control part (40) which controls the first moving part (23). After drawing external air and air within the needle (25) as a dead air space into the syringe (26) by drawing out a plunger (26b) of the syringe (26) prior to the needle (25) of the syringe (26) puncturing the container (24), the control part (40) carries out a process of transfusing a medical fluid (27) from the medical fluid container (24) to the syringe (26) via the needle (25) by puncturing the container (24) with the needle (25) and moving the plunger (26b).

Description

Chemical solution transfer method and chemical solution transfer apparatus

The present invention relates to a drug solution transfer method and a drug solution transfer apparatus for transferring a drug solution such as an injection drug filled in a container between a container and a syringe in the field of medicine and the like.

When a medical solution such as an injection drug is prescribed to a hospitalized patient or the like in a hospital or the like, several kinds of medical solutions may be taken out from different medical solution containers and mixed. When suctioning a drug solution from a sealed drug solution container into a syringe, a pumping operation is often performed because a strong force is required. In the pumping operation, an air layer with a volume smaller than the volume of the drug solution to be suctioned is created in advance in the syringe, and suction of the drug solution is started from this state, and the plunger of the syringe is pushed and pulled multiple times to It is an operation of gradually replacing air.

In order to reduce the burden of the pumping operation, a transfusion needle has been proposed in which a groove is provided in a part of the needle to eliminate the need for a pumping operation (see, for example, Patent Document 1). According to the transfer needle of Patent Document 1, the inside of the drug solution container can be made substantially equal to the atmospheric pressure by removing air from the groove.

FIG. 9 is a partial cross-sectional view of the transfusion needle 1 used in the conventional chemical liquid mixing apparatus. FIG. 9 is a partial cross-sectional view of the transfer needle 1 as viewed from a plane perpendicular to the thickness direction of the rubber plug 8c when the conventional transfer needle 1 is pulled out of the rubber plug 8c. As shown in FIG. 9, in the conventional transfusion needle 1, the needle 2 and the needle base 3 are integrated. Then, in the transfusion needle 1, the outer cylinder 4 is fitted to the outside of the needle 2 to form a groove 4 a between the needle 2 and the outer cylinder 4. In the vicinity of the air port 5 at one end of the groove 4a, a filter 6 formed of a hydrophobic synthetic resin is attached.

When the transfer needle 1 configured in this way is attached to the syringe 7 and the drug solution 9 is sucked into the syringe 7 from the drug solution container 8, the gas 10 in the drug solution container 8 is reduced by the volume of the drug solution 9 in the drug solution container 8. Expands, and the pressure of the gas 10 in the drug solution container 8 decreases. As a result, external air is drawn into the chemical solution container 8 through the filter 6 and the groove 4 a in order to eliminate the pressure difference between the pressure of the gas 10 in the chemical solution container 8 and the atmospheric pressure. As a result, the air 5a in the form of foam enters from the groove 4a of the transfer needle 1 into the drug solution container 8, and the pressure of the gas 10 in the drug solution container 8 becomes substantially the same as the atmospheric pressure. In Patent Document 1, this makes it possible to eliminate the need for the pump-pink operation of the syringe 7 and to reduce the burden of work when suctioning the drug solution from the drug solution container 8 into the syringe 7.

Further, according to Patent Document 2, after the clean air of an amount corresponding to the transfer amount is sucked into the syringe before the transfer of the drug solution, the suctioned clean air is injected into the drug solution container to Is disclosed to facilitate the transfer of the drug solution from inside the drug solution container into the syringe.

Japanese Utility Model Laid-Open No. 4-77946 Japanese Patent Publication No. 04-505403

However, the inventors found out the problem that variation occurs in the transfusion amount of the drug solution while conducting repeated experiments of suction and discharge operations using such a transfusion needle many times.

The present invention solves this problem, and provides a drug solution transfer method and a drug solution transfer apparatus capable of performing transfer of drug solution with high accuracy without occurrence of large variation in transfer amount of drug solution. The purpose is to

In order to achieve the above object, a drug solution transfer method according to one aspect of the present invention uses a syringe disposed below the vertical direction of a container having a drug solution inside, a gasket of a plunger of the syringe and the syringe The needle of the syringe is punctured into the container in a state where there is an air reservoir with the inner wall surface of the container, and then the plunger is moved to transfer the drug solution from the container to the syringe through the needle Let

Further, in order to achieve the above object, a drug solution transfer apparatus according to another aspect of the present invention is disposed at a first holding portion for holding a container having a drug solution inside, and vertically below the container, A second holding unit for holding a syringe with a needle, a first moving unit for moving the first holding unit up and down in the vertical direction, and a plunger of the syringe held by the second holding unit in the vertical direction A second moving unit that moves up and down, and a control unit that controls the first moving unit and the second moving unit, the control unit is between the gasket of the plunger and the inner wall surface of the syringe. After the needle is punctured into the container by relatively moving the first holding portion downward in the vertical direction in the presence of an air reservoir, the plunger is moved to move the plunger from the container to the syringe Processing to transpose Do.

According to each aspect of the present invention, it is possible to provide a drug solution transfer method and a drug solution transfer apparatus capable of performing transfer of the drug solution with high accuracy without causing large variations in the transfer amount of the drug solution.

