WO2013097599A1 - 一种血氧测量装置 - Google Patents

一种血氧测量装置 Download PDF

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Publication number
WO2013097599A1
WO2013097599A1 PCT/CN2012/086345 CN2012086345W WO2013097599A1 WO 2013097599 A1 WO2013097599 A1 WO 2013097599A1 CN 2012086345 W CN2012086345 W CN 2012086345W WO 2013097599 A1 WO2013097599 A1 WO 2013097599A1
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Prior art keywords
light
emitting device
photodetector
wavelength
electrical signal
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PCT/CN2012/086345
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English (en)
French (fr)
Inventor
岑建
周赛新
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases

Definitions

  • the invention relates to a blood oxygen measuring device.
  • hemorrhage oxygen saturation can be measured by measuring the change in light intensity of transmitted light of two wavelengths in a complete pulse wave.
  • the basic principle of pulse oximetry is to determine blood oxygen saturation by projecting red and infrared light into the capillaries and measuring periodic changes in cardiac light absorption.
  • the light source in the blood oxygen probe emits red light and infrared light.
  • Light, and the corresponding photodetector enables detection of red and infrared light.
  • the blood oxygen measurement method assumes that all the pulsating components in the light absorption signal are caused by the filling of arterial blood, and are absorbed by light of red light (wavelength near 500-700 nm) and infrared wavelength (wavelength near 800-1000 nm).
  • the ratio of the pulsating component (AC) to the upper DC component (DC) is calculated as:
  • this R-Spo2 table is a blood gas analysis based on the blood gas analyzer for the study of induced hypoxia in healthy adult volunteers. The result is determined.
  • the blood oxygen measuring device mainly comprises a light source 11, a detector 12 and a signal processing circuit 13.
  • the light source 11 uses two kinds of light sources, red light and infrared light, on one side of the detected object, and the detector 12 is located at the detected end. The other side of the object.
  • two sources of red light and infrared light alternately emit light and transmit the detected object
  • the detector 12 detects the transmitted light intensity of the red and infrared light transmitted through the detected object, and the red light and the infrared light are
  • the transmitted light is converted into an electrical signal and output to the signal processing circuit 13.
  • the signal processing circuit 13 is used to process and calculate the detected signal to obtain blood oxygen saturation, and to drive the light source according to the designed light source illumination timing.
  • the illumination timing is that the two sources of red light and infrared light alternately emit light, as shown in FIG. 2 .
  • the invention provides a novel blood oxygen measuring device, which can improve the accuracy of the measurement result of the blood oxygen measuring device.
  • an apparatus for measuring blood oxygenation includes: a light emitting device disposed on a side of an object to be detected for emitting at least first wavelength light and second wavelength light; and photodetecting device disposed at On the other side of the detected object opposite to the light emitting device, the light detecting device includes a first narrowband photodetector and a second narrowband photodetector, and the first narrowband photodetector is configured to receive the first wavelength light transmission to be detected The transmitted light of the object is converted into an electrical signal corresponding to the first wavelength light, and the second narrowband photodetector is configured to receive the transmitted light of the second wavelength light transmitted through the detected object and convert it into electricity corresponding to the second wavelength light.
  • a signal processing circuit coupled to the output ends of the first narrowband photodetector and the second narrowband photodetector, respectively, receiving an electrical signal corresponding to the first wavelength light and an electrical signal corresponding to the second wavelength light, according to The electrical signal corresponding to the first wavelength light and the electrical signal corresponding to the second wavelength light calculate blood oxygen saturation; the signal processing circuit is further coupled to the light emitting device.
  • an oximetry apparatus comprising: a light-emitting device disposed on a side of an object to be detected for emitting at least red light and infrared light; and a light detecting device disposed on the object to be detected On the other side opposite to the light-emitting device, the light detecting device includes a red light detector and an infrared light detector for receiving red light transmitted through the object to be detected and converted into red light.
  • the infrared light detector is configured to receive the transmitted light of the infrared light transmitted through the detected object, and is converted into an electrical signal corresponding to the infrared light;
  • the signal processing circuit is respectively coupled to the red light detector and the infrared light detector The output end receives an electrical signal corresponding to the red light and an electrical signal corresponding to the infrared light, and calculates the blood oxygen saturation according to the electrical signal corresponding to the red light and the electrical signal corresponding to the infrared light.
  • an oximetry apparatus comprising: a light-emitting device disposed on a side of an object to be detected, the light-emitting device including a first light-emitting device for emitting light of a first wavelength and a second light emitting device for emitting light of a second wavelength, the first light emitting device and the second light emitting device being configured such that a light emitting time of both has a set delay difference; and the light detecting device is disposed on the object to be detected On the other side opposite to the light emitting device, the light detecting device includes a first photodetector and a second photodetector, the first photodetector for detecting the transmitted light of the first wavelength light transmitted through the detected object, and converting For the electrical signal corresponding to the first wavelength light, the second photodetector is configured to detect the transmitted light of the second wavelength light transmitted through the detected object, and convert it into an electrical signal corresponding to the second wavelength light, the first photodetector and
  • FIG. 1 is a schematic structural view of a conventional blood oxygen measuring device
  • FIG. 2 is a timing diagram of a conventional oximetry device
  • FIG. 3 is a schematic structural view of a blood oxygen measuring device in the first embodiment
  • Figure 4 is a timing chart of the blood oxygen measuring device in the first embodiment
  • Figure 5 is a schematic structural view of two blood oxygen measuring devices of the embodiment
  • Figure 6 is a timing chart of the blood oxygen measuring device in the second embodiment
  • Figure 7 is a schematic structural view of a blood oxygen measuring device in the third embodiment
  • Figure 8 is a schematic structural view of a blood oxygen measuring device in the fourth embodiment
  • Figure 9 is a timing chart of the blood oxygen measuring device in the fourth embodiment.
  • Figure 10 is a schematic structural view of a blood oxygen measuring device in the fifth embodiment
  • Figure 11 is a timing chart of the blood oxygen measuring device of the fifth embodiment.
  • the oximetry device employs at least one narrowband photodetector to detect the transmitted light intensity of the two wavelengths transmitted through the object to be measured, and calculate the transmitted light intensity based on the two wavelengths. Blood oxygen saturation.
  • the narrow-band photodetector detects only a certain wavelength range of light, and significantly attenuates the light outside the passband wavelength range. Therefore, by selecting the filter parameters of the two narrow-band photodetectors, the narrow-band photodetector can only pass the need. Calculate the transmitted light of two wavelengths, and filter out the ambient light and other wavelengths of transmitted light, thereby reducing the influence of ambient light and other wavelengths of light, and improving the accuracy of the measurement results of the oximeter.
  • the light emitted by the light source includes at least two wavelengths of the first wavelength light and the second wavelength light, and the light source may respectively emit the first wavelength light and the second wavelength light, or may emit the first wavelength light and the second wavelength.
  • Wide-spectrum light of wavelength light In the blood oxygen calculation, only the transmitted light intensities of the predetermined two wavelengths are selected to participate in the calculation, for example, the first wavelength light and the second wavelength light.
  • the first wavelength light and the second wavelength light may be any two types of light suitable for different wavelengths that are detectable by the detected object and detectable on the light receiving side.
