WO2012170340A3 - Sonde neuronale pouvant être introduite ayant une structure flexible - Google Patents

Sonde neuronale pouvant être introduite ayant une structure flexible Download PDF

Info

Publication number
WO2012170340A3
WO2012170340A3 PCT/US2012/040709 US2012040709W WO2012170340A3 WO 2012170340 A3 WO2012170340 A3 WO 2012170340A3 US 2012040709 W US2012040709 W US 2012040709W WO 2012170340 A3 WO2012170340 A3 WO 2012170340A3
Authority
WO
WIPO (PCT)
Prior art keywords
probe
biological tissue
insertable
bioagent
tip
Prior art date
Application number
PCT/US2012/040709
Other languages
English (en)
Other versions
WO2012170340A2 (fr
Inventor
Euisik Yoon
Fan Wu
Original Assignee
The Regents Of The University Of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of Michigan filed Critical The Regents Of The University Of Michigan
Priority to US14/096,879 priority Critical patent/US9427164B2/en
Publication of WO2012170340A2 publication Critical patent/WO2012170340A2/fr
Publication of WO2012170340A3 publication Critical patent/WO2012170340A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0622—Optical stimulation for exciting neural tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system

Abstract

L'invention concerne une sonde neuronale (10) pour une communication in vivo avec un tissu biologique, comprenant la stimulation de neurones et/ou l'enregistrement de l'activité électrique neuronale. La sonde (10) peut être construite de telle sorte que la réponse immunitaire par le tissu biologique dans lequel le dispositif est implanté est réduite par rapport à des sondes implantables connues. La sonde (10) peut comporter une pointe (16) qui a une configuration ramifiée, des électrodes (24) se trouvant le long de chacune des ramifications (20). Un revêtement biodégradable (18) est disposé sur au moins la pointe (16) de la sonde (10) pour doter la sonde (10) d'une intégrité suffisante pour une introduction dans le tissu biologique et pour se dégrader après introduction. Le revêtement biodégradable (18) peut avoir un médicament anti-inflammatoire ou un autre agent biologique distribué dans celui-ci pour une libération localisée de l'agent biologique pour réduire davantage la réponse immunitaire.
PCT/US2012/040709 2011-06-04 2012-06-04 Sonde neuronale pouvant être introduite ayant une structure flexible WO2012170340A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/096,879 US9427164B2 (en) 2011-06-04 2012-06-04 Insertable neural probe with flexible structure

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161493442P 2011-06-04 2011-06-04
US61/493,442 2011-06-04

Publications (2)

Publication Number Publication Date
WO2012170340A2 WO2012170340A2 (fr) 2012-12-13
WO2012170340A3 true WO2012170340A3 (fr) 2013-02-28

Family

ID=47296690

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/040709 WO2012170340A2 (fr) 2011-06-04 2012-06-04 Sonde neuronale pouvant être introduite ayant une structure flexible

Country Status (2)

Country Link
US (1) US9427164B2 (fr)
WO (1) WO2012170340A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013016392A1 (fr) * 2011-07-25 2013-01-31 Neuronexus Technologies, Inc. Système de transfection pour neuromodulation avec administration de fluide passive
US9241651B2 (en) * 2011-11-17 2016-01-26 Carnegie Mellon University Fabrication, methods, apparatuses, and systems for ultra-compliant probes for neural and other tissues
US20130197468A1 (en) * 2012-01-26 2013-08-01 Carnegie Mellon University Device for Intramyocardial Delivery
CA2934504C (fr) * 2013-12-20 2023-04-11 Neuronano Ab Dispositif medical comprenant une electrode et une source de lumiere
WO2015120102A1 (fr) * 2014-02-04 2015-08-13 Board Of Regents, The University Of Texas Sytem Antennes à base de nanotubes de carbone
KR101700886B1 (ko) * 2015-07-24 2017-02-01 한국과학기술연구원 신경 손상을 최소화한 고성능 신경 탐침 구조체
US10588526B2 (en) * 2016-09-16 2020-03-17 International Business Machines Corporation Flexible neural probes
CA3112875C (fr) 2018-09-14 2023-08-15 Neuralink Corp. Implantation de dispositif a l'aide d'une cartouche
CN112120695A (zh) * 2020-09-29 2020-12-25 中国科学院上海微系统与信息技术研究所 一种结合给药通道的深部柔性脑电极及其制备方法
CN112386795A (zh) * 2020-11-18 2021-02-23 北京大学人民医院 一种植入式神经电刺激系统
CN113616211B (zh) * 2021-08-30 2024-04-09 江西脑虎科技有限公司 一种柔性神经电极结构及其制备方法
CN114671935A (zh) * 2022-04-25 2022-06-28 上海脑虎科技有限公司 基于基因重组蛛丝蛋白溶液的柔性探针的制备方法及结构
CN115770047B (zh) * 2022-11-09 2023-06-30 上海脑虎科技有限公司 一种柔性电极装置及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5900245A (en) * 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
US20050216072A1 (en) * 2000-08-16 2005-09-29 Vanderbilt University System and methods for optical stimulation of neural tissues
US20060030833A1 (en) * 2004-03-25 2006-02-09 Scimed Life Systems, Inc. Catheter with sensor tip and method of use of same
US20080140195A1 (en) * 2006-11-08 2008-06-12 National Tsing Hua University Multifunctional nano-probe interface structure for neural prostheses and manufacturing method thereof
US20090299167A1 (en) * 2006-01-26 2009-12-03 Seymour John P Microelectrode with laterally extending platform for reduction of tissue encapsulation
US20100331935A1 (en) * 2009-05-01 2010-12-30 Phillipe Tabada Rigid Spine Reinforced Polymer Microelectrode Array Probe and Method of Fabrication

