JP2014117295A - Medication mixing method - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a medication mixing method which directly prevents a phenomenon of leakage of medication, such as spill thereof, when adjusting or mixing the medication.SOLUTION: A medication mixing method using a medication mixing device 20 comprises ejecting medication 50 in a syringe 11 to a medication container 12 for mixing. When puncturing a needle 11a fitted to the syringe 11 into a rubber stopper 12a of the medication container 12, the needle 11a of the syringe 11 is punctured into the rubber stopper 12a of the medication container 12 while not gripping a plunger 11g of the syringe 11.

Description

  The present invention relates to drug mixing in which a drug is mixed using a syringe in a medical field.

  In hospitals and the like, in order to apply drugs to hospitalized patients, several types of drugs are often taken out from different drug containers and mixed. Among drugs applied at hospitals, some drugs such as anticancer drugs should be handled with due consideration for safety. Therefore, it is desired to develop a medicine mixing device that can be handled safely and reduces the work load.

  By the way, when mixing a drug from a drug container such as an infusion bag or a vial using a syringe, when mixing the drug and removing the needle of the syringe from the drug container, from the rubber stopper of the drug container or the needle tip of the syringe There is a case in which a liquid medicine leaks (hereinafter referred to as “spill”). Spills are problematic because they are volatile and have strong side effects on the human body (such as anticancer drugs). Therefore, there has been proposed a device that performs a drug mixing operation only inside the drug mixing device and prevents a person outside the device from being exposed to an anticancer drug or the like even if the drug leaks inside the device ( For example, see Patent Document 1).

  FIG. 12 shows a schematic plan view of a drug mixing device 1 of Patent Document 1 as an example of a conventional drug mixing device. The drug mixing device 1 shown in FIG. 12 has a storage chamber 4 surrounded by a box-type holding frame 5 or the like. The storage chamber 4 stores a magazine 2 and a dispensing station 3 for mixing medicines. In the magazine 2, a container 7 is disposed around a shaft 8 that is a central axis. The container 7 includes a plurality of grip conveyance units 6 that contain the medicine, and the desired grip conveyance unit 6 can be selected and acquired by rotating the container 7. When mixing the medicine, the grip transport means 9 arranged between the magazine 2 and the dispensing station 3 selects and acquires the grip transport unit 6 containing the medicine from the container 7 and transports it to the dispensing station 3. .

  An access aperture 10 is provided between the position where the magazine 2 is arranged and the box-type holding frame 5, and a sterile air flow flows vertically between the access aperture 10 and the box-type holding frame 5. ing. The sterile air flow and the access aperture 10 prevent the air inside the drug mixing device 1 from flowing out to the external environment. Thereby, even when a phenomenon in which a drug such as a spill leaks during mixing of the drugs, a person outside the drug mixing apparatus 1 can be prevented from being exposed to the anticancer drug or the like due to the spill or the like.

Special table 2009-544391

  However, in the conventional drug mixing device 1, it is possible to prevent the air inside the drug mixing device 1 from being exposed to the outside, but it is not possible to prevent a spill that is a phenomenon in which the drug leaks into the drug mixing device 1. Therefore, when a spill occurs, in order to avoid an influence on other drugs arranged in the drug mixing device 1, a process of wiping the drug quickly and detoxifying by neutralization or the like is necessary. . However, those who do these treatments may be exposed to drugs such as anticancer drugs during the treatment.

  This invention solves this subject, and it aims at providing the chemical | medical agent mixing method which can prevent the phenomenon where chemical | medical agents, such as a spill, leak when mixing a chemical | medical agent.

  In order to achieve the above object, the drug mixing method of the present invention is a drug mixing method in which a drug in a syringe is discharged and mixed into a drug container, and is attached to the syringe with respect to a rubber stopper of the drug container. When the needle is punctured, the rubber stopper is punctured with the needle without holding the plunger of the syringe.

  ADVANTAGE OF THE INVENTION According to this invention, the chemical | medical agent mixing method which can prevent the phenomenon that a chemical | medical agent leaks inside an apparatus when preparing or mixing a chemical | medical agent is realizable.

The top view which shows the chemical | medical agent mixing apparatus concerning Embodiment 1 of this invention. The front view which shows the principal part of the chemical | medical agent discharge part of the chemical | medical agent mixing apparatus concerning this Embodiment 1. FIG. The front view which shows the principal part of the chemical | medical agent discharge part of the chemical | medical agent mixing apparatus concerning this Embodiment 1. FIG. The figure for explaining the phenomenon that medicine leaks in the work of medicine mixing Flowchart of drug mixing method according to the first embodiment (A), (b), (c) Front view which shows plunger holding | grip operation | movement of the chemical | medical agent mixing apparatus of this Embodiment 1. FIG. The figure which shows the positional relationship of a plunger and a plunger holding part The figure which shows the positional relationship of a plunger and a plunger holding part Sectional drawing of the vicinity of the tip of the syringe in a state where gas has been sucked too much into the syringe Plan view of a conventional drug mixing device

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. In addition, the same code | symbol is attached | subjected to the same component and description may be abbreviate | omitted. Further, the drawings schematically show the respective constituent elements mainly for easy understanding.