  • the detected object is a human body tissue (for example, a finger), and the first wavelength light and the second wavelength light are respectively red light and infrared light.
  • the blood oxygen measuring device adopts a driving scheme of modulating a light source, so that the light source emits high-frequency pulse light having a set width according to a set time interval, and the frequency of the high-frequency pulse light is much higher than that of an ordinary one.
  • Ambient light ambient light interference is reflected as out-of-band noise, which can be easily filtered, thereby reducing the impact of ambient light.
  • Embodiment 1 is a diagrammatic representation of Embodiment 1:
  • the blood oxygen measuring device includes a light emitting device 21, a light detecting device 22, and a signal processing circuit 23.
  • the light emitting device 21 is disposed on one side of the human body tissue, and the light emitting device 21 includes a light source driving circuit 211, a first light emitting device 212, and a second light emitting device 213.
  • the first light emitting device 212 is red emitting red light.
  • the light-emitting device, the second light-emitting device 213 is an infrared light-emitting device that emits infrared light
  • the first light-emitting device 212 and the second light-emitting device 213 may specifically be a red light-emitting diode and an infrared light-emitting diode, a red light-emitting diode and an infrared light, respectively.
  • the light emitting diodes are connected in parallel in the same direction at both ends of the light source driving circuit 211, and are driven by the light source driving circuit 211 to simultaneously emit light.
  • the light detecting device 22 is disposed on the other side of the human body tissue opposite to the light emitting device 21, and the light detecting device 22 includes a first narrow band photodetector 221 and a second narrow band photodetector 222, when the first light emitting device 212 and the second When the light emitting device 213 emits red light and infrared light respectively, the first narrow band light detector 221 and the second narrow band light detector 222 correspond to a red light detector and an infrared light detector, and the red light detector is used to receive red light.
  • the transmitted light of the human tissue is converted into an electrical signal corresponding to the red light
  • the infrared light detector is configured to receive the transmitted light of the infrared light transmitted through the human tissue and convert it into an electrical signal corresponding to the infrared light.
  • the first narrowband photodetector 221 and the second narrowband photodetector 222 can adopt an existing narrowband photodetector, or a narrowband photodetector manufactured according to the prior art to meet the filtering parameter requirements, for example, with filtering a photodiode of the sheet to detect a transmitted light intensity of a specific light wavelength transmitted through the human body, and when the first narrow band photodetector 221 and the second narrow band photodetector 222 are a red light detector and an infrared light detector, respectively,
  • the wavelength can be set to 660 nm and 940 nm.
  • the wavelengths of light detected by the first narrowband photodetector 221 and the second narrowband photodetector 222 may also be other set wavelengths.
  • the signal processing circuit 23 is coupled to the output ends of the first narrowband photodetector 221 and the second narrowband photodetector 222, respectively, and receives an electrical signal corresponding to the red light and an electrical signal corresponding to the infrared light, according to the electrical power corresponding to the red light.
  • the signal and the electrical signal corresponding to the infrared light calculate blood oxygen saturation.
  • signal processing circuit 23 includes signal amplification/conditioning circuitry 231, analog to digital conversion circuitry 232, and processor 233 that are sequentially coupled.
  • the signal amplification/conditioning circuit 231 is connected to the output ends of the first narrowband photodetector 221 and the second narrowband photodetector 222, respectively, and receives the output of the first narrowband photodetector 221 and the second narrowband photodetector 222 corresponding to the red light.
  • the electrical signal and the electrical signal corresponding to the infrared light is amplified and other processing (other processing such as filtering), the analog-to-digital conversion circuit 232 performs analog-to-digital conversion on the amplified signal, and then outputs the signal to the processor 233 for processing.
  • the 233 calculates the blood oxygen saturation based on the analog-to-digital converted signal.
  • the blood oxygen saturation calculation method can use an existing algorithm or an algorithm that may occur in the future.
  • ambient light may exist in the detection environment in which the blood oxygen measuring device is located, and the ambient light has a direct current component and an alternating current component. If it is superimposed on the light emitted by the light emitting device, it is easy to cause interference on the transmitted light. Interference with the measurement.
  • the first narrowband photodetector detects only red light transmitted through the human tissue
  • the second narrowband photodetector detects only infrared light transmitted through the human tissue, thereby filtering out ambient light and the light source.
  • Other wavelengths of light reduce the interference of ambient light and other wavelengths of light.
  • the light source driving signals for the first light emitting device 212 and the second light emitting device 213 may be a pulse signal having a set period, as shown in FIG. 4, the light source driving signal driving the first light emitting device 212 and the second light emitting device.
  • the first narrow-band photodetector 221 and the second narrow-band photodetector 222 respectively detect red light transmitted light and infrared light transmitted through the human body tissue, and the detected red light transmitted light And the infrared light transmitted light signal is a synchronization signal. Therefore, this scheme improves the synchronism of the detection signal and facilitates the processing of the subsequent blood oxygen algorithm.
  • the blood flow of the pulse changes due to the movement of the detected object, there is also a time difference between the transmitted light of the red light and the transmitted light of the infrared light.
  • the subsequent blood oxygenation algorithm is difficult to recognize that the time difference between the two signals is caused by the asynchronousness of the signal itself.
  • the light source driving signal may be generated by the light source driving circuit 211 according to the set timing, or may be generated by the processor 233 in the signal processing circuit 23 according to the set timing, and the processor 233 outputs the light source driving signal to the light source driving circuit of the light emitting device 21. 211.
  • the first light emitting device 212 and the second light emitting device 213 are driven to emit light by the light source driving circuit 211 according to the light source driving signal.
  • the first light-emitting device 212 and the second light-emitting device 213 are connected in parallel at both ends of the light source driving circuit 211.
  • each of the light-emitting devices may also have independent light source driving circuits, that is, each The light emitting devices are connected to both ends of the respective light source driving circuits, and the light source driving circuit drives the light.
  • the first light-emitting device 212 and the second light-emitting device 213 may also emit light at different times, but have a set delay difference.
  • the light source driving circuit of the first light-emitting device passes the light source through the switch circuit or the delay circuit.
  • the driving signal is delayed for a certain time, and the light source driving circuit of the second light emitting device does not delay the light source driving signal, so that the light emitted by the first light emitting device is delayed by a certain time than the light emitted by the second light emitting device, and There is also a certain time difference between the two transmitted lights detected by a narrowband photodetector and a second narrowband photodetector.
  • Embodiment 2 is a diagrammatic representation of Embodiment 1:
  • the blood oxygen measuring device includes a light emitting device 31, a light detecting device 32, and a signal processing circuit 33.
  • the light emitting device 31 is disposed on one side of the human body tissue
  • the light detecting device 32 is disposed on the other side of the body tissue opposite to the light emitting device 31.
  • the light detecting device 32 includes a first narrow band photodetector 321 and a second narrow band photodetector.
  • the first narrowband photodetector 321 is configured to detect the transmitted light intensity of the red light transmitted through the human body tissue
  • the second narrowband light detector 322 is configured to detect the transmitted light intensity of the infrared light transmitted through the human tissue.