The features of the present invention will be apparent from the following description related to the embodiments of the attached drawings. In this figure,
FIG. 1A is a schematic block diagram of a drug solution transfer apparatus according to a first embodiment of the present invention, FIG. 1B is a schematic block diagram of an example of a control unit or the like of the drug solution transfer apparatus according to the first embodiment of the present invention, FIG. 2 is a flowchart of the drug solution transfer method according to the first embodiment, FIG. 3A is a partial cross-sectional view of the drug solution transfusion apparatus according to the first embodiment, FIG. 3B is a partial cross-sectional view of the drug solution transfusion apparatus according to the first embodiment, FIG. 3C is a partial cross-sectional view of the drug solution transfusion apparatus according to the first embodiment, FIG. 3D is a partial cross-sectional view of the drug solution transfusion apparatus according to the first embodiment, FIG. 3E is a partial cross-sectional view of the drug solution transfusion apparatus according to the first embodiment, FIG. 3F is a partial cross-sectional view of the drug solution transfusion apparatus according to the first embodiment, FIG. 3G is a partial cross-sectional view of the drug solution transfusion apparatus according to the first embodiment, FIG. 3H is a partial cross-sectional view of the drug solution transfusion apparatus according to the first embodiment, FIG. 3I is a partial cross-sectional view of the drug solution transfusion apparatus according to the first embodiment, FIG. 3J is a partial cross-sectional view of the drug solution transfusion apparatus according to the first embodiment, FIG. 4 is a partial cross-sectional view of the drug solution transfusion apparatus according to the first embodiment, FIG. 5 is a side view showing the chemical liquid mixing apparatus according to the first embodiment, FIG. 6A is a partial cross-sectional view of a conventional drug solution transfer device, FIG. 6B is a partial cross-sectional view of a conventional drug solution transfer device, FIG. 6C is a partial cross-sectional view of a conventional drug solution transfer device, FIG. 7 is a cross-sectional view schematically showing the state in which air bubbles are generated inside the syringe in the conventional drug solution transfer apparatus, FIG. 8 is a partial cross-sectional view of the drug solution transfer needle of the drug solution transfer device according to the second embodiment of the present invention; FIG. 9 is a partial sectional view of a conventional transfusion needle, FIG. 10 is a partial cross-sectional view for explaining the problem in the conventional transfusion needle.

Before describing the embodiments of the present invention, the problems of the conventional transfusion needle found by the inventors will be described. FIG. 10 is a partial cross-sectional view for explaining the problem of the conventional drug solution transfer needle. In FIG. 10, the same components as those in FIG. 9 are denoted by the same reference numerals, and the description thereof is omitted.

In the case where the drug solution 9 is aspirated for the first time in the syringe 7 during repeated experiments using the transfer needle a number of times, as shown in FIG. It has been found that the air of the air suddenly collides with the introduction portion 7a at the tip of the syringe 7. When the drug solution 9 and the air in the needle 2 collide with each other in this manner, air bubbles 8 f may be generated in the vicinity of the bottom in the syringe 7. The generated air bubbles 8 f may be attached to the wall surface 7 b in the vicinity of the tip of the inside of the syringe 7 to reduce the measurement accuracy of the drug solution 9 in the syringe 7. When the state shown in FIG. 11 is reached, a large number of air bubbles 8 f are contained in the liquid drug solution 9, so the exact volume of the drug solution 9 in the syringe 7 can not be determined. Therefore, in the conventional transfer needle, there is a problem that the drug solution 9 can not be transferred with high accuracy when a large amount of bubbles 8f are generated.

The present invention solves the problems in this conventional transfusion needle by the embodiment described below.

Hereinafter, embodiments of the present invention will be described with reference to the drawings. In addition, the same code | symbol is attached | subjected to the same component and description may be abbreviate | omitted. Also, in order to make the drawings easy to understand, each component is schematically shown mainly.

First Embodiment
FIG. 1A is a schematic configuration view of a part of a drug solution transfer apparatus 20 according to a first embodiment of the present invention. FIG. 1B is a schematic block diagram of an example of a control unit or the like of the drug solution transfusion apparatus according to the first embodiment of the present invention. FIG. 2 is a flowchart of a drug solution transfer method by the drug solution transfer apparatus according to the first embodiment of the present invention. FIGS. 3A to 3J are diagrams for explaining the drug solution transfer method in the first embodiment, using side views of a part of the container and the syringe.

As shown in FIGS. 1A and 1B, the drug solution transfer apparatus 20 according to the first embodiment includes a first holding unit 21, a second holding unit 22, a first moving unit 23, and a second moving unit 19. And a control unit 40. The drug solution transfer apparatus 20 functions as an example of a drug solution mixing apparatus. The liquid medicine mixing apparatus is an apparatus for injecting a liquid medicine transferred to a syringe 26 and injecting the liquid medicine transferred from the syringe 26 into an infusion vial or the like to mix the medicine.

The first holding unit 21 is an example of a container holding unit, and the second holding unit 22 is an example of a syringe holding unit. The first moving unit 23 is an example of a container moving unit that moves the container 24, and the second moving unit 19 is an example of a plunger moving unit that moves the plunger 26 b of the syringe 26. The container 24 is an example of a drug solution container such as a vial or an infusion bag, for example. Here, the first holding unit 21 holds the container 24. The second holding unit 22 is disposed vertically below the first holding unit 21 and holds the syringe 26 with the needle 25 attached thereto. The first moving unit 23 is controlled by the control unit 40 and moves the first holding unit 21 vertically and vertically. The second moving unit 19 is controlled by the control unit 40 to move the plunger 26 b of the syringe 26 in the vertical vertical direction. A movable plate 19k for fixing the plunger 26b is movably attached to the syringe base 22a. Further, the second holding portion 22 and the second moving portion 19 of the plunger 26b are fixed to the syringe base 22a.

