WO2013072777A2 - Clot removal devices and methods - Google Patents
Clot removal devices and methods Download PDFInfo
- Publication number
- WO2013072777A2 WO2013072777A2 PCT/IB2012/003053 IB2012003053W WO2013072777A2 WO 2013072777 A2 WO2013072777 A2 WO 2013072777A2 IB 2012003053 W IB2012003053 W IB 2012003053W WO 2013072777 A2 WO2013072777 A2 WO 2013072777A2
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- WIPO (PCT)
- Prior art keywords
- clot
- capture element
- blood vessel
- shaft
- engagement element
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22038—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with a guide wire
- A61B2017/22042—Details of the tip of the guide wire
- A61B2017/22044—Details of the tip of the guide wire with a pointed tip
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
- A61B2017/2215—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions having an open distal end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
- A61B2017/2217—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions single wire changing shape to a gripping configuration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/08—Accessories or related features not otherwise provided for
- A61B2090/0801—Prevention of accidental cutting or pricking
- A61B2090/08021—Prevention of accidental cutting or pricking of the patient or his organs
Definitions
- Embodiments of the present disclosure generally relate to devices and methods for treating occlusions within vasculature. More particularly, embodiments of the present disclosure relate to devices and methods for removal of clots (e.g., emboli and thrombi) found in blood vessels, among other things.
- clots e.g., emboli and thrombi
- Blood clots are examples of blockages that may form in mammalian blood vessels.
- a clot in an individual's blood vessel may become dangerous when it restricts blood flow, thereby placing the individual at risk for medical traumas, such as a stroke or a heart attack. Therefore, there may be a need to remove clots that are lodged within blood vessels.
- a variety of devices and procedures have beers used to remove clots from blood vessels.
- a catheter with a balloon on its distal tip may be inserted into a blood vessel and passed through the clot, after which the balloon is inflated. The balloon may then be withdrawn from the blood vessel to remove the clot.
- a clot removal device is a catheter containing a spiral section at its distal end.
- the catheter with spiral section may be delivered to a clot site within a blood vessel, and the spiral section may then be used to cut into the clot.
- the spiral section therefore, may grasp to an inner portion of the clot prior to withdrawing the clot from the blood vessel
- clot removal devices One risk that exists with clot removal devices is that a piece of the clot, may break away during the removal process, travel through the vasculature, and cause traumatic damage. This may occur for various reasons. For example, if the clot removal device passes through the clot prior to deployment, the pre-depioyment activity can disrupt the clot, causing pieces to break away. Further, there is an increased risk of deploying a device in uninvolved distal territory. There is a need for devices and methods that may allow a clot to be removed from a blood vessel, while reducing the risk that a clot or portion of a clot may become dislodged during the removal process, causing further risk to the patient. [007] Embodiments of the present disclosure provide devices and methods for removing clots from blood vessels.
- a first aspect of the inven tion provides a clot removal device, comprising an expandable clot engagement element; an expandable clot capture element; and a sheath surrounding and compressing the capture element and the engagement element, the sheath being removable to thereby enable the capture element to expand in a blood vessel in which the sheath is deployed, and to enable the engagement element to expand within the capture element.
- the capture element surrounds the engagement element, and/or the capture element includes a mesh-like structure, and/or the capture element has a length that is longer than a length of the engagement element, and/or the capture element is sized so that in a deployed state it engages a blood vessel wall, and wherein the engagement element is sized so that in a deployed state the engagement element is movable within the capture element.
- the engagement element is a coil, and/or the engagement element is sized to be movable within the capture element upon removal of the sheath, and/or the engagement element is sized to be rotatabie within the capture element upon removal of the sheath.
- the capture element and the engagement element can be configured such that when used, the engagement element is between the capture element and the clot,
- the device can further comprise a locking mechanism for locking the clot engagement element within the clot capture element,
- a second aspect of the invention provides a method of removing a clot from a blood vessel comprising the steps of: deploying a clot removal device in a blood vessel at a clot site, the clot removal device including, an expandable clot engagement element, an expandable clot capture element, and a sheath surrounding and compressing the capture element and the engagement element; and removing the sheath from the capture element and the engagement element such that the capture element expands within the blood vessel, and the engagement element expands within the capture element.
- the method according to the second aspect of the invention can be performed using any of the embodiments of the device according to the first aspect disclosed above.
- the engagement element moves within the capture element upon removal of the sheath, and/or the engagement elemen rotates within the capture element upon removal of the sheath.
- the method also comprises the step of using a locking mechanism to lock the clot engagement element within the clot capture element,
- the capture element engages the blood vessel wall in a deployed state, and wherein the engagement element moves within the capture element in the deployed state.
- a third aspect of the invention provides a clot removal device, comprising: a tubular clot capture element, wherein the clot capture element is configured for deployment in a blood vessel for surrounding a clot, the clot capture element having an opening therein configured to receive and guide a clot engaging element the clot capture element being configured to radially contract upon retraction, such that when the ciot capture element surrounds a clot and is retracted in a longitudinal direction of the blood vessel, the ciot capture element is configured to exert a radially inward compression force on the clot.
- the clot capture element is in the form of a mesh-like structure such as a net.
- the net can he braided, and/or the net includes a plurality of crossing braids, and wherein each of the plurality of crossing braids are movable relative to one another, and/or the net can include includes a plurality of wires, a proximal end, and a distal end, and wherein the proximal and distal ends are free of open ends of wires.
- the ciot engaging element includes a coil and a shaft connected to the coil.