  • the signal processing circuit 33 is coupled to the output ends of the first narrowband photodetector 321 and the second narrowband photodetector 322, respectively, and receives an electrical signal corresponding to the first wavelength light and an electrical signal corresponding to the second wavelength light, according to The oxygen saturation corresponding to the electrical signal corresponding to one wavelength of light and the electrical signal corresponding to the second wavelength of light are calculated.
  • the light-emitting device 31 is a wide-spectrum light source, and the emitted spectrum includes at least a red light spectrum and an infrared spectrum.
  • the light-emitting device 31 includes a light source driving circuit 311 and a wide-spectrum light source 312.
  • the wide-spectrum light source 312 is connected to both ends of the light source driving circuit 311, and the light source driving circuit 311 drives the light-emitting according to the light source driving signal.
  • the broad spectrum source 312 can employ an existing wide spectrum source or a new broad spectrum source in the future, such as a white LED or an incandescent source.
  • the structures of the first narrowband photodetector 321, the second narrowband photodetector 322, and the signal processing circuit 33 may be the same as or different from those in the first embodiment.
  • the first narrowband photodetector 321 and the second narrowband photodetector 322 are only sensitive to the infrared band or the red band, and are respectively used for detecting infrared and red transmitted light.
  • the timing of the illuminating and receiving light of this embodiment is as shown in FIG. 6.
  • the two detectors can simultaneously detect the transmitted light signals of the red light and the infrared light, thereby ensuring extremely high synchronism and also Reduces the limitation of the light source and reduces the cost of the light source.
  • Embodiment 3 is a diagrammatic representation of Embodiment 3
  • the blood oxygen measuring device includes a light emitting device 41, a light detecting device 42, and a signal processing circuit 43.
  • the light emitting device 41 is disposed on one side of the human body tissue
  • the light detecting device 42 is disposed on the other side of the body tissue opposite to the light emitting device 41.
  • the light detecting device 42 includes a first narrowband photodetector and a second narrowband photodetector. The first narrowband photodetector is used to detect the transmitted light intensity of the red light passing through the human tissue, and the second narrowband photodetector is used to detect the transmitted light intensity of the infrared light passing through the human tissue.
  • the first narrowband photodetector comprises a plurality of red light detectors
  • the second narrowband photodetector comprises a plurality of infrared light detectors
  • the red light detector and the infrared light detector can be arranged in the light detecting device in various ways according to design requirements. 42 is distributed on the photodetecting device 42 in a spaced manner or in a column spacing as shown in FIG.
  • a plurality of detectors are evenly distributed in space, so that the optical paths of the two light sources are more consistent. Further, these detectors can be arranged in an array by a semiconductor process, and are fabricated on one chip, so that the single area of these detectors is smaller, the number is larger, and the distribution is more uniform.
  • the structures of the light-emitting device 41 and the signal processing circuit 43 may be the same as or different from those of the first embodiment.
  • the light-emitting device 41 may be two independent light sources, respectively emitting red light and infrared light, or may be a wide-spectrum light source.
  • Embodiment 4 is a diagrammatic representation of Embodiment 4:
  • Ambient light sources such as incandescent lamps and fluorescent lamps, usually contain a direct current component (that is, the light intensity is substantially constant, which does not change with time), and an alternating component, which is generally a power frequency (50 Hz or 60 Hz) frequency doubling component. They are superimposed on the light emitted by the light source and easily interfere with the detection of transmitted light, thereby affecting the blood oxygen measurement. Therefore, the background light interference can be suppressed in the following manner: the light source outputs a certain width of high-frequency pulse light at a certain time interval, and the frequency requirement of the high-frequency pulse light is significantly higher than the light-emitting interval of the light source, and is convenient for detecting by the blood oxygen measuring device. Just handle it.
  • This high-frequency pulse light waveform may be a square wave or a high-frequency wave such as a sine wave.
  • the high-frequency pulse-transmitted light intensity is processed and used for blood oxygen value calculation. Due to the use of high-frequency pulsed light driving, ambient light interference is reflected as out-of-band noise, which can be easily filtered out and the corresponding transmitted light intensity is obtained.
  • the blood oxygen measuring device includes a light emitting device 51, a light detecting device 52, and a signal processing circuit 53.
  • the light-emitting device 51 is disposed on one side of the human body tissue
  • the light detecting device 52 is disposed on the other side of the body tissue opposite to the light-emitting device 51 for receiving transmitted light of a specific two wavelengths transmitted through the detected object.
  • the light emitting device emits high frequency pulse light having a set width according to a set time interval.
  • the light source driving signal is a high frequency modulated signal
  • the modulated signal source is a low frequency pulse signal, as shown in FIG.
  • the low-frequency modulation signal source may be a general light source driving signal of the light-emitting device, and the low-frequency modulation signal source is used to modulate a high-frequency signal having a frequency much higher than the frequency of the modulation signal source, and generated.
  • the modulated light source driving signal drives the light emitting device 51 to emit light as the light source driving signal.
  • the light-emitting device 51 including the light source driving circuit 511 and the broad-spectrum light source 512 as an example, the timing of the light emitted by the light-emitting device 51 under the driving of the modulated light source driving signal is as shown in (b) of FIG. 9, which includes Red and infrared light.
  • the light detecting device 52 includes a first narrowband photodetector 521 for detecting the transmitted light intensity of the red light transmitted through the human body, and a second narrowband photodetector 522 for the second narrowband photodetector 522. For detecting the transmitted light intensity of infrared light transmitted through human tissue.
  • the timings of the transmitted light of the red light and the infrared light detected by the first narrowband photodetector 521 and the second narrowband photodetector 522 are respectively shown in (c) and (d) of FIG. 9, and are the same as the light source driving signal. High frequency modulated signal.
  • the signal processing circuit 53 includes a signal amplifying/conditioning circuit 531, a detecting circuit 532, an analog-to-digital converting circuit 533 and a processor 534 which are sequentially connected, and an input end of the signal amplifying/conditioning circuit 531 is connected to the photo detecting device 52, and receives light detection.
  • the high frequency modulated electrical signal outputted by the device 52 amplifies and filters the high frequency modulated electrical signal, and outputs the high frequency modulated electrical signal to the detection circuit 532, which detects and demodulates the high frequency modulated electrical signal.
  • the analog to digital conversion circuit 533 performs analog-to-digital conversion on the detected electrical signal, and the processor 534 calculates blood oxygen saturation based on the analog-to-digital converted signal.
  • the light-emitting device 51 may also include two light sources that independently emit red light and infrared light.
  • the light source driving circuit 511 drives the two light sources to emit light simultaneously according to the modulated light source driving signal, and the first narrow-band light detector 521 And the second narrowband photodetector 522 detects the transmitted light of the red light and the infrared light, and the detected light transmission timings of the red light and the infrared light are as shown in (c) and (d) of FIG.
  • Embodiment 5 is a diagrammatic representation of Embodiment 5:
  • the light-emitting device still emits light at a certain frequency, and emits light at a higher frequency during the light-emitting of the light-emitting device. After detecting the transmitted light, the detector detects the frequency and detects the transmitted light intensity. .
  • the blood oxygen measuring device includes a light emitting device 61, a light detecting device 62, and a signal processing circuit 63.
  • the light-emitting device 61 is disposed on one side of the human body tissue
  • the light detecting device 62 is disposed on the other side of the human body tissue opposite to the light-emitting device 61 for receiving transmitted light of a specific two wavelengths transmitted through the detected object.
