WO2013066214A3 - Фармацевтический аэрозольный состав ингибиторов протеаз и его получение - Google Patents

Фармацевтический аэрозольный состав ингибиторов протеаз и его получение Download PDF

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Publication number
WO2013066214A3
WO2013066214A3 PCT/RU2012/000896 RU2012000896W WO2013066214A3 WO 2013066214 A3 WO2013066214 A3 WO 2013066214A3 RU 2012000896 W RU2012000896 W RU 2012000896W WO 2013066214 A3 WO2013066214 A3 WO 2013066214A3
Authority
WO
WIPO (PCT)
Prior art keywords
aerosol
production
pharmaceutical composition
protease inhibitors
water
Prior art date
Application number
PCT/RU2012/000896
Other languages
English (en)
French (fr)
Other versions
WO2013066214A2 (ru
Inventor
Олег Петрович ЖИРНОВ
Original Assignee
Zhirnov Oleg Petrovich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhirnov Oleg Petrovich filed Critical Zhirnov Oleg Petrovich
Priority to GB1409877.6A priority Critical patent/GB2511011A/en
Publication of WO2013066214A2 publication Critical patent/WO2013066214A2/ru
Publication of WO2013066214A3 publication Critical patent/WO2013066214A3/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение относится к медицине и описывает лекарственную композицию водорастворимых белковых или полипептидных соединений из группы ингибиторов протеолитических ферментов для создания аэрозоля с помощью водонерастворимого озон-сберегающего пропеллента в аэрозольных устройствах, снабженных дозирующим клапаном. Созданный аэрозольный состав может найти применение при лечении заболеваний, сопровождающихся нарушением протеолитического баланса, таких как респираторные инфекции, включая грипп, кератоконъюнктивиты вирусной и бактериальной этиологии, герпетические поражения слизистых оболочек и кожи, хроническая обструктивная бронхопневмония, астма и др.
PCT/RU2012/000896 2011-11-03 2012-11-01 Фармацевтический аэрозольный состав ингибиторов протеаз и его получение WO2013066214A2 (ru)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1409877.6A GB2511011A (en) 2011-11-03 2012-11-01 Aerosol pharmaceutical composition of protease inhibitors and production thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU2011144624A RU2657523C2 (ru) 2011-11-03 2011-11-03 Фармацевтический аэрозольный состав ингибиторов протеаз с озон-сберегающим пропеллентом и его получение
RU2011144624 2011-11-03
RU2011144624/20 2011-11-03

Publications (2)

Publication Number Publication Date
WO2013066214A2 WO2013066214A2 (ru) 2013-05-10
WO2013066214A3 true WO2013066214A3 (ru) 2013-08-22

Family

ID=48192963

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2012/000896 WO2013066214A2 (ru) 2011-11-03 2012-11-01 Фармацевтический аэрозольный состав ингибиторов протеаз и его получение

Country Status (4)

Country Link
EA (1) EA034991B1 (ru)
GB (1) GB2511011A (ru)
RU (1) RU2657523C2 (ru)
WO (1) WO2013066214A2 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2711080C2 (ru) * 2015-06-15 2020-01-15 Олег Петрович Жирнов Комбинированный аэрозольный состав на основе ингибиторов протеаз и его получение
WO2022216172A1 (ru) * 2021-04-06 2022-10-13 Андрей Александрович ИВАЩЕНКО Водная апротинин-содержащая противовирусная фармацевтическая композиция

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003708A1 (en) * 1991-08-21 1993-03-04 Oleg Petrovich Zhyrnov Pharmaceutical aerosol preparation and its use for treatment and prophylaxis of viral diseases
RU2425691C1 (ru) * 2010-07-15 2011-08-10 ВАКЕ спол с.р.о. Аэрозольный препарат на основе апротинина для лечения вирусных респираторных инфекций

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2656944B2 (ja) * 1987-04-30 1997-09-24 クーパー ラボラトリーズ タンパク質性治療剤のエアロゾール化
US6524557B1 (en) * 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
US20010006939A1 (en) * 1997-10-03 2001-07-05 Ralph W. Niven Secretory leukocyte protease inhibitor dry powder pharmaceutical compositions
US6294153B1 (en) * 1998-12-21 2001-09-25 Generex Pharmaceuticals, Inc. Aerosol pharmaceutical formulation for pulmonary and nasal delivery
US6849263B2 (en) * 1998-12-21 2005-02-01 Generex Pharmaceutical Incorporated Pharmaceutical compositions for buccal delivery of pain relief medications
WO2000074736A1 (en) * 1999-06-04 2000-12-14 Delrx Pharmaceutical Corporation Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same
WO2002043750A2 (en) * 2000-12-01 2002-06-06 Battelle Memorial Institute Method for the stabilizing of biomolecules (e.g. insulin) in liquid formulations
GB0507577D0 (en) * 2005-04-14 2005-05-18 Novartis Ag Organic compounds
RU2356537C2 (ru) * 2007-07-25 2009-05-27 Закрытое Акционерное Общество (ЗАО) "Пульмомед" Фармацевтический состав дозированных аэрозолей, содержащий противоастматические лекарственные средства в виде суспензий, растворов, эмульсий, растворов и эмульсий

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003708A1 (en) * 1991-08-21 1993-03-04 Oleg Petrovich Zhyrnov Pharmaceutical aerosol preparation and its use for treatment and prophylaxis of viral diseases
RU2425691C1 (ru) * 2010-07-15 2011-08-10 ВАКЕ спол с.р.о. Аэрозольный препарат на основе апротинина для лечения вирусных респираторных инфекций

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
AVDEEV S.N.: "Novaia besfreonovaia tekhnologia ingaliatsionnoi terapii. Consilium Medicum", PULMONOLOGIIA, 2005, pages 1 - 3, Retrieved from the Internet <URL:URL:http:www.consiliutn-medicum.com/magazines/magazines/cm/pylmo/article/9546> [retrieved on 20130418] *

Also Published As

Publication number Publication date
RU2011144624A (ru) 2013-05-10
EA034991B1 (ru) 2020-04-15
WO2013066214A2 (ru) 2013-05-10
GB201409877D0 (en) 2014-07-16
RU2657523C2 (ru) 2018-06-14
GB2511011A (en) 2014-08-20
EA201201362A1 (ru) 2013-05-30

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