BR112014014675A2 - method for biosynthesizing one or more products and recombinant host - Google Patents

method for biosynthesizing one or more products and recombinant host

Info

Publication number
BR112014014675A2
BR112014014675A2 BR112014014675A BR112014014675A BR112014014675A2 BR 112014014675 A2 BR112014014675 A2 BR 112014014675A2 BR 112014014675 A BR112014014675 A BR 112014014675A BR 112014014675 A BR112014014675 A BR 112014014675A BR 112014014675 A2 BR112014014675 A2 BR 112014014675A2
Authority
BR
Brazil
Prior art keywords
pathways
biosynthesizing
recombinant host
products
enzymes
Prior art date
Application number
BR112014014675A
Other languages
Portuguese (pt)
Inventor
Botes Adriana
Van Eck Conradie Alex
Original Assignee
Invista Tech Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Invista Tech Sarl filed Critical Invista Tech Sarl
Publication of BR112014014675A2 publication Critical patent/BR112014014675A2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

resumo “método para biossintetizar um ou mais produtos e hospedeiro recombinante” este documento descreve trajetos bioquímicos para produzir ácido adípico, caprolactama, ácido 6-aminohexanóico, hexametilenodiamina, ou 1,6-gexanodiol formando dois grupos funcionais terminais, compreendidos de grupos carboxila, amina ou hidroxila, em um substrato de cadeia principal alifática de c6. estes trajetos, engenharia metabólica e estratégias de cultivo descritos aqui baseiam-se em enzimas de alongamento dependentes de coa ou enzimas análogas com os trajetos de armazenamento de carbono de bactérias acumuladoras de polihidroxialcanoato. 1/1abstract "method for biosynthesizing one or more recombinant host products" This document describes biochemical pathways to produce adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine, or 1,6-hexanediol forming two terminal functional groups, comprised of carboxyl, amino groups or hydroxyl, on a c6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein are based on coa-dependent stretching enzymes or analogous enzymes with the carbon storage pathways of polyhydroxyalkanoate accumulating bacteria. 1/1

BR112014014675A 2011-12-16 2012-12-14 method for biosynthesizing one or more products and recombinant host BR112014014675A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161576401P 2011-12-16 2011-12-16
PCT/US2012/069934 WO2013090837A2 (en) 2011-12-16 2012-12-14 METHODS OF PRODUCING 6-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE

Publications (1)

Publication Number Publication Date
BR112014014675A2 true BR112014014675A2 (en) 2017-06-13

Family

ID=47470235

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014014675A BR112014014675A2 (en) 2011-12-16 2012-12-14 method for biosynthesizing one or more products and recombinant host

Country Status (4)