  • the light emitting device 61 includes a light source driving circuit 611, a first light emitting device 612, and a second light emitting device 613.
  • the first light emitting device 612 is a red light emitting device that emits red light
  • the second light emitting device 613 is an infrared light emitting device that emits infrared light.
  • the first light emitting device 612 and the second light emitting device 613 are oppositely connected in parallel at both ends of the light source driving circuit 611, and the light source driving circuit 611 drives the first light emitting device 612 and the second light emitting device 613 to alternately emit light according to the modulated light source driving signal.
  • the timing of the light emitted by the first light-emitting device 612 and the second light-emitting device 613 is as shown in (a) and (b) of FIG. 11, and the light detecting device 62 is a wide-spectrum detector that detects red light and infrared light.
  • the timing of the transmitted light is as shown in (c) of FIG.
  • the signal processing circuit 53 includes a signal amplifying/conditioning circuit 531, a detecting circuit 532, an analog-to-digital converting circuit 533 and a processor 534 which are sequentially connected, and an input end of the signal amplifying/conditioning circuit 531 is connected to the photo detecting device 52, and receives light detection.
  • the high frequency modulated electrical signal outputted by the device 52 amplifies and filters the high frequency modulated electrical signal, and outputs the high frequency modulated electrical signal to the detection circuit 532, which detects and demodulates the high frequency modulated electrical signal.
  • the analog to digital conversion circuit 533 performs analog-to-digital conversion on the detected electrical signal, and the processor 534 calculates blood oxygen saturation based on the analog-to-digital converted signal.
  • the modulated light source driving signal may be generated by the light source driving circuit according to the set timing, or may be generated by the processor in the signal processing circuit according to the set timing, and the processor outputs the light source driving signal to the light emission.
  • the light source driving circuit of the device is driven by the light source driving circuit to drive the light source according to the modulated light source driving signal.
  • the modulated light source driving signal may be a voltage driving type or a current driving type, and the light source driving circuit may perform different circuit designs according to different driving types of the modulated light source driving signals.
  • the light emitting device when the light emitting device includes a first light emitting device for emitting light of a first wavelength and a second light emitting device for emitting light of a second wavelength, respectively, adjusting a light source driving signal to cause the first light emitting device And the illuminating time of the second illuminating device has a set delay difference, for example, the light emitting device comprises a red illuminating device that emits red light and an infrared illuminating device that emits infrared light, and the light source driving signal is as shown in FIG. There is a delay between the optical drive signal and the infrared drive signal.
  • the photodetecting device also includes a first photodetector for detecting the transmitted light of the first wavelength light transmitted through the detected object, and a second photodetector corresponding to the first wavelength light.
  • An electrical signal the second photodetector is configured to detect the transmitted light of the second wavelength light transmitted through the detected object, and convert it into an electrical signal corresponding to the second wavelength light
