WO2013107206A1 - Chinese herbal medicine composition for treating diabetic foot - Google Patents

Abstract

A Chinese herbal medicine composition for treating diabetic foot, consisting of the following raw material medicines in parts by weight: 1-30 parts of scorpion, 1-30 parts of lithargite, 1-30 parts of centipede, 1-20 parts of borneol, 1-20 parts of cirsium japonicum, 1-20 parts of pangolin, 1-20 parts of castor beans, 1-20 parts of garden burnet, and 1-20 parts of safflower. The composition has the effects of clearing heat and detoxicating, eliminating necrotic tissue and promoting granulation, stimulating blood circulation and removing blood stasis, warming and activating arteries and veins, and reducing swelling and stopping pain, and is used to treat nerve patho-type, artery ischemia-type and mixed-type diabetic foot with the symptoms of foot muscular atrophy, deformity, skin infection, purulence, rhagades and ulcers, and toe tip ulcers and gangrene.

Description

 Description of the invention relates to a traditional Chinese medicine composition for treating diabetic foot

 [0001] The present invention relates to a traditional Chinese medicine composition for treating diabetic foot, and belongs to the field of traditional Chinese medicine.

Background technique

 [0002] Diabetic foot (DF) refers to the destruction of lower extremity infection, ulceration, and/or deep tissue caused by diabetic patients with neuropathy and various degrees of peripheral vascular disease. Clinically, because diabetic patients have long been affected by hyperglycemia, lower extremity arteriosclerosis, thickening of blood vessel wall, and decreased elasticity, blood vessels are prone to thrombosis, and they form plaques, which cause vascular occlusion of the lower extremities and damage of the branch nerves. Causes lower extremity tissue lesions. The "foot" is the farthest and the most occluded, causing edema, blackening, rot, necrosis, and dislocation. It is one of the chronic complications of diabetes and one of the leading causes of disability in diabetic patients. The main clinical manifestations are foot ulcers and gangrene. In severe cases, amputation is required and the amputation rate is as high as 40%. In China, the proportion of diabetic patients with gangrene is about 0.9%~1.7%. The elderly patients over 60 years old with diabetes gangrene account for 2.8%~14.5%, and the amputation rate of this disease is 21%~66%.

 [0003] Diabetic foot is clinically divided into neuropathy type, arterial ischemia type, and mixed type (i.e., neuropathy and arterial ischemia simultaneously exist).

 [0004] High risk factors for ulceration and gangrene in diabetic foot include peripheral vascular neuropathy, autonomic neuropathy, loss of protection, microvascular disease, metabolic factors, history of foot ulcers, foot deformity, convulsions, blindness, and severe vision loss. , combined with renal disease, the elderly, poor cognitive ability of diabetes, etc., is very important for the prevention and treatment of these high risk factors; the occurrence of senile ischemic diabetic foot is particularly common, mainly caused by peripheral vascular neuropathy; capillary basement membrane Thickening is due to stenosis of the lumen, rough intima, decreased blood vessel elasticity and contraction, poor blood flow, tissue ischemia and hypoxia, poor red blood cell deformability, abnormal blood rheology, vascular endothelial injury and other factors easily cause capillary The vascular basement membrane is thickened, and there is deposition of a transparent substance, which causes microvascular lesion pressure. Diabetic patients cause neurotrophic disorders and ischemic neuritis due to vascular lesions.

 [0005] Diabetic foot is a Chinese medicine "dislocation" category, the motherland medicine believes that the core cause of diabetic foot is qi deficiency, yang deficiency, cold qi, qi deficiency, can not be handsome, yang can not be warm, cold stagnation, blood stagnant, long-term limb Necrosis is dislocated.

[0006] At present, the main drugs for treating diabetic foot are: 1. Improve microcirculation treatment, mainly including anisodamine, prostaglandin El, traditional Chinese medicine preparation compound Danshen injection, etc.; 2. Reduce blood coagulation, mainly Pan Shengding, aspirin, warfarin, Pei Da, etc.; 3, anti-infective treatment, mainly applied broad-spectrum antibiotics and metronidazole; 4, improve neuropathic drugs, such as epasita. The above drugs can only help treat diabetic foot, can not cure the symptoms, and have large side effects, which easily lead to other complications.

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disease.

