WO2013036015A3 - 아제티딘 유도체 및 이를 함유하는 항우울제 조성물 - Google Patents
아제티딘 유도체 및 이를 함유하는 항우울제 조성물 Download PDFInfo
- Publication number
- WO2013036015A3 WO2013036015A3 PCT/KR2012/007076 KR2012007076W WO2013036015A3 WO 2013036015 A3 WO2013036015 A3 WO 2013036015A3 KR 2012007076 W KR2012007076 W KR 2012007076W WO 2013036015 A3 WO2013036015 A3 WO 2013036015A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- azetidine derivative
- composition containing
- containing same
- antidepressant composition
- antidepressant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
아제티딘 유도체 또는 이의 약학적으로 허용 가능한 염, 및 이를 포함하는 항우울제 또는 정신질환 예방 또는 치료용 조성물이 제공된다. 상기 아제티딘 유도체는 신경전달물질인 도파민, 세레토닌, 노에피네프린의 재흡수를 동시에 억제할 수 있는 삼중 흡수 억제제(triple reuptake inhibitor)로서 유용하다.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12829591.2A EP2754653B1 (en) | 2011-09-05 | 2012-09-04 | Azetidine derivative and antidepressant composition containing same |
US14/239,890 US9120771B2 (en) | 2011-09-05 | 2012-09-04 | Azetidine derivative and antidepressant composition including the same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020110089820A KR101273566B1 (ko) | 2011-09-05 | 2011-09-05 | 신규한 아제티딘 유도체 및 이를 함유하는 항우울제 조성물 |
KR10-2011-0089820 | 2011-09-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2013036015A2 WO2013036015A2 (ko) | 2013-03-14 |
WO2013036015A3 true WO2013036015A3 (ko) | 2013-05-02 |
Family
ID=47832694
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2012/007076 WO2013036015A2 (ko) | 2011-09-05 | 2012-09-04 | 아제티딘 유도체 및 이를 함유하는 항우울제 조성물 |
Country Status (4)
Country | Link |
---|---|
US (1) | US9120771B2 (ko) |
EP (1) | EP2754653B1 (ko) |
KR (1) | KR101273566B1 (ko) |
WO (1) | WO2013036015A2 (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101651994B1 (ko) * | 2014-01-29 | 2016-08-30 | 한국과학기술연구원 | 아릴옥시 아제티딘 화합물, 및 이를 포함하는 약학 조성물 |
CN107646031B (zh) * | 2015-05-20 | 2020-11-17 | 综合研究实验室瑞典股份公司 | 用作皮质儿茶酚胺能神经传递调节剂的氮杂环丁烷衍生物 |
CN109963834B (zh) | 2016-11-18 | 2023-04-14 | 综合研究实验室瑞典股份公司 | 可用作皮质儿茶酚胺能神经传递调节剂的新型氮杂环丁烷衍生物 |
EP4159725A4 (en) | 2020-05-29 | 2023-12-20 | Daegu-Gyeongbuk Medical Innovation Foundation | CARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF AS AN ACTIVE SUBSTANCE FOR THE PREVENTION OR TREATMENT OF MENTAL DISEASES |
CN116057053A (zh) | 2020-05-29 | 2023-05-02 | 大邱庆北尖端医疗产业振兴财团 | 含至少一个n的5元杂芳基衍生物和含其为活性成分用于预防或治疗精神障碍的药物组合物 |
US20230212121A1 (en) | 2020-05-29 | 2023-07-06 | Daegu-Gyeongbuk Medical Innovation Foundation | Sulfonamide derivative and pharmaceutical composition comprising same as active ingredient for preventing or treating mental illness |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006028961A2 (en) * | 2004-09-03 | 2006-03-16 | Athersys, Inc. | Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators |
WO2009109743A1 (en) * | 2008-03-04 | 2009-09-11 | Vernalis (R&D) Ltd. | Azetidine derivatives |
WO2011103196A1 (en) * | 2010-02-17 | 2011-08-25 | Amgen Inc. | Aryl carboxamide derivatives as sodium channel inhibitors for treatment of pain |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA83230C2 (ru) * | 2003-06-11 | 2008-06-25 | Мерк Энд Ко., Инк. | Замещенные производные 3-алкил- и 3-алкенилазетидинов |
EP1718609A1 (en) | 2004-02-17 | 2006-11-08 | Laboratorios Del Dr. Esteve, S.A. | Substituted azetidine compounds, their preparation and use as medicaments |
BRPI0813837A2 (pt) * | 2007-07-27 | 2015-01-06 | Hoffmann La Roche | 2-azetidinametanoaminas e 2-pirrolidinametanoaminas como ligantes de taar |
US8575364B2 (en) * | 2008-10-30 | 2013-11-05 | Janssen Pharmaceutica Nv | Modulators of serotonin receptor |
WO2010059393A1 (en) | 2008-10-30 | 2010-05-27 | Janssen Pharmaceutica Nv | Serotonin receptor modulators |
CA2761445A1 (en) | 2009-05-27 | 2010-12-02 | Genentech, Inc. | Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use |
-
2011
- 2011-09-05 KR KR1020110089820A patent/KR101273566B1/ko active IP Right Grant
-
2012
- 2012-09-04 WO PCT/KR2012/007076 patent/WO2013036015A2/ko active Application Filing
