WO2013090837A3 - METHODS OF PRODUCING 6-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE - Google Patents

METHODS OF PRODUCING 6-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE Download PDF

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Publication number
WO2013090837A3
WO2013090837A3 PCT/US2012/069934 US2012069934W WO2013090837A3 WO 2013090837 A3 WO2013090837 A3 WO 2013090837A3 US 2012069934 W US2012069934 W US 2012069934W WO 2013090837 A3 WO2013090837 A3 WO 2013090837A3
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Prior art keywords
carbon
producing
dependent
methods
chain elongation
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PCT/US2012/069934
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French (fr)
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WO2013090837A2 (en
Inventor
Adriana BOTES
Alex van Eck CONRADIE
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Invista Technologies S.A.R.L.
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Priority to BR112014014675A priority Critical patent/BR112014014675A2/en
Priority to CN201280069823.9A priority patent/CN104220601A/en
Priority to EP12809062.8A priority patent/EP2791347A2/en
Publication of WO2013090837A2 publication Critical patent/WO2013090837A2/en
Publication of WO2013090837A3 publication Critical patent/WO2013090837A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogues enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
PCT/US2012/069934 2011-12-16 2012-12-14 METHODS OF PRODUCING 6-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE WO2013090837A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
BR112014014675A BR112014014675A2 (en) 2011-12-16 2012-12-14 method for biosynthesizing one or more products and recombinant host
CN201280069823.9A CN104220601A (en) 2011-12-16 2012-12-14 Methods of producing 6-carbon chemicals via coa-dependent carbon chain elongation associated with carbon storage
EP12809062.8A EP2791347A2 (en) 2011-12-16 2012-12-14 METHODS OF PRODUCING 6-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161576401P 2011-12-16 2011-12-16
US61/576,401 2011-12-16

Publications (2)

Publication Number Publication Date
WO2013090837A2 WO2013090837A2 (en) 2013-06-20
WO2013090837A3 true WO2013090837A3 (en) 2014-03-13

Family

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PCT/US2012/069934 WO2013090837A2 (en) 2011-12-16 2012-12-14 METHODS OF PRODUCING 6-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE

Country Status (4)

Country Link
EP (1) EP2791347A2 (en)
CN (1) CN104220601A (en)
BR (1) BR112014014675A2 (en)
WO (1) WO2013090837A2 (en)

Families Citing this family (30)

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KR101930540B1 (en) 2009-05-07 2019-03-15 게노마티카 인코포레이티드 Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid
WO2012174451A1 (en) 2011-06-17 2012-12-20 Invista Technologies S.A.R.L. Use of hydrolases to increase monomer content in waste stream
EP2726627A2 (en) 2011-06-30 2014-05-07 Invista Technologies S.à.r.l. Bioconversion process for producing nylon-7, nylon-7,7 and polyesters
US9102960B2 (en) 2011-12-16 2015-08-11 Invista North America S.á.r.l. Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage
US9102958B2 (en) * 2011-12-16 2015-08-11 Invista North America S.á.r.l. Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage
BR112015013413A2 (en) 2012-12-14 2017-11-14 Invista Tech Sarl method for biosynthesizing a recombinant product and host
EP2938734A2 (en) 2012-12-31 2015-11-04 Invista Technologies S.A R.L. Methods of producing 7-carbon chemicals via aromatic compounds
CN105073214A (en) 2012-12-31 2015-11-18 英威达技术有限责任公司 Methods of producing 6-carbon chemicals via methyl-ester shielded carbon chain elongation
EP2938732A1 (en) 2012-12-31 2015-11-04 Invista Technologies S.à.r.l. Methods of producing 7-carbon chemicals from long chain fatty acids via oxidative cleavage
EP2938736A2 (en) 2012-12-31 2015-11-04 Invista Technologies S.A R.L. Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme b synthesis
EP2938733A2 (en) 2012-12-31 2015-11-04 Invista North America S.a.r.l. Methods of producing 7-carbon chemicals via methyl-ester shielded carbon chain elongation
CN105026569A (en) 2012-12-31 2015-11-04 英威达技术有限责任公司 Methods of producing 7-carbon chemicals via pyruvate and succinate semialdehyde aldol condensation
WO2014105788A2 (en) 2012-12-31 2014-07-03 Invista North America S.A.R.L. Methods of producing 7-carbon chemicals via carbon chain elongation associated with cyclohexane carboxylate synthesis
WO2015002916A1 (en) * 2013-07-03 2015-01-08 Butamax Advanced Biofuels Llc Post-transcriptional regulation of biosynthetic pathways
BR112016005689A2 (en) * 2013-09-17 2018-01-30 Zymochem Inc high-yield route for the production of compounds from renewable sources
US12104160B2 (en) 2013-09-17 2024-10-01 Zymochem, Inc. Production of 4,6-dihydroxy-2-oxo-hexanoic acid
BR122020001956B1 (en) 2013-12-05 2023-03-14 Genomatica, Inc RECOMBINANT BACTERIAL CELL FOR THE PRODUCTION OF A FATTY AMINE AND METHOD OF PRODUCTION OF A FATTY AMINE
TWI512105B (en) * 2014-01-17 2015-12-11 Univ Feng Chia Bacterial strain for producing butyrate, bacterial strain for producing n-butanol, and method of production of n-butanol from butyrate
EP2944697A1 (en) * 2014-05-13 2015-11-18 Evonik Degussa GmbH Method of producing nylon
BR112016026461A2 (en) 2014-05-15 2017-12-12 Invista Tech Sarl 6-carbon chemical production methods using 2,6-diaminopimelate as precursor for 2-aminopimelate
EP3155106A2 (en) 2014-06-16 2017-04-19 Invista Technologies S.à.r.l. Methods, reagents and cells for biosynthesizing compound
US20170152531A1 (en) * 2014-06-16 2017-06-01 North America S.A.R.L. Process for producing glutarate and glutaric acid methyl ester
BR112016029375A2 (en) 2014-06-16 2017-10-17 Invista Tech Sarl methods, reagents and cells to biosynthesize compounds
BR112016029399A2 (en) 2014-06-16 2017-10-17 Invista Tech Sarl methods, reagents and cells to biosynthesize compound
NO2721710T3 (en) 2014-08-21 2018-03-31
BR112017003733A2 (en) * 2014-09-03 2017-12-05 Global Bioenergies "Recombinant microorganism that produces alkenes from acetyl coa".
CN107636156A (en) * 2014-11-26 2018-01-26 英威达纺织（英国）有限公司 The method that 6 carbon monomers are produced by 8 carbon compounds
US20160201097A1 (en) * 2014-12-22 2016-07-14 Invista North America S.á.r.l. Materials and Methods of Producing 7-Carbon Monomers
AU2020262490A1 (en) 2019-04-25 2021-11-25 Zymochem, Inc. Production of chemicals from renewable sources
CN114774338B (en) * 2022-03-29 2023-08-08 北京航空航天大学 Probiotics for producing butyric acid, construction method and application thereof

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Also Published As

Publication number Publication date
WO2013090837A2 (en) 2013-06-20
BR112014014675A2 (en) 2017-06-13
CN104220601A (en) 2014-12-17
EP2791347A2 (en) 2014-10-22

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