WO2013016804A1 - Lentille déformable soumise à une pression négative - Google Patents

Lentille déformable soumise à une pression négative Download PDF

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Publication number
WO2013016804A1
WO2013016804A1 PCT/CA2012/000716 CA2012000716W WO2013016804A1 WO 2013016804 A1 WO2013016804 A1 WO 2013016804A1 CA 2012000716 W CA2012000716 W CA 2012000716W WO 2013016804 A1 WO2013016804 A1 WO 2013016804A1
Authority
WO
WIPO (PCT)
Prior art keywords
lens
sealed fluid
filled
fluid
flexible
Prior art date
Application number
PCT/CA2012/000716
Other languages
English (en)
Inventor
Garth T. Webb
Original Assignee
Webb Garth T
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Webb Garth T filed Critical Webb Garth T
Publication of WO2013016804A1 publication Critical patent/WO2013016804A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A61F2/1635—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing shape
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B3/00—Simple or compound lenses
    • G02B3/12—Fluid-filled or evacuated lenses
    • G02B3/14—Fluid-filled or evacuated lenses of variable focal length

Definitions

  • the invention relates to the field of refractive interfaces, in particular optical lenses and intraocular lens implants.
  • Thin optical interfaces made of elastic materials can change shape in response to hydraulic pressure; however, curvature change thus achieved is bi-phasic and of poor optical quality. Other problems, such as material fatigue and material stability also arise with such interfaces. Thin optical interfaces composed of flexible materials with good shape memory properties do not easily change curvature. [0005] United States patent application no. 12/671,573 discloses control mechanisms which regulate curvature change (Optical spring' and 'grooved optical interface'); however, there remains a need for
  • a sealed fluid-filled lens which comprises an internal lens compartment that is subject to negative partial pressure; while at rest, further comprising internal structural elements which regulate shape change when the sealed fluid-filled lens is engaged by either intrinsic or extrinsic force. While the present invention has particular application as an improvement in flexible optical interfaces and support structures of the type shown in United States patent application no. 12/671,573, it also has more general application to cameras and other optical equipment.
  • the invention therefore provides a sealed fluid-filled lens, comprising: i) a flexible deformable liquid-impermeable membrane, forming a hollow interior chamber filled with a refractive fluid, and comprising a central transparent optical zone; and ii) a flexible internal structural element which bears against the inner surface of the flexible deformable liquid-impermeable membrane to thereby modify the curvature of the deformable liquid-impermeable membrane when the sealed fluid- filled lens is engaged by extrinsic or intrinsic force, wherein the hollow interior chamber is maintained at a negative partial pressure relative to the exterior of the lens
  • Fig. 1 is a cross-sectional view of annular inflatable intraocular retainers positioned within the intra-capsular space of a human eye.
  • FIG. 2 is a perspective view of an inflatable lens according to the invention.
  • Fig. 3 is a cross-section along lines 3-3 of Fig. 2 showing the invention in distended configuration with maximum negative partial pressure.
  • Fig. 4 is a cross-section along lines 3-3 of Fig. 2 showing the invention in extended configuration with reduced negative partial pressure.
  • Fig. 1 illustrates the structure disclosed in United States patent application no. 12/671,573 where annular inflatable intraocular retainer 26 is positioned within the intra-capsular space, directly in front of posterior lens capsule 14 and annular inflatable intraocular retainer 28 is positioned behind anterior lens capsule 12.
  • Liquid is introduced into inflatable intraocular retainer 26 through filling port 30.
  • Liquid is introduced into inflatable intraocular retainer 28 through filling port 32.
  • Lens compartment 34 is defined as the space between posterior lens support 36 and anterior lens support 38.
  • Posterior lens support 36 is a diaphragm that stretches across the front surface of inflatable intraocular retainer 26 and anterior lens support 38 is an annular diaphragm that stretches across the front surface of inflatable intraocular retainer 28.