  • the first photodetector and the second photodetector At least one is a narrowband photodetector. Taking the first wavelength light as red light and the second wavelength light as infrared light, for example, in a specific example, the first photodetector is a narrow band photodetector with a passband wavelength of red wavelength, which can detect red light transmission.
  • the second photodetector is a wide-spectrum detector, which can detect the transmitted light of the red and infrared light passing through the detected object, since the red light and the infrared light have the light-emitting timing.
  • a certain time difference, according to the illumination timing, can detect the transmitted light intensity signal of the infrared light passing through the detected object.
  • the first photodetector can also be a narrow-band photodetector with a passband wavelength of infrared light wavelength
  • the second photodetector is a wide-spectrum detector, according to illumination.
  • the transmitted light intensity signal of the red light passing through the detected object can be detected.
  • the first photodetector and the second photodetector may also be narrow-band photodetectors, one of which is a narrow-band photodetector having a passband wavelength of red wavelength, and the other is a narrowband of a passband wavelength of infrared wavelength. Photodetector.
  • Signal processing circuits are coupled to the outputs of the first photodetector and the second photodetector, respectively, receiving signals output by the first photodetector and the second photodetector and calculating blood oxygen saturation.

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Abstract

本发明公开了一种血氧测量装置，包括：光发射器件，设置在被检测物体的一侧，用于至少发出第一波长光和第二波长光；光检测器件，设置在被检测物体的与光发射器件相对的另一侧，所述光检测器件包括第一窄带光探测器和第二窄带光探测器，第一窄带光探测器用于接收第一波长光透过被检测物体的透射光，并转换为与第一波长光对应的电信号，第二窄带光探测器用于接收第二波长光透过被检测物体的透射光，并转换为与第二波长光对应的电信号；信号处理电路，其分别耦合到第一窄带光探测器和第二窄带光探测器的输出端，计算血氧饱和度。本发明有效抑制了环境光的干扰，同时也为提高血氧测量装置在抑制被测物体运动干扰方面的能力提供了可能。

Description

一种血氧测量装置
【技术领域】
本发明涉及一种血氧测量装置。
【背景技术】
通过对脉搏血氧测量原理的研究，人们发现，只要测量出两种波长的透射光在一个完整的脉搏波中的光强度的变化，即可测量出血氧饱和度。目前，脉搏血氧测量的基本原理是：通过将红光、红外光投射到毛细血管并测量周期性的心动光吸收变化来确定血氧饱和度，血氧探头中的光源部分发射红光、红外光，而对应的光探测器实现对红光和红外光的检测。
血氧测量方法是假设光吸收信号中所有脉动分量是由动脉血的充盈所引起的，并以红光（500-700纳米附近波长）、红外波长（800-1000纳米附近波长）的光吸收的脉动分量（AC）比上直流分量（DC）的比值来计算比值：
Red=Red(AC)/Red(DC)
Ir=Ir(AC)/Ir(DC)
再进一步计算这两个光波的光吸收比值
R=Red/Ir
就可以通过这个R值在已经建立的R-Spo2表来查找对应血氧饱和度，而这个R-Spo2表是依据血气分析仪对健康成人自愿者在诱发的组织缺氧的研究中的血气分析结果来确定的。
如图1所示，血氧测量装置主要包括光源11、探测器12和信号处理电路13，光源11采用红光和红外光两种光源，位于被检测物体的一侧，探测器12位于被检测物体的另一侧。在进行血氧测量时，红光和红外光两种光源交替发光并透射被检测物体，探测器12检测红光和红外光透过被检测物体的透射光强，并将红光和红外光的透射光转换成电信号输出给信号处理电路13，信号处理电路13一方面用于对检测的信号进行处理和运算，得到血氧饱和度，另一方面根据设计的光源发光时序对光源进行驱动，其发光时序是红光和红外光两种光源交替发光，如图2所示。
【发明内容】
本发明提供一种新型的血氧测量装置，可提高血氧测量装置测量结果的准确性。
根据本发明的一方面，提供一种血氧测量装置,包括：光发射器件，设置在被检测物体的一侧，用于至少发出第一波长光和第二波长光；光检测器件，设置在被检测物体的与光发射器件相对的另一侧，所述光检测器件包括第一窄带光探测器和第二窄带光探测器，第一窄带光探测器用于接收第一波长光透过被检测物体的透射光，并转换为与第一波长光对应的电信号，第二窄带光探测器用于接收第二波长光透过被检测物体的透射光，并转换为与第二波长光对应的电信号；信号处理电路，其分别耦合到第一窄带光探测器和第二窄带光探测器的输出端，接收与第一波长光对应的电信号和与第二波长光对应的电信号，根据与第一波长光对应的电信号和与第二波长光对应的电信号计算血氧饱和度；所述信号处理电路还耦合到光发射器件。
根据本发明的另一方面，提供一种血氧测量装置,包括：光发射器件，设置在被检测物体的一侧，用于至少发出红光和红外光；光检测器件，设置在被检测物体的与光发射器件相对的另一侧，所述光检测器件包括红光探测器和红外光探测器，红光探测器用于接收红光透过被检测物体的透射光，并转换为与红光对应的电信号，红外光探测器用于接收红外光透过被检测物体的透射光，并转换为与红外光对应的电信号；信号处理电路，其分别耦合到红光探测器和红外光探测器的输出端，接收与红光对应的电信号和与红外光对应的电信号，根据与红光对应的电信号和与红外光对应的电信号计算血氧饱和度。
根据本发明的另一方面，提供一种血氧测量装置,包括：光发射器件，设置在被检测物体的一侧，所述光发射器件包括用于发出第一波长光的第一发光器件和用于发出第二波长光的第二发光器件，所述第一发光器件和第二发光器件被配置为两者的发光时间具有设定的延时差；光检测器件，设置在被检测物体的与光发射器件相对的另一侧，所述光检测器件包括第一光探测器和第二光探测器，第一光探测器用于检测第一波长光透过被检测物体的透射光，并转换为与第一波长光对应的电信号，第二光探测器用于检测第二波长光透过被检测物体的透射光，并转换为与第二波长光对应的电信号，第一光探测器和第二光探测器中至少一个为窄带光探测器；信号处理电路，其分别耦合到第一光探测器和第二光探测器的输出端，接收第一光探测器和第二光探测器输出的信号并计算血氧饱和度。
【附图说明】
图1为现有血氧测量装置的一种结构示意图；
图2为现有血氧测量装置的一种时序图；
图3为实施例一中血氧测量装置的结构示意图；
图4为实施例一中血氧测量装置的时序图；
图5为实施例二种血氧测量装置的结构示意图；
图6为实施例二中血氧测量装置的时序图；
图7为实施例三中血氧测量装置的结构示意图；
图8为实施例四中血氧测量装置的结构示意图；
图9为实施例四中血氧测量装置的时序图；
图10为实施例五中血氧测量装置的结构示意图；
图11为实施例五中血氧测量装置的时序图。
【具体实施方式】
下面通过具体实施方式结合附图对本发明作进一步详细说明。
在本申请一种实施例中，血氧测量装置采用至少一种窄带光探测器，以分别检测透过被测物体的两种波长的透射光强，并基于两种波长的透射光强计算出血氧饱和度。窄带光探测器只检测某一特定波长范围的光，而对通带波长范围之外的光产生明显衰减，因此通过选择两种窄带光探测器的滤光参数可使窄带光探测器只通过需要计算的两种波长的透射光，而滤除环境光和其它波长的透射光，从而减少环境光和其它波长光的影响，提高血氧测量装置测量结果的准确性。
