WO2012173161A1 - Dispositif de purification de sang et procédé pour amorcer automatiquement un dispositif de purification de sang - Google Patents

Dispositif de purification de sang et procédé pour amorcer automatiquement un dispositif de purification de sang Download PDF

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Publication number
WO2012173161A1
WO2012173161A1 PCT/JP2012/065169 JP2012065169W WO2012173161A1 WO 2012173161 A1 WO2012173161 A1 WO 2012173161A1 JP 2012065169 W JP2012065169 W JP 2012065169W WO 2012173161 A1 WO2012173161 A1 WO 2012173161A1
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WO
WIPO (PCT)
Prior art keywords
blood
air
priming
venous
circuit
Prior art date
Application number
PCT/JP2012/065169
Other languages
English (en)
Japanese (ja)
Inventor
洋一 鴨下
将太 中村
Original Assignee
ニプロ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ニプロ株式会社 filed Critical ニプロ株式会社
Priority to JP2013520570A priority Critical patent/JP5929912B2/ja
Publication of WO2012173161A1 publication Critical patent/WO2012173161A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3643—Priming, rinsing before or after use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3643—Priming, rinsing before or after use
    • A61M1/3644—Mode of operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3643—Priming, rinsing before or after use
    • A61M1/3644—Mode of operation
    • A61M1/3649—Mode of operation using dialysate as priming or rinsing liquid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3643—Priming, rinsing before or after use
    • A61M1/3644—Mode of operation
    • A61M1/3652—Mode of operation using gas, e.g. air