- the device according to the third aspect of the invention further comprises a control shaft, wherein the clot capture element includes a proximal end and a distal end, and wherein the control shaft extends from the proximal end.
- control shaft and the clot capture element are configured such that when the control shaft is retracted in a longitudinal direction of the blood vessel, the clot capture element is retracted in the longitudinal direction of the blood vessel.
- the clot capture element is configured such that when retracted in a longitudinal direction of the blood vessel, the ciot capture element exerts a longitudinal shearing force on the clot.
- a fourth aspect of the invention provides a method of removing a ciot from a blood vessel comprising the steps of: deploying a tubular clot capture element in a blood vessel, the clot capture element having an opening therein that receives and guides a clot engaging element; surrounding a clot with the clot capture element; and retracting the clot capture element in a longitudinal direction of the blood vessel, such that the clot capture element radially contracts, exerting a radially inward compression force on the clot,
- the method according to the fourth aspect can be performed using a device according to the third aspect of the invention.
- the clot capture element is retracted via a control shaft thai extends from the clot capture element
- retracting the clot capture element in a longitudinal direction of the blood vessel includes exerting a longitudinal shearing force on the clot.
- a fifth aspect of the invention provides a clot removal device, comprising; a tubular clot capture element having a first internal diameter; and a clot engaging element having a second externa! diameter, wherein the first diameter and the second diameter are selected to permit the clot engaging element to be rotated within the tubular clot capture element.
- the tubular clot capture element includes a mesh-like structure.
- the clot engaging element includes a coil.
- the tubular clot capture element includes a mesh-like structure and the clot engaging element includes a coil
- the coil can be configured to be rotated about the exterior of a clot and the mesh-like structure can be configured to contain the coil and the clot.
- the first diameter and the second diameter are chosen such that an outer surface area of the clot engaging element contacts an inner surface area of the clot capture element, and/or the first diameter and the second diameter are selected to permit the clot engaging element to longitudinally move within clot capture element, and/or the first diameter and the second diameter are selected to permit the clot engaging element to expand within the clot capture element,
- the device according to the fifth embodiment of the invention further comprises a locking mechanism locking the clot engaging element within the clot capture element.
- the device according to the fifth embodiment of the invention further comprises a first shaft that extends from a proximal end of clot capture element, and a second shaft extends from a proximal end of clot engaging element, and wherein the second shaft is configured to rotate within the first shaft.
- a sixth aspect of the invention provides a method of removing a clot from a blood vessel comprising the steps of: delivering a tubular clot capture element having a first diameter to a clot site; delivering a clot engaging element having a second external diameter to the clot site, wherein the first diameter and the second diameter are selected to such that the clot engaging element rotates within the tubular clot capture element.
- the method according to the sixth aspect of the invention can be performed by a device according to the fifth aspect of the invention.
- a locking mecha ism locks the clot engaging element within the clot capture element.
- the method according to the sixth aspect of the invention can further comprise longitudinally moving the clot engaging element within the ciot capture element.
- the method according to the sixth aspect of the invention can further comprise expanding the clot engaging element within the clot capture element.
- a first shaft extends from a proximal end of clot capture element, and a second shaft extends from a proximal end of clot engaging element, and wherein the method further comprises rotating the econd shaft within the first shaft.
- a seventh aspects of the invention provides a clot removal device, comprising: a shaft; a ciot engagement element on an end of the shaft, the clot engagement element and the shaft being configured for deployment in a blood vessel; and a stabilizer configured to at least partially surround the shaft and to maintain a portion of the shaft in a non-contacting relationship with the blood vessel wall.
- the clot engagement element is a coil.
- the coil can include a plurality of windings having a substantially constant pitch, and/or the coil can include a plurality of windings having a substantially constant radius.
- the stabilizer is configured to maintain the coil in a generally axial orientation in the blood vessel.
- the device according to the seventh aspect can former comprise a ciot capture element.
- the stabilizer can be connected to the clot capture element, and/or the clot capture element is a mesh-like tube, and wherein the stabilizer includes an opening in an end of the mesh-iike tu be, and/or the stabilizer includes a portion of a control shaft extending from a proximal end of the clot capture element.
- An eighth embodiment of the invention provides a clot removal device, comprising: a shaft; a clot engagement element on an end of the shaft, the clot engagement element including a rotatabfe coil, wherein the coil extends from the shaft, and wherein the shaft and the coil are configured for deployment in a blood vessel; and a stabilizer, including an opening through which the shaft passes, the stabilizer being configured to maintain the shaft generally in a center of the blood vessel during rotation of the coil.
- the stabilizer includes a tube with a tapered end, and wherein the opening is located in the tapered end.
- the tube can be made of a mesh-like structure.
- the mesh-like structure can be configured to contract radially when the tube is retracted in a longitudinal direction of the vessel
- a ninth aspect of the invention provides a method for removing a clot from a blood vessel, the method comprising the steps of: deploying a clot engagement element, in a blood vessel, the clot engagement element located on an end of a shaft; and deploying a stabilizer in the blood vessel in a manner at least partially surrounding the shaft, and to maintain a portion of the shaft in a non-contacting relationship with a wall of the blood vessel,
- the method further comprises positioning the stabilizer in a location adjacent the clot engagement element, and wherein the stabilizer is configured to substantially center the clot engagement element in the vessel, and optionally further comprises the step of rotating the clot engagement element about a clot while the clot engagement element is substantially centered by the stabilizer,
- the method according to the ninth aspect of the invention can be performed using a device according to the eighth aspect of the invention.