(Embodiment 1)
FIG. 1 is a plan view of a drug mixing device 20 used in the method for controlling the drug mixing device according to the first embodiment of the present invention.

  As shown in FIGS. 1 and 2, the medicine mixing device 20 of the first embodiment includes a medicine suction part 21, a transport part 22, a medicine discharge part 23, a frame body 24, a meter 25, and an audit. A machine 26, a shaker 27, a trash box 28, a storage area 30, an operation panel 31, and a control unit 40 are provided.

  The medicine suction unit 21 uses the syringe 11 to suck the medicine from the medicine container 12 into the syringe 11 by a predetermined amount. The medicine discharge unit 23 discharges the medicine sucked into the conveyed syringe 11 by a predetermined amount into another medicine container 12 in which a powder medicine is sealed. For example, the conveyance unit 22 such as a robot arm conveys the syringe 11 or the drug container 12 to be used to the inside of the drug suction unit 21 and the drug discharge unit 23. In the medicine container 12, a gas 12c and a medicine 50a exist. The meter 25 measures the weight of the syringe 11 and the drug container 12 before and after the drug suction and audits the mixing amount. The auditing machine 26 audits the type of the medicine container 12 using an image or the like. The shaker 27 further mixes the mixed medicine by rocking. The trash box 28 is for discarding the medicine container 12 or the like that has finished sucking the medicine. The storage area 30 stores a drug container 12, a syringe 11, an infusion bag 29, and the like containing a drug used for mixing drugs. The operation panel 31 performs operation of the apparatus, input of information, display of the current operation status, and the like. Unless otherwise specified, various operations of the drug mixing device 20 of the first embodiment are controlled by the control unit 40.

  Subsequently, the operation of the medicine ejection unit 23 according to the first embodiment will be described with reference to FIGS.

  2 and 3 are front views showing a main part of the medicine discharge section 23 of the medicine mixing apparatus 20 according to the first embodiment of the present invention. FIG. 4 is a diagram for explaining a phenomenon (spill) in which a drug leaks during a drug mixing operation. FIG. 5 is a flowchart of the operation of the medicine ejection unit 23 of the medicine mixing device 20 according to the first embodiment of the present invention. 6A to 6C are front views showing continuously the plunger gripping operation of the medicine mixing device according to the first embodiment of the present invention.

  As shown in FIGS. 2 and 3, the drug discharge unit 23 of the drug mixing device 20 of the first embodiment includes a syringe holding unit 32, a syringe base 33, a container holding unit 34, a moving mechanism 35, and a plunger. A drive unit 36 and a position measurement unit 41 are provided.

  The syringe holding unit 32 holds the syringe 11 that has sucked the medicine 50 in an upright posture with the tip of the needle 11a directed vertically downward. The syringe base 33 fixes the syringe holding part 32 to the medicine discharge part 23. The container holding part 34 arrange | positions the rubber stopper 12a which is a port part of the chemical | medical agent container 12 vertically upwards, and hold | maintains the chemical | medical agent container 12 which has the chemical | medical agent 50a inside. The moving mechanism 35 moves the container holding part 34 in the vertical up and down direction. The plunger gripping part 37 grips the plunger 11 g of the syringe 11. The plunger driving unit 36 drives the plunger 11 g held by the plunger holding unit 37. The position measuring unit 41 is provided, for example, on the syringe base 33 and includes a light emitting / receiving unit 41a having a light emitting element and a light receiving element. The position measuring unit 41 optically detects the position of the surface of the base 11h of the plunger 11g, and The position of 11g is detected. The position measuring unit 41 is, for example, a laser distance meter.

  When the medicine 50 inside the syringe 11 is discharged to the medicine container 12, the needle 11a of the syringe 11 penetrating the rubber stopper 12a of the medicine container 12 is moved from the state of FIG. After performing a puncturing operation for insertion into the inside of the medicine container 12, a plunger gripping operation for gripping the base 11h of the plunger 11g of the syringe 11 by the plunger gripping portion 37 is performed to the state shown in FIG.