Country Link
EP (1) EP2791347A2 (en)
CN (1) CN104220601A (en)
BR (1) BR112014014675A2 (en)
WO (1) WO2013090837A2 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI1011227A8 (en) 2009-05-07 2019-02-26 Genomatica Inc microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid.
MY166083A (en) 2011-06-17 2018-05-24 Invista Tech Sarl Use of hydrolases to increase monomer content in waste stream
US9650653B2 (en) 2011-06-30 2017-05-16 Invista North America S.A.R.L. Bioconversion process for producing nylon-7, nylon-7,7 and polyesters
US9102958B2 (en) * 2011-12-16 2015-08-11 Invista North America S.á.r.l. Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage
US9102960B2 (en) 2011-12-16 2015-08-11 Invista North America S.á.r.l. Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage
EP2931907A2 (en) 2012-12-14 2015-10-21 Invista Technologies S.A R.L. METHODS OF PRODUCING 7-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE
WO2014105796A2 (en) 2012-12-31 2014-07-03 Invista North America S.A.R.L. Methods of producing 7-carbon chemicals via aromatic compounds
CN105189764A (en) 2012-12-31 2015-12-23 英威达技术有限责任公司 Methods of producing 7-carbon chemicals via C1 carbon chain elongation associated with coenzyme B synthesis
CN105026570A (en) 2012-12-31 2015-11-04 英威达技术有限责任公司 Methods of producing 7-carbon chemicals from long chain fatty acids via oxidative cleavage
US9738911B2 (en) 2012-12-31 2017-08-22 Invista North America S.A.R.L. Methods of producing 7-carbon chemicals via pyruvate and succinate semialdehyde aldol condensation
US9637764B2 (en) 2012-12-31 2017-05-02 Invista North America S.A.R.L. Methods of producing 7-carbon chemicals via carbon chain elongation associated with cyclohexane carboxylate synthesis
CN105408487A (en) 2012-12-31 2016-03-16 英威达技术有限责任公司 Methods of producing 7-carbon chemicals via methyl-ester shielded carbon chain elongation
US9580733B2 (en) 2012-12-31 2017-02-28 Invista North America S.A.R.L. Methods of producing 6-carbon chemicals via methyl-ester shielded carbon chain elongation
WO2015002916A1 (en) * 2013-07-03 2015-01-08 Butamax Advanced Biofuels Llc Post-transcriptional regulation of biosynthetic pathways
WO2015042201A2 (en) * 2013-09-17 2015-03-26 Zymochem Inc. A high yield route for the production of compounds from renewable sources
ES2772774T3 (en) 2013-12-05 2020-07-08 Genomatica Inc Microbial production of fatty amines
TWI512105B (en) * 2014-01-17 2015-12-11 Univ Feng Chia Bacterial strain for producing butyrate, bacterial strain for producing n-butanol, and method of production of n-butanol from butyrate
EP2944697A1 (en) * 2014-05-13 2015-11-18 Evonik Degussa GmbH Method of producing nylon
US9745607B2 (en) 2014-05-15 2017-08-29 Invista North America S.A.R.L. Methods of producing 6-carbon chemicals using 2,6-diaminopimelate as precursor to 2-aminopimelate
WO2015195611A2 (en) 2014-06-16 2015-12-23 Invista Technologies S.À.R.L. Methods, reagents and cells for biosynthesizing compound
EP3155108A1 (en) 2014-06-16 2017-04-19 Invista Technologies S.à.r.l. Methods, reagents and cells for biosynthesizing compounds
BR112016029375A2 (en) 2014-06-16 2017-10-17 Invista Tech Sarl methods, reagents and cells to biosynthesize compounds
US9938543B2 (en) 2014-06-16 2018-04-10 Invista North America S.A.R.L. Methods, reagents and cells for biosynthesizing glutarate methyl ester
NO2721710T3 (en) 2014-08-21 2018-03-31
EP3189130A1 (en) * 2014-09-03 2017-07-12 Global Bioenergies Recombinant microorganism producing alkenes from acetyl-coa
BR112017010973A2 (en) * 2014-11-26 2018-02-14 Invista Tech Sarl methods for making 7-hydroxyoctanoate and for biosynthesizing 6-hydroxyhexanoate, recombinant host, bioderivated product, biobased product or fermentation derivative, organism, biochemical network, nucleic acid construct or expression vector, and, composition .
EP3237634A1 (en) * 2014-12-22 2017-11-01 Invista Technologies S.à r.l. Materials and methods of producing 7-carbon monomers
CN114026246A (en) 2019-04-25 2022-02-08 兹莫克姆有限公司 Production of chemicals from renewable sources
CN114774338B (en) * 2022-03-29 2023-08-08 北京航空航天大学 Probiotics for producing butyric acid, construction method and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106119112B (en) * 2008-03-27 2021-07-13 基因组股份公司 Microorganisms for the production of adipic acid and other compounds
BRPI1011936A2 (en) * 2009-07-02 2016-05-03 Verdezyne Inc biological methods for the preparation of adipic acid

Also Published As

Publication number Publication date
CN104220601A (en) 2014-12-17
EP2791347A2 (en) 2014-10-22
WO2013090837A2 (en) 2013-06-20
WO2013090837A3 (en) 2014-03-13

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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B350 Update of information on the portal [chapter 15.35 patent gazette]