- the stabilizer maintains the coil in a generally axial orientation of the blood vessel.
- the method according to the ninth aspect of the invention can fur ther comprise the step of deploying a clot capture element in the blood vessel, and wherein the stabilizer is connected to the clot capture element.
- Figure 1 A is a sectional view of a medical device for removing a clot from a blood vessel, consistent with an embodiment of the disclosure.
- Figures I B and 1C are a sectional views of a the medical device of Figure 1A in expanded configurations.
- Figure 2 is a perspective view of a clot capture element and clot engagement element of the medical device of Figure 1 A.
- Figures 3A-3B are perspective views of a clot capture element, consistent with a second embodiment of the disclosure, in contracted and expanded configurations, respectively.
- Figures 4A-4B are perspective views of a clot capture elements, consistent with third and fourth embodiments of the disclosure, respectively.
- Figure 5 is a perspective view of a conventional locking mechanism for use with the medical device of Figure 1A.
- Figure 6A-6B are sectional views of a body portion showing steps of a method of removing a clot from the body portion, using the medical device of Figure I.A.
- Figures 7A-7B are sectional views of the body portion of Figures 6A-6B showing movement of a clot engagement element during a method of removing a clot from the body portion, using the medical device of Figure 1A,
- Figures 7C-7D are sectional views of the body portion of Figures 6A-6B showing steps of removing a clot from the body portion, using the medical device of Figure 1A.
- Figure 8 is a sectional view of the body portion of Figures 6A-6B showing forces acting on a clot during a method of removing the clot from the body portion, using the medical device of Figure I A,
- Embodiments of the present disclosure relate generally to medical devices and methods for treating occlusions in a body. More particularly, embodiments of the present disclosure relate to devices and method for removing clots, including, but not limited to, emboli and thrombi from blood vessels, it should be emphasized, however, that embodiments of the present disclosure may also be utilized in other medical procedures where removal of a blockage or a foreign body is desired.
- a clot removal device including an expandable clot engagement element.
- An expandable clot engagement element may be any structure that, upon deployment in a blood vessel, may be able to grip, grasp, circumscribe, or retain and/or retrieve a blood clot or other obstruction.
- FIG. 1 A illustrates one example of a clot engagement element 102, in connection with exemplary clot removal device 100.
- a clot engagement element 102 in connection with exemplary clot removal device 100.
- proximal refers to the end closer to the device operator during use
- distal refers to the end further from the device operator duri g use.
- clot engagement element 102 may include a coil with one or more windings 108.
- the windings 108 may be angled relative to a longitudinal axis 1006 of a blood vessel 1002 (Fig. 7 A).
- the angle of the windings 108 may range from approximately 0 degrees to approximately 180 degrees, and more preferably from approximately 90 degrees to approximately 180 degrees,
- a plurality of windings 108 may further form a helical configuration, whereby the plurality of windings 108 share a substantially constant pitch P and/or a substantially constant radius R, as illustrated with reference lines in Fig. 7A.
- the one or more windings 108 may includes a varied pitch and/or a varied radius.
- the one or more windings 108 may be any shape and/or configuration such that they may be configured to rotate about a clot lodged withi a blood vessel, to grasp at least a portion of the outer circumference of the clot, and to separate the clot from the blood vessel (Fig. 6B).
- the one or more windings 108 may be wound in any suitable shape, including, but not limited to a circle and an ovai.
- the one or more windings 108 may also be a continuous piece of material.
- the continuous piece of material may have any suitable cross- sectional shape, including, but not limited to, a circle, a oval, a ploygon, or any other shape that is capable of being wound.
- the one or more windings 108 may further include an atraumatic bottom, clot contacting surface that may be substantially flat or rounded. The bottom, clot contacting surface of the one or more windings 108 may mitigate the tendency of a clot 1000 to break into multiple pieces upon contact.
- the bottom, clot contacting surface of the one or more windings 108 may be textured for enhanced gripping of a clot 1000.
- a top, exterior surface of the one or more windings 108 may also be an atraumatic surface. The atraumatic top, exterior surface of the one or more windings 108 may mitigate damage to tissue that the one or more windings 108 may contact at a clot site.
- Windings 108 may also include a coating on their top and/or bottom surfaces. The coating may include, but is not limited to. a lubricant and/or an anesthetic.
- Clot engagement element 102 may further he a spring-like member configured to self-expand and retract. Expansion and retraction may be in longitudinal and/or radiai directions. Accordingly, clot engagement element 102 may include a contracted configuration (Fig. 1 A) and an expanded configuration (Fig. 1 B). The contracted configuration may he maintained when a sheath 1 18 substantially surrounds an outer surface of clot engagement, element 102. The expanded configuration may be achieved when sheath 1 18 is removed from at least a portion of the outer surface of clot engagement element 102 (Sheath 1 8 will be discussed in further detail below).
- Clot engagement element 102 may be configured to expand to approximately an inner diameter of a blood vessel 1002 (Fig. 7 A). Expansion to approximately an inner diameter of blood vessel 1002 may result (but not necessarily result) in clot engagement element 102 exerting a force on a wall 1004 of blood vessel 1002. if a force is exerted on the vessel wall 1004. the force may result in separation of a clot 000 from wall 1004 of blood vessel 1002. The resulting separation may be beneficial because in many instances, clot 1000 may be lodged in blood vessel 1002. Accordingly, separation of clot 1000 from wall 1004 of blood vessel may reduce the amount of feree required to further remove clot 1000 from blood vessel 1002 and mitigate the tendency of clot 1000 to break into multiple fragments during removal from blood vessel 1002.