  • Fig. 2 through 4 illustrate a sealed fluid-filled lens 40, lens 40 being a symmetric circular disc sized for insertion in lens compartment 34. It is covered in a transparent, liquid-impervious, sealed, flexible film or membrane 42, also referred to herein as the flexible optical interface, which forms an interior volume 46 containing a refractive fluid medium 44.
  • flexible optical interface 42 is stretchable and elastic, in that it returns to its original shape after being deformed.
  • Flexible optical interface 42 may be constructed of silicone rubber, silicone hydrogel materials, polyethylene or polyurethane.
  • Refractive fluid medium 44 is preferably a refractive liquid, such as silicone oil, although the term "liquid” could also include glycerine, silicone gel or gas.
  • Gasses used as refractive fluid medium 44 should be relatively inert, physiologically compatible and preferably of large molecular weight, such as methane or the gasses used for reparative retinal surgery, available from Alcon Laboratories Inc under the trademark Ispan C3F8 for medical grade perflurocarbon gas and Ispan SG6 for medical grade sulfurhexafloride gas. Air may also be used.
  • the interior volume 46 of lens 40 forms an internal lens compartment that is subject to negative partial pressure in order to maintain the film or membrane 42 in tight relationship to the internal structure of the lens 40.
  • the internal lens compartment further comprises internal structural elements 48, 50 which regulate shape change when the sealed fluid-filled lens is engaged by either intrinsic or extrinsic force.
  • Transparent rigid disk 48 has a curved surface 52 which bears tightly against film 42. It has a lower generally planar surface 54 which bears against a transparent flexible hemi-spherical shell 50.
  • Shell 50 is made of a spring-like flexible material such as a suitable transparent plastic, which is provided with slots 56 along the longitudinal meridians of the hemispherical shell 50.
  • the internal supportive structure may be constructed as independent elements 48, 50 positioned within the sealed lens compartment or it may be integrated within or upon a wall of the sealed lens
  • the internal supportive structure is shaped and positioned within the sealed lens compartment so that it presses against the inner surface of the flexible optical interface 42.
  • peripheral regions of the flexible optical interface 42 remain free to flex and change shape in response to hydraulic pressure. In others, central regions of the flexible optical interface remain free to flex and change shape.
  • the internal supportive structure 48, 50 may be deformable. In some embodiments, it may be a rigid structure that is pressed against a second flexible optical interface simultaneously with the first flexible optical interface. There are many variations to the shape of the collapsible supportive structure 48, 50 as it is invisible while it is immersed within an index-matched fluid 44.
  • the shape of the sursaces of the flexible optical interface 42 may be grooved for maximum range and cohesiveness of curvature change, or not. They may be smooth or irregular.
  • the flexible optical interface 42 may contain fortified structural elements within its walls, or not. It may have well defined optical zones, or not. Variables such as these may be considered for specific applications but they are not critical to the fundamental operation of a negatively pressurized sealed fluid-filled lens.
  • Negative partial pressure within the sealed lens compartment 40 draws the flexible optical interface 42 against the internal supportive structure 48, 50.
  • Peripheral and mid-peripheral regions of a flexible optical interface 42 may be configured to flex inwardly, thereby generating greater convexity.
  • central regions of a flexible optical interface 42 may be configured to flex inwardly, thereby generating reduced convexity.
  • the diameter of the flexible optical interface 42 of a sealed fluid-filled lens 10 may reduce in unison with negative pressurization. Radial traction upon peripheral regions of a negatively pressurized flexible optical interface 42 may be utilized to compress the internal lens compartment 40 to impart curvature change.

