WO2013086649A3 - Flavonoles como agonistas de coenzima q (ubiquinona y ubiquinol) en la modulación de la actividad de los complejos de la cadena de transporte de electrones mitocondrial - Google Patents

Flavonoles como agonistas de coenzima q (ubiquinona y ubiquinol) en la modulación de la actividad de los complejos de la cadena de transporte de electrones mitocondrial Download PDF

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Publication number
WO2013086649A3
WO2013086649A3 PCT/CL2012/000072 CL2012000072W WO2013086649A3 WO 2013086649 A3 WO2013086649 A3 WO 2013086649A3 CL 2012000072 W CL2012000072 W CL 2012000072W WO 2013086649 A3 WO2013086649 A3 WO 2013086649A3
Authority
WO
WIPO (PCT)
Prior art keywords
flavonols
agonists
coenzyme
ubiquinol
ubiquinone
Prior art date
Application number
PCT/CL2012/000072
Other languages
English (en)
French (fr)
Other versions
WO2013086649A2 (es
Inventor
Hernán SPEISKY COSOY
Cristian SANDOVAL ACUÑA
Original Assignee
Universidad De Chile
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad De Chile filed Critical Universidad De Chile
Publication of WO2013086649A2 publication Critical patent/WO2013086649A2/es
Publication of WO2013086649A3 publication Critical patent/WO2013086649A3/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Uso de flavonoles naturales, semi-sintéticos o sintéticos, de análogos y/o de derivados de flavonoles naturales, semi-sintéticos o sintéticos, de sus mezclas y/o de mezclas que los contengan, como agonistas (parciales o totales) de la coenzima Q oxidada o reducida como "electron-carriers" (EC).
PCT/CL2012/000072 2011-12-13 2012-12-12 Flavonoles como agonistas de coenzima q (ubiquinona y ubiquinol) en la modulación de la actividad de los complejos de la cadena de transporte de electrones mitocondrial WO2013086649A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CL3142-2011 2011-12-13
CL2011003142A CL2011003142A1 (es) 2011-12-13 2011-12-13 Uso de flavonoles naturales, de sus mezclas y/o de mezclas que los contengan que sirven como mimeticos, agonistas o agonistas parciales de ubiquinona y/o ubiquinol.

Publications (2)

Publication Number Publication Date
WO2013086649A2 WO2013086649A2 (es) 2013-06-20
WO2013086649A3 true WO2013086649A3 (es) 2013-10-10

Family

ID=48613300

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CL2012/000072 WO2013086649A2 (es) 2011-12-13 2012-12-12 Flavonoles como agonistas de coenzima q (ubiquinona y ubiquinol) en la modulación de la actividad de los complejos de la cadena de transporte de electrones mitocondrial

Country Status (2)

Country Link
CL (1) CL2011003142A1 (es)
WO (1) WO2013086649A2 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109369589A (zh) * 2018-10-12 2019-02-22 王刚 黄栌黄酮苷的同步提取工艺和其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009012465A1 (de) * 2008-03-12 2009-12-10 Qineva Gmbh & Co. Kg Pharmazeutische Zusammensetzung zur Prophylaxe und Behandlung der Arteriosklerose, sowie zur Schmerzbekämpfung und zur Entzündungshemmung
WO2010118789A1 (en) * 2009-04-17 2010-10-21 Dsm Ip Assets B.V. Hydroxytyrosol combinations for enhancing mitochondrial function and energy production
WO2010135589A2 (en) * 2009-05-20 2010-11-25 Sakura Properties, Llc Dietary supplement drink for delivery of resveratrol and other polyphenols

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100599496B1 (ko) 2001-04-23 2006-07-12 한국생명공학연구원 간염 예방 또는 치료용 약학적 조성물
CN1436524A (zh) 2003-03-03 2003-08-20 杭州浙大力夫生物科技有限公司 竹叶总黄酮作为抗衰老护肤因子在化妆品中的应用
JP4790561B2 (ja) 2006-10-12 2011-10-12 東洋精糖株式会社 フラボノイド組成物、その製造方法および用途
KR101176524B1 (ko) 2008-12-09 2012-08-24 주식회사 코리아나화장품 플라보노이드계 화합물을 유효 성분으로 함유하는 피부 노화 방지용 화장료 조성물
KR101117561B1 (ko) 2008-12-09 2012-02-29 주식회사 코리아나화장품 플라보노이드계 화합물을 유효성분으로 함유하는 항노화 화장료 조성물

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009012465A1 (de) * 2008-03-12 2009-12-10 Qineva Gmbh & Co. Kg Pharmazeutische Zusammensetzung zur Prophylaxe und Behandlung der Arteriosklerose, sowie zur Schmerzbekämpfung und zur Entzündungshemmung
WO2010118789A1 (en) * 2009-04-17 2010-10-21 Dsm Ip Assets B.V. Hydroxytyrosol combinations for enhancing mitochondrial function and energy production
WO2010135589A2 (en) * 2009-05-20 2010-11-25 Sakura Properties, Llc Dietary supplement drink for delivery of resveratrol and other polyphenols

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LAGOA ETAL: "Complex Iand cytochrome c are molecular targets of flavanoids that inhibit hydrogen peroxide production ny mitochondria", BIOCHIMICA ET BIOPHYSICA ACTA, 12 October 2011 (2011-10-12) - 12 October 2011 (2011-10-12), pages 1562 - 1572, XP002707633 *
RATNAM ET AL: "Role of antioxidants in prophylaxis and therapy;", J. CONTROL. REL., vol. 113, 13 May 2006 (2006-05-13) - 13 May 2006 (2006-05-13), pages 189 - 207, XP002707634 *

Also Published As

Publication number Publication date
WO2013086649A2 (es) 2013-06-20
CL2011003142A1 (es) 2012-07-20

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