- 2012-09-04 EP EP12829591.2A patent/EP2754653B1/en active Active
- 2012-09-04 US US14/239,890 patent/US9120771B2/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006028961A2 (en) * | 2004-09-03 | 2006-03-16 | Athersys, Inc. | Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators |
WO2009109743A1 (en) * | 2008-03-04 | 2009-09-11 | Vernalis (R&D) Ltd. | Azetidine derivatives |
WO2011103196A1 (en) * | 2010-02-17 | 2011-08-25 | Amgen Inc. | Aryl carboxamide derivatives as sodium channel inhibitors for treatment of pain |
Non-Patent Citations (4)
Title |
---|
ALESCIO. T.: "Effect of a proline analogue, azetidine-2-carboxylic acid, on the morphogenesis in vitro of mouse embryonic lung", J. EMBRYOL. EXP. MORPH., vol. 29, no. 2, 1973, pages 439 - 451, XP055143150 * |
FELEDZIAK ET AL.: "SAR and LC/MS Studies of beta-Lactamic Inhibitors of Human Fatty Acid Amide Hydrolase (hFAAH): Evidence of a Nonhydrolytic Process", J. MED. CHEM., vol. 54, no. 19, 8 September 2011 (2011-09-08), pages 6812 - 6823, XP055143153 * |
HAN, YOUNGHUE ET AL.: "Exploration of Novel 3‑Substituted Azetidine Derivatives As Triple Reuptake Inhibitors", J. MED. CHEM., vol. 55, 31 August 2012 (2012-08-31), pages 8188 - 8192, XP055143159 * |
See also references of EP2754653A4 * |
Also Published As
Publication number | Publication date |
---|---|
KR20130026292A (ko) | 2013-03-13 |
EP2754653A2 (en) | 2014-07-16 |
EP2754653B1 (en) | 2016-11-09 |
US9120771B2 (en) | 2015-09-01 |
US20140171402A1 (en) | 2014-06-19 |
KR101273566B1 (ko) | 2013-06-11 |
EP2754653A4 (en) | 2015-02-18 |
WO2013036015A2 (ko) | 2013-03-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2013036015A3 (ko) | 아제티딘 유도체 및 이를 함유하는 항우울제 조성물 | |
GEP20125566B (en) | Aryl-and heteroaryl-substituded tetrahydro-benzazepines and use thereof to block reuptake of norepinephrine, dopamine and serotonin | |
MX2013007336A (es) | Compuestos de bi-heteroarilo como inhibidores de vps34. | |
GEP20207129B (en) | Inhibitors of influenza viruses replication | |
MY196427A (en) | Piperidinyl Indole Derivatives And Their Use As Complement Factor B Inhibitors | |
JO3530B1 (ar) | مركبات بيريدازين 1،4-ثنائية الإرتباط ونظائرها وطرق معالجة نقص smn وحالاته المرضية. | |
EP4219465A3 (en) | Prmt5 inhibitors and uses thereof | |
EA201490320A1 (ru) | Соединения тетрагидропиридопиридина и тетрагидропиридопиримидина и их применение в качестве модуляторов рецептора c5a | |
IN2014KN00948A (ko) | ||
WO2010110545A3 (ko) | 신규한 하이드록사메이트 유도체, 이의 제조방법, 및 이를 함유하는 약제학적 조성물 | |
WO2010011811A3 (en) | 3-(phenoxyphenylmethyl)pyrrolidine compounds | |
ECSP11011048A (es) | Inhibidores de cinasa akt y p70 s6 | |
WO2006057950A3 (en) | 4-phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin | |
PH12014502567A1 (en) | Piperidine derivatives for gpr119 agonist | |
RS53613B1 (en) | COMPOUNDS, COMPOSITIONS, AND PROCEDURES FOR TREATMENT OF BETA-AMYLOID DISEASES AND SYNUCLEINOPATHY | |
MY151211A (en) | 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compounds | |
WO2012103226A3 (en) | Bendamustine formulations | |
EA017249B8 (ru) | Арил- и гетероарилзамещенные тетрагидробензо-1,4-диазепины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина | |
SA517390552B1 (ar) | مركبات بلورية مثبط امتصاص ثلاثي غير متوازن | |
WO2009118765A3 (en) | Novel monoamine re-uptake inhibitor | |
WO2012118308A3 (ko) | 피라졸 유도체를 포함하는 심혈관 질환 예방 및 치료용 조성물. | |
WO2011008666A3 (en) | 3-phenoxymethylpyrrolidine compounds | |
HK1185878A1 (zh) | 用於治療或預防由血清素、去甲腎上腺素或多巴胺的神經傳遞的減少而引起的疾病的雜環化合物 | |
WO2010117979A3 (en) | Serotonin and norepinephrine reuptake inhibitor | |
WO2012173382A3 (ko) | 탄시논ⅱa를 유효성분으로 함유하는 피부 외용제 조성물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 12829591 Country of ref document: EP Kind code of ref document: A2 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 14239890 Country of ref document: US |
|
REEP | Request for entry into the european phase |
Ref document number: 2012829591 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2012829591 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |