WO2012159639A1 - Complément alimentaire pour thérapie du virus de l'hépatite c - Google Patents

Complément alimentaire pour thérapie du virus de l'hépatite c Download PDF

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Publication number
WO2012159639A1
WO2012159639A1 PCT/EG2012/000018 EG2012000018W WO2012159639A1 WO 2012159639 A1 WO2012159639 A1 WO 2012159639A1 EG 2012000018 W EG2012000018 W EG 2012000018W WO 2012159639 A1 WO2012159639 A1 WO 2012159639A1
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Prior art keywords
virus
liver
treatment
plant
herb
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PCT/EG2012/000018
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English (en)
Inventor
Abdel Khalek Hassan YOUNES
Original Assignee
Younes Abdel Khalek Hassan
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Publication of WO2012159639A1 publication Critical patent/WO2012159639A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger

Definitions

  • the long-acting interferon is the drug situation in Egypt for the treatment of hepatitis c virus.
  • Dosage the patient gives an 48 injection IM for a year.
  • Ribavrin are given by mouth with interferon muscular injection.
  • Artichokes is Aharhov or thorns, ground floor, with other names, including: Knker, and Kenjr, and Canar, andJnarh, this herb is greatlike plant spinal home is the regions ofsouthern Europe and North
  • immature can also contain useful medical compounds.
  • Dr. Hu has published over 70 scientific articles in various medical professional journals; many of which focus on viral Hepatitis B and C, cirrhosis and liver cancer.
  • silybin Indicating milk thistle's broad spectrum of anti-liver cancer effects, the researchers found that silybin can significantly reduce the growth of four different human liver cancer cell lines. In addition, they demonstrated that silybin exhibits its anti-liver cancer effects by:
  • Thistle is known as silymarin.
  • E - Raw herb feverfew is a herb and a paper was used dry fruits
  • Fatty acids can be obtained by extraction, as in the case of caraway, in the remainders of oil extraction via steam distillation.
  • Laurie acid which is most important to oleochemistry, is obtained from petroselinic acid which is found in high quantities (50-70%) in anise.
  • Fatty oil shows excellent future potential. Successful production of anise seed for economical oil production would probably occur if the seed yields could be improved significantly, and high content of oil and essential oils and large quantity of petroselinic acids could be reached.6,7
  • anisaldehyde anisic acid (oxidation products of anethole), linalool, limonene
  • a - Turmeric powder is turmeric root of (Rizumat) to yellow brown, a herbaceous plant perennial roots Ascola Yearbook and its market is of the platoon. Alzenajiliah, and they saw some of the platoon Alhmamawih. A tropical plant grows in abundance in the land of the East India, turmeric has several types of it growing in different places of the world. Called by several names in Arabic, including turmeric and Alkirkb colonel and India, Indian saffron and Aljduar Alzernb veins and dyers and celandine and fug and Alasgr.
  • Turmeric contains a yellow colored substance resembling resin and oil
  • turmeric is more effective than green tea extract in the inhibition of viral damage to liver cells, and after that proved its ability to stimulate self-programmed suicide of cancer cells.
  • curcumin B - Latin name: curcumin.
  • Curcumin the active ingredient in turmeric, contains a mixture of powerful phytonutrients known as curcuminoids. Curcuminoids have antioxidant properties, meaning they fight the damaging effects of free radical molecules in the body.
  • Source NCCAM , National Institutes of Health, 9000 Rockville Pike , Bethesda, Maryland 20892 USA , E-mail: info(3 ⁇ 4nccam.nih.go
  • Curcumin contain 411.28 ug / gm curcuminoids Kasetsart ( Nat. sci. 44: 123- 144 2010 )
  • Botanical Name Curcuma longa L.
  • Curcumin is a water soluble orange-yellow coloured powder. Curcumin is obtained by solvent extraction from dried turmeric roots.
  • Curcumin has antioxidant, anti-inflammatory, antiviral and antifungal actions.
  • Aloe plant belongs to the quarterly Abbaria and most types of cactus live in the environmental conditions and dry desert, is one of the plants that bear the thirst and dehydration, which may extend for many years. And produces some fruit and flowers.
  • Aloleuen Aloleuen
  • the cactus normal or Aloe Vera with papers grouped rosy shape, Rmohah long, ranging from 20 to 30 cm, width of between 4-7 cm, the end of a pointed very end with a fork sharp - and the edge of the thorns of brushes and color paper, gray, and when you grow plants in old graduated market up to a meter long or more, branched inflorescence is made up of small yellow flowers in color.
  • the Alolo Vera is the most important and best types of cactus, because of its content of a high proportion of material actors in which a Aloleuen Aloin which are found by 18 to 25% of the weight of the plant. Paper cactus, containing two types of drug compounds, namely: Alawleuen, and gel
  • Acemannan refers to a D-isomer mucopolysaccharide that is extracted from aloe vera leaves. This compound has been known to have
  • 2- Acemannan has been demonstrated to induce macrophages to secrete interferon (INF), tumor necrosis factor-a (TNF-a) and interleukins (IL-1) - which might help in preventing or abrogating viral infection. These three cytokines are known to cause inflammation and interferon is released in response to viral infections. In vitro studies have shown to inhibit HIV replication; however, in vivo studies have been inconclusive. Acemannan is currently being used for treatment and clinical management of fibrosarcoma in dogs and cats. Administration of acemannan has been shown to increase tumor necrosis or prolonged survival and the animals have demonstrated lymphoid infiltration and encapsulation.
  • INF interferon
  • TNF-a tumor necrosis factor-a
  • IL-1 interleukins
  • Botanical Name Rheum palmatum L.
  • a - Garlic is a herbal plant from plants annuals perennial species of Al zenbkiet spread cultivation throughout world, consists of plant garlic cloves wrapped in leaves cellulose transparent to the reservation of
  • Garlic oil and DDB comprised in a pharmaceutical composition for the treatment of patients with viral hepatitis, prevents acute liver injuries potentiated by glutathione deficiency in rats. Chem. Biol. Interact. 155:82-96. 4- Hassan ZM, Yaraee R, Zare N, et al. Immunomodulatory affect of RIO fraction of garlic extract on natural killer activity. Int Immunopharmacol. 2003;3(10-11): 1483-1489.
  • E - Garlic is an herb and a paper was used dry seeds
  • Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models. J Cell Mol Med. 2008 Jan-Feb; 12(l):330-42.
  • rosmarinic acid The most important constituents of rosemary are carnosol, carnosic acid, caffeic acid and its derivatives such as rosmarinic acid. These compounds have powerful antioxidant activity. Rosmarinic acid is well absorbed from gastrointestinal tract and from the skin. It increases the production of prostaglandin E2 and reduces the production of leukotriene B4 in human white blood cells, and inhibits the complement system. This makes
  • rosmarinic acid a strong anti-inflammatory agent.
  • honey bee bread Like honey and propolis, other well-known honey bee products, the exact chemical composition of pollen gathered depends on which plants the worker bees are gathering the pollen from, and can vary from hour to hour, day to day, week to week, colony to colony, even in the same apiary, and no two samples of bee bread will be exactly identical. Accordingly, chemical and nutritional analyses of bee bread apply only to the specific samples being tested, and cannot be extrapolated to samples gathered in other places or other times.
  • Bee pollen is considered to contain all the major building blocks of life and by weight is therefore the most nourishing food we can consume. It contains all of the following:
  • Vitamins A, B-l, B-3, B-5, B-6, B-12, C, and D and E
  • a - propolis or propolis is a resinous material sticky resin, protects the buds leafy plants and trees from pathogens, and to protect them from drought, and frequent presence on the poplars and conifers, and according to some scientific research that the bees used casings pollen ashamed, after its treatment Bafrazach salivary, and Asarath infectious-rich enzymes and yeasts, in the work of propolis, and this is what Iggsz therapeutic benefits him greatly.
  • Used bee pliers first to collect propolis, and introducing it with the couple the front and middle of the legs to the series combination are positioned on a pair hind legs, and then the bee accumulate large quantities of chips gum resin until you get a load sufficient return to the cell and in many cases, it is difficult for entry of discharge this load, especially when the temperature drops a lot, so it helps other worker after a waiting period so often, it becomes the strength of propolis then softer, the acquisition of some of the warmth from the center of the cell.
  • propolis F Specification of the physical and chemical properties of propolis, which contains:
  • Propolis consists mainly of specific tree resins collected by honeybees. Bees use propolis like putty to seal cracks and openings in the hive, strengthen combs and seal brood cells. Propolis also helps sterilize the hive—the resins protect both trees and bees from infections.1 1 Most research has been conducted predominantly on poplars, but beech, birch, chestnut and several conifer species have also been studied.
  • Flavonoids are abundant, including many that are anti-inflammatory, antiallergenic, antioxidant and/or antimutagenic and antispasmodic.
  • Propolis is uniquely rich in properties which have been shown to inhibit cancer growth in animal studies 14 and reduce inflammation as effectively as drugs.
  • Propolis also contains organic acids and their derivatives. These constituents contribute antibiotic, antifungal and antiviral effects.
  • propolis inhibits the growth of various viruses and fungi including herpes, influenza, rota, Candida and aspergillus.
  • Clostridium spp. Escherichia coli, Staphylococcus spp. and Streptococcus spp.
  • Propolis is active against bacteria isolated from people with upper respiratory infections, including penicillin- resistant strains.
  • Propolis promotes pharmaceutical antibiotics, including streptomycin, penicillin, neomycin and tetracycline; the combined products act
  • Propolis can be taken in conjunction with prescribed medications but not in place of them.
  • Olive leaf contains the active iridoid constituent oleuropein (chief constituent 60 to 90 mg/g).
  • Other secoiridoids include 1 1-demethyl-oleuropein, 7,11- dimethyl ester of oleoside, ligustroside, oleuroside, and unconjugated secoiridoid aldehydes.
  • Other compounds found in the leaves are oleasterol, leine, and glycoside oleoside.
  • vehicle tent features parsley smell aromatic force and leaves bright green.
  • Alkhimih is of the platoon, and part of the plant used all its parts including the roots
  • a - Phyllanthus plant Phyllanthus or hooks is the tree of Indian produce the fruit of black resembling bovine eyes have nuclei rounded a sharp two parties, if stripped of his shell split-core three pieces and
  • stomach, nerve, heart ..
  • Amla is highly nutritious and is an important dietary source of
  • Vitamin C This is approximately 20 times the vitamin C content of an orange 1800 mg- 2000mg / 1 OOgm.
  • the edible fruit tissue contains protein concentration 3 -fold and
  • gallic acid 1.32%, tannin, sugar 36.10%; gum 13.75%; albumin
  • 8- Amla fruit ash contains chromium, 2.5 ppm; zinc 4 ppm; and
  • Cinnamon belongs to the family of A lgarriet It is not only the bark of trees, with leaves a permanent root in the sandy land on the shores of the sea, and gathered when the tree reaches the age of four years, cut
  • the compound eugenol compound II in the oil which is due to a calming influence, and there are other compounds is less important than former two compounds. It also contains cobalt materials fsih and fluid
  • Cinnamon B Latin name:
  • Cinnamon extract induces tumor cell death through inhibition of NFkappaB and AP1.;BMC Cancer. 2010 Jul 24; 10:392
  • Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells. ;Cancer Lett. 2009 Jun
  • Cinnamaldehyde inhibits lymphocyte proliferation and modulates T-cell differentiation.
  • E-Cinnamon Dry grass and paper was used all the inner bark
  • the primary constituents of the essential oil are 65% to 80% cinnamaldehyde and lesser percentages of other phenols and terpenes, including eugenol, trans- cinnamic acid, hydroxyl-cinnamaldehyde, o-methoxycinnamaldehyde, cinnamyl alcohol and its acetate, limonene, alpha-terpineol, tannins, mucilage, oligomeric procyanidins, and trace amounts of coumarin.
  • a - Fenugreek is an herb around me Fabaceae, which ranges in height from 20 to 60 cm, and her leg hollow and fork to the legs of a small, each bearing at the end of three papers serrated long, andthe base leg leaves appear small yellow flowers that turn into fruitsin the form of centuries Mekovh the length of each one century about 10 cm, and contain the seeds of similar in
  • North Africa is the original home of the arena, but they are grown in other countries, has become the arena now grown in many countries, and
  • E- Fenugreek is an herb and a paper was used dry seeds
  • F- Physical and chemical specifications of the circuit which contains: Chemical components of fenugreek seed include iron, vitamin A, vitamin B 1 , vitamin C, phosphates, flavonoids, saponins, trigonelline, and other alkaloids.
  • the seed is also high in fiber and protein.
  • Fenugreek seeds are high on polysaccharide galactomannan. They are also a rich source of saponins such as diosgenin, yamogenin, gitogenin, tigogenin, and neotigogens.
  • bioactive constituents of fenugreek include mucilage, volatile oils, and alkaloids such as choline and trigonelline.
  • the leaves contain at least 7 saponins, known as graecunins.
  • Seeds contain 0.1% to 0.9% diosgenin and are extracted on a commercial basis Sauvaire et al 1978 and Elujoba et al 1987
  • Plant tissue cultures from seeds grown under optimal conditions have been found to produce as much as 2% diosgenin with smaller amounts of
  • the seeds also contain the saponin fenugrin B. Gangrade et al 1979
  • alkaloids eg, trigonelline, gentianine, carpaine.
  • a large proportion of the trigonelline is degraded to nicotinic acid and related pyridines during roasting. These degradation products are, in part, responsible for the flavor of the seed.
  • the seeds also yield as much as 8% of a fixed, foul-smelling oil.
  • the C-glycoside flavones vitexin, vitexin glycoside, and the arabinoside isoorientin have been isolated from the plant. Adamska 1971.
  • Fenugreek gel consists chiefly of galactomannans characterized by their high water-holding capacity. These galactomannans have a unique structure and may be responsible for some of the characteristic therapeutic properties attributed to fenugreek. Madar et al 2002.
  • a - Green Tea is a shrub originating from Asia, which is ever green
  • leaves with dark green elongated oval with serrated tail Goes air length from 5-10 cm increased number of leaves at the top of the branches and at least at the bottom, and also has strength which is covered with soft, silky texture, but it is barren, dry leaves are smooth and glossy.
  • Green tea camellia sinensis
  • Phenolic compounds 30% More than 4000 types of flavonoids have been identified.
  • One of the main flavonoids that is found in green teas are catechins.
  • Other polyphenols found in green tea include gallic acid (GA), chlorogenic acids, caffeic acid and the flavonols kaempferol, myricetin and quercetin.
  • Vitamins B, C, E.
  • Hunbat climber Muammar height of up to 5 meters itleaves large oval and ears, or clusters of white flowers and smallclusters of fruits retained the small changes color change to grow, where changes from green to red at maturity and shall prevail if leftwithout picking.
  • black pepper also known
  • E - is an herb and a paper was used dry fruits
  • Botanical Name Piper nigrun L.
  • Piperine is a kind of alkaloid extracted from pepper fruit.
  • High-purity piperine is needle-shaped or short rod-shaped light yellow or white crystal powder.
  • Cost of ribavirin on average 600 mg / day 4.5 pounds
  • HCV infection in all Egyptian population is not less than ten million infected person. Only One hundred thousand of them
  • Endogenous interferon is a protein that secreted by the
  • influenza virus The influenza virus.
  • Supplementary food was developed in the form of a capsule containing the raw material:
  • Each capsule contains 750 mg.
  • 2- CBC including:
  • the raw medicine is packaged in capsules, each capsule contains a 750 mg
  • the patient take one capsule on early morning on an empty stomach, and then followed by eating 2 cups of water, two hours after a light breakfast deals
  • the patient can use the drug for 3 months to 2years and even for long periods
  • Balantrveron treatment for ten million people seven hundred and twenty billion pounds, that is intramuscular interferon treatment if all ten million patients have cost a hundred to a hundred times compared to the cost of supplementing the diet.
  • intramuscular interferon treatment if all ten million patients have cost a hundred to a hundred times compared to the cost of supplementing the diet.
  • Intramuscular long-acting interferon gives only one hundred thousand patients per year Egyptian

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Abstract

L'invention concerne un médicament qui est un complément nutritionnel comprenant des plantes médicinales et des herbes naturelles sous forme de capsules emballées dans un matériau brut. Ce médicament permet à des patients de retrouver la santé afin de travailler et de vivre normalement leur vie quotidienne par renforcement de leur système immunitaire. Le corps peut de cette façon résister au virus de l'hépatite C par restauration de l'équilibre du système immunitaire, ce qui lui permet de produire de grandes quantités d'interféron au moyen de lymphocytes.
PCT/EG2012/000018 2011-05-24 2012-05-22 Complément alimentaire pour thérapie du virus de l'hépatite c WO2012159639A1 (fr)

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EG2011050814 2011-05-24
EG2011050814 2011-05-24

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014116093A1 (fr) * 2013-01-28 2014-07-31 Universite Moulay Ismail Produit a base d'une preparation naturelle contre l'anemie
CN104770701A (zh) * 2015-04-29 2015-07-15 赵建平 一种卤料及其用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166861A (en) * 1976-03-23 1979-09-04 Inverni Della Beffa S.P.A. Pharmacologically active polyphenolic substances
JPS6263517A (ja) * 1985-09-13 1987-03-20 Riken Kagaku Kogyo Kk 肝臓疾患治療剤
US6117884A (en) 1997-07-31 2000-09-12 Daeuble; John 4-substituted quinoline derivatives having fungicidal activity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166861A (en) * 1976-03-23 1979-09-04 Inverni Della Beffa S.P.A. Pharmacologically active polyphenolic substances
JPS6263517A (ja) * 1985-09-13 1987-03-20 Riken Kagaku Kogyo Kk 肝臓疾患治療剤
US6117884A (en) 1997-07-31 2000-09-12 Daeuble; John 4-substituted quinoline derivatives having fungicidal activity

Non-Patent Citations (116)

* Cited by examiner, † Cited by third party
Title
"Garlic and cancer: a critical review of the epidemiologic literature", J NUTR., vol. 131, 2001, pages 1032S - 1040S
"Garlic-induced alteration in rat liver and kidney morphology and associated changes in endogenous antioxidant status", FOOD CHEM TOXICOL, vol. 39, 2001, pages 793 - 797
"Immunomodulatory affect of RIO fraction of garlic extract on natural killer activity", INT IMMUNOPHARMACOL., vol. 3, no. 10-11, 2003, pages 1483 - 1489
"Inhibition of chemically induced liver carcinogenesis in Wistar rats by garlic (Allium sativum", PHYTOTHER RES., vol. 14, 2000, pages 5 64 - 7
AGARWAL R; AGARWAL C; ICHIKAWA H; SINGH RP; AGGARWAL BB: "Anticancer potential of silymarin: from bench to bed side", ANTICANCER RES., vol. 26, no. 6B, November 2006 (2006-11-01), pages 4457 - 98, XP009081798
AGGARWAL BB; KUMAR A; BHARTI AC: "Anticancer potential of Curcumin: preclinical and clinical studies", ANTICANCER RES., vol. 23, no. 1A, January 2003 (2003-01-01), pages 363 - 98, XP008152461
AL-AZZAWIE HF; ALHAMDANI MS: "Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits", LIFE SCI, vol. 78, 2006, pages 1371 - 1377, XP028050541, DOI: doi:10.1016/j.lfs.2005.07.029
AL-KASSIE, G.A.M.: "The Effect of Anise and Rosemary on Broiler performance", INTERNATIONAL JOURNAL OF POULTRY SCI., vol. 7, no. 3, 2008, pages 243 - 245
AMOROS M ET AL.: "Comparison of the anti-herpes simplex virus activities of propolis and 3-methyl-but-2-enyl caffeate", J NAT PROD, vol. 57, 1994, pages 644 - 7, XP002527697, DOI: doi:10.1021/np50107a013
ANTONY S ET AL.: "Immunomodulatory activity of curcumin", IMMUNOL INVEST, vol. 28, 1999, pages 291 - 303, XP009180793
ARUN N; NALINI N: "Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats", PLANT FOODS HUM NUTR., vol. 57, no. 1, 2002, pages 41 - 52
BADARY OA; TAHA RA; GAMAL EL-DIN AM ET AL.: "Thymoquinone is a potent superoxide anion scavenger", DRUG CHEM TOXICOL., vol. 26, no. 2, May 2003 (2003-05-01), pages 87 - 98
BANERJEE SK; MAULIK M; MANCHANDA SC; DINDA AK; DAS TK; MAULIK SK: "Garlic-induced alteration in rat liver and kidney morphology and associated changes in endogenous antioxidant status", FOOD CHEM TOXICOL, vol. 39, 2001, pages 793 - 797
BETANCOR-FEMANDEZ A; PEREZ-GALVEZ A; SIES H ET AL.: "Screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil's claw root and garlic or salmon oil for antioxidant capacity", J PHARM PHARMACOL, vol. 55, no. 7, 2003, pages 981 - 986
BHATTACHARYA, A. ET AL.: "Antioxidant Activity of Active Tannoid Principles of Emblica officinalis (Amla", INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, vol. 37, 1999, pages 676 - 680, XP008016252
BORDIA A; VERMA SK; SRIVASTAVA KC: "Effect of ginger and fenugreek (Trigonella foenumgraecum L) on blood lipids, blood sugar, and platelet aggregation in patients with coronary artery disease", PROSTAGLAND LEUKOTRIENES ESSENTIAL FATTY ACIDS, vol. 56, 1997, pages 379 - 384
BRIANTE R; PATUMI M; TERENZIANI S; BISMUTO E; FEBBRAIO F; NUCCI R: "Olea europaea L. leaf extract and derivatives: antioxidant properties", J AGRIC FOOD CHEM, vol. 50, 2002, pages 4934 - 4940
BUCK AC ET AL.: "Treatment of outflow tract obstruction due to benign prostatic hyperplasia with the pollen extract Cemilton, a double-blind, placebo-controlled study", BR J UROL, vol. 66, 1990, pages 398 - 404
BUNDY R; WALKER AF; MIDDLETON RW ET AL.: "Artichoke leaf extract reduces symptoms of irritable bowel syndrome and improves quality of life in otherwise healthy volunteers suffering from concomitant dyspepsia: a subset analysis", J ALTEM.COMPLEMENT MED, vol. 10, no. 4, 2004, pages 667 - 669, XP009076693
CABRERA ET AL.: "Beneficial effects of green tea - a review", J. AM. COLL. NUTR., vol. 25, 2006, pages 79 - 99, XP003021660
CALABRESE, V. ET AL.: "Biochemical studies of a natural antioxidant isolated from rosemary and its application in cosmetic dermatology", INTERNATIONAL JOURNAL OF TISSUE REACTIONS, vol. 22, no. 1, 2000, pages 5 - 13, XP009092509
CHANDA N; SHUKLA R; ZAMBRE A; MEKAPOTHULA S; KULKARNI RR; KATTI K; BHATTACHARYYA K; FENT GM; CASTEEL SW; BOOTE EJ: "An effective strategy for the synthesis ofbiocompatible gold nanoparticles using cinnamon phytochemicals for phantom CT imaging and photoacoustic detection of cancerous cells.", PHARM RES., vol. 28, no. 2, 25 September 2010 (2010-09-25), pages 279 - 91, XP019876492, DOI: doi:10.1007/s11095-010-0276-6
CHAUDHURI RK.: "Emblica cascading antioxidant: a novel natural skin care ingredient", SKIN PHARMACOL APPL SKIN PHYSIOL., vol. 15, no. 5, pages 374 - 80, XP008016256, DOI: doi:10.1159/000064544
CHENG PC; WONG G: "Honey bee propolis: prospects in medicine", BEE WORLD, vol. 77, 1996, pages 8 - 14
CHU, KO; KAI ON CHU; KWOK PING CHAN; CHI CHIU WANG; CHING YAN CHU; WAI YING LI; KWONG WAI CHOY; MICHAEL SCOTT ROGERS; CHI PUI PAN: "Green Tea Catechins and Their Oxidative Protection in the Rat Eye", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 58, no. 3, February 2010 (2010-02-01), pages 1523 - 1534
CHURCHILL M ET AL.: "Inhibition of intestinal tumors by curcumin is associated with changes in the intestinal immune cell profile", J SURG RES, vol. 89, 2000, pages 169 - 75, XP002256270, DOI: doi:10.1006/jsre.2000.5826
CIFFTCI, M.; T. GULER; B. DALKILIC; O.N.ERTAS.: "The effect of anise oil ( Pimpinella anisum L. ) on broiler performance", INTEMATIONAL J. POULTRY SCI., vol. 4, no. 11, 2005, pages 851 - 855
DR. KE-QIN HU, WORLD JOURNAL OF GASTROENTEROLOGY, 28 October 2007 (2007-10-28)
EI-MAHMOUDY A; MATSUYAMA H; BORGAN MA ET AL.: "Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages", INT IMMUNOPHARMACOL., vol. 2, no. 11, October 2002 (2002-10-01), pages 1603 - 11
EMAD AL-DUJAILI; JON-PAUL BRADLEY; SUZANA ALMOOSAWI; LORNA FYFE: "Effects of green tea consumption on blood pressure, total cholesterol, body weight and fat in healthy volunteers", ENDOCRINE ABSTRACTS, vol. 20, 2009, pages 470, Retrieved from the Internet <URL:http://www.endocrine-abstracts.org/ea>
FAHIM, FA; ESMAT, FAWZIA A.; FADEL, AY; HASSAN, HM: "Allied studies on the effect of Rosmarinus officinalis L. on experimental hepatotoxicity and mutagenesis", INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, vol. 50, no. 6, 1999, pages 413 - 427, XP009085439, DOI: doi:10.1080/096374899100987
FLEISCHAUER AT; ARAB L.: "Garlic and cancer: a critical review of the epidemiologic literature", J NUTR., vol. 131, 2001, pages 1032S - 1040S
FRANKEL S ET AL.: "Antioxidant capacity and correlated characteristics of 14 unifloral honeys", J APIC RES, vol. 37, 1998, pages 27 - 31
FURUSAWA E ET AL.: "Antitumor potential of pollen extract on Lewis lung carcinoma implanted intraperitoneally in syngenic mice", PHYTOTHER RES, vol. 9, 1995, pages 255 - 9
GALI-MUHTASIB H; OCKER M; KUESTER D ET AL.: "Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models", J CELL MOL MED., vol. 12, no. L, January 2008 (2008-01-01), pages 330 - 42
GALI-MUHTASIB H; ROESSNER A; SCHNEIDER-STOCK R: "Thymoquinone: a promising anti-cancer drug from natural sources", INT J BIOCHEM CELL BIOL., vol. 3 8, no. 8, 2006, pages 1249 - 53, XP024987522, DOI: doi:10.1016/j.biocel.2005.10.009
GALI-MUHTASIB HU; ABOU KHEIR WG; KHEIR LA ET AL.: "Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes", ANTICANCER DRUGS., vol. LS, no. 4, April 2004 (2004-04-01), pages 389 - 99
GEDIK N; KABASAKAL L; SEHIRLI O ET AL.: "Long-term administration of aqueos garlic extract (AGE) alleviates liver fibrosis and oxidative damage induced by biliary obstruction in rats", LIFE SCI., vol. 76, 2005, pages 2593 - 606
GHANNADI A; HAJHASHEMI V; JAFARABADI H: "An investigation of the analgesic and anti-inflammatory effects ofNigella sativa seed polyphenols", J MED FOOD., vol. 8, no. 4, 2005, pages 488 - 93
GORDON A; HOBBS DA; BOWDEN DS; BAILEY MJ; MITCHELL J; FRANCIS AJ; ROBERTS SK: "Effects of Silybum marianum on serum hepatitis C virus RNA, alanine aminotransferase levels and well-being in patients with chronic hepatitis C", J GASTROENTEROL HEPATOL., vol. 21, January 2006 (2006-01-01), pages 275 - 80
GREENAWAY W ET AL.: "The composition and plant origins of propolis: a report of work at Oxford", BEE WORLD, vol. 71, 1990, pages 107 - 18
HANNAN JM; ROKEYA B; FARUQUE O ET AL.: "Effect of soluble dietary fiber fraction of Trigonella foenum graecum on glycemic, insulinemic, lipidemic and platelet aggregation status of Type 2 diabetic model rats", J ETHNOPHARMACOL, vol. 88, 2003, pages 73 - 77
HARRIS C; PIERCE K; KING G; YATES KM; HALL J; TIZARD I: "Efficacy of acemannan in treatment of canine and feline spontaneous neoplasms", MOL BIOTHER., vol. 3, no. 4, December 1991 (1991-12-01), pages 207 - 13
HASSAN ZM; YARAEE R; ZARE N ET AL.: "Immunomodulatory affect of RIO fraction of garlic extract on natural killer activity", INT IMMUNOPHARMACOL., vol. 3, no. 10-11, 2003, pages 1483 - 1489
HAZRA B; SARKAR R; BISWAS S; MANDAL N.: "BMC :Comparative study of the antioxidant and reactive oxygen species scavenging properties in the extracts of the fruits of Terminalia chebula, Terminalia belerica and Emblicaofficinalis", COMPLEMENT ALTERN MED., vol. 10, 13 May 2010 (2010-05-13), pages 20
HEMPEL J; PFORTE H; RAAB B; ENGST W; BOHM H; JACOBASCH G.: "Flavonols and flavones of parsley cell suspension culture change anti- oxidative capacity of plasma in rats", NAHRUNG, vol. 43, no. 3, June 1999 (1999-06-01), pages 201 - 4
HUANG, M. T. ET AL.: "Inhibition of skin tumorigenesis by rosemary and its constituents camosol and ursolic acid", CANCER RESEARCH, vol. 54, no. 3, 1 February 1994 (1994-02-01), pages 701 - 708
HUBER R ET AL: "Artichoke leave extract for chronic hepatitis C - A pilot study", PHYTOMEDICINE, GUSTAV FISCHER VERLAG, STUTTGART, DE, vol. 16, no. 9, 1 September 2009 (2009-09-01), pages 801 - 804, XP026338273, ISSN: 0944-7113, [retrieved on 20090508], DOI: 10.1016/J.PHYMED.2009.03.007 *
HUBER, R. ET AL.: "Artichoke leave extract for chronic hepatitis C - a pilot study", PHYTOMEDICINE, vol. 16, no. 9, September 2009 (2009-09-01), pages 801 - 4, XP026338273, DOI: doi:10.1016/j.phymed.2009.03.007
JIMENEZ-ESCRIG A; DRAGSTED LO; DANESHVAR B ET AL.: "In vitro antioxidant activities of edible artichoke (Cynara scolymus L.) and effect on biomarkers of antioxidants in rats", J AGRIC.FOOD CHEM., vol. 51, no. 18, 27 August 2003 (2003-08-27), pages 5540 - 5545
JIN MJ; HAN HK: "Effect of piperine, a major component of black pepper, on the intestinal absorption of fexofenadine and its implication on food-drug interaction", J FOOD SCI., vol. 75, no. 3, April 2010 (2010-04-01), pages H93 - 6
JOHNSON J.J.: "Camosol: A promising anti-cancer and anti-inflammatory agent", CANCER LETTERS, vol. 305, no. 1, 2011, pages 1 - 7
KHAYYAL MT; EL-GHAZALY MA; ABDALLAH DM; NASSAR NN; OKPANYI SN; KREUTER MH: "Blood pressure lowering effect of an olive leaf extract ( Olea europaea ) in L-NAME induced hypertension in rats", ARZNEIMITTELFORSCHUNG, vol. 52, 2002, pages 797 - 802, XP001526063
KIRSCH C; LOGEMANN E; LIPPOK B; SCHMELZER E; HAHLBROCK K: "A highly specific pathogen-responsive promoter element from the immediate-early activated CMPG1 gene in Petroselinum crispum", PLANT J., vol. 26, no. 2, April 2001 (2001-04-01), pages 217 - 27
KOH, W.S. ET AL.: "Cinnamaldehyde inhibits lymphocyte proliferation and modulates T-cell differentiation", INT J IMMUNOPHARMACOL, vol. 20, no. 11, 1998, pages 643 - 660
KREYDIYYEH, SAWSAN IBRAHIM; JULNAR USTA: "Diuretic effect and mechanism of action of parsley", JOURNAL OF ETHNOPHARMACOLOGY, vol. 79, no. 3, March 2002 (2002-03-01), pages 353 - 357, XP008123704, DOI: doi:10.1016/S0378-8741(01)00408-1
KRISHNAVENI M; MIRUNALINI S. J: "Therapeutic potential of Phyllanthus emblica (amla): the ayurvedic wonder", BASIC CLIN PHYSIOL PHARMACOL., vol. 21, no. 1, 2010, pages 93 - 105
KROL W ET AL.: "Inhibition of neutrophils chemiluminescence by ethanol extracts of propolis (EEP) and its phenolic components", J ETHNOPHARM, vol. 55, 1996, pages 19 - 25
KWON HK; HWANG JS; SO JS; LEE CG; SAHOO A; RYU JH; JEON WK; KO BS; IM CR; LEE SH: "Cinnamon extract induces tumor cell death through inhibition of NFkappaB and AP1.", BMC CANCER., vol. 10, 24 July 2010 (2010-07-24), pages 392, XP021075214, DOI: doi:10.1186/1471-2407-10-392
KWON HK; JEON WK; HWANG JS; LEE CG; SO JS; PARK JA; KO BS; IM SH: "Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells.", CANCER LETT., vol. 278, no. 2, 18 June 2009 (2009-06-18), pages 174 - 82, XP026046108, DOI: doi:10.1016/j.canlet.2009.01.015
L. MENGONI E.S.; VICHERA G.; RIGANO L.A.; RODRIGUEZ-PUEBLA M.L.; GALLIANO S.R.; CAFFERATA E.E.; PIVETTA O.H.; MORENO S.; VOJNOV A.: "Suppression of COX-2, IL-1 [3 and TNF-a expression and leukocyte infiltration in inflamed skin by bioactive compounds from Rosmarinus officinalis", FITOTERAPIA, vol. 82, no. 3, 2011, pages 414 - 421
LAH JJ; CUI W; HU KQ: "Effects and mechanisms of silibinin on human hepatoma cell lines", WORLD J GASTROENTEROL, vol. 13, no. 40, 2007, pages 5299 - 5305
LEE-HUANG S; ZHANG L; HUANG PL; CHANG YT; HUANG PL: "Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment", BIOCHEM BIOPHYS RES COMMUN, vol. 307, 2003, pages 1029 - 1037, XP004439240, DOI: doi:10.1016/S0006-291X(03)01292-0
LIN ET AL.: "Factors affecting the levels of tea polyphenols and caffeine in tea leaves", J AGRIC FOOD CHEM, vol. 51, 2003, pages 1864 - 1873
MAHMOUD MR; EL-ABHAR HS; SALEH S: "The effect of Nigella sativa oil against the liver damage induced by Schistosoma mansoni infection in mice", J ETHNOPHARMACOL., vol. 79, no. 1, January 2002 (2002-01-01), pages 1 - 11
MAJEED M; BHAT B; JADHAV AN; SRIVASTAVA JS; NAGABHUSHANAM K.: "Ascorbic acid and tannins from Emblica officinalis Gaertn. Fruits--a revisit.", J AGRIC FOOD CHEM., vol. 57, no. 1, 14 January 2009 (2009-01-14), pages 220 - 5, XP008151953, DOI: doi:10.1021/jf802900b
MANCINI-FILHO J; VAN-KOIIJ A; MANCINI DA; COZZOLINO FF; TORRES RP: "Antioxidant activity of cinnamon (Cinnamomum Zeylanicum, Breyne) extracts", BOLL CHIM FARM, vol. 137, no. 11, December 1998 (1998-12-01), pages 443 - 7
MARKHAM KR; CAMPOS M: "7- and 8-o-methylherbacetin-3-o-sophorosides from bee pollens and some structure/activity observations", PHYTOCHEMISTRY, vol. 43, 1996, pages 763 - 7
MARON DJ; LU GP; CAI NS ET AL.: "Cholesterol-lowering effect of a theaflavin-enriched green tea extract: a randomized controlled trial", ARCH. INTERN. MED., vol. 163, no. 12, June 2003 (2003-06-01), pages 1448 - 53, XP009078223, DOI: doi:10.1001/archinte.163.12.1448
MAYER KE; MYERS RP; LEE SS: "Silymarin treatment of viral hepatitis: a systematic review", J VIRAL HEPAT., vol. 12, no. 6, November 2005 (2005-11-01), pages 559 - 67, XP002477921, DOI: doi:10.1111/j.1365-2893.2005.00636.x
MCDANIEL, H.R. ET AL.: "An increase in circulating monocyte/macrophages (MM) is induced by oral acemannan (ACE-M) in HIV-1 patients", AM. J CLIN. PATHOL., vol. 94, 1990, pages 516 - 17
MCDANIEL, H.R. ET AL.: "CD4 and CD8 lymphocyte levels in acemannan (ACM)-treated HIV-1 infected longer-term survivors", INT. CONF. AIDS, vol. 9, no. 1, 1993, pages 438
MCDANIEL, H.R. ET AL.: "Extended survival and prognostic criteria for acemannan(ACE-M) treated HIV-1 patients", ANTIVIRAL RES., vol. 13, no. 1, 1990, pages 117, XP023704040
