WO2013081290A1 - Procédé de modification de surface hydrophile d'implant dentaire et procédé de stockage d'implant pour maintenir une surface hydrophile - Google Patents

Procédé de modification de surface hydrophile d'implant dentaire et procédé de stockage d'implant pour maintenir une surface hydrophile Download PDF

Info

Publication number
WO2013081290A1
WO2013081290A1 PCT/KR2012/008016 KR2012008016W WO2013081290A1 WO 2013081290 A1 WO2013081290 A1 WO 2013081290A1 KR 2012008016 W KR2012008016 W KR 2012008016W WO 2013081290 A1 WO2013081290 A1 WO 2013081290A1
Authority
WO
WIPO (PCT)
Prior art keywords
implant
ozone treatment
hydrophilic
maintaining
dental implant
Prior art date
Application number
PCT/KR2012/008016
Other languages
English (en)
Korean (ko)
Inventor
최홍영
박재준
엄태관
최규옥
Original Assignee
오스템임플란트 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 오스템임플란트 주식회사 filed Critical 오스템임플란트 주식회사
Publication of WO2013081290A1 publication Critical patent/WO2013081290A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A61C8/0013—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating
    • A61C8/0015—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating being a conversion layer, e.g. oxide layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23F—NON-MECHANICAL REMOVAL OF METALLIC MATERIAL FROM SURFACE; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL; MULTI-STEP PROCESSES FOR SURFACE TREATMENT OF METALLIC MATERIAL INVOLVING AT LEAST ONE PROCESS PROVIDED FOR IN CLASS C23 AND AT LEAST ONE PROCESS COVERED BY SUBCLASS C21D OR C22F OR CLASS C25
    • C23F1/00—Etching metallic material by chemical means
    • C23F1/10—Etching compositions
    • C23F1/12—Gaseous compositions
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23G—CLEANING OR DE-GREASING OF METALLIC MATERIAL BY CHEMICAL METHODS OTHER THAN ELECTROLYSIS
    • C23G5/00—Cleaning or de-greasing metallic material by other methods; Apparatus for cleaning or de-greasing metallic material with organic solvents