The control unit 40 controls various operations of the drug solution transfer apparatus 20. Specifically, the control unit 40 includes an arithmetic unit 40a, a storage unit 40b, and a determination unit 40c, and controls driving devices such as the

motors

23a and 19m, the first moving unit 23, and the second moving unit 19, respectively. Do. In the storage unit 40b, the identification data of the container 24, the data of the empty amount for each container 24, the data of the position of the rubber plug 30, the data of the thickness of the rubber plug 30, and the sampling of the tip of the needle 25 Data on the position of the tip of the mouth 25a is stored in advance as a database. These data are stored for each rubber plug 30 or each needle 25 or each container 24. Here, the data of the emptying amount for each container 24 is the data of the lowering amount of the plunger 26b at the time of the emptying operation. The camera 100 or the encoder 101 may be used to acquire necessary data and store the data in the storage unit 40 b without storing a part of the data in the storage unit 40 b in advance. Alternatively, the storage unit 40b may be connected to a database storing a prescription or the like by communication or the like to acquire a predetermined amount of the drug solution recorded in the prescription of the database and store the predetermined amount in the storage unit 40b. The operation unit 40a acquires necessary data from the storage unit 40b, and based on the position information of the rubber plug 30 of the container 24 and the position information of the tip of the liquid collection port 25a at the tip of the needle 25 and the position information of the plunger 26b. An arithmetic operation is performed in each step to be described later to obtain the relative position of the liquid collection port 25a with respect to the rubber plug 30, and also obtain the movement amounts of the container 24 and the plunger 26b. The determination unit 40c confirms and determines the end (completion) of the operation in each step described later based on the calculation result in the calculation unit 40a, and outputs a drive stop signal to the drive device such as the

motors

23a and 19m. Output

As the container 24, for example, a vial or an infusion bag is used. The container 24 has a drug solution stored in advance in its inside 24a. In the first embodiment, a vial is used as an example of the container 24 as shown in FIG. 1A. The vial, which is an example of the container 24, is held by the first holding unit 21 in a state where the rubber plug 30 is disposed on the lower side in the vertical direction. In the first embodiment, the state in which the rubber stopper 30 of the vial is disposed on the lower side in the vertical direction is the inverted state of the container 24 (vial). As a material of the rubber plug 30, butyl, chlorinated butyl, butadiene or isoprene is used.

The first holding unit 21 is fixed to the first moving unit 23. As an example, the first moving unit 23 has a motor 23a whose rotation axis rotates forward and reverse, a ball screw shaft 23b rotated forward and reverse by the rotation of the rotation axis of the motor 23a, and a movable plate engaged with the ball screw shaft 23b. And 23c. The movable plate 23 c is connected to the first holding unit 21 and vertically moves together with the first holding unit 21. The motor 23a is driven and controlled by the control unit 40 to rotate the rotation shaft in the forward and reverse directions, and functions as an example of a first moving unit driving device.

A gasket 31 is fixed to the tip of the plunger 26b. The drug solution transferred into the syringe 26 or the gas (for example, air) sucked into the syringe 26 contacts the gasket 31. In the following description, in order to simplify the description, the gasket 31 is not referred to and is simply described as the plunger 26 b. In the first embodiment, the surface of the gasket 31 is the upper end surface of the plunger 26b.

The drug solution transfer method of the first embodiment is a method for transferring a drug solution between the container 24 and the syringe 26 by controlling the drug solution transfer apparatus 20 including the above-described components.

As shown in FIG. 2, the drug solution transfer method according to the first embodiment includes step S01, which is an example of a data acquisition step, step S02, which is an example of a blanking step, and step S03, which is an example of a needle insertion step. Performing step S04, which is an example of the first push and pull step, step S05, which is an example of the drug solution transfer step, step S06, which is an example of the negative pressure adjustment step, and step S07, which is an example of the withdrawal step. Will be implemented in Among these, steps S01 to S03 are performed before the predetermined amount of the drug solution 27 is transferred (moved) from the inside 24a of the container 24 to the inside 26a of the syringe 26.

In step S01, the control unit 40 performs various types of data on the position of the rubber plug 30 of the container 24, data on the thickness of the rubber plug 30, data on the position of the tip of the liquid collection port 25a at the tip of the needle 25, etc. Acquired from the sensor and storage unit 40b. The various sensors are, for example, the camera 100 attached to the front or side of the syringe 26, the encoder 101 for measuring the movement amount of the first moving unit 23 of the first holding unit 21, or the second movement of the second holding unit 22. The encoder 102 measures the amount of movement of the unit 19. The

encoders

101 and 102 are an example of a position sensor as a movement amount detection device. Step S01 is, specifically, based on the information acquired by the camera 100 or the encoder 101 and the information stored in the storage unit 40b, the collection of the needle 25 with respect to the position and thickness of the rubber plug 30 of the container 24. The relative position of the mouth 25a is detected.

Step S02 is a step of emptying a predetermined amount of gas into the interior 26a of the syringe 26 before puncturing the needle 25 into the container 24. Specifically, in step S 02, the plunger 26 b of the syringe 26 is lowered by driving the motor 19 m of the second moving unit 19 in a state where the needle 25 is not inserted into the container 24. By drawing a predetermined amount of gas from the inside of the needle 25 into the syringe 26, it is evacuated. In the first embodiment, this suction forms an air reservoir between the surface 31a (see FIG. 4) of the gasket 31 of the plunger 26b in the syringe 26 and the inner wall surface 26h (see FIG. 4) of the tip 26j of the syringe 26. A constituent gas 28 is present.

Step S03 is a step of inserting the needle 25 into the container 24 by causing the needle 25 to puncture the rubber plug 30. Here, in the operation in which the needle 25 punctures the rubber plug 30, the container 24 is lowered by driving the motor 23a of the first moving unit 23, and the liquid collection port 25a of the needle 25 is inserted into the container 24. It is a step. In the first embodiment, the container 24 is lowered to puncture the needle 25 of the syringe 26 into the rubber plug 30 of the container 24. However, the syringe 26 is raised and the needle 25 is inserted into the rubber plug 30 of the container 24 Also good. That is, the container 24 and the needle 25 may be moved relative to each other to puncture the needle 25 in the rubber plug 30 of the container 24.