Definitions

  • the present invention relates to a blood purification device that assists or substitutes for organ functions of a living body by purifying blood taken out of a body from a blood vessel and, if necessary, replenishing it with useful substances. Is characterized in that it can be automatically primed.
  • the present invention also relates to an automatic priming method performed using the blood purification device.
  • the blood purification apparatus performs a process (referred to as priming) for removing foreign substances and air in the circuit by introducing and filling a priming solution (generally, physiological saline) into the blood circuit when used.
  • a priming solution generally, physiological saline
  • an arterial side blood circuit and a venous side blood circuit are connected, a blood circulation path is formed, a blood pump is operated, and a priming liquid is circulated to the blood circulation path
  • the artificial dialysis apparatus is configured to discharge a part of the priming liquid from the overflow tube provided in the drip chamber.
  • Patent Document 1 overflow the priming liquid from the priming liquid supply system from the arterial circuit portion upstream of the blood pump through the venous circuit using its own head.
  • the blood purification devices of Patent Document 1 and Patent Document 2 described above connect the arterial blood circuit and the venous blood circuit to form a blood circulation path, and require an overflow line for priming.
  • This overflow line is formed by detachably connecting an overflow tube having a length of about 1 meter to the liquid level adjustment line of the venous drip chamber, and it is difficult to adjust the liquid level during treatment. During the treatment, it was necessary to remove the overflow tube. Therefore, it takes extra time to connect and disconnect, and the remaining spent priming solution attached to the tube is dirty because it adheres to the hand or drops on the floor. There is a problem.
  • the blood purification device of Patent Document 3 does not require an overflow line for priming. However, in order to expel air by filling the drip chamber with a priming solution (saline), an arterial drip chamber, a vein It was necessary to invert the side drip chamber and blood purifier, which necessitated extra manual work during priming.
  • Patent Document 4 This includes a blood purifier and a blood circuit, a blood pump, a priming fluid supply line connected to the arterial blood circuit upstream of the blood pump, a venous air trap and a bubble sensor provided in the venous blood circuit.
  • a blood purification device in which the venous air trap is provided with a line connectable to the priming fluid supply line, and a connecting portion with the priming fluid supply line using a head Priming the upstream arterial blood circuit and the venous blood circuit downstream of the venous air trap; driving the blood pump to prime the upstream blood circuit from the venous air trap;
  • a method for priming the blood circulation path of the blood purifier comprising:
  • the present invention has been made in view of the above circumstances, and an object of the present invention is to provide a blood purification device capable of fully automating the priming operation of the blood circuit, and a priming method for the blood purification device.
  • the blood purification apparatus of the present invention includes a blood purifier, a blood circuit, a blood pump, a priming fluid supply line connected to an arterial blood circuit upstream of the blood pump, and a venous air trap provided in the venous blood circuit.
  • An air pressurization line for introducing air into the blood side of the blood purifier and pressurizing the vein chamber, and the air pressurization line includes a chamber (venous chamber).
  • a pressure control means for controlling the internal pressure on the blood side is provided.
  • the air pressurization line includes an air supply path provided with an air filter at the upstream end and a downstream end connected to the venous chamber, an upstream air supply means provided in the air supply path, and a downstream side. Comprising an on-off valve.
  • the priming method of the blood purifier of the present invention increases the internal pressure of the blood side by introducing air to the blood side of the blood purifier, and the dialysate introduced to the dialysate side of the blood purifier is the blood
  • the blood side is primed after filling the dialysate side with the dialysate side, without shifting to the side.
  • the following effects can be expected. That is, according to the blood purification apparatus of the present invention, during priming, air can be introduced into the blood side of the blood purification device to increase the internal pressure on the blood side, so that dialysis is first performed on the dialysate side of the blood purification device.
  • the internal pressure on the blood side can be made larger than the internal pressure on the dialysate side, and the transition of the dialysate introduced to the dialysate side to the blood side, which has occurred in the past ( It was possible to prevent air blocking).
  • the blood side can be primed after first filling the dialysate side with the dialysate side, the venous side chamber and blood purifier required when the priming solution is introduced to the blood side first. No reversing operation is required.
  • the priming operation can be performed from a state in which the coupler is attached to the dialysate side of the blood purifier and the dialysate line is connected, the priming operation of the blood purifier can be completely automated. .
  • the air pressurization line includes an air supply path provided with an air filter at the upstream end and a downstream end connected to the venous chamber, an upstream air supply means provided in the air supply path, and a downstream on-off valve. Consists of.
  • FIG. 1 is a schematic explanatory view of a blood purification apparatus (hemodialysis apparatus) showing an embodiment of the present invention.
  • the blood analysis apparatus of Example 1 includes a blood purifier (blood dialyzer) 1, blood circuits 21 and 22, a blood pump 3, and an arterial blood circuit 21 upstream of the blood pump 3.
  • the priming fluid supply line 4 is connected to a venous chamber 23 provided in the venous blood circuit 22.
  • the venous chamber 23 is pressurized by introducing air into the blood side of the hemodialyzer 1 and pressurizing it.
  • a line 5 is provided, and pressure control means 6 for controlling the internal pressure on the blood side of the hemodialyzer 1 is provided in the air pressurization line 5.
  • blood from a patient at the time of dialysis treatment is supplied from the arterial blood circuit 21 to the blood passage of the hemodialyzer 1 and returned to the patient through the venous blood circuit 22 (hereinafter referred to as the blood passage).
  • the arterial blood circuit 21 is provided with an on-off valve V1 and a blood pump 3 in order from the upstream side (an arterial air trap chamber may be provided if necessary).
  • a priming fluid supply line 4 is connected to the arterial blood circuit 21 between the blood pump 3 and the opening / closing means V1, and a priming fluid container 41 is provided upstream of the priming fluid supply line 4.
  • An opening / closing means V3 is provided downstream.
  • the venous blood circuit 22 is provided with a venous chamber 23, a bubble sensor 24 for detecting the presence or absence of bubbles in the venous blood circuit 22, and an opening / closing means V2 in order from the upstream side.
  • the applied priming liquid flows into a waste liquid container (not shown).
  • the venous chamber 23 is provided with a pressure gauge PV so that the internal pressure on the venous side is measured.
  • an air pressurization line 5 is provided in the venous chamber 23, and pressure control means 6 for controlling the internal pressure on the blood side of the hemodialyzer 1 is provided in the air pressurization line 5.
  • the air pressurization line 5 is a line for introducing and pressurizing air to the blood side of the hemodialyzer 1.
  • the air supply line 51 is provided with an air filter 52 at the upstream end and connected to the venous chamber 23 at the downstream end.
  • an upstream air supply means (air pump) 53 provided in the air supply passage 51 and a downstream on-off valve V4.
  • the air pump 53 is controlled by the pressure control means 6 so that the pressure of the air introduced into the blood side of the hemodialyzer 1 is 250 to 500 mmHg.
  • 7 is a water removal control apparatus
  • 71 is a dialysate supply line
  • 72 is a dialysate discharge line.
  • the on-off valve V4 is first opened, the air pump 53 is driven, and the air pressurization line 5 passes through the venous chamber 23. Thus, air is introduced into the blood side of the hemodialyzer 1.
  • the on-off valve V3 is opened, the dialysate pump (not shown) is driven, and the dialysate passes from the water removal control device 7 through the dialysate supply line 71 to the dialysate side of the hemodialyzer 1. Filled.
  • the air pressure is controlled by the pressure control means 6 so that the internal pressure on the blood side is equal to or greater than the internal pressure on the dialysate side.
  • the on-off valve V4 When the dialysate-side filling of the dialysate is completed, the on-off valve V4 is closed, the on-off valves V1, V3 are opened, and the priming liquid in the priming container 41 passes through the priming line 4 due to the drop, and the arterial blood
  • the circuit 21 and the priming liquid supply line 4 are introduced into the blood circulation path upstream from the connection portion 25, and this portion is primed.
  • the on-off valve V1 When priming of the blood circulation path upstream from the connecting portion 25 is completed, the on-off valve V1 is closed, the on-off valve V2 is opened, the blood pump 3 is driven, and the arterial blood circuit 21 and the priming fluid supply It is introduced into the blood circulation path downstream from the connection part 25 with the line 4, and the blood circulation path downstream from the connection part 25 including the blood side of the hemodialyzer 1 is primed.
  • FIG. 2 is a schematic explanatory view of a blood purification apparatus (hemodialysis apparatus) showing another embodiment of the present invention.
  • the hemodialysis apparatus of the present invention has a priming fluid supply line 4 connected to a dialysis fluid supply line 71 downstream of a dialysis fluid pump (not shown) of the dialysis fluid supply device 7 in FIG. It is connected.
  • the priming of the blood circuit is such that the priming fluid on the blood side of the hemodialyzer 1 becomes the dialysis fluid, and the upstream side of the connection portion 25 between the arterial blood circuit 21 and the priming fluid supply line 4 Except that a dialysate pump (not shown) is driven for priming the blood circulation path, it is the same as in the first embodiment.
  • Blood purifier (hemodialyzer) 21 Arterial blood circuit 22 Venous blood circuit 23 Venous air trap chamber (venous chamber) 24 Bubble Sensor 25 Connection Portion between Arterial Blood Circuit and Priming Fluid Supply Line 3 Blood Pump 4 Priming Fluid Supply Line 41 Priming Fluid Container 5 Air Pressure Line 51 Air Supply Path 52 Air Filter 53 Air Supply Means (Air Pump) 6 Pressure control means 7 Dewatering control device 71 Dialysate supply line 72 Dialysate discharge line V1, V2, V3, V4 On-off valve