Definitions

  • the present invention relates to a hydrophilic modification method of the dental implant surface and to an implant storage method for maintaining the hydrophilic surface, the hydrophobic surface of the implant through a dry cleaning method using UV- ozone does not change the physical shape of the implant surface
  • the present invention relates to a method of modifying superhydrophilicity and storing the hydrophilicity of the modified surface for a long time.
  • Prior art EP 1,150,620 describes an implant having a hydrophilic surface after SLA surface treatment.
  • the manufacturing method in this document describes i) mechanically roughening the titanium surface through various methods, and ii) containing additives. After washing the surface with pure water, iii) a method of manufacturing the titanium surface in a container having an inert atmosphere without further processing, and thus the wettability of the titanium surface is 20 to 50 with respect to water. It is stated to maintain a hydrophilic surface that exhibits a contact angle of ° .
  • water containing salts is mentioned as a method of maintaining an inert atmosphere.
  • salt concentration 100 to 200 meq / i for monovalent salts such as Na and K, and l to bivalent salts such as Mg and Ca. The concentration range of 20 meq / is described.
  • PVD Physical Vapor Deposition
  • the prior art has applied a method of storing in an aqueous solution containing a salt in order to maintain the surface hydrophilicity, in the case of the monovalent salt in the concentration of the applied salt, while the concentration is sufficient to 2 ⁇ 200 meq / 2 If the divalent salts have l ⁇ 20meq e range eggnog degrees too low and too small an amount, so the problem is not enough to cover the entire surface of the congestion when applied to the actual dental implant fixture for i.
  • the prior art EP 2,121,058 is to overcome the limitation of the hydrophilicity of the technology according to the EP 1,150,620, it is necessary to form a nano-pore structure of 50-100 nm on the titanium surface through the surface treatment of sulfuric acid
  • a superhydrophilic surface with a contact angle of 10 ° or less can be secured and must be stored in a salt-containing water solution with a total ion concentration of at least 0.5 mol / ⁇ and preferably at least 1 mol / £ in order to maintain the hydrophilicity of the surface after drying It is describing.
  • the present invention provides a method of modifying the hydrophobic surface of an implant with superhydrophilicity through a precise dry surface cleaning method without changing the inherent physical shape of the titanium surface and the modified surface.
  • the aim is to provide a storage method that can maintain the superhydrophilicity of a long time.
  • the present invention is to provide a method for modifying the implant surface and implant storage method to improve the body fluid and blood affinity of the implant surface to obtain an excellent initial bone formation effect and shortening the bone fusion period after the implant procedure The purpose.
  • the present invention for achieving the above object is a titanium with a surface contact angle of 50 ° or more
  • it provides a method of hydrophilic modification of the dental implant surface by modifying the dental implant surface of titanium alloy material to a super-hydrophilic surface having a surface contact angle of less than 5 ° by UV-ozone treatment.
  • the present invention comprises the steps of i) modifying a dental implant surface of titanium or titanium alloy material to a superhydrophilic surface having a surface contact angle of 5 ° or less by UV-ozone treatment, and ⁇ ) of the modified surface.
  • an implant storage method for maintaining a hydrophilic surface comprising immersing at least a portion of the implant in a solution containing a divalent salt to maintain hydrophilicity.
  • the UV wavelength band for the UV- ozone treatment is the ozone generation is most activated
  • the UV flux density for the UV-ozone treatment is preferably 20 mW / cnf to 1.0 W / ciii, and more preferably 45 mW / cnf to 0.2 W / cnf.
  • the UV irradiation time for the UV- ozone treatment is preferably 1 minute to 1 hour
  • the temperature in the reaction chamber for the UV- ozone treatment is preferably 10 ⁇ 80 ° C.
  • the solution containing the divalent salt preferably contains Mg 2+ , Ca 2+ , Sr 2+ , Mr / + , Z n 2+ or a mixed form thereof, and the divalent salt containing The concentration of the solution is preferably O.molol / i to 0.5mdAe so that the contact angle does not exceed 20 ° even if the titanium surface is left in the air for a long time.
  • the hydrophobic surface of the implant can be modified and stored as a superhydrophilic surface without going through a complicated process, and the biohydrophilic surface can increase the bioactivity and blood affinity of the implant during implantation. It is possible to obtain an effect of shortening the procedure period while improving initial bone adhesion.
  • 1 and 2 are graph and photographic results showing the change of surface contact angle with UV-ozone treatment time of SA disk.
  • FIG. 3 is a surface analysis result of a dental implant stored in an aqueous calcium chloride solution of 2mM, 20mM and 200mM concentration after UV-ozone treatment.
  • SA acid treatment
  • SA ultrasonic cleaning
  • SA0JV-ozone treatment UV ⁇ ozone treatment after acid treatment
  • 5 is a bone interface according to the concentration of the low concentration of chloride solution in which the implant is stored The result of measuring the binding force.
  • the present invention is a method of hydrophilic modification of the dental implant surface to modify the surface of the dental implant of titanium or titanium alloy material having a surface contact angle of more than 50 ° UV-ozone treatment to a super-hydrophilic surface having a surface contact angle of 5 ° or less To provide.
  • the present invention provides a method for preparing a dental implant surface comprising: i) dental implant surface all UV—ozone treatment of titanium or titanium alloy to modify a superhydrophilic surface having a surface contact angle of 5 ° or less, and ii) Provided is an implant storage method for maintaining a hydrophilic surface comprising immersing at least a portion of the implant in a solution containing a bivalent salt for maintaining the aqueous.
  • the surface of the dental implant can be stored for a long time by modifying the dental implant surface without using a complicated process, improving the bioactivity and blood affinity of the implant surface, thereby improving the initial bone adhesion of the implant and the duration of the procedure. Can be shortened.
  • the term "implant” refers to a substitute for restoring lost human tissue, and a dental implant generally has a natural root removed to replace the root of the lost tooth. After fixing fixtures to the alveolar bone and adhering them, it refers to a substitute for restoring the original function of the teeth by fixing artificial teeth on the upper part.
  • the surface of the dental implant herein refers to the surface of the fixture that can be bonded to the alveolar bone, at least one of titanium or aluminum, tantalum, niobium, vanadium, zirconium, platinum, magnesium and sodium And it may be made of a titanium alloy containing titanium.
  • the property of the implant surface is an important factor in the bone adhesion process in which new bone tissue is fused to the implant surface, and changes the surface of the implant to improve the fixation of the implant to hard tissue and also improve implant implantability.
  • the healing process can be accelerated by enhancing bone adhesion.
  • micro-units of microorganisms can be used in the process of 3 ⁇ 4 ⁇ ⁇ scanning 3 ⁇ 4, saw spraying medium method, acid etching method, alkali etching method, titanium plasma spray method, post-particle spray acid treatment method, anodization method, laser It may be formed by various methods such as surface processing.
  • the micro-roughness of the implant has the advantage of increasing the surface area to improve bone adhesion.
  • contamination by various sources of air increases.
  • the carbon pollutant present in the air is irreversibly adsorbed on the surface of the implant to hydrophobic the surface of the implant.
  • the present invention provides a 5 ° C treatment by applying UV-ozone treatment to a surface of a dental implant having a hydrophobic surface having a surface contact angle of 50 ° or more. It is characterized by modifying a super-aqueous aqueous surface having the following surface contact angle.
  • this method does not change the physical shape of the titanium surface by using a solvent to decompose the micro-polluted layer on the surface by reaction of ionized components in vacuum or air without using a solvent. Therefore, even a simple process can change the surface contact angle to a super hydrophilicity of 5 ° or less.
  • the implants modified with super hydrophilicity have superior body fluid and blood affinity after the procedure, and thus have an excellent bone formation effect and shorten bone fusion period.
  • the UV wavelength band for the uv-ozone treatment preferably includes a region of 150-254 ⁇ ' so that ozone generation due to UV is most activated.
  • the UV flux density for the UV-ozone treatment is 20 mW / ciif to l.OW / cuf, preferably 45 mW / cuf to 0.2 W / cin 2 .
  • the UV irradiation time is preferably preferably in the 1-1 minutes, and, the temperature in the reaction chamber is made of the UV- ozone treatment is 10 ⁇ 80 ° C order to be made .
  • the surface of the modified implant is dried.
  • the modified implant is characterized in that at least part of the implant is immersed in a solution containing a divalent salt so that it can be hydrophobized at least 20 ° or less without being hydrophobized later.
  • the solution containing the divalent salt preferably includes Mg 2+ , Ca 2+ , Sr 2+ , Mn 2+ , Zn 2+, or a mixed form thereof.
  • the salt in the solution may cover the surface of the implant to block the carbon pollution in the air, even if the surface of the implant is left in the air for a long time, the contact angle
  • the concentration of the divalent salt-containing solution is preferably 0.01 mol / 0.5 mol /, which means that in the case of divalent salts such as calcium chloride, the concentration that can cover the implant surface is at least O.Omolmol / ⁇ . This is because more than 0.5mol / can kill cells due to toxicity.
  • Machined titanium implants or discs are blasted for 1 to 60 seconds with a blasting pressure of 1 to 10 atm using A1 2 0 3 powders with particle size lirai or less, followed by acid treatment using a mixed acid aqueous solution. Macro & micro morphology was applied to the surface of the implant or disc.
  • the acid-treated dental titanium implant or disc was ultrasonically cleaned with ethane for 30 minutes and with distilled water for 30 minutes and then dried.
  • UV-Ozone treatment was performed on the implant or disk subjected to the SA (Sandblasting and Acid etching) process for 5 minutes to remove the adsorbed and stabilized contaminants on the surface. Used at ⁇ 6.
  • the implant was placed in a micropig tibia and a torsional torque measurement was performed after the bone formation period for 16 days. .
  • the SA control that was not treated with UV- ozone was used as a negative control.
  • the implant After implanting the dental implant prepared in Example 1 in three concentrations of aqueous solution of chlorine chloride through UV-ozone treatment, the implant is placed in a micropig tibia to confirm the implant-bone interface binding force. After 21 days, the bone formation period was measured for removal torque.
  • the test group stored in the 600 mM calcium chloride solution compared to the test group stored in the 20 mM, 200 mM, and 400 mM aqueous solution of calcium chloride showed a large deviation width and slight average binding force in the removal ability of the strain. By confirming the decrease, it was confirmed that the impulsive-bone interface binding force may be relatively weak.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dentistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Materials Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Metallurgy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ceramic Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Dental Prosthetics (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La présente invention concerne un procédé pour modifier une surface hydrophile d'un implant dentaire et un procédé de stockage d'implant pour maintenir une surface hydrophile, la surface hydrophobe d'un implant étant modifiée en une surface ultra-hydrophile par un procédé de nettoyage à sec utilisant ozone UV qui n'altère pas la forme physique intrinsèque de la surface d'un implant, et l'implant étant stocké d'une manière telle que l'ultra-hydrophilie de la surface modifiée doit être maintenue pendant une longue période. Conformément à la présente invention, l'implant modifié et stocké est amélioré en affinité aux fluides corporels et au sang de la surface, permettant ainsi l'amélioration de l'ostéogenèse initiale et réduisant la période d'ostéo-intégration après l'implantation d'un implant dentaire.
PCT/KR2012/008016 2011-11-28 2012-10-04 Procédé de modification de surface hydrophile d'implant dentaire et procédé de stockage d'implant pour maintenir une surface hydrophile WO2013081290A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110124979A KR101271403B1 (ko) 2011-11-28 2011-11-28 치과용 임플란트의 친수성 표면 유지를 위한 임플란트 보관방법
KR10-2011-0124979 2011-11-28

Publications (1)

Publication Number Publication Date
WO2013081290A1 true WO2013081290A1 (fr) 2013-06-06

Family

ID=48535704

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/008016 WO2013081290A1 (fr) 2011-11-28 2012-10-04 Procédé de modification de surface hydrophile d'implant dentaire et procédé de stockage d'implant pour maintenir une surface hydrophile

Country Status (2)

Country Link
KR (1) KR101271403B1 (fr)
WO (1) WO2013081290A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014027595A1 (fr) * 2012-08-13 2014-02-20 学校法人愛知学院 Procédé de traitement et dispositif de traitement pour matériau d'implant présentant une excellente biocompatibilité

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113814418B (zh) * 2021-08-05 2022-10-28 珠海乔丹科技股份有限公司 一种钛或钛合金牙齿种植体的表面处理工艺

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1150620A1 (fr) * 1999-01-29 2001-11-07 Institut Straumann AG Implants osteophiles
KR20090117807A (ko) * 2007-02-14 2009-11-12 허벌트 제니슨 초친수성 표면을 갖는 저장성 임플란트의 제조 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2660393A1 (fr) * 2006-08-22 2008-02-28 Thommen Medical Ag Implant, notamment implant dentaire
ES2433723T3 (es) 2010-12-30 2013-12-12 Universitätsklinikum Freiburg Polímeros antimicrobianos anclados covalentemente

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1150620A1 (fr) * 1999-01-29 2001-11-07 Institut Straumann AG Implants osteophiles
KR20090117807A (ko) * 2007-02-14 2009-11-12 허벌트 제니슨 초친수성 표면을 갖는 저장성 임플란트의 제조 방법

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LINDERBACK, P. ET AL., BIOMATERIALS, vol. 31, 2010 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014027595A1 (fr) * 2012-08-13 2014-02-20 学校法人愛知学院 Procédé de traitement et dispositif de traitement pour matériau d'implant présentant une excellente biocompatibilité
JP2014036716A (ja) * 2012-08-13 2014-02-27 Aichi Gakuin 生体親和性に優れたインプラント材料の処理方法及び処理装置

Also Published As

Publication number Publication date
KR101271403B1 (ko) 2013-06-05

Similar Documents

Publication Publication Date Title
KR101248785B1 (ko) 초친수성을 갖는 티타늄 임플란트, 그 표면처리 및 보관 방법
AU2002328762B2 (en) Osteophilic implants
JP6336150B2 (ja) セラミック材料から作られた本体
CN113015501B (zh) 牙科植入物、用于牙科应用的部件和植入物系统
KR101311990B1 (ko) 임플란트 표면의 생체활성과 골결합력 및 골융합을 증진시키는 물질이 코팅된 임플란트와 그 제조방법 및 임플란트의 보관 방법
JP2019511346A (ja) 組織接着性向上用コーティング
CN104434539B (zh) 可植入人或动物体内的装置的表层的制备方法
KR20140095551A (ko) 인산칼슘의 표면 층을 갖는 금속 재료들, 및 이의 제조방법
Areid et al. Ultraviolet photofunctionalization of nanostructured titanium surfaces enhances thrombogenicity and platelet response
KR101972122B1 (ko) 표면 형태학적 특성 및 골 유착성이 개선된 치과용 임플란트의 제조방법
CN110753560A (zh) 牙科植入物
KR101306803B1 (ko) 임플란트 표면의 생체활성을 증진시키는 유기용매를 이용한 임플란트 및 그 제조방법
WO2013081290A1 (fr) Procédé de modification de surface hydrophile d'implant dentaire et procédé de stockage d'implant pour maintenir une surface hydrophile
JP5535647B2 (ja) 金属インプラント
KR20130028509A (ko) 친수성 보습막이 코팅된 치과용 임플란트 및 그 제조 방법
KR101296591B1 (ko) 치과용 임플란트 표면의 ｈａ 코팅층 후처리 장치
KR101460973B1 (ko) 표면이 코팅되어 생체 친화성과 생체 적합성이 향상된 치과용 임플란트 및 이의 제조 방법
KR101460974B1 (ko) 표면이 코팅되어 생체 적합성이 향상된 치과용 임플란트 및 이의 제조 방법
WO2013027928A2 (fr) Implant ayant une surface hydrophile
JP5785435B2 (ja) インプラントの製造方法
US20240189480A1 (en) Polyphenol coating and preparation method and use thereof
Alpay et al. The Investigation of Corrosion Performance and Durability of Hydroxyapatite-Coated Titanium Implants and the Effect of Antibiotic Additives
JP4472267B2 (ja) 骨結合を得るためのチタン製インプラント及びその表面処理方法
KR20220090934A (ko) 친수성 표면을 갖는 임플란트의 제조방법 및 상기 방법으로 제조된 임플란트
CN116669656A (zh) 牙种植体

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12853990

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 12853990

Country of ref document: EP

Kind code of ref document: A1