Step S04 is a step of transferring the drug solution 27 or the gas 28 between the container 24 and the syringe 26 by pushing and pulling the plunger 26b of the syringe 26. The discharge of a predetermined amount of gas 28 from the syringe 26 to the container 24 or the suction of the chemical solution 27 from the container 24 to the syringe 26 is the same operation as in the prior art, and thus the detailed description is omitted. Here, the step of discharging the gas 28 of a predetermined amount or suctioning the chemical solution 27 is performed by driving the motor 19 m of the second moving unit 19 forward and reverse to move the plunger 26 b of the syringe 26 up and down.

In step S04, the speed at which the plunger 26b is pulled is made lower than the speed at which the plunger 26b is pushed, thereby reducing the occurrence probability of air bubbles in the push and pull operation in step S04, and the accuracy of the transfusion operation. Can be raised. According to the experiments of the inventors, the transfer speed is set to 1 m / s or less for the pulling speed of the plunger 26b (the suction speed for the drug solution) and 5 m / s or more for the pressing speed (the drug discharge speed) to the plunger 26b. I was able to improve the accuracy of the operation.

Step S05 is a step of transferring a predetermined amount of the drug solution 27 from the container 24 to the inside 26a of the syringe 26. Here, the step of transferring the chemical solution 27 of a predetermined amount is performed by driving the motor 19 m of the second moving unit 19 to lower the plunger 26 b of the syringe 26.

Step S06 is a step of adjusting the pressure of the gas 28 in the container 24 to a negative pressure by returning a part of the drug solution 27 in the syringe 26 to the container 24. In the step of returning a part of the drug solution 27 to the container 24, the motor 19 m of the second moving unit 19 is driven to raise the plunger 26 b of the syringe 26 to discharge a part of the drug solution 27 in the syringe 26 into the container 24. It does by doing.

Step S07 is a step of pulling out the needle 25 of the syringe 26 from the rubber plug 30 of the container 24. Here, the operation of pulling out the needle 25 is to move the needle 25 relatively in the direction away from the container 24 by raising the container 24 in the direction of the arrow 24 c by driving the motor 23 a of the first moving unit 23. To do.

In the first embodiment, by performing step S02 prior to step S03 of FIG. 2, the air (not shown) previously existing in the inside of the needle 25 is drawn to the inside 26 a of the syringe 26 so that the needle 25 can be operated. It is possible to treat the gas in the inside of the needle 25 and the evacuated gas as one mass of gas in the vicinity of the inside of the nozzle 26 and the mouth 26 x of the syringe 26. Here, the opening 26 x of the syringe 26 is in the vicinity of the tip 26 j of the syringe 26 and is a portion connecting the needle 25 and the inside 26 a of the syringe 26.

That is, in the first embodiment, the gas in the needle 25 and the gas outside the syringe 26 are integrally suctioned by performing the empty pulling operation in step S02. As a result, the possibility of irregular mixing of air and the drug solution 27 in the syringe 26 is reduced, and the generation of small air bubbles in the drug solution 27 transferred into the syringe 26 can be suppressed. As a result, transfusion of the drug solution 27 becomes possible in a state where generation of small air bubbles is suppressed, the possibility of deterioration of transfusion accuracy due to air bubbles is reduced, and transfusion of the drug solution 27 with high accuracy becomes possible. In the first embodiment, the transfer of the drug solution is described as an example, but it goes without saying that the mixing of the drug solution by the transfer of the drug solution is an example of the transfer of the drug solution.

According to the first embodiment, when the chemical solution 27 starts to be sucked into the syringe 26, the generation of air bubbles can be suppressed by performing the empty pulling in this manner. Specifically, the gas 28 and the drug solution 27 remaining inside the needle 25 are rapidly dropped in a narrow space surrounded by the inner wall surface 26 h of the syringe 26 and the gasket 31 of the plunger 26 by performing the emptying. It is possible to suppress the generation of air bubbles due to being mixed in the If generation of air bubbles can be suppressed in this manner, almost no air bubbles will be present inside the syringe 26, and transfusion of the drug solution 27 can be performed with high accuracy. For example, in a 20 ml syringe, although the variation in transfusion amount was 0.107 ml when the blanking process in step S02 in FIG. 2 was not performed, the blanking process in step S02 in FIG. 2 was performed The variation of the transfusion amount in the case (in the case of the first embodiment) was 0.025 ml. Also, according to the experiments of the inventors, air bubbles that affect the accuracy of transfusion have a diameter of 50 μm or more and 3 mm or less, and in particular, air bubbles with a small diameter adhere to the wall surface of the syringe 26 and are difficult to peel off from the wall surface I know. The first embodiment is considered to be particularly effective in suppressing the generation of air bubbles of this size.

Next, the basic operation of the drug solution transfusion apparatus 20 of the first embodiment will be described. Here, as shown in FIG. 1A, the chemical solution transfer apparatus 20 in which the container 24 is disposed in the upper part in the vertical direction and the syringe 26 is disposed in the lower part along the axial center of the container 24 will be described as an example. .

The syringe 26 is held by the second holding portion 22 in a state where the needle tip of the needle 25 is directed substantially upward in the vertical direction. The plunger 26 b of the syringe 26 is freely moved up and down by the second moving unit 19 along the direction (vertical direction) of the arrow 26 d. As an example, the second moving unit 19 vertically moves together with the motor 19m whose rotation axis rotates forward and reverse, the ball screw shaft 19p rotated forward and reverse by the rotation of the rotation axis of the motor 19m, and the plunger 26b. And a movable plate 19k. The motor 19m functions as an example of a drive unit for the second moving unit, and is drive-controlled by the control unit 40 to rotate the rotation shaft in the forward and reverse directions. The movable plate 19k is coupled to the plunger 26b and engaged with the ball screw shaft 19p. By driving the motor 19m under the control of the control unit 40, the plunger 26b moves up and down in the direction of the arrow 26d to transfer the chemical solution 27 or gas between the inside 26a of the syringe 26 and the inside of the container 24. It can be carried out.