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

La présente invention concerne une lentille scellée remplie de fluide, la lentille comprenant un compartiment interne de lentille qui est soumis à une pression partielle négative. Elle comporte une membrane de surface imperméable aux liquides et à déformation élastique, formant une chambre interne creuse remplie avec un liquide réfractif. Des éléments structuraux internes interagissent avec la membrane de surface, ce qui permet à la courbure de la lentille d'être modifiée quand la lentille scellée remplie de fluide est soumise à une force intrinsèque ou extrinsèque.
PCT/CA2012/000716 2011-08-03 2012-07-27 Lentille déformable soumise à une pression négative WO2013016804A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161514746P 2011-08-03 2011-08-03
US61/514,746 2011-08-03

Publications (1)

Publication Number Publication Date
WO2013016804A1 true WO2013016804A1 (fr) 2013-02-07

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2012/000716 WO2013016804A1 (fr) 2011-08-03 2012-07-27 Lentille déformable soumise à une pression négative

Country Status (1)

Country Link
WO (1) WO2013016804A1 (fr)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015148673A1 (fr) * 2014-03-28 2015-10-01 Forsight Labs, Llc Lentille intraoculaire d'accommodation
US9186244B2 (en) 2012-12-21 2015-11-17 Lensgen, Inc. Accommodating intraocular lens
US9913712B2 (en) 2011-02-04 2018-03-13 Forsight Labs, Llc Intraocular accommodating lens and methods of use
US10004596B2 (en) 2014-07-31 2018-06-26 Lensgen, Inc. Accommodating intraocular lens device
US10159564B2 (en) 2013-11-01 2018-12-25 Lensgen, Inc. Two-part accomodating intraocular lens device
US10258462B2 (en) 2012-12-26 2019-04-16 Rainbow Medical Ltd. Accommodative intraocular lens
US10327886B2 (en) 2016-06-01 2019-06-25 Rainbow Medical Ltd. Accomodative intraocular lens
US10441411B2 (en) 2016-12-29 2019-10-15 Rainbow Medical Ltd. Accommodative intraocular lens
US10526353B2 (en) 2016-05-27 2020-01-07 Lensgen, Inc. Lens oil having a narrow molecular weight distribution for intraocular lens devices
WO2020041890A1 (fr) * 2018-08-30 2020-03-05 Ventura Holdings Ltd. Lentille intra-oculaire hybride d'accommodation et son procédé d'utilisation
US10646330B2 (en) 2012-12-26 2020-05-12 Rainbow Medical Ltd. Accommodative intraocular lens
US10647831B2 (en) 2014-09-23 2020-05-12 LensGens, Inc. Polymeric material for accommodating intraocular lenses
US10772721B2 (en) 2010-04-27 2020-09-15 Lensgen, Inc. Accommodating intraocular lens
US10842616B2 (en) 2013-11-01 2020-11-24 Lensgen, Inc. Accommodating intraocular lens device
US10939994B2 (en) 2016-04-22 2021-03-09 Ventura Holdings Ltd. Collapsible cavities within suspension systems for intra-ocular lenses
US11065107B2 (en) 2015-12-01 2021-07-20 Lensgen, Inc. Accommodating intraocular lens device
US11523898B2 (en) 2016-10-28 2022-12-13 Forsight Vision6, Inc. Accommodating intraocular lens and methods of implantation
RU2820014C2 (ru) * 2018-08-30 2024-05-28 Окуметикс Текнолоджи Корп. Аккомодирующая интраокулярная линза и способ ее вставки в капсулу хрусталика глаза

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4932966A (en) * 1988-08-15 1990-06-12 Storz Instrument Company Accommodating intraocular lens
US7981155B2 (en) * 2005-12-07 2011-07-19 C&C Vision International Limited Hydrolic accommodating intraocular lens
US20110224788A1 (en) * 2007-08-13 2011-09-15 Webb Garth T Inflatable intra ocular lens/lens retainer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4932966A (en) * 1988-08-15 1990-06-12 Storz Instrument Company Accommodating intraocular lens
US7981155B2 (en) * 2005-12-07 2011-07-19 C&C Vision International Limited Hydrolic accommodating intraocular lens
US20110224788A1 (en) * 2007-08-13 2011-09-15 Webb Garth T Inflatable intra ocular lens/lens retainer

