WO2013025064A3 - Wnt 유인 수용체를 포함하는 항암 조성물 - Google Patents
Wnt 유인 수용체를 포함하는 항암 조성물 Download PDFInfo
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- WO2013025064A3 WO2013025064A3 PCT/KR2012/006527 KR2012006527W WO2013025064A3 WO 2013025064 A3 WO2013025064 A3 WO 2013025064A3 KR 2012006527 W KR2012006527 W KR 2012006527W WO 2013025064 A3 WO2013025064 A3 WO 2013025064A3
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- cancer
- composition
- wnt
- decoy receptors
- cancer composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10321—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
본 발명은 Wnt 유인 수용체를 유효성분으로 포함하는 암의 예방 또는 치료용 조성물에 관한 것이다 본 발명의 조성물 또는 이의 발현 산물은 Wnt 리간드에 결합하여 리간드-수용체 상호작용을 차단함으로써 암의 발생, 성장, 증식 및 전이를 억제하고 암세포의 사멸을 유도함으로써 효율적인 항암 조성물로 유용하게 이용될 수 있다.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/239,259 US9657069B2 (en) | 2011-08-18 | 2012-08-16 | Anti-cancer compositions containing WNT decoy receptor |
CN201280040178.8A CN103764161B (zh) | 2011-08-18 | 2012-08-16 | 包含Wnt 诱因受体的抗癌组合物 |
EP12824372.2A EP2745842B1 (en) | 2011-08-18 | 2012-08-16 | Anti-cancer composition comprising wnt decoy receptors |
US15/494,211 US9920099B2 (en) | 2011-08-18 | 2017-04-21 | Anti-cancer compositions containing Wnt decoy receptor |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020110082087A KR101399062B1 (ko) | 2011-08-18 | 2011-08-18 | Wnt 유인 수용체를 포함하는 항암 조성물 |
KR10-2011-0082087 | 2011-08-18 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/239,259 A-371-Of-International US9657069B2 (en) | 2011-08-18 | 2012-08-16 | Anti-cancer compositions containing WNT decoy receptor |
US15/494,211 Division US9920099B2 (en) | 2011-08-18 | 2017-04-21 | Anti-cancer compositions containing Wnt decoy receptor |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2013025064A2 WO2013025064A2 (ko) | 2013-02-21 |
WO2013025064A3 true WO2013025064A3 (ko) | 2013-06-13 |
Family
ID=47715607
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2012/006527 WO2013025064A2 (ko) | 2011-08-18 | 2012-08-16 | Wnt 유인 수용체를 포함하는 항암 조성물 |
Country Status (5)
Country | Link |
---|---|
US (2) | US9657069B2 (ko) |
EP (1) | EP2745842B1 (ko) |
KR (1) | KR101399062B1 (ko) |
CN (1) | CN103764161B (ko) |
WO (1) | WO2013025064A2 (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108289920A (zh) * | 2015-10-12 | 2018-07-17 | 汉阳大学校产学协力团 | 用于基因转移和基因治疗的腺病毒复合物 |
US11564954B2 (en) * | 2019-02-22 | 2023-01-31 | Arizona Board Of Regents On Behalf Of Arizona State University | Tumor-delivered multi-target therapeutics for colon cancer |
WO2020172461A1 (en) * | 2019-02-22 | 2020-08-27 | Arizona Board Of Regents On Behalf Of Arizona State University | Using tumor-navigating salmonella to modulate tumor metabolism |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
JPWO2006077824A1 (ja) * | 2005-01-18 | 2008-08-07 | 国立大学法人京都大学 | 神経細胞再生のための医薬 |
WO2007142987A2 (en) * | 2006-05-30 | 2007-12-13 | Wisconsin Alumni Research Foundation | Mammary stem cell marker |
KR100807069B1 (ko) * | 2007-09-21 | 2008-02-25 | 고려대학교 산학협력단 | 암 치료용 의약 조성물 |
KR20100091170A (ko) * | 2007-11-02 | 2010-08-18 | 노파르티스 아게 | 저밀도-지단백질 수용체-관련 단백질 6 (lrp6)을 조정하기 위한 분자 및 방법 |
TWI535445B (zh) * | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
-
2011
- 2011-08-18 KR KR1020110082087A patent/KR101399062B1/ko active IP Right Grant
-
2012
- 2012-08-16 WO PCT/KR2012/006527 patent/WO2013025064A2/ko active Application Filing
- 2012-08-16 EP EP12824372.2A patent/EP2745842B1/en active Active
- 2012-08-16 US US14/239,259 patent/US9657069B2/en active Active
- 2012-08-16 CN CN201280040178.8A patent/CN103764161B/zh active Active
-
2017
- 2017-04-21 US US15/494,211 patent/US9920099B2/en active Active
Non-Patent Citations (3)
Title |
---|
AKIRI, G. ET AL.: "Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma", ONCOGENE, vol. 28, no. 21, 2009, pages 2163 - 2172, XP055071213 * |
LIU, C-C. ET AL.: "Cooperative Folding and Ligand-binding Properties of LRP6 beta- Propeller Domains", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 22, 2009, pages 15299 - 15307, XP055145560 * |
RUSSELL, W. C. ET AL.: "Update on adenovirus and its vectors", JOURNAL OF GENERAL VIROLOGY, vol. 81, 2000, pages 2573 - 2604, XP002247418 * |
Also Published As
Publication number | Publication date |
---|---|
US9920099B2 (en) | 2018-03-20 |
US20140315825A1 (en) | 2014-10-23 |
EP2745842A2 (en) | 2014-06-25 |
EP2745842B1 (en) | 2018-01-17 |
EP2745842A4 (en) | 2015-05-27 |
KR20130019847A (ko) | 2013-02-27 |
CN103764161B (zh) | 2015-09-02 |
US20170275340A1 (en) | 2017-09-28 |
WO2013025064A2 (ko) | 2013-02-21 |
KR101399062B1 (ko) | 2014-05-27 |
CN103764161A (zh) | 2014-04-30 |
US9657069B2 (en) | 2017-05-23 |
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