- a shaft 1 16 may extend from a proximal end of clot engagement element 102.
- Shaft 1 16 may be an elongate member configured to control rotational and longitudinal movement of clot engagement element 102.
- movement of shaft 1 16 in the directions shown by arrow 1010 may cause movement of clot engagement element 102 in the directions of arrow 1010'.
- rotation of shaft 1 16 in the direction of arrow 1012 may cause rotational movement of clot engagement element 102 in the direction of arrow 1012*.
- Shaft 1 16 may have any shape and/or configuration so long as shaft 1 16 may be configured to rotate and advance clot engaging element 102. Further, shaft 1 16 may have any suitable cross-sectional shape so long as shaft 1 16 may be configured to rotate. (Fig. 7A).
- the clot engagement element may have any shape and/or configuration so long as it is capable of grasping and removing a clot from a blood vessel. Further, the clot engagement element may be any size such that it is capable of traversing a lumen of a blood vessel,
- the clot engagement element may be constructed of any suitable biocompatible material having sufficient flexibility and/or rigidity to traverse the lumen of the blood vessel.
- Biocompatible materials may include, but are not limited to, synthetic plastics, stainless steel, ePTFE, PTFE, metal-polymer composites, and metal alloys of nickel, titanium, nickel- titanium, copper cobalt, chromium, and iron.
- a clot engagement element may include any structure or mechanism capable of engaging with a clot or other obstruction.
- a clot engaging element may include one or more hooks, forceps, expandable cages, expandable balloons, or thermal or chemical mechanisms for causing a mechanical structure to connect with a clot or obstruction.
- an expandable clot capture element may be any structure that, upon deployment in a blood vessel, is able to capture a clot that has been engaged by a clot engaging element,
- a clot capture element 104 is illustrated in Fig. 1.
- the clot capture element 104 may be constructed to enable clot engagement element 102 to be movable therein upon deployment in a blood vessel.
- clot engagement element 102 may be configured to rotate, expand, and/or longitudinally slide within clot capture element 104.
- clot capture element 104 may include, but is not limited to, a catheter having a proximal end 104a and a distal end 204b. Proximal and distal ends 104a, 104b may each include an opening therein 112. Opening 1 12 at proximal and distal ends 104a, 104b may be in communication with a central lumen 110 in clot capture element 104 (Fig.
- Central lumen 1 10 in clot capture element 104 may allow for insertion of clot engagement element 102, as well as other components that may aid in a medical procedure, including, but not limited to, an optional gutdewire 120, vacuum source, illumination and/or imagining devices, and tools for grasping a clot,
- Clot capture element 104 may further be configured to expand and contract. Accordingly, clot capture element 104 may be configured to transition between a contracted configuration (Fig. 1A) and an expanded configuration (Fig. IB), in a spring-like manner, in response to movement relative to a surrounding sheath 1 18. Similar to clot engagement element 102, clot capture element 104 may be configured to expand to a size that is substantially the same as an inner diameter of blood vessel 1002 at a clot site. The expansion of clot capture element 104 to the inner diameter of blood vessel 1002 and exerted force on blood vessel wall 1004 at the clot site may aid in separating a clot 1000 from a wall 1004 of blood vessel 1002. The separation may result in a reduction of the required force to remove clot 1000 from blood vessel 1002. The separation may also aid in mitigating the tendency of clot 1000 to break into multiple pieces during removal of clot 1000 from blood vessel 1002.
- Clot capture element 104 may be any shape and/or configuration such that it may traverse a lumen of a blood vessel in one embodiment, clot capture element 104 may be a hollow tube having a constant diameter. Alternatively, clot capture element 104 may have a diameter that varies along its length, For example, as illustrated in Fig. 2, clot capture element 104 may have a diameter that tapers at proximal end 104a, such that proximal end 104a may be configured to connect to a distal end of a control shaft 1 14 (Control shaft 114 will be discussed in further detail below).
- Clot capture element 104 may be constructed of any known, suitable biocompatible material having sufficient flexibility and/or rigidity to traverse the lumen of the blood vessel.
- Biocompatible material of clot capture element 04 may further include properties that may enable clot capture element 104 to expand and contract in the manner previously discussed.
- biocompatible materials may include, but are not limited to, synthetic plastics, silicone elastomers, thermoplastic elastomers, nickel-titanium, stainless steel, ePTFE, PTFE, polyimides, poiyamides, HDPE, polypropylene, polyvinylchloride, LDPE, metal-polymer composites, and metal alloys.
- Clot capture element 104 may include a single biocompatible material or a combination of multiple biocompatible materials.
- clot capture element 104 may include a variety of biocompatible materials, such that the type and properties of the biocompatible material may vary dependent on the location of the biocompatible material on clot capture element 104.
- distal end 104b of clot capture element 104 may include materials having spring-like properties.
- biocompatible materials may include, but are not limited to, polyurethanes, low density polyethylene, polyvinylehloride, Nitinol and THV.
- proximal end 104a of clot capture element 104 may include a stiffer biocompatible material than that of distal end 104b.
- the biocompatible material of proximal end 104a of clot capture element 104 may be any suitable degree of stiffness, so long as clot capture element 1 04 may be configured to traverse a lumen of a blood vessel.
- the biocompatible materials of proximal end 104a of clot capture element 104 may include, but are not limited to, poiyimides, polyamides, high density polyethylene, polypropylene, polyvinylehloride, PTFE, polysulfones, copolymers and blends or mixtures of the aforementioned materials.
- Clot capture element 104 may be a unitary structure, formed of a continuous piece of material.
- clot capture element 104 may include a multiple components 106.
- the multiple components 106 may include a plurality of woven braids intertwined to form a mesh-like structure (Fig. 2).
- the plurality of woven braids 106 may be connected to one another via any known means.
- the mesh-like structure may be in the form of a net, and the plurality of woven braids 106 may cross one another without being connected, whereby the plurality of woven braids 106 may be configured to move relative to one another.
- the plurality of woven braids 106 may include a plurality of wires .
- the wires may be crossed and bent to form the mesh-like structure in a manner such that proximal and distal ends 104a, 104b of clot capture element 104 may be free of open ends of wires (Fig, 2).
- An absence of open ends may result in reduced trauma to the blood vessel.
- free open ends may be used.
- the open ends may be bent slightly inward or may be otherwise physically structure to minimize vessel trauma.
- the mesh can be constructed in a manner similar to a Chinese finger trap, such that longitudinal retraction forces cause the cylindrical structure to contract radially,
- one embodiment of the disclosure may simply include a tubular clot capture element, wherein the clot capture element is configured for deployment in a blood vessel for surrounding a clot, the clot capture element having an opening therein configured to receive and guide a clot engaging element, the clot capture element being configured to radially contract upon retraction, such that when the clot capture element surrounds a clot and is retracted in a longitudinal direction of the blood vessel, the clot capture element is configured to exert a radially inward compression force on the clot.
- one embodiment of the disclosure may simply be the structure of capture element 104 in Fig. 2, which has a tubular shape formed of a mesh 106 with an opening 112 at proximal end 104a for receiving and guiding a shaft 116. As the result of its mesh-like structure, upon retraction, the capture element 104 contracts radially inward.
- the mesh-like structure can be a net or it can be braided.
- the net itself might include a plurality of crossing braids such that the crossing braids are movable relative to each other.
- the net might include a plurality of wires where one or more of the proximal and distal ends of the capture element are free of open ends of wires (see, e.g., distal end of capture element 104 in Fig. 2, where the there are no exposed free ends of wires.),
- Figs. 3A-3B and 4A-4B illustrate alternatives to the mesh-like structure, which may include any suitable self-expanding structure.
- suitable self-expanding structures may include, but are not limited to, rounded coils, flat ribbon coils, a plurality of expandable rings (Figs, 3A-3B), and/or stent-like structures (Fig, 4A-4B).
- Self-expanding structures may further be supported between multiple layers of material 306 (e.g., polymers) which may provide suitable structure to clot capture element 104,
- Clot capture element 104 may further include an atraumatic exterior surface that may limit tissue damage upon deployment at a clot site. Clot capture element 104 may also include a coating on its exterior and/or interior surfaces. The coating may include an anesthetic and/or a lubricant, which may aid in deployment of clot capture element. 104 and clot engagement element 102 and/or may aid in movement of clot engagement element 102 within clot capture element 104.
- proximal end 104a of clot capture element 104 may be connected to control shaft 114.
- Control shaft 114 may be an elongate member configured to pull clot capture element 104 into the contracted configuration
- Elongate member of control shaft 1 14 may be a hollow tube with a solid wall construction, a braided wall construction, a wound wall construction, a hypo-tube (i.e., solid wall construction with portions removed to facilitate flexing.
- the hollow tube may have openings on each end such that control shaft 1 14 may be in communication with central lumen 110 (Fig. 1) of clot capture element 104.
- Control shaft 1 14 may thereby allow for passage of tools, including, but not limited to a guidewire 120, and instrumentation for engaging with a clot 1000.
- Control shaft 114 may further allow for passage of shaft 116 of clot engagement element 102, as illustrated, for example in Fig. 2.
- control shaft 1 14 may be of solid construction, and shaft 1 16 may be positioned adjacent shaft 1 14, as opposed to running through it.
- Shaft 1 16 may have a diameter that is less than a diameter of control shaft 1 14, which may allow for clot engagement element 102 to move along a longitudinal axis of clot capture element 104.
- Shaft 116 may also include a friction minimizing exterior surface.
- the exterior surface of shaft 1 16 may be smooth and/or may include a lubricious coating such that shaft 1 16 may slide with relative ease within control shaft 1 14..
- Shaft 1 16 may further include a lumen therein. The !uinen may be in communication with clot capture element 1 04.
- the lumen may also be in communication with a lumen 1008 in a blood vessel 1002 when clot removal device 100 is delivered to a clot site. Accordingly, the lumen may allow for insertion of tools useful during a clot removal procedure, including, but not limited to, a guide wire 120, a suction device, illumination devices, imaging devices, and/or suitable instrumentation for grasping a clot,
- Control shaft 1 14 may include a diameter sized to receive shaft 116 in order to allow clot engagement element 102 to be moved within clot capture element 104 through movement of shaft 1 16.
- Shaft 1 16 may have a length that is longer than a length of control shaft 1 14 (Fig. 2) such that control shaft 1 14 may at least partially surround shaft 1 16, which may allow for a device operator to control longitudinal and rotational movement of clot engagement element 102.
- Control shaft 1 14 may further be configured to maintain a portion of shaft 116 of clot engagement element 102 in a non-contacting relationship with blood vessel wall 1004 and may be configured to maintain clot engagement element 102 in a desired position relative to clot 1000 at a clot site.
- control shaft 1 14 may act as a stabilizer for clot engagement element 102 when clot engagement element 102 is within clot capture element 104.
- the diameter of control shaft 1 14 may be large enough to allow for longitudinal and rotational movement of shaft i 1 , but small enough to prevent shaft 1 16, and thereby clot engagement element 102. from substantially deviating from a predetermined location relative to clot 1000. in an embodiment, therefore, a second shaft (shaft 1 16) can be rotatable and/or movable within a first shaft (control shaft 1 14).
- one function of control shaft 1 14 may be to center shaft 1 16 within the vessel, such that when engagement element 102 is rotated, the rotation occurs in a substantially longitudinal direction of the vessel.
- the clot engagement element 102 may be maintained in a generally axial orientation of the blood vessel as well, which may reduce the risk of damage to the blood vessel as the clot engagement element 102 is rotated, [097]
- centering of the engagement element within the vessel can occur as the result of a tapering of capture element 104, or through the use of a spacer, not shown, for centering shaft 116 in the vessel.
- another embodiment of the disclosure may include a clot removal device, having a shaft, a clot engagement element on an end of the shaft, the clot engagement element and the shaft being configured for deployment in a blood vessel; and a stabilizer configured to at ieast partially surround the shaft and to maintain a portion of the shaft in a non-contacting relationship with the blood vessel wall.
- shaft 116 is maintained in non-contacting relationship with the vessel wall through control shaft I 14's central interconnection to capture element 104.
- shaft 1 16 enters the lumen defined by capture element 104, it is biased in a direction toward the center of the vessel. .
- This helps to maintain the engagement element in manner that when rotated, tends to rotate in the longitudinal direction of the vessel rather than substantially transverse to the longitudinal direction.
- This is just one example of a stabilizer structure. Any structure that holds an engaging element's shaft away from a vessel wail is also contemplated to be encompassed by this embodiment.
- Control shaft 1 14 may also be configured to transition clot capture element 104 from the expanded configuration to an at least partially contracted configuration. For example, movement of control shaft 1 14 in the direction shown by arrow 1 15 in Fig. 2 may result in an applied force to proximal end 104a of clot engagement element 104, The applied force to proximal end 104a of clot capture element 104 may also be in the direction shown by arrow 1 15, which may thereby result in contraction of clot capture element 104.
- clot capture element 104 may contract, exerting forces 1016, 1018 (Fig. 8) on dot 1000 and/or clot engagement element 102 when clot 1000 and/or clot engagement element 102 are within central lumen 110 of clot capture element.
- Forces 1016, 1018 may maintain clot 1000 within central lumen 1 10 of clot capture element 104 during removal of clot 1000 from a blood vessel 1002 and may mitigate a tendency of clot 1000 to break into multiple pieces. The clot may then be retrieved from the vessel with the clot retained solely within the capture element and engagement element, as illustrated in Figs.
- the clot can be pulled into the sheath 118 before removal from the vessel, as illustrated in Figs. 7C and 7D. in this manner, the sheath 118 might exert further holding force on the clot.
- a sheath may be provided, surrounding and compressing the capture element and the engagement element.
- the sheath may be removable to thereby enable the capture element to expand in a blood vessel in which the sheath is deployed, and to enable the engagement element to expand within the capture element,
- a sheath may be any structure that is capable of retaining one or more of a clot engaging element and a clot capture element while being capable of sufficiently flexing in order to deploy one or more of those elements in a vessel,
- an exemplary sheath 1 1 8 is illustrated in Fig. 1.
- Clot engagement element 102 and clot capture element 104 may be delivered to a clot site within the sheath 1 18.
- Sheath 1 18 may be a hollow tubular structure having a central lumen configured to surround clot engagement element 102 and clot capture element 104 (Fig. 1A).
- Sheath 1 18 may further be configured to protect clot engagement element 102 and clot capture element 104 as they follow a delivery path to the clot site, Accordingly, sheath 1 18 may be made of any suitable biocompatible material and have any suitable shape and/or configuration so long as sheath 1 18 may be configured to traverse a patient's vasculature while maintaining clot engagement element 102 and clot capture element 504 in their respective contracted configurations upon delivery to and removal from a clot site. Further, upon removal of clot engagement element 102 and clot capture element 104 from the clot site, sheath may be configured to maintain a clot within its central lumen as well ⁇ Fig, 7D).
- sheath 1 18 may be configured to allow for controlled expansion of clot capture element 104 and clot engagement element 102.
- clot capture element 104 and clot engagement element 102 may be configured to expand upon removal of sheath 118.
- Sheath 1 18 may be retracted in a direction away from distal end 104b of clot capture element 104. Accordingly, sheath 1 1 8 may be removed at a rate that may control the rate of expansion of clot capture element 104 and clot engagement. Further, sheath 1 18 may be retracted a distance that may control the amount of clot capture element 104 and clot engagement element 102 that may be exposed and expanded (Figs, I B).
- the sheath 1 18 may be help substantially stationary, and the clot capture element 104 and clot engagement element 102 may be advanced, resulting in expansion of those elements.
- a tubular clot capture element having a first internal diameter, and a clot engaging element having a second external diameter, wherein the first diameter and the second diameter are selected to permit the clot engaging element to be rotated within the tubular clot capture element.
- the inner diameter of clot capture element 104 is sufficiently sized so that clot engaging element 102 is able to be rotated therein.
- this may provide the operator with the freedom to encircle a clot with an engaging element 102 at the same time that the clot is being drawn into the capture element 104, Or it may provide the operator with the ability to turn the clot once it is within the capture element 104.