  Here, when the puncture operation is performed in a state where the flange 11c of the syringe 11 and the base 11h of the plunger 11g are fixed to stabilize the puncture operation as in the conventional drug mixing device, as shown in FIG. In some cases, a phenomenon (spill) in which the liquid droplet 11b of the drug leaks out from the upper part of the rubber stopper 12a of the container 12 occurs. This case will be described. The puncture operation in the state shown in FIG. 4 is stable because the plunger 11g and the plunger 11g are fixed, but the resistance between the rubber stopper 12a and the needle 11a is held by the plunger in the medicine inside the syringe 11. It may be transmitted through the part 37 and the plunger 11g and pressure may be applied to the medicine. In this case, before the needle 11a of the syringe 11 penetrates the rubber stopper 12a of the medicine container 12, the medicine droplet 11b may leak to the upper part of the rubber stopper 12a of the medicine container 12. Further, the medicine inside the syringe 11 may leak from the needle 11a due to the gripping force transmitted when the plunger 11g grips the base 11h of the plunger 11g. That is, in the puncturing operation or the grasping operation of the plunger 11g in the conventional drug mixing device, there is a possibility that the drug leaks into the drug mixing device, so that the drug wiping or detoxification processing is necessary. The worker may be exposed to the drug.

  Therefore, in the first embodiment, by performing the medicine mixing operation according to the flowchart shown in FIG. 5, the possibility that the medicine is exposed in the medicine mixing device 20 is reduced even in the puncturing operation or the gripping operation of the plunger 11g. The drug mixing method was realized. The flowchart of the medicine mixing method of the first embodiment shown in FIG. 5 will be described.

  First, in the puncturing step S01, the medicine container 12 is moved by the moving mechanism 35 from the state where the syringe 11 is held in the upright posture by the syringe holding part 32 as shown in FIG. The needle 11a is punctured into the rubber stopper 12a as shown in FIG. At this time, in the first embodiment, as shown in FIGS. 6A and 6B, the plunger 11g is not grasped, and the needle 11a is punctured into the rubber stopper 12a. As described in detail later by performing the puncturing operation without grasping the plunger 11g as described above, in the first embodiment, leakage of the drug during the puncturing operation is prevented.

  Next, in the plunger position measuring step S02, the position of the plunger 11g of the syringe 11 is measured using the position measuring unit 41.

  Next, in the offset amount calculation step S03, an offset amount is set for the position of the plunger 11g measured in the plunger position measurement step S02. The offset amount calculation step S3 will be described later with reference to FIGS.

  Next, in the plunger gripping step S04, based on the position of the plunger 11g measured in the position measuring step S02 and the offset amount calculated in the offset amount calculating step S03, as shown by the arrow in FIG. 37 is moved, and the base 11h of the plunger 11g is gripped by the plunger gripping portion 37 from the horizontal direction. Here, when the plunger gripping portion 37 is moved based on the offset amount, the position where the plunger 11g is gripped is shifted to a position close to the medicine container 12 by the offset amount. Further, by grasping the base 11h of the plunger 11g from the horizontal direction, the possibility that the plunger 11g is displaced is reduced.

  Next, in the mixing step S05, the plunger 11g is pushed by the plunger driving unit 36, and the medicine 50 inside the syringe 11 is discharged into the medicine container 12 by a predetermined amount. Then, the medicine 50 sucked into the syringe 11 and the medicine 50a in the medicine container 12 are mixed to perform medicine mixing.

  In the first embodiment, by performing the puncturing step S01 without holding the plunger 11g in this way, the resistance between the rubber stopper 12a and the needle 11a is prevented from being transmitted to the medicine inside the syringe 11 at the time of puncturing. Yes. Furthermore, in Embodiment 1, since the plunger 11g is gripped after the puncture is completed, even if the gripping force is transmitted to the medicine inside the syringe 11 at the time of gripping, the medicine inside the syringe 11 only moves into the medicine container 12. Thus, the medicine is prevented from leaking from the medicine container 12. Therefore, in the medicine mixing method of the first embodiment, it is possible to realize a medicine mixing method that reduces the possibility that the medicine leaks into the medicine mixing apparatus 20.

  Here, the offset amount calculation step S03 will be described with reference to FIGS. 7 and 8 are front views of the syringe 11 and its vicinity showing the positional relationship between the plunger 11g and the plunger gripping portion 37. FIG. FIG. 9 is a cross-sectional view of the distal end portion of the syringe 11 when the gas is excessively sucked into the syringe 11 when the plunger 11g is gripped. As shown in FIGS. 7 and 8, in the first embodiment, the detection position of the plunger 11g is indicated by the reference line 11j as the position of the base 11h, and this position is 0 in the y direction.