在实际应用中，光源发出的光至少包括第一波长光和第二波长光两种波长，光源可以分别发出第一波长光和第二波长光，也可以发出包含有第一波长光和第二波长光的宽谱光。在血氧计算时，只选取预定的两种波长的透射光强参与计算，例如，第一波长光和第二波长光。理论上，第一波长光和第二波长光可以为任意适合通过被检测物体并可在光接收侧可被检测到的不同波长的两种光。以下实施例中，以被检测物体为人体组织（例如手指）、第一波长光和第二波长光分别为红光和红外光为例进行说明。
在本申请另一种实施例中，血氧测量装置采用调制光源的驱动方案，使光源按照设定时间间隔发射具有设定宽度的高频脉冲光，高频脉冲光的频率远高于普通的环境光，环境光干扰体现为带外噪声，可以方便的滤除，从而也可减少环境光的影响。
实施例一：
请参考图3，血氧测量装置包括光发射器件21、光检测器件22和信号处理电路23。光发射器件21设置在人体组织的一侧，光发射器件21包括光源驱动电路211、第一发光器件212和第二发光器件213，本实施例中，第一发光器件212为发射红光的红光发光器件，第二发光器件213为发射红外光的红外光发光器件，第一发光器件212和第二发光器件213具体可以分别是红光发光二极管和红外光发光二极管，红光发光二极管和红外光发光二极管同向并联在光源驱动电路211两端，由光源驱动电路211驱动同时发光。光检测器件22设置在人体组织的与光发射器件21相对的另一侧，光检测器件22包括第一窄带光探测器221和第二窄带光探测器222，当第一发光器件212和第二发光器件213分别发射红光和红外光时，第一窄带光探测器221和第二窄带光探测器222对应的为红光探测器和红外光探测器，红光探测器用于接收红光透过人体组织的透射光，并转换为与红光对应的电信号，红外光探测器用于接收红外光透过人体组织的透射光，并转换为与红外光对应的电信号。当第一窄带光探测器221和第二窄带光探测器222可采用现有的窄带光探测器，或采用现有技术制作成的符合滤波参数要求的窄带光探测器，例如采用带有滤光片的光电二极管来检测透过人体组织的特定光波长的透射光强，当第一窄带光探测器221和第二窄带光探测器222分别为红光探测器和红外光探测器时，其通过波长可以设定为660nm和940nm。当然，根据本申请公开的内容和已有技术，本领域技术应当理解，第一窄带光探测器221和第二窄带光探测器222检测的光波长还可以是其它设定的波长。信号处理电路23分别耦合到第一窄带光探测器221和第二窄带光探测器222的输出端，接收与红光对应的电信号和与红外光对应的电信号，根据与红光对应的电信号和与红外光对应的电信号计算血氧饱和度。一具体实例中，信号处理电路23包括顺序连接的信号放大/调理电路231、模数转换电路232和处理器233。信号放大/调理电路231分别与第一窄带光探测器221和第二窄带光探测器222的输出端连接，接收第一窄带光探测器221和第二窄带光探测器222输出的与红光对应的电信号和与红外光对应的电信号，对电信号进行放大和其它处理（其它处理例如滤波），模数转换电路232将放大后的信号进行模数转换，然后输出到处理器233，处理器233根据模数变换后的信号计算血氧饱和度。血氧饱和度的计算方法可采用已有的算法或将来可能出现的算法。
在实际应用中，在血氧测量装置所处的检测环境中可能存在环境光，而环境光有直流成分也有交流成分，如果叠加在光发射器件发射的光线上，容易在透射光上产生干扰，对测量产生干扰。本实施例中，第一窄带光探测器只检测透过人体组织的红光透射光，第二窄带光探测器只检测透过人体组织的红外光透射光，因此可滤除环境光和光源中其它波长的光，减少环境光和其它波长光的干扰。
另外本实施例中，分别采用两种窄带光探测器检测两种光信号的透射光强，为两种光同时发射和接收提供了可能。例如，对第一发光器件212和第二发光器件213的光源驱动信号可以如图4所示，是一具有设定周期的脉冲信号，该光源驱动信号驱动第一发光器件212和第二发光器件213同时发出红光和红外光，第一窄带光探测器221和第二窄带光探测器222分别对透过人体组织的红光透射光和红外光透射光进行检测，检测到的红光透射光和红外光透射光信号为同步信号。因此这种方案提高了检测信号的同步性，方便后续血氧算法的处理。由于被检测物运动导致脉搏血流变化时，也会导致红光透射光和红外光透射光信号之间存在时间差，后续血氧算法很难识别两信号之间的时间差是信号本身不同步性导致的还是被检测物的运动导致的，当提高红光和红外光本身检测信号的同步性时，也为后续血氧算法更准确地识别由被测物体运动导致的干扰并进行有效抑制提供了可能。
光源驱动信号可由光源驱动电路211根据设定的时序产生，也可由信号处理电路23中的处理器233根据设定的时序产生，处理器233将光源驱动信号输出至光发射器件21的光源驱动电路211，由光源驱动电路211按照光源驱动信号驱动第一发光器件212和第二发光器件213发光。
上述实施例中，第一发光器件212和第二发光器件213同向并联在光源驱动电路211两端，在另外的具体实例中，每个发光器件也可以有独立的光源驱动电路，即每个发光器件连接在各自的光源驱动电路的两端，由光源驱动电路驱动发光。这种情况下，第一发光器件212和第二发光器件213也可以不同时发光，而是具有设定的延时差，例如第一发光器件的光源驱动电路通过开关电路或延时电路将光源驱动信号进行一定时间的延时，而第二发光器件的光源驱动电路不对光源驱动信号进行延时，从而可使第一发光器件发出的光比第二发光器件发出的光滞后一定时间，而第一窄带光探测器和第二窄带光探测器检测到的两种透射光也有一定的时间差。
实施例二：
请参考图5，血氧测量装置包括光发射器件31、光检测器件32和信号处理电路33。光发射器件31设置在人体组织的一侧，光检测器件32设置在人体组织的与光发射器件31相对的另一侧，光检测器件32包括第一窄带光探测器321和第二窄带光探测器322，第一窄带光探测器321用于检测红光透过人体组织的透射光强，第二窄带光探测器322用于检测红外光透过人体组织的透射光强。信号处理电路33分别耦合到第一窄带光探测器321和第二窄带光探测器322的输出端，接收与第一波长光对应的电信号和与第二波长光对应的电信号，根据与第一波长光对应的电信号和与第二波长光对应的电信号计算血氧饱和度。本实施例中，光发射器件31为一宽光谱光源，其发射的光谱中至少包括红光光谱和红外光谱。当然，本领域技术人员应该理解，如果血氧计算采用的是另外两种波长的光，宽光谱光源发射的光谱中至少应包括血氧计算采用的两种波长的光，而第一窄带光探测器321和第二窄带光探测器322对应的也检测这两种波长的透射光强。本实施例中，光发射器件31包括光源驱动电路311和宽光谱光源312，宽光谱光源312连接在光源驱动电路311的两端，由光源驱动电路311按照光源驱动信号驱动发光。宽光谱光源312可采用现有的宽光谱光源或将来新出现的宽光谱光源，例如白光LED或白炽灯类光源。第一窄带光探测器321、第二窄带光探测器322和信号处理电路33的结构可以与实施例一中的相同或不同。第一窄带光探测器321和第二窄带光探测器322只对红外波段或者红光波段敏感，分别用于检测红外和红光透射光。本实施例的发光和接收光的时序如图6所示，该宽光谱光源发光时，两个探测器可同时检测红光和红外光的透射光信号，可以保证极高的同步性，同时也降低了对光源的限制，降低了光源成本。
实施例三：
请参考图7，血氧测量装置包括光发射器件41、光检测器件42和信号处理电路43。光发射器件41设置在人体组织的一侧，光检测器件42设置在人体组织的与光发射器件41相对的另一侧，光检测器件42包括第一窄带光探测器和第二窄带光探测器，第一窄带光探测器用于检测红光透过人体组织的透射光强，第二窄带光探测器用于检测红外光透过人体组织的透射光强。第一窄带光探测器包括多个红光探测器，第二窄带光探测器包括多个红外光探测器，红光探测器和红外光探测器根据设计需要可以多种方式排布在光检测器件42上，如图7所示，以相互间隔方式或按列间隔方式分布在光检测器件42上。
本实施例中，多个探测器在空间上均匀分布，这样可以保证两种光源的光路更加一致。进一步，这些探测器可以通过半导体工艺，排布成阵列，制作在一个芯片上，使得这些探测器的单个面积较小，个数较多，而分布更加均匀。
本实施例中，光发射器件41和信号处理电路43的结构可以与实施例一相同或不同。光发射器件41可以是独立的两个光源，分别发出红光和红外光，也可以是一宽光谱光源。
实施例四：
环境光源如白炽灯、荧光灯，其光强通常包含了直流成分（即光强基本恒定，不随时间变化），以及交变成分，一般为工频（50Hz或60Hz）的倍频成分。它们叠加在光源发出的光上，容易干扰透射光的检测，从而影响血氧测量。因此可以采用以下方式抑制背景光干扰：光源以一定的时间隔输出一定宽度的高频率脉冲光，这个高频脉冲光的频率要求明显高于光源的发光间隔，并且便于通过血氧测量装置检测和处理即可。
在光源的更高频率发光期间，可以通过光源驱动电路的开关控制或者驱动电流的变化来实现。这个高频率脉冲光波形可以是方波，也可以是正弦波等高频波形式。测量装置检测到这个高频率的脉冲透射光后，对此高频率的脉冲透射光强进行处理，并用于血氧值计算。由于采用了高频脉冲光驱动，环境光干扰体现为带外噪声，可以方便的滤除，并得到对应的透射光强。