Abstract

La présente invention concerne un dispositif de purification de sang dans lequel une opération pour amorcer un trajet de circulation de sang peut être complètement automatisée, et un procédé pour amorcer automatiquement le dispositif de purification de sang. Le dispositif de purification de sang comprend : un dialyseur de sang (1) et des circuits de sang (21, 22) ; une pompe à sang (3) ; un conduit d'alimentation en liquide d'amorçage (4) relié au circuit de sang artériel (21) sur le côté amont de la pompe à sang (3) ; et une chambre veineuse (23) disposée dans le circuit de sang veineux (22). La chambre veineuse (23) comporte un conduit de mise sous pression d'air (5) pour introduire et mettre sous pression de l'air sur le côté sang du dialyseur de sang (1), et un moyen de commande de pression (6) pour réguler la pression interne sur le côté sang du dialyseur de sang (1) est disposé dans le conduit de mise sous pression d'air (5).
PCT/JP2012/065169 2011-06-15 2012-06-13 Dispositif de purification de sang et procédé pour amorcer automatiquement un dispositif de purification de sang WO2012173161A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2013520570A JP5929912B2 (ja) 2011-06-15 2012-06-13 血液浄化装置および血液浄化装置の自動プライミング方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011-133476 2011-06-15
JP2011133476 2011-06-15

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WO2012173161A1 true WO2012173161A1 (fr) 2012-12-20

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Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0360671A (ja) * 1989-07-28 1991-03-15 Yokogawa Electric Corp 人工透析装置
JPH0413144U (fr) * 1990-05-24 1992-02-03
JP2002325837A (ja) * 2000-06-15 2002-11-12 Nefuronetto:Kk 自動血液透析装置
WO2004096321A1 (fr) * 2003-04-28 2004-11-11 Teijin Pharma Limited Procede de nettoyage d'un circuit du flux sanguin dans un dialyseur
JP2005253555A (ja) * 2004-03-10 2005-09-22 Asahi Kasei Medical Co Ltd 血液浄化装置のプライミング方法および血液浄化装置
JP2007282737A (ja) * 2006-04-14 2007-11-01 Nikkiso Co Ltd プライミング液用ドリップチャンバの液面調整方法
JP2010000161A (ja) * 2008-06-19 2010-01-07 Sepi Koko:Kk 人工透析における血液回路及びダイアライザのプライミング方法
JP2012139405A (ja) * 2010-12-29 2012-07-26 Nipro Corp 血液浄化装置及びその血液循環路の自動プライミング方法

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0360671A (ja) * 1989-07-28 1991-03-15 Yokogawa Electric Corp 人工透析装置
JPH0413144U (fr) * 1990-05-24 1992-02-03
JP2002325837A (ja) * 2000-06-15 2002-11-12 Nefuronetto:Kk 自動血液透析装置
WO2004096321A1 (fr) * 2003-04-28 2004-11-11 Teijin Pharma Limited Procede de nettoyage d'un circuit du flux sanguin dans un dialyseur
JP2005253555A (ja) * 2004-03-10 2005-09-22 Asahi Kasei Medical Co Ltd 血液浄化装置のプライミング方法および血液浄化装置
JP2007282737A (ja) * 2006-04-14 2007-11-01 Nikkiso Co Ltd プライミング液用ドリップチャンバの液面調整方法
JP2010000161A (ja) * 2008-06-19 2010-01-07 Sepi Koko:Kk 人工透析における血液回路及びダイアライザのプライミング方法
JP2012139405A (ja) * 2010-12-29 2012-07-26 Nipro Corp 血液浄化装置及びその血液循環路の自動プライミング方法

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JP5929912B2 (ja) 2016-06-08

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