- the elements 102, 104 may be sized such that an outer surface area of the clot engaging element 102 may contact an inner surface area of the clot capture element 104,
- a device operator may find it useful to prevent movement of clot engagement element 102 relative to clot capture element 104. This may be desirable, for example, during delivery of clot removal device 100 to the clot site and/or during removal of clot 1000 from a patient.
- Fig, 5 illustrates a locking mechanism 150 that may be used with clot removal device 100 for selectively locking shaft 116 of clot engagement element 102 in a fixed position with respect to control shaft 1 14 of clot capture element 104.
- Locking mechanism may be any suitable device that selectively prevents relative movement between the clot engagement element and the clot capture element.
- locking mechanisms may include, but are not limited to, snap locks, rotational locks, and interference fits.
- locking mechanism may be a torquer 150.
- a similar or differing locking mechanism may be used to control relative movement between sheath 1 18 and capture element 104.
- Clot removal device 100 may also include a component that may allow a device operator to know the location of clot removal device 100 as it travels to the clot site.
- Location components may include, but are not limited to, radiopaque markers, sensors, and/or imaging devices.
- distal end 104b of clot capture element 104 may include a radiopaque marker (not shown).
- Clot removal device 100 may be delivered to a clot site within a blood vessel 1002. Delivery of clot removal device 100 may include transporting sheath 1 18, which may substantially surround clot engagement element 102 and clot capture element 104, within a patient's vasculature to a location proximate a clot 1000. A device operator may insert clot removal device 100 over a guidewire 120 in order to assure clot removal device 100 follows a correct path to the clot site.
- clot engagement element 102 may be substantially surrounded by clot capture element 104, as illustrated in Fig. 1A.
- clot engagement element 102 may be located outside of clot capture element 104, and may he pulled into clot capture element 102 after grasping clot 1000 during a later point in the procedure.
- a device operator may monitor the location of clot removal device 100 as it approaches the clot site via sensors, radiopaque markers, and/or imaging devices.
- the device operator may remove guidewire 120 from clot removal device 100.
- the device operator may retract the sheath 1 18 (or advance the engagement element) sufficiently so that the engagement element 102 can rotate.
- the sheath 1 18 may be removed in its entirety.
- clot engagement element 102 may then expand radially and be movable (e.g., longitudinal and rotational movement) within clot capture element 104.
- Both the clot engaging element 102 and the clot capture element 104 may be self-expanding in a spring-like manner.
- Clot capture element 104 may expand to the approximate size of the inner diameter of blood vessel 1002, As previously discussed, the expansion of clot capture element 104 may initiate separation of clot 1000 from blood vessel wall 1004.
- the device operator may move shaft 1 16 of clot engagement element 102 in the direction of arrow 1010 towards clot 1000 and rotate shaft 1 16 in the direction of arrow 1012 which may cause clot engagement element 102 to engage with clot 1000.
- Longitudinal movement of shaft 1 16 may cause longitudinal movement of clot engagement element 102 in the direction of arrow 1010', and rotational movement of shaft 1 16 may cause rotational movement of clot engagement element 102 in the direction of arrow 1012'.
- Clot engagement element 102 may be moved along a longitudinal axis 1006 of blood vessel towards clot 1000.
- clot engagement element 102 may be between clot 1000 and clot capture element.
- rotation of clot engagement element 102 might result in an Archimedes screw effect, drawing the clot further into the engagement element 102 without the need to significantly advance the engagement element.
- the extent of the Archimedes effect, and whether it occurs at ail, may vary depending on the specific nature of the clot and the extent of its connection to the vessel wail 1004,
- Encircling of clot 1000 by clot engagement element 102 may cause additional expansion of clot engagement element 102.
- radially expansion of clot engagement element 102 may ca use an outer surface of clot engagement element 102 to exert a force on a wall 1004 of blood vessel 1002, which may further aid in separating clot 1000 from blood vessel wail 1004.
- the separation may aid in reducing the force needed to remove clot 1000 from blood vessel 1002.
- the separation may also aid in mitigating the tendency of clot 1000 to break into multiple pieces during removal of the clot from blood vessel 1002.
- the device operator may encircle clot 1000 with clot engagement device such that the device operator may be capable of pulling clot engagement element 102 and clot 1000, together, into clot capture element 104. Accordingly, the device operator may move shaft 1 6 in the direction of arrow 1014 such that clot 1000 encircled by clot engagement element 102 may be pulled through opening 1 12 and into central lumen 110 of clot capture element 104.
- the device operator may also pull control shaft 1 14 of clot capture element 104 in the direction of arrow 115. This pulling may result, in clot capture element 104 applying radially contracting forces 1016 and a longitudinal shearing force 1018 to clot 1000 and clot engagement element 102. These applied forces may aid the device operator in maintaining clot 1000 within clot capture- elemen 104 and removing clot 1000 from blood vessel 1002 without breaking clot 1000 into multiple pieces. And if the clot does break, capture element 104 may protect against pieces becoming loose in the bloodstream.
- the clot may be removed from the vasculature without pulling the capture element and the engaging element back into the sheath. Instead, as the clot may be trapped within the capture element, the radial forces exerted upon retraction may be sufficient to compress the clot within the capture element such that the structure may be retracted in a substantially expanded form,
- the device operator may alter the method of removing clot 1000 from blood vessel 1002 as necessary, For example, prior to positioning clot engagement element 102 for encircling of clot 1000, the device operator may insert instrumentation through central lumen of clot capture element 104 which may be necessary for cleaning out the clot site.
- removal of clot 1000 may be accompanied by suitable tools for grasping and/or maintaining clot 1000 within clot capture element 104,
- the device operator may employ a suctioning device at a proximal end of clot removal device 100.
