WO2013042065A3 - Inhibiteurs de protéines inactivatrices de ribosome de type ii - Google Patents

Inhibiteurs de protéines inactivatrices de ribosome de type ii Download PDF

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Publication number
WO2013042065A3
WO2013042065A3 PCT/IB2012/054999 IB2012054999W WO2013042065A3 WO 2013042065 A3 WO2013042065 A3 WO 2013042065A3 IB 2012054999 W IB2012054999 W IB 2012054999W WO 2013042065 A3 WO2013042065 A3 WO 2013042065A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitors
aromatic
type
ribosome inactivating
inactivating proteins
Prior art date
Application number
PCT/IB2012/054999
Other languages
English (en)
Other versions
WO2013042065A2 (fr
WO2013042065A4 (fr
Inventor
Kevin Jonathan NAIDOO
Ranga Srinath JAYAKODY
Original Assignee
University Of Cape Town
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Cape Town filed Critical University Of Cape Town
Publication of WO2013042065A2 publication Critical patent/WO2013042065A2/fr
Publication of WO2013042065A3 publication Critical patent/WO2013042065A3/fr
Publication of WO2013042065A4 publication Critical patent/WO2013042065A4/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés qui sont inhibiteurs de ricine, d'abrine, de Shiga ou de saporine et qui ont une configuration bipartite comprenant une structure hétérocyclique aromatique ressemblant à une fraction adénine en dimension et en forme, connectée à la position C8 d'une structure de cycle cyclique aromatique ou non aromatique ressemblant à une fraction ribose en dimension et en forme. Plus particulièrement, les inhibiteurs ont la formule (I) : (I) où X = -S-, -O-, -CH 2 -, -NH-, -PH-, -O-Y-, -CH 2 -Y-, -NH-Y-, -PH-Y ou -S-Y ; Y = -S-, -O-, -CH 2 -, -NH- ou -PH- ; et W = un cycle cyclique aromatique ou non aromatique à 5 ou 6 chaînons. L'invention concerne également des utilisations de ces composés dans la fabrication d'un médicament et dans le traitement d'un sujet, ainsi qu'un procédé d'identification d'inhibiteurs appropriés.
PCT/IB2012/054999 2011-09-20 2012-09-20 Inhibiteurs de protéines inactivatrices de ribosome de type ii WO2013042065A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA2011/06840 2011-09-20
ZA201106840 2011-09-20

Publications (3)

Publication Number Publication Date
WO2013042065A2 WO2013042065A2 (fr) 2013-03-28
WO2013042065A3 true WO2013042065A3 (fr) 2013-06-20
WO2013042065A4 WO2013042065A4 (fr) 2013-08-15

Family

ID=47116143

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2012/054999 WO2013042065A2 (fr) 2011-09-20 2012-09-20 Inhibiteurs de protéines inactivatrices de ribosome de type ii

Country Status (1)

Country Link
WO (1) WO2013042065A2 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028298A1 (fr) * 1996-12-24 1998-07-02 Research Development Foundation Inhibiteurs de ricin et procedes d'utilisation
WO2001073438A1 (fr) * 2000-03-24 2001-10-04 Research Development Foundation Inhibiteurs de ricine et procedes d'utilisation de ces inhibiteurs
WO2005023203A2 (fr) * 2003-09-09 2005-03-17 Albert Einstein College Of Medicine Of Yeshiva University Inhibiteurs d'analogues d'etat de transition de chaine a de toxine de ricin
WO2006084030A2 (fr) * 2005-02-01 2006-08-10 Sloan-Kettering Institute For Cancer Research Petites molecules inhibitrices du hsp90

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028298A1 (fr) * 1996-12-24 1998-07-02 Research Development Foundation Inhibiteurs de ricin et procedes d'utilisation
WO2001073438A1 (fr) * 2000-03-24 2001-10-04 Research Development Foundation Inhibiteurs de ricine et procedes d'utilisation de ces inhibiteurs
WO2005023203A2 (fr) * 2003-09-09 2005-03-17 Albert Einstein College Of Medicine Of Yeshiva University Inhibiteurs d'analogues d'etat de transition de chaine a de toxine de ricin
WO2006084030A2 (fr) * 2005-02-01 2006-08-10 Sloan-Kettering Institute For Cancer Research Petites molecules inhibitrices du hsp90

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BAI Y ET AL: "Identification of new classes of ricin toxin inhibitors by virtual screening", TOXICON, ELMSFORD, NY, US, vol. 56, no. 4, 15 September 2010 (2010-09-15), pages 526 - 534, XP027154311, ISSN: 0041-0101, [retrieved on 20100520] *
DE S K ET AL: "Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 17, no. 7, 1 April 2009 (2009-04-01), pages 2712 - 2717, XP026073620, ISSN: 0968-0896, [retrieved on 20090226], DOI: 10.1016/J.BMC.2009.02.046 *
HO MENG-CHIAO ET AL: "Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1 DEC 2009, vol. 106, no. 48, 1 December 2009 (2009-12-01), pages 20276 - 20281, XP002693882, ISSN: 1091-6490 *

Also Published As

Publication number Publication date
WO2013042065A2 (fr) 2013-03-28
WO2013042065A4 (fr) 2013-08-15

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