  FIG. 7 is a diagram showing a state in which the plunger gripping portion 37 is disposed at the position of the gripping line 37j representing the position −Δy from the reference line 11j, and the base 11h of the plunger 11g is about to be gripped at this position. Thus, the deviation generated between the reference line 11j and the grip line 37j is the position detection accuracy when the position of the plunger 11g is detected by the position measurement unit 41 or the like, or when the plunger 11g is driven by the plunger drive unit 36. It is caused by driving accuracy. When the base 11h of the plunger 11g is gripped by the positional relationship between the reference line 11j and the gripping line 37j as shown in FIG. 7, the plunger 11g is pushed down closer to the needle 11a when the plunger gripping part 37 grips the base 11h. It will be. Therefore, it is desirable to set the offset amount of the plunger gripping portion 37 in the state shown in FIG. 7 to an upper position (a position far from the medicine container 12) to the extent that this pressing does not occur.

  On the other hand, FIG. 8 is a diagram showing a state in which the plunger gripping portion 37 is disposed at the position of the gripping line 37j representing the position of + Δy from the reference line 11j, and the base 11h of the plunger 11g is about to be gripped at this position. When the base 11h of the plunger 11g is gripped in such a positional relationship, the plunger 11g is pushed away from the needle 11a when the plunger gripping portion 37 grips the base 11h. Then, as shown in FIG. 9, the gas is drawn into the syringe 11, and the gas 11 k enters the joint 11 f of the syringe 11. Here, if the volume of the gas 11k is large, a part thereof adheres to the lower part of the gasket 11d as bubbles 11l. In such a state, when the medicine 50 is ejected, the bubbles 11l which are compressible fluids are interposed between the medicine 50 and the gasket 11d, and the ejection accuracy is deteriorated. Therefore, it is desirable to set the offset amount of the plunger gripping portion 37 in the state shown in FIG. 8 to a lower position (position close to the drug container 12) to the extent that this push-up does not occur.

  The offset amount may be the sum of the position detection error in the position measurement unit 41 and the drive accuracy of the plunger drive unit 36 that drives the plunger 11g, or the position detection error in the position measurement unit 41. The square root of the sum of the square of the square and the square of the drive accuracy of the plunger drive unit 36 that drives the plunger 11g may be adopted. For example, when the position detection error is ± 1 mm and the driving accuracy is ± 1 mm, the offset amount calculated from the addition by simple sum is 2 mm, and the offset amount calculated by the square root of the sum of the square values is 1.41 mm. Become. By setting an offset amount of 2 mm or 1.41 mm and shifting the position closer to the drug container 12 by this offset amount to hold the plunger 11g, the mixing operation is enhanced without generating bubbles 11l inside the syringe 11. Can be done with precision.

  In mixing the medicine 50 sucked into the syringe 11 and the medicine 50a in the medicine container 12, a predetermined amount of medicine is injected without sucking the gas in the medicine container 12 in advance, and the gas 12c in the medicine container 12 is injected. The needle 11a may be withdrawn from the drug container 12 after a part thereof is sucked and the pressure in the syringe 11 is adjusted. Thereby, after completion of the discharge, the pressure of the gas 12c inside the drug container 12 increased by the discharge of the drug 50 can be reduced to the same level as the external pressure, and when the needle 11a is pulled out, the pressure from the drug container 12 can be reduced. Spills can be prevented.

  According to the present invention, it is possible to directly prevent a phenomenon that a medicine leaks when the medicine is mixed, so that it is useful for the medicine mixing in a hospital or the like.

DESCRIPTION OF SYMBOLS 11 Syringe 11a Needle 11b Droplet 11c Flange 11d Gasket 11f Joint part 11g Plunger 11h Base 11j Reference line 11k Gas 11l Bubble 12 Drug container 12a Rubber stopper 12c Gas 20 Drug mixing device 21 Drug suction part 22 Transport part 23 Drug discharge part 24 Body 25 Meter 26 Auditor 27 Shaker 28 Trash box 29 Infusion bag 30 Storage area 31 Operation panel 32 Syringe holding part 33 Syringe base 34 Container holding part 35 Moving mechanism 36 Plunger driving part 37 Plunger gripping part 37j Grasping wire 39 Supporting part 40 Control unit 41 Position measurement unit 41a Light emitting / receiving unit 50, 50a Drug

Claims (4)

A drug mixing method for discharging and mixing a drug in a syringe into a drug container,
When the needle attached to the syringe is punctured against the rubber stopper of the drug container, the needle is punctured into the rubber stopper without holding the plunger of the syringe.
Drug mixing method. After puncturing the rubber stopper with the needle, the position of the plunger is measured and an offset amount is set with respect to the measured plunger position, and the position for gripping the plunger is shifted based on the offset amount.
The drug mixing method according to claim 1. The offset amount is a sum of an error in detecting the position of the plunger and a driving accuracy of a plunger driving unit that drives the plunger.
The drug mixing method according to claim 2. The offset amount is a square root of the sum of the square of the error in detecting the position of the plunger and the square of the driving accuracy of the plunger driving unit that drives the plunger.
The drug mixing method according to claim 2.

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