WO2013009102A3 - 콜라겐, 히알루론산 유도체 및 포유류의 탯줄 유래 줄기세포를 포함하는 연골세포치료제 - Google Patents

콜라겐, 히알루론산 유도체 및 포유류의 탯줄 유래 줄기세포를 포함하는 연골세포치료제 Download PDF

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WO2013009102A3
WO2013009102A3 PCT/KR2012/005518 KR2012005518W WO2013009102A3 WO 2013009102 A3 WO2013009102 A3 WO 2013009102A3 KR 2012005518 W KR2012005518 W KR 2012005518W WO 2013009102 A3 WO2013009102 A3 WO 2013009102A3
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treating agent
biomaterial
collagen
hyaluronic acid
acid derivative
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PCT/KR2012/005518
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English (en)
French (fr)
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WO2013009102A2 (ko
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최용수
노상은
이영준
정상윤
김선미
한규범
정형민
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(주)차바이오앤디오스텍
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Priority to JP2014520128A priority Critical patent/JP2014520844A/ja
Priority to CN201280044621.9A priority patent/CN103796659A/zh
Priority to US14/232,569 priority patent/US20140227235A1/en
Publication of WO2013009102A2 publication Critical patent/WO2013009102A2/ko
Publication of WO2013009102A3 publication Critical patent/WO2013009102A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/48—Reproductive organs
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3852—Cartilage, e.g. meniscus
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

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Abstract

본 발명은 의료용 복합 생체소재에 관한 것이다. 보다 상세하게는, 본 발명은 콜라겐 및 히알루론산 유도체를 포함하는 의료용 복합 생체소재에 대한 것이다. 또한, 상기 생체소재 및 포유류의 탯줄 유래 줄기세포를 이용한 연골세포치료제에 관한 것이다. 이러한, 생체소재는 면역 반응을 야기하지 않고, 내구성이 우수하며, 이러한 생체소재와 줄기세포를 포함한 연골세포치료제는 관절경을 이용한 시술이 가능하여 환자의 고통을 줄여줄 뿐만 아니라 효과적으로 퇴행성 관절염 및 연골 손상을 치료할 수 있다.
PCT/KR2012/005518 2011-07-13 2012-07-11 콜라겐, 히알루론산 유도체 및 포유류의 탯줄 유래 줄기세포를 포함하는 연골세포치료제 WO2013009102A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2014520128A JP2014520844A (ja) 2011-07-13 2012-07-11 コラーゲン、ヒアルロン酸誘導体及び哺乳類の臍帯由来幹細胞を含む軟骨細胞治療剤
CN201280044621.9A CN103796659A (zh) 2011-07-13 2012-07-11 包含胶原、透明质酸衍生物和哺乳动物脐带来源干细胞的软骨细胞治疗物
US14/232,569 US20140227235A1 (en) 2011-07-13 2012-07-11 Cartilage cell treatment comprising collagen, hyaluronic acid derivative, and stem cell derived from mammal umbilical cord

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2011-0069551 2011-07-13
KR20110069551 2011-07-13

Publications (2)

Publication Number Publication Date
WO2013009102A2 WO2013009102A2 (ko) 2013-01-17
WO2013009102A3 true WO2013009102A3 (ko) 2013-04-11

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PCT/KR2012/005518 WO2013009102A2 (ko) 2011-07-13 2012-07-11 콜라겐, 히알루론산 유도체 및 포유류의 탯줄 유래 줄기세포를 포함하는 연골세포치료제

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US (1) US20140227235A1 (ko)
JP (1) JP2014520844A (ko)
KR (1) KR101422689B1 (ko)
CN (1) CN103796659A (ko)
WO (1) WO2013009102A2 (ko)

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CN108289825B (zh) * 2015-11-24 2022-03-25 株式会社Bmi韩国 含透明质酸衍生物和dna片段的注射用透明质酸组合物及其应用
KR20180092348A (ko) 2017-02-09 2018-08-20 주식회사 엑소코바이오 연골세포로 분화되고 있는 제대 및 제대혈 유래 줄기세포로부터 분리된 엑소좀을 포함하는 연골세포 분화 유도 또는 연골조직 재생용 조성물
CN107828401B (zh) * 2017-06-08 2020-07-14 中国石油化工股份有限公司 一种增强co2与原油互溶、降低原油粘度的驱油添加剂
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WO2019088656A1 (ko) * 2017-11-02 2019-05-09 주식회사 엑소코바이오 안정화된 엑소좀의 필러 조성물
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CN112048469A (zh) * 2020-09-11 2020-12-08 山东大学 一种增强间充质干细胞分泌功能的方法及应用
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CN113384753A (zh) * 2021-03-19 2021-09-14 杭州协合医疗用品有限公司 一种含脂肪间充质干细胞的可注射温敏复合型水凝胶及其制备方法和应用
CN113616675A (zh) * 2021-08-23 2021-11-09 上海太安堂生物医学有限公司 含间充质干细胞的组合物及其在治疗退行性关节炎的应用
CN115531297B (zh) * 2022-10-28 2024-09-17 东莞市东南部中心医院 负载富血小板血浆和脐带间充质干细胞球的可注射水凝胶系统及其制备方法和应用
PL444427A1 (pl) * 2023-04-16 2024-01-15 Politechnika Śląska Polipeptydowa powłoka pro-adhezyjna i sposób jej otrzymywania

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