- the suctioning device may further aid in pulling clot 1000 into clot capture element 104 and retaining clot 104 within clot capture element 104 as clot 1000 is drawn out of the patient's vasculature,
- a method of removing a clot from a blood vessel may include deploying a tubular clot capture element in a blood vessel, the clot capture element having an opening therein that receives and guides a clot engaging element, surrounding a clot with the clot capture element, and retracting the clot- capture element in a longitudinal direction of the blood vessel, such that the clot capture element radially contracts, exerting a radially inward compression force on the clot,
- This embodiment of the disclosure may be practiced with any of the clot capture elements described above, including, clot capture element 104.
- a method of removing a clot from a blood vessel may include delivering a tubular clot capture element having a first diameter to a clot site and delivering a clot engaging element having a second external diameter to the clot site, wherein the first diameter and the second diameter are selected to such that the clot engaging element rotates within the tubular clot capture element.
- a method may be accomplished, for example, when clot capture element 104 is delivered to a clot site, clot engaging element 102 is delivered to a clot site, and when the two elements' diameters permit the engaging element to be rotated within the capture element.
- the disclosure in its broadest sense does not necessarily so require.
- the engaging element may, for example, be delivered first, and the capture element may be subsequently delivered.
- the engaging element when rotated may be sized to contact the inner wall of the capture element, or the engaging element may be sized to avoid contact.
- a method for removing a clot from a blood vessel may include deploying a clot engagement element in a blood vessel, the clot engagement element located on an end of a shaft; and at least partially surrounding the shaft with a stabilizer to maintain a portion of the shaft in a non-contacting relationship with the blood vessel wall.
- This method may be practiced with or without a clot capture element, such as structure 104, and without regard to any specific stabilizing structure.
- some embodiments of the disclosure may benefit from a rotation of the engagement element 102 when the engagement element is centered in the vessel This may minimize the pressure exerted on the vessel walls, while maximizing movement of the engagement element 102 in the longitudinal direction of the vessel to surround the clot.
- the shaft e.g., shaft 1 16
- longitudinal motion may be maximized.
- stabilization may occur by surrounding shaft 1 16 with any structure that generally maintains it near the center of the vessel at locations proximate the intersection of shaft 1 16 and windings 108.
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Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014537752A JP2015505250A (en) | 2011-10-24 | 2012-10-23 | Clot removal apparatus and method |
EP12849606.4A EP2770914A4 (en) | 2011-10-24 | 2012-10-23 | Clot removal devices and methods |
AU2012338476A AU2012338476A1 (en) | 2011-10-24 | 2012-10-23 | Clot removal devices and methods |
CN201280063095.0A CN104159525A (en) | 2011-10-24 | 2012-10-23 | Clot removal devices and methods |
KR1020147013679A KR20140098749A (en) | 2011-10-24 | 2012-10-23 | Clot removal devices and methods |
IL232252A IL232252B (en) | 2011-10-24 | 2014-04-24 | Clot removal devices and methods |
HK15102246.1A HK1201708A1 (en) | 2011-10-24 | 2015-03-05 | Clot removal devices and methods |
IL256733A IL256733B (en) | 2011-10-24 | 2018-01-04 | Clot removal devices and methods |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/279,880 US9005237B2 (en) | 2008-08-29 | 2011-10-24 | Device and method for clot capture |
US13/279,891 US8864792B2 (en) | 2008-08-29 | 2011-10-24 | Device and method for clot engagement |
US13/279,898 US9034008B2 (en) | 2008-08-29 | 2011-10-24 | Device and method involving stabilization during clot removal |
US13/279,880 | 2011-10-24 | ||
US13/279,898 | 2011-10-24 | ||
US13/279,870 | 2011-10-24 | ||
US13/279,891 | 2011-10-24 | ||
US13/279,870 US8758364B2 (en) | 2008-08-29 | 2011-10-24 | Device and method for clot engagement and capture |
Publications (3)
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WO2013072777A2 true WO2013072777A2 (en) | 2013-05-23 |
WO2013072777A9 WO2013072777A9 (en) | 2013-07-11 |
WO2013072777A3 WO2013072777A3 (en) | 2013-11-21 |
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Application Number | Title | Priority Date | Filing Date |
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PCT/IB2012/003053 WO2013072777A2 (en) | 2011-10-24 | 2012-10-23 | Clot removal devices and methods |
Country Status (8)
Country | Link |
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EP (1) | EP2770914A4 (en) |
JP (1) | JP2015505250A (en) |
KR (1) | KR20140098749A (en) |
CN (1) | CN104159525A (en) |
AU (1) | AU2012338476A1 (en) |
HK (1) | HK1201708A1 (en) |
IL (2) | IL232252B (en) |
WO (1) | WO2013072777A2 (en) |
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Also Published As
Publication number | Publication date |
---|---|
EP2770914A2 (en) | 2014-09-03 |
IL232252A0 (en) | 2014-06-30 |
CN104159525A (en) | 2014-11-19 |
JP2015505250A (en) | 2015-02-19 |
KR20140098749A (en) | 2014-08-08 |
WO2013072777A3 (en) | 2013-11-21 |
HK1201708A1 (en) | 2015-09-11 |
AU2012338476A1 (en) | 2014-05-08 |
WO2013072777A9 (en) | 2013-07-11 |
IL256733B (en) | 2019-02-28 |
IL232252B (en) | 2020-04-30 |
EP2770914A4 (en) | 2015-09-16 |
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