 [0007] Chinese patent document CN101757152A discloses a traditional Chinese medicine composition for treating ischemic diabetic foot, ginseng, leeches, earthworms, frankincense, red peony, scent, sandalwood, scorpion, scorpion, scorpion, Borneol, jujube kernel composition, with the effect of replenishing qi and activating blood circulation, resolving phlegm and blood stasis, 3⁄4 composition of the product name is Tongxinluo Capsule, used for coronary heart disease, angina pectoris is a deficiency of heart and blood stasis, although it is ischemic Diabetic foot has a certain effect, but it has a slow onset and is ineffective for neuropathic and mixed diabetic foot.

Summary of the invention

 [0008] The technical problem to be solved by the present invention is that the traditional Chinese medicine composition for treating diabetic foot in the prior art has a slow onset of action, and provides a kind of effect on the problem of ineffectiveness of neuropathic type, arterial ischemic type, and mixed type diabetic foot. Fast, a traditional Chinese medicine composition effective for neuropathic, arterial ischemic, mixed diabetic foot and a preparation method thereof.

[0009] The present invention provides a traditional Chinese medicine composition for treating diabetic foot, the weight of the raw material of the composition is: 1-30 parts of whole glutinous rice, 1-30 parts of medusa, 1-30 parts of medlar, 1-20 parts of borneol, 1-20 parts of eucalyptus, 1-20 parts of pangolin, 1-20 parts of castor, 1-20 parts of mantle, 1-20 parts of safflower.

 [0010] The preferred parts of the drug substance of the traditional Chinese medicine composition of the present invention are: 2-20 parts of whole glutinous rice, 2-20 parts of medusa, 蜈蚣2- 20 parts, 2-10 parts of borneol, 2-10 parts of sorghum 2-10 parts of pangolin, 2-10 parts of castor, 2-10 parts of mantle, 2-10 parts of safflower.

 [0011] The most preferred parts of the traditional Chinese medicine composition of the present invention are: 1 part, 1 part of medusa, 1 part of medlar, 1 part of borneol, 1 part of eucalyptus, 1 part of pangolin, 1 part of castor bean. , 1 part of the cellar, 1 part of safflower.

 [0012] The traditional Chinese medicine composition of the present invention can be formulated into a pill, a tablet, a capsule, a syrup, a granule, and a paste.

 [0013] The substrate selected for the preparation of the traditional Chinese medicine composition is one or more of eucalyptus oil, petrolatum, and eucalyptus oil.

 [0014] The preparation method of the traditional Chinese medicine composition of the present invention comprises the following steps:

Including the following steps:

a) weighing a specific weight of each drug substance for use;

b) crushing the whole scorpion, medusa, scorpion, borneol, scorpion, pangolin, castor bean, mantle, safflower, and grinding into powder;

c) Mix the above powders, add one or more of eucalyptus oil, petrolatum, and eucalyptus oil, and mix well to obtain a topical cream.

 [0015] The present invention also relates to the use of the traditional Chinese medicine composition for the preparation of a medicament for treating diabetic foot.

 [0016] The principles and methods for treating diabetic foot in Chinese medicine mainly include detoxification, phlegm and stasis, promoting blood circulation and removing blood stasis, and warming

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 Collapse, swelling and pain relief.

 It is full of sputum, taste, poisonous, liver, qi and stagnation, attacking and dispersing, the effect of Tongluo and pain relief, listed as Jun medicine; Mito is flat, tastes salty, poisonous, into the foot Quyin liver meridian, with dampness, detoxification, astringent, antiseptic effect; phlegm temperature, taste spicy, toxic, liver, spleen and lung, spleen and phlegm, phlegm and blood stasis, Tongluo analgesic effect; The combination of Mito, enhances the efficacy of clearing away heat and detoxifying, relieving collaterals and relieving pain.