本实施例中，请参考图8，血氧测量装置包括光发射器件51、光检测器件52和信号处理电路53。光发射器件51设置在人体组织的一侧，光检测器件52设置在人体组织的与光发射器件51相对的另一侧，用于接收特定的两种波长的透过被检测物体的透射光。光发射器件按照设定时间间隔发射具有设定宽度的高频脉冲光，如图9所示，光源驱动信号为一高频调制信号，其调制信号源为一低频的脉冲信号，如图9中的（a）所示，该低频的调制信号源可以是光发射器件通常的光源驱动信号，采用该低频的调制信号源对一频率远高于调制信号源频率的高频信号进行调制，生成的已调光源驱动信号如图9中的（b）所示，将该已调信号作为光源驱动信号驱动光发射器件51发光。以光发射器件51包括光源驱动电路511和宽光谱的光源512为例，光发射器件51在已调光源驱动信号的驱动下发出的光的时序如图9中的（b）所示，其中包含红光和红外光。光检测器件52包括第一窄带光探测器521和第二窄带光探测器522，第一窄带光探测器521用于检测红光透过人体组织的透射光强，第二窄带光探测器522用于检测红外光透过人体组织的透射光强。第一窄带光探测器521和第二窄带光探测器522检测到的红光和红外光的透射光的时序分别如图9中的（c）和（d）所示，是与光源驱动信号相同的高频调制信号。信号处理电路53包括顺序连接的信号放大/调理电路531、检波电路532、模数转换电路533和处理器534，所述信号放大/调理电路531的输入端与光检测器件52连接，接收光检测器件52输出的高频调制电信号，对高频调制电信号进行放大和滤波处理，并将高频调制电信号输出到检波电路532，所述检波电路532对高频调制电信号进行检波解调，模数转换电路533对检波后的电信号进行模数变换，所述处理器534根据模数变换后的信号计算血氧饱和度。
在另外的具体实例中，光发射器件51也可以包括独立发出红光和红外光的两个光源，光源驱动电路511按照已调光源驱动信号驱动两个光源同时发光，第一窄带光探测器521和第二窄带光探测器522检测红光和红外光的透射光，其检测到的红光和红外光的透射光时序如图9中的（c）和（d）所示。
实施例五：
本实施例中，光发射器件仍然以一定的频率发光，在该光发射器件的发光期间以更高频率进行发光，探测器检测到这个透射光后，针对此频率进行检波，检出透射光强。仍然采用已调的光源驱动信号，请参考图10，血氧测量装置包括光发射器件61、光检测器件62和信号处理电路63。光发射器件61设置在人体组织的一侧，光检测器件62设置在人体组织的与光发射器件61相对的另一侧，用于接收特定的两种波长的透过被检测物体的透射光。光发射器件61包括光源驱动电路611、第一发光器件612和第二发光器件613，第一发光器件612为发射红光的红光发光器件，第二发光器件613为发射红外光的红外光发光器件，第一发光器件612和第二发光器件613反向并联在光源驱动电路611的两端，光源驱动电路611按照已调光源驱动信号驱动第一发光器件612和第二发光器件613交替发光，第一发光器件612和第二发光器件613发出的光的时序如图11中的（a）和（b）所示，光检测器件62为宽光谱探测器，其检测到的红光和红外光的透射光的时序如图11中的（c）所示。信号处理电路53包括顺序连接的信号放大/调理电路531、检波电路532、模数转换电路533和处理器534，所述信号放大/调理电路531的输入端与光检测器件52连接，接收光检测器件52输出的高频调制电信号，对高频调制电信号进行放大和滤波处理，并将高频调制电信号输出到检波电路532，所述检波电路532对高频调制电信号进行检波解调，模数转换电路533对检波后的电信号进行模数变换，所述处理器534根据模数变换后的信号计算血氧饱和度。
上述实施例四和五中，已调光源驱动信号可由光源驱动电路根据设定的时序产生，也可由信号处理电路中的处理器根据设定的时序产生，处理器将光源驱动信号输出至光发射器件的光源驱动电路，由光源驱动电路按照已调光源驱动信号驱动光源发光。已调光源驱动信号可以是电压驱动型的，也可以是电流驱动型的，光源驱动电路根据已调光源驱动信号的驱动类型不同可进行不同的电路设计。
在另外的实施例中，当光发射器件包括分别用于发出第一波长光的第一发光器件和用于发出第二波长光的第二发光器件时，调整光源驱动信号，使第一发光器件和第二发光器件的发光时间具有设定的延时差，例如光发射器件包括发射红光的红光发光器件和发射红外光的红外光发光器件，光源驱动信号如图2所示，使红光驱动信号和红外光驱动信号之间具有一延时。这种情况下光检测器件也包括第一光探测器和第二光探测器，第一光探测器用于检测第一波长光透过被检测物体的透射光，并转换为与第一波长光对应的电信号，第二光探测器用于检测第二波长光透过被检测物体的透射光，并转换为与第二波长光对应的电信号，并且第一光探测器和第二光探测器中至少一个为窄带光探测器。以第一波长光为红光、第二波长光为红外光为例，例如在一具体实例中，第一光探测器是通带波长为红光波长的窄带光探测器，可检测红光透过被检测物体的透射光，第二光探测器为宽光谱探测器，可检测到红光和红外光两种光透过被检测物体的透射光，由于红光和红外光在发光时序上具有一定时差，根据发光时序，可检测出红外光透过被检测物体的透射光强信号。当然，根据本申请公开的内容，本领域技术人员应该理解第一光探测器也可以是通带波长为红外光波长的窄带光探测器，而第二光探测器为宽光谱探测器，根据发光时序，可检测出红光透过被检测物体的透射光强信号。另外，第一光探测器和第二光探测器也可以都是窄带光探测器，其中一个是通带波长为红光波长的窄带光探测器，另一个是通带波长为红外光波长的窄带光探测器。
信号处理电路分别耦合到第一光探测器和第二光探测器的输出端，接收第一光探测器和第二光探测器输出的信号并计算血氧饱和度。
以上内容是结合具体的实施方式对本发明所作的进一步详细说明，不能认定本发明的具体实施只局限于这些说明。对于本发明所属技术领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干简单推演或替换，都应当视为属于本发明的保护范围。

Claims (11)

  1. 一种血氧测量装置,其特征在于包括：
    光发射器件，设置在被检测物体的一侧，用于至少发出第一波长光和第二波长光；
    光检测器件，设置在被检测物体的与光发射器件相对的另一侧，所述光检测器件包括第一窄带光探测器和第二窄带光探测器，第一窄带光探测器用于接收第一波长光透过被检测物体的透射光，并转换为与第一波长光对应的电信号，第二窄带光探测器用于接收第二波长光透过被检测物体的透射光，并转换为与第二波长光对应的电信号；
    信号处理电路，其分别耦合到第一窄带光探测器和第二窄带光探测器的输出端，接收与第一波长光对应的电信号和与第二波长光对应的电信号，根据与第一波长光对应的电信号和与第二波长光对应的电信号计算血氧饱和度；所述信号处理电路还耦合到光发射器件。
  2. 如权利要求1所述的血氧测量装置，其特征在于，所述光发射器件包括用于发出第一波长光的第一发光器件和用于发出第二波长光的第二发光器件，所述第一发光器件和第二发光器件被配置为基于光源驱动信号同步发光或发光时间具有设定的延时差。
  3. 一种血氧测量装置,其特征在于包括：
    光发射器件，设置在被检测物体的一侧，用于至少发出红光和红外光；
    光检测器件，设置在被检测物体的与光发射器件相对的另一侧，所述光检测器件包括红光探测器和红外光探测器，红光探测器用于检测红光透过被检测物体的透射光，红外光探测器用于检测红外光透过被检测物体的透射光；
    信号处理电路，其分别耦合到红光探测器和红外光探测器的输出端，接收与红光对应的电信号和与红外光对应的电信号，根据与红光对应的电信号和与红外光对应的电信号计算血氧饱和度。
  4. 如权利要求3所述的血氧测量装置，其特征在于，所述信号处理电路还耦合到光发射器件，向光发射器件输出光源驱动信号，驱动光发射器件发光。
  5. 如权利要求3所述的血氧测量装置，其特征在于，所述红光探测器有多个，红外光探测器有多个。
  6. 如权利要求5所述的血氧测量装置，其特征在于，多个红光探测器和红外光探测器集成在一个芯片上。
  7. 如权利要求3-6中任一项所述的血氧测量装置，其特征在于，所述光发射器件包括红光发光器件和红外光发光器件，所述红光发光器件和红外光发光器件经配置为同步发光或发光时间具有设定的延时差。
  8. 如权利要求1或3-6中任一项所述的血氧测量装置，其特征在于，所述光发射器件为一宽光谱光源。
  9. 一种血氧测量装置,其特征在于包括：
    光发射器件，设置在被检测物体的一侧，所述光发射器件包括用于发出第一波长光的第一发光器件和用于发出第二波长光的第二发光器件，所述第一发光器件和第二发光器件被配置为两者的发光时间具有设定的延时差；
    光检测器件，设置在被检测物体的与光发射器件相对的另一侧，所述光检测器件包括第一光探测器和第二光探测器，第一光探测器用于检测第一波长光透过被检测物体的透射光，并转换为与第一波长光对应的电信号，第二光探测器用于检测第二波长光透过被检测物体的透射光，并转换为与第二波长光对应的电信号，第一光探测器和第二光探测器中至少一个为窄带光探测器；
    信号处理电路，其分别耦合到第一光探测器和第二光探测器的输出端，接收第一光探测器和第二光探测器输出的信号并计算血氧饱和度。
  10. 如权利要求1-9中任一项所述的血氧测量装置，其特征在于，所述光发射器件按照设定时间间隔发射具有设定宽度的高频脉冲光。
