WO2013038424A3 - Process for purifying diacerein - Google Patents

Process for purifying diacerein Download PDF

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Publication number
WO2013038424A3
WO2013038424A3 PCT/IN2012/000464 IN2012000464W WO2013038424A3 WO 2013038424 A3 WO2013038424 A3 WO 2013038424A3 IN 2012000464 W IN2012000464 W IN 2012000464W WO 2013038424 A3 WO2013038424 A3 WO 2013038424A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
diacerein
compound
purifying
silylated
Prior art date
Application number
PCT/IN2012/000464
Other languages
French (fr)
Other versions
WO2013038424A2 (en
Inventor
Milind Gharpure
Dnyandev Rane
Manish Chandrakant SHUKLA
Pramod Vitthal PATIL
Girish Tilakchand PATLE
Sachin Mahadeo LAD
Deepak B. BAVISKAR
Original Assignee
Glenmark Generics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Generics Limited filed Critical Glenmark Generics Limited
Publication of WO2013038424A2 publication Critical patent/WO2013038424A2/en
Publication of WO2013038424A3 publication Critical patent/WO2013038424A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/29—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by introduction of oxygen-containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1896—Compounds having one or more Si-O-acyl linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention provides a process for purification of diacerein, compound of Formula I, the process comprising a. reacting diacerein, compound of Formula I with a silylating agent to form a compound of Formula II, silylated diacerein wherein R is alkyl; and [Formula (I)] [Formula (II)] b. deprotecting compound of Formula II, silylated diacerein in presence of a polar solvent.
PCT/IN2012/000464 2011-07-13 2012-06-29 Process for purifying diacerein WO2013038424A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2013MU2011 2011-07-13
IN2013/MUM/2011 2011-07-13

Publications (2)

Publication Number Publication Date
WO2013038424A2 WO2013038424A2 (en) 2013-03-21
WO2013038424A3 true WO2013038424A3 (en) 2013-05-10

Family

ID=47883865

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2012/000464 WO2013038424A2 (en) 2011-07-13 2012-06-29 Process for purifying diacerein

Country Status (1)

Country Link
WO (1) WO2013038424A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001096276A1 (en) * 2000-06-13 2001-12-20 Synteco S.P.A. A process for the purification of diacerein
WO2004050601A2 (en) * 2002-11-29 2004-06-17 Synteco S.P.A. Process for purifying diacerein
KR20080102804A (en) * 2007-05-22 2008-11-26 주식회사 엔지켐 Process for purification of diacerein

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001096276A1 (en) * 2000-06-13 2001-12-20 Synteco S.P.A. A process for the purification of diacerein
WO2004050601A2 (en) * 2002-11-29 2004-06-17 Synteco S.P.A. Process for purifying diacerein
KR20080102804A (en) * 2007-05-22 2008-11-26 주식회사 엔지켐 Process for purification of diacerein

Also Published As

Publication number Publication date
WO2013038424A2 (en) 2013-03-21

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