 [0017] 蓟 蓟 cool, sweet and bitter, heart, liver, with dilation, detoxification, eliminate phlegm; pangolin slightly cold, taste salty, with blood circulation, eliminate the effect of sputum; castor Ping, sweetine, to the large intestine, lung, with swelling and detoxification, diarrhea and stagnation; cellar cold, bitter acid, liver, lung, kidney, large intestine, with cooling blood to stop bleeding, detoxification The effect of reducing swelling and soreness; safflower is warm, fragrant, heart-to-heart, liver, has the effect of activating blood circulation, dispersing phlegm and relieving pain, and is adjunctive with Datun, Pangolin, Castor, and Mantle.瘀, blood circulation, cooling blood, swelling and detoxification, analgesic effect; borneol is cool, tastes hard, heart, lung, with the effect of phlegm窜, in-depth treatment, strong penetration, can promote the absorption of the active ingredients of the drug, and act on the affected area for a long time to achieve transdermal action.

[0018] The above nine herbs are used together to play the role of clearing away heat and detoxifying, phlegm and stasis, promoting blood circulation and removing blood stasis, warming meridians and collaterals, reducing swelling and relieving pain. For neuropathy, arterial ischemia, mixed type diabetic foot, syndrome Muscle atrophy, foot deformity, foot skin infections, purulent, cleft palate, ulcers, finger ulcers, gangrene, etc. are effective.

[0019] The present invention has the following advantages:

According to the traditional Chinese medicine theory, the invention selects whole glutinous rice, medusa, medlar, borneol, medlar, pangolin, castor bean, mantle, safflower as raw materials, the raw materials are easy to obtain and the cost is low, and the heat and detoxification are synergistically exerted through various medicinal materials. , phlegm and stasis, promoting blood circulation and removing blood stasis, warming meridians and collaterals, reducing swelling and relieving pain, for treating neuropathic type, arterial ischemic type, mixed type diabetic foot, syndrome of foot muscle atrophy, foot deformity, foot skin infection and suppuration, Cleft palate, ulcer, finger ulcer, gangrene, both symptoms and symptoms, and no toxic side effects, patients are not easy to relapse after use, to avoid the side effects caused by Western medicine treatment of diabetic foot and the great pain caused by amputation.

detailed description

Embodiment 1

Weighed 30g, 蜈蚣30g, borneol 20g, glutinous rice 20g, pangolin 20g, castor bean 20g, mantle 20g, safflower 20g, crushed separately, ground into powder; mix the above powder, add 60g of oyster sauce, stir Evenly, it can be used as a topical cream.

 Embodiment 2

Weigh 20g of medusa, 蜈蚣20g, borneol 15g, eucalyptus 15g, pangolin 15g, castor bean 15g, mantle 15g, safflower 15g, crushed separately, ground into powder; mix the above powder, add Vaseline oil 45g, stir External cream

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Agent.

 Embodiment 3

Weigh 10g, 10g, borneol 10g, eucalyptus 10g, pangolin 10g, castor bean 10g, mantle 10g, safflower 10g, crushed separately, ground into powder; mix the above powder, add 30g of oyster sauce, stir Evenly, it can be used as a topical cream.

Embodiment 4

Weigh 10g, 10g, borneol 8g, eucalyptus 8g, pangolin 8g, castor bean 8g, mantle 8g, safflower 8g, crushed separately, ground into powder; mix the above powder, capsule, ready Get capsules.

[0024] Example 5

Weighed 25g, 25g, borneol 20g, glutinous rice 20g, pangolin 20g, castor bean 20g, mantle 20g, safflower 20g, crushed separately, ground into powder; mix the above powder, add oyster sauce 30g and 蛤蟆30 g of oil, stir well to obtain a topical paste.

[0025] Example 6

Weigh 20g of medusa, 蜈蚣20g, borneol 15g, eucalyptus 15g, pangolin 15g, castor bean 15g, mantle 15g, safflower 15g, crushed separately, ground into powder; mix the above powder, add oyster sauce 20g and vaseline 20g, stir evenly to get a topical cream.

Example 7

Weigh 15g, 15g, borneol 15g, eucalyptus 15g, pangolin 15g, castor bean 15g, mantle 15g, safflower 15g, crushed separately, ground into powder; mix the above powder, add Vaseline 20g, oyster sauce 10g and oyster sauce 10g, stir well to obtain a topical paste.

[0027] Experimental example

In order to show the therapeutic effect of the traditional Chinese medicine composition on the neuropathic type, arterial ischemic type, mixed type diabetic foot, the present invention was systematically observed in 100 cases, and the medical history, the condition, the age and the original treatment method were recorded for comparative efficacy experiments.