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6091979A (en) * 1998-07-07 2000-07-18 Children's Medical Center Corporation Subdural electrode arrays for monitoring cortical electrical activity
US6829498B2 (en) * 2000-03-29 2004-12-07 Arizona Board Of Regents Device for creating a neural interface and method for making same
US8750957B2 (en) 2004-06-01 2014-06-10 California Institute Of Technology Microfabricated neural probes and methods of making same
US7774053B2 (en) 2005-03-31 2010-08-10 Wisconsin Alumni Research Foundation Neural probe array
WO2008035285A2 (fr) * 2006-09-22 2008-03-27 Koninklijke Philips Electronics N.V. Dispositif implantable comprenant plusieurs électrodes
EP2219726B1 (fr) * 2007-12-10 2013-02-13 Neuronano Ab Électrode médicale, faisceau d'électrodes et ensemble de faisceau d'électrodes
WO2010111238A2 (fr) 2009-03-23 2010-09-30 Micell Technologies, Inc. Polymères biodégradables améliorés
US8870857B2 (en) * 2009-11-05 2014-10-28 Greatbatch Ltd. Waveguide neural interface device
WO2011068696A2 (fr) * 2009-11-19 2011-06-09 The Regents Of The University Of Michigan Sonde neurale avec capacité de stimulation optique
KR101837481B1 (ko) * 2010-03-17 2018-03-13 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 생체흡수성 기판 상 이식가능한 바이오의료 장치
US8442614B2 (en) * 2010-06-21 2013-05-14 Alfred E. Mann Foundation For Scientific Research Stiffness enhanced filaments

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5900245A (en) * 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
US20050216072A1 (en) * 2000-08-16 2005-09-29 Vanderbilt University System and methods for optical stimulation of neural tissues
US20060030833A1 (en) * 2004-03-25 2006-02-09 Scimed Life Systems, Inc. Catheter with sensor tip and method of use of same
US20090299167A1 (en) * 2006-01-26 2009-12-03 Seymour John P Microelectrode with laterally extending platform for reduction of tissue encapsulation
US20080140195A1 (en) * 2006-11-08 2008-06-12 National Tsing Hua University Multifunctional nano-probe interface structure for neural prostheses and manufacturing method thereof
US20100331935A1 (en) * 2009-05-01 2010-12-30 Phillipe Tabada Rigid Spine Reinforced Polymer Microelectrode Array Probe and Method of Fabrication

Also Published As

Publication number Publication date
US9427164B2 (en) 2016-08-30
US20140288458A1 (en) 2014-09-25
WO2012170340A2 (fr) 2012-12-13

Similar Documents

Publication Publication Date Title
WO2012170340A3 (fr) Sonde neuronale pouvant être introduite ayant une structure flexible
Nolta et al. BBB leakage, astrogliosis, and tissue loss correlate with silicon microelectrode array recording performance
EP4279004A3 (fr) Utilisation de champs électromagnétiques dans l'administration de dispositif ire et la surveillance de thérapie
WO2012009377A3 (fr) Substrat biocompatible destiné à faciliter les interconnexions entres les cellules souches et les tissus cibles et procédés d'implantation associés
EP3510919A3 (fr) Systèmes d'évaluation fonctionnelle et/ou de modification de trafic neurologique et/ou de récepteur
WO2009075750A3 (fr) Système d'administration d'une neurostimulation à partir d'une artère pulmonaire
WO2010093489A3 (fr) Plateforme déployable de capteurs sur le système de dérivation d'un dispositif implantable
WO2013076588A3 (fr) Dispositifs endovasculaires de surveillance de nerfs et systèmes et procédés associés
WO2008039619A3 (fr) Systèmes et procédés de stimulation temporaire sans conducteur
Khurram et al. Chronic monitoring of lower urinary tract activity via a sacral dorsal root ganglia interface
WO2010123704A3 (fr) Thérapie contre l'incontinence
WO2015039108A3 (fr) Coupleur à éléments multiples permettant la production d'une énergie électromagnétique
WO2011057210A3 (fr) Procédés et systèmes pour retirer des dispositifs intravasculaires implantables
WO2008049087A3 (fr) Système pour induire des effets thermiques désirables sur un tissu anatomique
WO2013063530A3 (fr) Procédés d'administration de médicament
WO2012166656A3 (fr) Collecte de données cliniques pour une représentation graphique et une analyse
WO2008094952A3 (fr) Eléments de rétention sans suture pour dérivation
JP2013505793A5 (fr)
WO2012071559A3 (fr) Procédés et compositions thérapeutiques pour administration de solide
AU2012209095A8 (en) Combined stimulation with controlled light distribution for electro-optical cochlear implants
MX346885B (es) Conductor implantable.
WO2011094073A3 (fr) Conception d'aiguille pour enregistrer un potentiel d'action monophasique et application de thérapie
WO2016126340A3 (fr) Procédés, compositions et systèmes pour implantation de dispositif
WO2010099796A3 (fr) Appareil pour une stimulation électrique, en particulier pour bruxisme
WO2013136312A3 (fr) Mécanisme, système, procédé pour la fixation de dérivation in vivo

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12797497

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 14096879

Country of ref document: US

122 Ep: pct application non-entry in european phase

Ref document number: 12797497

Country of ref document: EP

Kind code of ref document: A2