Cited By (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10772721B2 (en) 2010-04-27 2020-09-15 Lensgen, Inc. Accommodating intraocular lens
US11076947B2 (en) 2011-02-04 2021-08-03 Forsight Vision6, Inc. Intraocular accommodating lens and methods of use
US10639141B2 (en) 2011-02-04 2020-05-05 Forsight Vision6, Inc. Intraocular accommodating lens and methods of use
US9913712B2 (en) 2011-02-04 2018-03-13 Forsight Labs, Llc Intraocular accommodating lens and methods of use
US11918458B2 (en) 2011-02-04 2024-03-05 Forsight Vision6, Inc. Intraocular accommodating lens and methods of use
US9186244B2 (en) 2012-12-21 2015-11-17 Lensgen, Inc. Accommodating intraocular lens
US10111745B2 (en) 2012-12-21 2018-10-30 Lensgen, Inc. Accommodating intraocular lens
US10646330B2 (en) 2012-12-26 2020-05-12 Rainbow Medical Ltd. Accommodative intraocular lens
US10258462B2 (en) 2012-12-26 2019-04-16 Rainbow Medical Ltd. Accommodative intraocular lens
US11278393B2 (en) 2012-12-26 2022-03-22 Rainbow Medical Ltd. Accommodative intraocular lens
US11471273B2 (en) 2013-11-01 2022-10-18 Lensgen, Inc. Two-part accommodating intraocular lens device
US11000364B2 (en) 2013-11-01 2021-05-11 Lensgen, Inc. Two-part accommodating intraocular lens device
US10842616B2 (en) 2013-11-01 2020-11-24 Lensgen, Inc. Accommodating intraocular lens device
US10159564B2 (en) 2013-11-01 2018-12-25 Lensgen, Inc. Two-part accomodating intraocular lens device
US11464622B2 (en) 2013-11-01 2022-10-11 Lensgen, Inc. Two-part accommodating intraocular lens device
US11464624B2 (en) 2013-11-01 2022-10-11 Lensgen, Inc. Two-part accommodating intraocular lens device
US10285805B2 (en) 2014-03-28 2019-05-14 Forsight Labs, Llc Accommodating intraocular lens
US12090044B2 (en) 2014-03-28 2024-09-17 Forsight Vision6, Inc. Accommodating intraocular lens
CN106572903A (zh) * 2014-03-28 2017-04-19 弗赛特实验室有限责任公司 可调节眼内透镜
US11331182B2 (en) 2014-03-28 2022-05-17 Forsight Vision6, Inc. Accommodating intraocular lens
AU2015236131B2 (en) * 2014-03-28 2019-05-30 Forsight Vision6, Inc. Accommodating intraocular lens
CN106572903B (zh) * 2014-03-28 2019-10-25 弗赛特实验室有限责任公司 可调节眼内透镜
EA034510B9 (ru) * 2014-03-28 2021-01-18 ФОРСАЙТ ЛЭБС, ЭлЭлСи Аккомодирующая интраокулярная линза
WO2015148673A1 (fr) * 2014-03-28 2015-10-01 Forsight Labs, Llc Lentille intraoculaire d'accommodation
EA034510B1 (ru) * 2014-03-28 2020-02-14 ФОРСАЙТ ЛЭБС, ЭлЭлСи Аккомодирующая интраокулярная линза
US11826246B2 (en) 2014-07-31 2023-11-28 Lensgen, Inc Accommodating intraocular lens device
US10485654B2 (en) 2014-07-31 2019-11-26 Lensgen, Inc. Accommodating intraocular lens device
US10004596B2 (en) 2014-07-31 2018-06-26 Lensgen, Inc. Accommodating intraocular lens device
US11464621B2 (en) 2014-07-31 2022-10-11 Lensgen, Inc. Accommodating intraocular lens device
US10647831B2 (en) 2014-09-23 2020-05-12 LensGens, Inc. Polymeric material for accommodating intraocular lenses
US11065107B2 (en) 2015-12-01 2021-07-20 Lensgen, Inc. Accommodating intraocular lens device
US11471270B2 (en) 2015-12-01 2022-10-18 Lensgen, Inc. Accommodating intraocular lens device
US10939994B2 (en) 2016-04-22 2021-03-09 Ventura Holdings Ltd. Collapsible cavities within suspension systems for intra-ocular lenses
US10526353B2 (en) 2016-05-27 2020-01-07 Lensgen, Inc. Lens oil having a narrow molecular weight distribution for intraocular lens devices
US10327886B2 (en) 2016-06-01 2019-06-25 Rainbow Medical Ltd. Accomodative intraocular lens
US11523898B2 (en) 2016-10-28 2022-12-13 Forsight Vision6, Inc. Accommodating intraocular lens and methods of implantation
US10441411B2 (en) 2016-12-29 2019-10-15 Rainbow Medical Ltd. Accommodative intraocular lens
EP3843663A4 (fr) * 2018-08-30 2022-06-01 Ocumetics Technology Corp. Lentille intra-oculaire hybride d'accommodation et son procédé d'utilisation
US11529231B2 (en) 2018-08-30 2022-12-20 Ocumetics Technology Corp. Hybrid accommodating intra-ocular lens and method of use thereof
CN112638325A (zh) * 2018-08-30 2021-04-09 眼科技术公司 混合调节性眼内透镜及其使用方法
WO2020041890A1 (fr) * 2018-08-30 2020-03-05 Ventura Holdings Ltd. Lentille intra-oculaire hybride d'accommodation et son procédé d'utilisation
RU2820014C2 (ru) * 2018-08-30 2024-05-28 Окуметикс Текнолоджи Корп. Аккомодирующая интраокулярная линза и способ ее вставки в капсулу хрусталика глаза

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