[0028] Among the 100 patients, there were 30 patients with neuropathic diabetic foot, 40 patients with arterial ischemic diabetes, and 30 patients with mixed diabetes. In the above-mentioned patients, most of the manifestations are foot muscle atrophy, foot deformity, foot skin infection, purulent, cleft palate, ulcer, fingertip ulcer, gangrene.

[0029] The criteria for judging clinical treatment effects are:

Clinical cure: The original symptoms disappear.

[0030] Significant effect: The original symptoms partially disappeared.

[0031] Improvement: The original condition has been alleviated.

[0032] Invalid: There is no change in symptoms and signs.

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 [0033] The administration method is as follows: The ointment prepared in Example 3 is applied to the affected part of the patient.

 [0034] Treatment: 15 days for a course of treatment, once a day.

 [0035] The results of clinical trials show that the original symptoms are alleviated by using only one course of the traditional Chinese medicine composition. According to statistics, 5% of patients with mild symptoms can be cured at one time. After one course of treatment, the cure rate is 95%, 5% V. Efficacy or improvement, no invalidity (see Table 1).

[0036] In the above clinical experiment, the hematuria routine, liver and kidney function, electrocardiogram, etc. before and after the patient's medication were examined and recorded, and no abnormalities were found in the comparison, and the Chinese medicine composition was found to have no toxic and side effects, and the case was obtained two years later. A return visit was made to patients without recurrence.

 Comparative Experimental Example

Weigh 39.6g ginseng, 72.6g leeches, 46.2g soil mites, 13.2g frankincense, 33g red peony, 13.2g scent, 13.2g sandalwood, 19.8g radix, 46.2g 蝉蜕, 6.6g 蜈蚣, 33g Borneol, 33 g of jujube kernel (fried), was made into a capsule according to the method disclosed in the aforementioned Chinese patent document CN101757152A. The capsule was used for clinical trials in 100 patients of the same constitution and condition, and the administration method was 4 capsules at a time, 3 times a day.

 [0038] After 15 days of continuous administration, the results are shown in Table 2. The average cure rate was only 30%, and only the arterial ischemic diabetic foot was better.

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 [0039] While the invention has been described in detail hereinabove by the foregoing specific embodiments, those of ordinary skill in the art All belong to the scope of the invention to be protected.

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Claims

Claim

 A traditional Chinese medicine composition, characterized in that the weight of the raw material of the composition is: 1-30 parts of whole glutinous rice, 1-30 parts of medusa, 1-30 parts of medlar, 1-20 parts of borneol, large蓟 1-20 parts, 1-20 parts of pangolin, 1-20 parts of castor, 1-20 parts of mantle, 1-20 parts of safflower.

 2. The traditional Chinese medicine composition according to claim 1, wherein the weight of the raw material drug is: 2-20 parts of whole mash, 2-20 parts of medhong, 2-20 parts of 蜈蚣, borneol 2 10 parts, 2-10 parts of sorghum, 2-10 parts of pangolin, 2-10 parts of castor, 2-10 parts of mantle, 2-10 parts of safflower.

 The traditional Chinese medicine composition according to claim 2, wherein the weight of the raw material drug is: 1 part, 1 part of medusa, 1 part of mash, 1 part of borneol, 1 part of sorghum, 1 part of pangolin, 1 part of castor, 1 part of mantle, 1 part of safflower.

 The traditional Chinese medicine composition according to any one of claims 1 to 3, wherein the traditional Chinese medicine composition is formulated into a pellet, a tablet, a capsule, a syrup, a granule, and a paste.

 The traditional Chinese medicine composition according to claim 4, wherein the substrate selected for the preparation of the traditional Chinese medicine composition is one or more of eucalyptus oil, petrolatum, and eucalyptus oil.

 6. The method for preparing a traditional Chinese medicine composition according to claim 5, comprising the steps of:

a) weighing a specific weight of each drug substance for use;

b) crushing the whole scorpion, medusa, scorpion, borneol, scorpion, pangolin, castor bean, mantle, and safflower, and grinding into powder;

c) Mix the above powders, add one or more of eucalyptus oil, petrolatum, and eucalyptus oil, and mix well to obtain a topical cream.

 7. Use of a traditional Chinese medicine composition according to any one of claims 1 to 3 for the preparation of a medicament for treating diabetic foot.