In the first embodiment, since the first holding unit 21 is disposed in the upper part in the vertical direction and the second holding unit 22 is disposed in the lower part in the vertical direction, when the container 24 is held in an inverted state, The drug solution 27 moves to a region adjacent to the rubber plug 30 in the container 24. Therefore, the drug solution 27 can be easily sucked from the needle 25 of the syringe 26.

Here, in the needle insertion operation of step S03, the confirmation as to whether or not the needle 25 has been punctured by the rubber plug 30 and completely penetrated is specifically performed as follows. In the first embodiment, the state in which the needle 25 completely penetrates the rubber plug 30 is the state in which the liquid collection port 25 a of the needle 25 is inserted into the container 24. Therefore, based on the data stored in the storage unit 40b, the calculation unit 40a calculates the relative position of the liquid collection port 25a before the movement with respect to the position of the container 24 and the position and thickness of the rubber plug 30, The relative position of the liquid collection port 25a after movement with respect to the positions of the container 24 and the rubber plug 30 is calculated by calculating the amount of movement of the container 24 by the detection operation of the encoder 101 of the first moving unit 23. Then, based on the position of the liquid collection port 25a relative to the position of the container 24 and the rubber plug 30 determined by the calculation unit 40a, the determination unit 40c of the control unit 40 determines whether the needle 25 completely penetrates the rubber plug 30 Confirm and judge. Here, when the determination unit 40c determines that the needle 25 completely penetrates the rubber plug 30, the drive stop signal is output from the determination unit 40c to the motor 23a of the first moving unit 23 to drive the motor 23a. The operation is stopped, and the liquid collection port 25 a at the tip of the needle 25 is held in the state of being inserted into the container 24. On the other hand, when the judgment unit 40c judges that the needle 25 does not completely penetrate the rubber plug 30, the motor 23a is kept driven until the needle 25 completely penetrates the rubber plug 30.

In the push and pull operation in step S04, the position of the liquid surface of the chemical solution 27 in the syringe 26 is detected by the imaging operation of the camera 100, and the amount of movement of the encoder 102 is calculated. The transfusion amount is calculated by calculating the increase or decrease of the amount of. For example, when the movement of the gas 28 in the syringe 26 into the container 24 is confirmed, a predetermined amount of gas (the gas 28 forming the air pool) based on the change in the position of the liquid surface of the drug solution 27 in the syringe 26 The determination unit 40c confirms and determines whether all the ink has been discharged into the container 24 or not. Here, when the determination unit 40c determines that all the predetermined amount of gas has been discharged to the container 24, the drive stop signal is output to the motor 19m of the second moving unit 19 to stop the drive of the motor 19m. On the other hand, when the determination unit 40c determines that the predetermined amount of gas is not discharged into the container 24, the motor 19m is kept driven until the plunger 26b is raised by the amount of movement.

Next, a series of operations of the drug solution transfer method of the first embodiment will be described using FIGS. 3A to 3J and FIG. 4. FIGS. 3A to 3J are partial cross-sectional views of the drug solution transfer device 20 according to the first embodiment of the present invention, showing the positional relationship between the container 24 and the syringe 26. In FIGS. 3A to 3J and FIG. 4, in order to make it easy to understand the position of the needle 25 in the inside 24 a of the container 24, the amount of the drug solution 27, the position and size of the air bubbles, etc. , In a cross-sectional view. FIG. 4 is a view for explaining a state in which the inner wall surface 26h at the tip of the syringe 26 does not get wet with the drug solution 27 at the time of transfer of the drug solution 27, and as a result, adhesion of air bubbles is prevented. Since the wetted surface is likely to adhere and be difficult to remove air bubbles, the first embodiment capable of transfusion of the drug solution without wetting the inner wall surface 26h of the syringe 26 can maintain high accuracy. (A) of FIG. 4 shows the state immediately after the start of drug solution transfer operation (the state immediately before the state of FIG. 3D), (b) of FIG. 4 shows the state of FIG. 3D, (c) of FIG. The state of FIG. 3E is shown, (d) of FIG. 4 shows the state immediately before FIG. 3F, and (e) of FIG. 4 shows the state of FIG. 3F.

First, FIG. 3A shows an initial state, for example, immediately after taking out the syringe 26 from the sterilization pack of the syringe 26 before moving a predetermined amount of the drug solution 27 from the container 24 to the inside 26 a of the syringe 26. In this initial state, as shown in FIG. 3A, the plunger 26 b is located near the tip 26 j of the syringe 26. In this initial state, the inner wall surface 26h of the tip 26j of the syringe 26 and the gasket 31 at the tip of the plunger 26b are not in direct contact, but the gasket 31 of the inner wall surface 26h of the tip of the syringe 26 and the tip of the plunger 26b is The gap with is as small as possible. In this initial state, the gas 28 in the syringe 26 is approximately zero on the scale of the syringe 26.

In the first embodiment, in such an initial state, as shown in FIG. 3B, blanking is performed (see step S02 in FIG. 2). Specifically, for example, in a syringe having a volume of 2.5 ml, air having a volume of 0.1 ml or more and less than 0.5 ml is evacuated. In a 20 ml syringe or 50 ml syringe, air of 0.5 ml or more and less than 2.0 ml is evacuated. The amount of emptying here does not depend on the diameter and length of the needle 25. Here, the reason for setting the maximum amount of emptying is that if the amount of emptying is large, the generation of air bubbles can be suppressed, but transfer takes time and work efficiency is deteriorated. The minimum amount of emptying is set because, if the amount of emptying is too small, the inner wall surface 26h of the tip 26j of the syringe 26 gets wet with the transferred chemical solution 27. Moreover, as an example of the movement distance of the plunger 26b at the time of a pull-down operation | movement, it is 5 mm or more. This is because if the moving distance of the plunger 26b is smaller than 5 mm, the distance between the gasket 31 and the inner wall surface 26h of the syringe 26 is too small, and the transferred chemical solution 27 strikes the gasket 31 and scatters and adheres to the inner wall surface 26h It is because there is a possibility. When the movement distance of the plunger 26b is 5 mm or more, the distance between the gasket 31 and the inner wall surface 26h of the syringe 26 is sufficiently large, the transferred chemical solution 27 strikes the tip of the plunger 26b and spatters off and the inner wall surface 26h The possibility of adhering to

In FIG. 3C, the container 24 is moved down via the rubber plug 30 while keeping the evacuated gas in the interior 26a of the syringe 26 (ie, maintaining the gas 28 as an air reservoir in the syringe 26). A state in which the needle 25 is punctured in the container 24 is shown (see step S03 in FIG. 2).

FIGS. 3D and 4B show a state where the liquid medicine 27 in the container 24 is sucked into the syringe 26 by pushing down the plunger 26b of the syringe 26 in the direction of the arrow 26e from the state of FIG. 3C. . Here, in the first embodiment, immediately after the start of the suction operation, as shown in (a) to (b) of FIG. 4 and FIG. 3D, the gas 28 is preliminarily contained in the syringe 26 to form a lump of air pool. By doing so, the air (not shown) present inside the needle 25 is prevented from becoming a small air bubble.

Furthermore, as shown in FIG. 3D and FIG. 4B, the plunger 26b of the syringe 26 is pushed downward in the direction of the arrow from the state of FIG. Aspirate to 26

In FIG. 3E and (c) of FIG. 4, the depressing operation of the plunger 26 b is stopped, and the chemical solution 27 is accumulated on the gasket 31, and the gas 28 as an air accumulation remains on the accumulated chemical solution 27. It shows.

Thereafter, the plunger 26b is pushed up in the direction of the arrow 26f, and as shown in FIGS. 3F to 3G and (d) to (e) in FIG. 28) are discharged into the container 24 as a mass of air 26y. The operation shown in FIGS. 3D to 3G is step S04 shown in FIG.

After the gas 28 in the syringe 26 is pushed out into the container 24 as a mass of air 26y in step S04, as shown in FIG. 3H, the plunger 26b is pulled in the direction of the arrow 26e, It is moved into the syringe 26 (see step S05 in FIG. 2). When this step S05 is performed, the volume of the gas 36 in the container 24 is increased by the volume of the drug solution 27 transferred (moved) into the syringe 26. As a result, the pressure of the gas 36 in the container 24 with the increased volume is reduced from atmospheric pressure to negative pressure.

Therefore, in the first embodiment, as shown in FIG. 3I, the pressure in the container 24 maintains a negative pressure to such an extent that the liquid medicine 27 does not leak from the tip of the needle 25 (hereinafter referred to as spill). I'm adjusting. Specifically, in the first embodiment, part of the drug solution 27 in the inside 26a of the syringe 26 is returned to the container 24 by raising the plunger 26b of the syringe 26 (see step S06 in FIG. 2). Thereby, the pressure of the gas 36 in the container 24 is adjusted to the optimal negative pressure.

Thereafter, as shown in FIG. 3J, the container 24 is relatively raised, and the needle 25 attached to the tip of the syringe 26 is pulled out of the rubber plug 30 of the container 24 (see step S07 in FIG. 2).

FIG. 5: is a side view which shows the chemical | medical solution mixing apparatus 32 provided with multiple transfusion modules as an example of the chemical | medical solution transfusion apparatus 20 which concerns on 1st Embodiment of this invention.

As shown in FIG. 5, the chemical solution mixing device 32 has a cylindrical third holding portion 33 in a chemical solution mixing area 32b surrounded by a cylindrical outer wall 32a. The chemical solution mixing area 32b is an area for forming a working space for reliably preventing the leakage of the chemical solution 27 to the outside of the apparatus. The cylindrical third holding portion 33 is configured by the second holding portion 22 and the first holding portion 21 which are divided in the vertical direction along the central axis 32 c.

The chemical liquid mixing apparatus 32 includes the first moving unit 23, the second moving unit 19, and the control unit 40 in addition to the third holding unit 33.

The control unit 40 controls the position of the combination of the syringe 26 and the container 24 (hereinafter referred to as the mixing set) around the axis of the cylindrical support 35 at a plurality of positions. The plurality of positions include at least an installation position and a chemical solution transfer position. Here, the installation position is a position for installing the syringe 26 and the container 24 in the drug solution mixing device 32, and the drug solution transfer position is a position for performing the drug solution transfer method of steps S01 to S07 described above. is there.

The second holding unit 22 and the first holding unit 21 are configured to include a plurality of

holders

34a and 34b, respectively. In addition, the second holding unit 22 and the first holding unit 21 are independently rotatable around the central axis 32c of the support unit 35 under the control of the control unit 40, and are relatively rotated. Thus, the selected syringe 26 and the selected container 24 can be switched to be aligned in the vertical direction.

Moreover, the 2nd holding part 22 of the chemical | medical solution mixing apparatus 32 shown in FIG. 5 can hold | maintain multiple types of syringes 26 irrespective of a shape in each of

several holder

34a, 34b. The syringe 26 may have different shapes, such as “volume 2.5 ml”, “volume 20 ml”, “volume 50 ml”, etc., depending on the type of the drug solution 27 to be aspirated. In the first embodiment 32, a dedicated jig corresponding to the syringes 26 of a plurality of types of shapes is prepared, and the outer cylinder of the syringes 26 of a plurality of types of shapes can be securely fixed and held. Furthermore, in the first embodiment, also in the second moving unit 10, a dedicated jig corresponding to the plungers 26b having different shapes is prepared.

In addition, in the chemical | medical solution mixing apparatus 32, you may make it perform each step not only what implements a chemical | medical solution transfusion method in one position (chemical | medical solution transfusion position) but a different position for every step. For example, after disposing the mixing set at the installation position, an empty pulling position for performing step S02, a needle insertion position for performing step S03, a primary push / pulling position for performing step S04, a drug solution transfer position for performing step S05, and step S06 The negative pressure adjustment position and the extraction position at which step S07 is performed may be performed at different positions. In this case, the first moving unit 23 or the second moving unit 19 or the like is required at each position. The present invention is not limited to this, and it goes without saying that two or three steps may be performed at one position.

With such a configuration, the chemical solution mixing device 32 can efficiently and safely mix the chemical solution 27 even when mixing the plurality of types of chemical solution 27 using the plurality of types of containers 24 and the plurality of types of syringes 26.

Here, in order to confirm the effect of the drug solution transfer apparatus 20 and the drug solution mixing apparatus 32 according to the first embodiment, conventional drug solution mixing will be described using FIGS. 6A to 8B. 6A to 8B are diagrams for explaining a conventional drug solution transfer method. In particular, FIG. 7 is a view for explaining a state in which the inner wall surface 26h at the tip of the syringe 26 is partially wetted by the chemical solution 27, and air bubbles adhere to the wetted surface. 7 (a) shows the state of FIG. 6A, FIG. 7 (b) shows the state of FIG. 6B, and FIG. 7 (e) shows the state of FIG. 6C. In order to make it easy to understand, here, the case where the conventional drug solution transfer method is performed using the syringe 26 and the container 24 of the drug solution transfer apparatus according to the first embodiment will be described.

In the conventional drug solution transfer method, the emptying (step S02 in FIG. 2) is not performed as in the first embodiment. After the needle 25 is inserted into the container 24 (step S03) as shown in FIG. 6B from the initial state shown in FIG. 6A without emptying (ie, without step S02), FIG. 6C and FIG. As shown in a) to (e), the plunger 26b is pushed down in the direction of the arrow 26e to aspirate the drug solution 27 from the container 24 into the syringe 26 (step S04). In the conventional drug solution transfer apparatus, at this time, air bubbles 29 shown in FIG. 6C may be generated.

That is, in (a) of FIG. 7, the plunger 26 b is pushed downward in the vertical direction, and suction of the drug solution 27 from the container 24 into the inside 26 a of the syringe 26 is started. Then, since there is almost no gap between the gasket 31 and the inner wall surface 26 h of the syringe 26, the chemical solution 27 sucked into the syringe 26 has no clearance for the drug solution 27 that collides with the gasket 31, and a complicated flow It becomes easy to generate small air bubbles. If suction is continued in this state, as shown in FIG. 7B, when the chemical solution 27 collides with the gasket 31 and spatters, a small air bubble 29 is generated.

Then, as shown in (c) to (e) of FIG. 7, when the plunger 26 b is further pressed downward in the vertical direction, the inside of the syringe 26 is filled with the drug solution 27. In many cases, the air bubbles 29 attached to the inner wall surface 26h of the syringe 26 in a) and b) remain. Furthermore, when the air bubble 29 adheres while the inner wall surface 26 h is wet, the air bubble 29 becomes difficult to peel off, and may not peel off even if the syringe 26 is vibrated.

On the other hand, as described above, according to the first embodiment, generation of small air bubbles (conventional small air bubbles 29) in the chemical solution 27 is suppressed, and variations in transfusion amount are reduced. Transfusion and mixing can be performed precisely. As an example of the variation reduction of the transfusion amount, in the case where the first embodiment is not applied, there is an error of 0.107 ml at 3σ in the case of applying the first embodiment in a syringe having a volume of 20 ml. Is an error of 0.025 ml at 3σ, and the variation can be reduced by 77%. Moreover, in a syringe with a volume of 50 ml, there is an error of 0.095 ml at 3σ when the first embodiment is not applied, but an error of 0.035 ml at 3σ when the first embodiment is applied. The variation can be reduced by 63%.

Second Embodiment
FIG. 8 is a cross-sectional view of a transfer needle 51 used in the drug solution transfer method according to the second embodiment of the present invention. The drug solution transfer method of the second embodiment differs from the first embodiment in that a transfer needle 51 shown in FIG. 8 is used instead of the needle 25 of the first embodiment described above, and the other embodiment is the first embodiment. And the description of the same parts will be omitted.

The needle used in the second embodiment is a transfusion needle 51 including a cylindrical needle base 52, a first needle 53, and a second needle 54, as shown in FIG. Here, the needle base 52 is attached to the end of the syringe 26. The first needle 53 has an air passage 55 inside. The second needle 54 is longer than the first needle 53 and disposed parallel to the first needle 53. Further, the first needle 53 is provided with a first air vent 56 which is one end of the air passage 55 at the tip end side of the second needle 54 than the second air vent 57 which is the other end. The second needle 54 connects one end of the liquid passage 58 to the inside of the needle base 52, and the other end is a liquid passage port 59 of the second needle 54. The second needle 54 also has a tip 54 a having a liquid passage 59 and a base 54 b connected to the needle base 52.