  11. 如权利要求10所述的血氧测量装置，其特征在于，所述信号处理电路包括顺序连接的信号放大/调理电路、检波电路、模数转换电路和处理器，所述信号放大/调理电路的输入端与光检测器件连接，接收光检测器件输出的高频调制电信号，对高频调制电信号进行放大和滤波处理，并将高频调制电信号输出到检波电路，所述检波电路对高频调制电信号进行检波解调，模数转换电路对检波后的电信号进行模数变换，所述处理器根据模数变换后的信号计算血氧饱和度，所述处理器还耦合到光发射器件，输出经高频调制的已调光源驱动信号至光发射器件。
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108760054A (zh) * 2018-02-09 2018-11-06 永林电子有限公司 一种单边供电贴片红外探测器
CN114403904A (zh) * 2021-12-31 2022-04-29 北京津发科技股份有限公司 基于肌电信号与肌肉血氧饱和度确定肌肉状态的装置
CN116211298A (zh) * 2023-01-16 2023-06-06 杭州沃维医疗科技有限公司 一种集成血液氧含量与电信号采集的系统、方法及传感器

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105380619B (zh) * 2015-11-09 2019-01-04 深圳诺康医疗设备股份有限公司 用于驱动脉搏波检测的方法和用于脉搏波检测的方法
US10376223B2 (en) * 2016-03-28 2019-08-13 Fuji Xerox Co., Ltd. Living-body information measurement device and non-transitory computer readable medium
CN105943054A (zh) * 2016-04-21 2016-09-21 南京医科大学第附属医院 一种血管穿刺置管领域血氧饱和度测试仪
CN108926340B (zh) * 2017-05-23 2023-04-28 松下知识产权经营株式会社 计测装置
CN109247931A (zh) * 2017-07-12 2019-01-22 松下知识产权经营株式会社 计测装置
JP6965066B2 (ja) * 2017-09-12 2021-11-10 オムロン株式会社 脈波測定装置、血圧測定装置、機器、脈波測定方法、および血圧測定方法
CN111685726A (zh) * 2019-03-12 2020-09-22 华为终端有限公司 一种血氧检测方法及装置
WO2021232375A1 (zh) * 2020-05-21 2021-11-25 深圳市汇顶科技股份有限公司 一种血氧参数检测模组及其电子设备
CN112423451A (zh) * 2020-11-25 2021-02-26 北京领主科技有限公司 驱动方法及检测光源、检测方法及装置、检测仪
TWI809581B (zh) * 2021-12-03 2023-07-21 財團法人工業技術研究院 用於生理訊號監測的監測裝置及其操作方法
CN119867685A (zh) * 2023-10-16 2025-04-25 荣耀终端股份有限公司 测试电路和方法、电子设备

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4586513A (en) * 1982-02-19 1986-05-06 Minolta Camera Kabushiki Kaisha Noninvasive device for photoelectrically measuring the property of arterial blood
US5246002A (en) * 1992-02-11 1993-09-21 Physio-Control Corporation Noise insensitive pulse transmittance oximeter
US20030069487A1 (en) * 2001-10-10 2003-04-10 Mortara Instrument, Inc. Method and apparatus for pulse oximetry
US20080139906A1 (en) * 2006-11-20 2008-06-12 Karlheinz Bussek Device and method for non-invasive optical detection of chemical and physical blood values and body content substances
US20100026995A1 (en) * 2008-08-04 2010-02-04 Masimo Laboratories, Inc. Multi-stream sensor for noninvasive measurement of blood constituents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4948248A (en) * 1988-07-22 1990-08-14 Invivo Research Inc. Blood constituent measuring device and method
US5995858A (en) * 1997-11-07 1999-11-30 Datascope Investment Corp. Pulse oximeter
CN1326487C (zh) * 2003-06-18 2007-07-18 魏蔚 经气管进行医用监测的装置
CN2798135Y (zh) * 2005-01-10 2006-07-19 捷飞科研有限公司 监测生理系统参数的眼镜
GB0607270D0 (en) * 2006-04-11 2006-05-17 Univ Nottingham The pulsing blood supply
US8666466B2 (en) * 2009-06-10 2014-03-04 Medtronic, Inc. Device and method for monitoring of absolute oxygen saturation and tissue hemoglobin concentration
CN201436981U (zh) * 2009-06-22 2010-04-14 乐夫达康(北京)科技有限公司 指夹式血氧仪
CN102258365B (zh) * 2011-08-17 2014-04-09 天津大学 一种正弦波调制光电容积脉搏波测量装置和测量方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4586513A (en) * 1982-02-19 1986-05-06 Minolta Camera Kabushiki Kaisha Noninvasive device for photoelectrically measuring the property of arterial blood
US5246002A (en) * 1992-02-11 1993-09-21 Physio-Control Corporation Noise insensitive pulse transmittance oximeter
US20030069487A1 (en) * 2001-10-10 2003-04-10 Mortara Instrument, Inc. Method and apparatus for pulse oximetry
US20080139906A1 (en) * 2006-11-20 2008-06-12 Karlheinz Bussek Device and method for non-invasive optical detection of chemical and physical blood values and body content substances
US20100026995A1 (en) * 2008-08-04 2010-02-04 Masimo Laboratories, Inc. Multi-stream sensor for noninvasive measurement of blood constituents

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108760054A (zh) * 2018-02-09 2018-11-06 永林电子有限公司 一种单边供电贴片红外探测器
CN108760054B (zh) * 2018-02-09 2024-04-05 永林电子股份有限公司 一种单边供电贴片红外探测器
CN114403904A (zh) * 2021-12-31 2022-04-29 北京津发科技股份有限公司 基于肌电信号与肌肉血氧饱和度确定肌肉状态的装置
CN114403904B (zh) * 2021-12-31 2023-01-13 北京津发科技股份有限公司 基于肌电信号与肌肉血氧饱和度确定肌肉状态的装置
CN116211298A (zh) * 2023-01-16 2023-06-06 杭州沃维医疗科技有限公司 一种集成血液氧含量与电信号采集的系统、方法及传感器

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