WO2012168512A3 - Materiales biocerámicos para el tratamiento de la osteomielitis - Google Patents

Materiales biocerámicos para el tratamiento de la osteomielitis Download PDF

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Publication number
WO2012168512A3
WO2012168512A3 PCT/ES2012/000160 ES2012000160W WO2012168512A3 WO 2012168512 A3 WO2012168512 A3 WO 2012168512A3 ES 2012000160 W ES2012000160 W ES 2012000160W WO 2012168512 A3 WO2012168512 A3 WO 2012168512A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibiotics
present
adsorption
materials
combination
Prior art date
Application number
PCT/ES2012/000160
Other languages
English (en)
French (fr)
Other versions
WO2012168512A2 (es
Inventor
María VALLET REGI
Miguel MANZANO GARCÍA
Jaime Esteban Moreno
Diana MOLINA MANSO
Enrique Gomez Barrena
Original Assignee
Universidad Complutense De Madrid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad Complutense De Madrid filed Critical Universidad Complutense De Madrid
Priority to EP12797636.3A priority Critical patent/EP2719400A4/en
Publication of WO2012168512A2 publication Critical patent/WO2012168512A2/es
Publication of WO2012168512A3 publication Critical patent/WO2012168512A3/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B37/00—Compounds having molecular sieve properties but not having base-exchange properties
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B37/00—Compounds having molecular sieve properties but not having base-exchange properties
    • C01B37/005—Silicates, i.e. so-called metallosilicalites or metallozeosilites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Ceramic Engineering (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención describe la preparación de materiales mesoporosos ordenados de sílice, con capacidad para promover el desarrollo óseo, y su utilización como sistema de liberación de una combinación de antibióticos para tratar de una forma local y efectiva las infecciones óseas. De esta forma, la presente invención propone el uso de estos materiales para el tratamiento de la osteomielitis, puesto que su alta porosidad y elevada superficie específica permite adsorber una gran cantidad de antibióticos para luego liberarlos de una forma modulada, en función de los requerimientos del paciente. En la presente invención se propone el empleo de la biocerámica SBA-15 para la adsorción de una combinación de tres antibióticos cuya actividad antimicrobiana ha sido ampliamente reconocida: vancomicina, linezolid y rifampicina.
PCT/ES2012/000160 2011-06-09 2012-06-08 Materiales biocerámicos para el tratamiento de la osteomielitis WO2012168512A2 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP12797636.3A EP2719400A4 (en) 2011-06-09 2012-06-08 BIOKERAMIC MATERIALS FOR THE TREATMENT OF OSTEOMYELITIS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP201100655 2011-06-09
ES201100655A ES2393602B1 (es) 2011-06-09 2011-06-09 Materiales biocerámicos para el tratamiento de la osteomielitis.

Publications (2)

Publication Number Publication Date
WO2012168512A2 WO2012168512A2 (es) 2012-12-13
WO2012168512A3 true WO2012168512A3 (es) 2013-04-04

Family

ID=47296541

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2012/000160 WO2012168512A2 (es) 2011-06-09 2012-06-08 Materiales biocerámicos para el tratamiento de la osteomielitis

Country Status (3)

Country Link
EP (1) EP2719400A4 (es)
ES (1) ES2393602B1 (es)
WO (1) WO2012168512A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105611914B (zh) 2013-06-19 2020-09-08 加利福尼亚大学董事会 局部递送治疗剂的化学构造物
ES2880468T3 (es) 2014-03-14 2021-11-24 Univ California Conjugados de TCO y métodos para el suministro de agentes terapéuticos
CN117567535A (zh) 2015-09-10 2024-02-20 坦伯公司 生物正交组合物
AU2018250312B2 (en) 2017-04-07 2022-03-17 Tambo, Inc. Bioorthogonal compositions
RU2699742C1 (ru) * 2018-05-21 2019-09-09 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр травматологии и ортопедии имени Н.Н. Приорова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТО им. Н.Н. Приорова" Минздрава России) Способ комплексного лечения первично-хронического рецидивирующего остеомиелита у детей на фоне соматического статуса
CN108992706A (zh) * 2018-08-08 2018-12-14 上海应用技术大学 一种抗生素持续高效释放的丙烯酸树脂骨水泥及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7223414B1 (en) 2002-06-03 2007-05-29 Ahmed El-Ghannam Silica-calcium phosphate bioactive composite for improved synthetic graft resorbability and tissue regeneration
DE102004060666B3 (de) 2004-12-15 2006-03-30 Heraeus Kulzer Gmbh Antibiotikum/Antibiotika enthaltendes Knochenersatzmaterial mit retardierender Wirkstofffreisetzung
US20070015685A1 (en) * 2005-04-04 2007-01-18 Naomi Balaban Bone cement compositions and the like comprising an RNAIII-inhibiting peptide

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DOADRIO AL. ET AL.: "A rational explanation of the vancomycin release from SBA-15 and its derivative by molecular modelling.", MICROPOROUS AND MESOPOROUS MATERIALS., vol. 132, no. 3, 2010, pages 559 - 566, XP027049603 *
GIACOMETTI A. ET AL.: "RNAIII-inhibiting peptide improves efficacy of clinically used antibiotics in a murine model of staphylococcal sepsis.", PEPTIDES., vol. 26, no. 2, 2005, pages 269 - 175, XP004698837 *
MANZANO M. ET AL.: "New Developments in ordered mesoporous materials for drug delivery.", JOURNAL OF MATERIALS CHEMISTRY., vol. 20, no. 27, 2010, pages 5593 - 5604, XP055140446 *
WANG S.: "Ordered mesoporous materials for drug delivery.", MICROPOROUS AND MESOPOROUS MATERIALS., vol. 117, no. 1-2, 2009, pages 1 - 9, XP025658739 *

Also Published As

Publication number Publication date
WO2012168512A2 (es) 2012-12-13
ES2393602B1 (es) 2013-10-02
EP2719400A4 (en) 2015-04-01
ES2393602A1 (es) 2012-12-26
EP2719400A2 (en) 2014-04-16

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