A case will be considered where the drug solution 27 in the container 24 is aspirated from the passage opening 59 of the second needle 54 using the transfusion needle 51 configured as described above. The drug solution 27 is aspirated from the liquid passage port 59 of the second needle 54 and transferred to the inside 26 a of the syringe 26 through the inside of the second needle 54 and the needle base 52. Then, since the chemical solution 27 inside the container 24 decreases and the volume of the gas 36 inside the container 24 increases, the pressure of the gas 36 inside the container 24 decreases and the pressure of the gas 36 becomes lower than atmospheric pressure. . Here, in the second embodiment, since the transfer needle 51 is used, when the pressure of the gas 36 is lower than the atmospheric pressure, the atmosphere outside the container 24 is the second vent 57 of the first needle 53. The pressure difference between the inside 24a of the container 24 and the atmospheric pressure is reduced. The drug solution transfer method according to the second embodiment uses this transfer needle 51, so a large force is not necessary between suction of the drug solution 27 and completion of suction of a predetermined amount, and the pumping operation is also performed. It is not necessary. Further, in the drug solution transfer method of the second embodiment, as in the first embodiment described above, the empty pulling operation of step S02 of FIG. 2 is performed before transferring the drug solution 27 from the container 24 to the syringe 26. The generation of the air bubbles 29 can be suppressed, and transfusion and mixing of the chemical solution can be performed accurately and efficiently.

In the second embodiment, regardless of the transfusion amount, it is possible to set the emptying amount at step S02 which is the emptying operation constant. On the other hand, in the first embodiment described above, in the case of moving the chemical solution 27 using the pumping operation, it is necessary to change the emptying amount in step S02 according to the transfusion amount. However, the second embodiment is the same as the second embodiment for a small amount of transfusion that does not require a pumping operation. The small amount of transfusion referred to here means, for example, transfusion of 2 ml or less.

Further, in the first and second embodiments, the case where the first holding unit 21 is moved by the first moving unit 23 has been described, but the second holding unit 22 is moved first while the first holding unit 21 is fixed. Even if it moves by the part 23, it can be set as the same movement relatively.

In addition, the effect which each has can be show | played by combining suitably the arbitrary embodiment or modification of said various embodiment or modification.

According to the drug solution transfer method and the drug solution transfer apparatus according to the present invention, since the drug solution can be transferred with high accuracy, it is useful, for example, for drug solution transfer in a hospital or the like.

While the present invention has been fully described in connection with the preferred embodiments with reference to the accompanying drawings, various changes and modifications will be apparent to those skilled in the art. Such variations or modifications are to be understood as being included therein without departing from the scope of the present invention as set forth in the appended claims.

Claims

Using the syringe disposed vertically below the container having the drug solution inside, the needle of the syringe is transferred to the container in a state where an air reservoir exists between the gasket of the plunger of the syringe and the inner wall surface of the syringe After puncture
Moving the plunger to transfer the drug solution from the container to the syringe via the needle;
Chemical solution transfer method.
In the state where the air pool exists between the gasket and the inner wall surface of the syringe, a gap of 5 mm or more is formed between the gasket and the inner wall surface of the syringe.
The drug solution transfer method according to claim 1.
The volume of the air reservoir is 0.1 ml or more and less than 0.5 ml when the volume of the syringe is 2.5 ml, and 0.5 ml or more and less than 2.0 ml when the volume of the syringe is 20 ml or 50 ml Is
The drug solution transfer method according to claim 1 or 2.
When transferring the drug solution from the container to the syringe, the plunger is moved so that the drug solution hitting the gasket and splattering does not fly to the inner wall surface of the tip of the syringe.
The drug solution transfer method according to claim 1 or 2.
Before puncturing the needle into the container, the plunger of the syringe is moved to suck the gas outside the syringe and the gas inside the needle into the syringe to form the air reservoir.
The drug solution transfer method according to claim 1 or 2.
When transferring the drug solution from the container to the syringe, the moving speed of the plunger is 1 m / s or less.
The drug solution transfer method according to claim 1 or 2.
Moving the air reservoir in the syringe to the container before the transfer of the drug solution is completed and before the needle is withdrawn from the container;
The drug solution transfer method according to claim 1 or 2.
The negative pressure in the container is adjusted by transferring the drug solution from the syringe to the container before the transfer of the drug solution is completed and the needle is pulled out of the container.
The drug solution transfer method according to claim 1 or 2.
A first holding unit that holds a container having a chemical solution therein;
A second holding unit disposed below the container in the vertical direction and holding a syringe with a needle;
A first moving unit that moves the first holding unit up and down in the vertical direction;
A second moving unit configured to move the plunger of the syringe held by the second holding unit up and down in the vertical direction;
A control unit that controls the first moving unit and the second moving unit;
The control unit relatively moves the first holding unit downward in the vertical direction in a state in which an air reservoir exists between the gasket of the plunger and the inner wall surface of the syringe, and the container is the container. And puncturing, the plunger is moved to transfer the drug solution from the container to the syringe.
Chemical solution transfer device.
The control unit forms a gap of 5 mm or more between the gasket and the inner wall surface of the syringe when puncturing the needle into the container.
The drug solution transfer apparatus according to claim 9.
The volume of the air reservoir formed by the control unit is 0.1 ml or more and less than 0.5 ml when the volume of the syringe is 2.5 ml, and 0 when the volume of the syringe is 20 ml or 50 ml. Not less than .5 ml and less than 2.0 ml,
The drug solution transfusion apparatus according to claim 9 or 10.
The first holding unit and the second holding unit respectively hold a plurality of the containers and the syringes, and switch the plurality of containers and the syringes to transfer a chemical solution.
The drug solution transfusion apparatus according to claim 9 or 10.
The control unit controls the second moving unit to move the plunger before puncturing the needle into the container, thereby moving the external gas of the syringe and the internal gas of the needle into the syringe. Suction to form the air pool,
The drug solution transfusion apparatus according to claim 9 or 10.