MEERA R ET AL: "Antioxidant and hepatoprotective activities of Ocimum basilicum Linn. and Trigonella foenum-graecum, against H2O2 and CCl4 induced hepatotoxicity in goat liver", MEDICINAL & AROMATIC PLANTS ABSTRACTS, SCIENTIFIC PUBLISHERS, SCIENTIFIC PUBLISHERS, NEW DELHI - INDIA, vol. 32, no. 2, 1 April 2010 (2010-04-01), XP018028267, ISSN: 0250-4367 *
MESA MD; AGUILERA CM; RAMIREZ-TORTOSA CL ET AL.: "Oral administration of a turmeric extract inhibits erythrocyte and liver micro- some membrane oxidation in rabbits fed with an atherogenic diet", NUTRITION, vol. 19, no. 9, September 2003 (2003-09-01), pages 800 - 04
MICCADEI, S.: "Antioxidative and apoptotic properties ofpolyphenolic extracts from edible part of artichoke( Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells", NUTR. CANCER, vol. 60, no. 2, 2008, pages 276 - 83, XP009174917, DOI: doi:10.1080/01635580801891583
MICOL V; CATURLA N; PEREZ-FONS L; MAS V; PEREZ L; ESTEPA A: "The olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia rhabdovirus (VHSV", ANTIVIRAL RES., vol. 66, 2005, pages 129 - 136, XP004903391, DOI: doi:10.1016/j.antiviral.2005.02.005
MIRZOEVA OK; CALDER PC: "The effect of propolis and its components on eicosanoid production during the inflammatory response", PROSTAGLAND LEUKOT ESSENT FATTY ACID, vol. 55, 1996, pages 441 - 9
MONTANER JS; GILL J; SINGER J ET AL.: "Double-blind placebo-controlled pilot trial of acemannan in advanced human immunodeficiency virus disease", J ACQUIR IMMUNE DEFIC SYN HUM RETROVIROL, vol. 12, 1996, pages 153 - 157
MOSS, M. ET AL.: "Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adults", INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2003, pages 113
NAT. SCI., vol. 44, 2010, pages 123 - 144
NGO SN; WILLIAMS DB; COBIAC L; HEAD RJ: "Does garlic reduce the risk of colorectal cancer? A systematic review", J NUTR., vol. 137, no. 10, 2007, pages 2264 - 9
OZSOY-SACAN O; YANARDAG R; ORAK H; OZGEY Y; YARAT A; TUNALI T: "Effects of parsley (Petroselinum crispum) extract versus glibomuride on the liver of streptozotocin-induced diabetic rats", J ETHNOPHARMACOL., vol. 104, no. 1-2, 11 October 2005 (2005-10-11), pages 175 - 81, XP025085665, DOI: doi:10.1016/j.jep.2005.08.069
PARK E Y ET AL: "Garlic oil and DDB, comprised in a pharmaceutical composition for the treatment of patients with viral hepatitis, prevents acute liver injuries potentiated by glutathione deficiency in rats", CHEMICO-BIOLOGICAL INTERACTIONS, ELSEVIER SCIENCE IRLAND, IR, vol. 155, no. 1-2, 30 June 2005 (2005-06-30), pages 82 - 96, XP027648377, ISSN: 0009-2797, [retrieved on 20050630] *
PARK EJ ET AL.: "Protective effect of curcumin in rat liver injury induced by carbon tetrachloride", J PHARM PHARMACOL, vol. 52, 2000, pages 437 - 40
PARK EY; KI SH; KO MS; KIM CW; LEE MH; LEE YS; KIM SG: "Garlic oil and DDB, comprised in a pharmaceutical composition for the treatment of patients with viral hepatitis, prevents acute liver injuries potentiated by glutathione deficiency in rats", CHEM. BIOL. INTERACT., vol. 155, 2005, pages 82 - 96, XP004951058, DOI: doi:10.1016/j.cbi.2005.04.006
PIERONI A ET AL.: "In vitro anti-complementary activity of flavonoids from olive (Olea europaea L.) leaves", PHARMAZIE., vol. 51, no. 10, October 1996 (1996-10-01), pages 765 - 8, XP001207648
POLTANOV EA; SHIKOV AN; DORMAN HJ; POZHARITSKAYA ON; MAKAROV VG; TIKHONOV VP; HILTUNEN R: "Chemical and antioxidant evaluation of Indian gooseberry (Emblica officinalis Gaertn., syn. Phyllanthus emblica L.) supplements", PHYTOTHER RES., vol. 23, no. 9, September 2009 (2009-09-01), pages 1309 - 15
POZHARITSKAYA ON; IVANOVA SA; SHIKOV AN; MAKAROV VG.: "Separation and evaluation of free radical-scavenging activity of phenol components of Emblica officinalis extract by using an HPTLC-DPPH* method", J SEP SCI, vol. 30, no. 9, June 2007 (2007-06-01), pages 1250 - 4
QIN B; PANICKAR KS; ANDERSON RA: "Cinnamon: potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetes", J DIABETES SCI TECHNOL., vol. 4, no. 3, 1 May 2010 (2010-05-01), pages 685 - 93
RADHA K DHIMAN ET AL: "Herbal Medicines for Liver Diseases", DIGESTIVE DISEASES AND SCIENCES, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 50, no. 10, 1 October 2005 (2005-10-01), pages 1807 - 1812, XP019237127, ISSN: 1573-2568, DOI: 10.1007/S10620-005-2942-9 *
RIBES G; SAUVAIRE Y; DA COSTA C ET AL.: "Antidiabetic effects of sub-fractions from fenugreek seeds in diabetic dogs", PROC SOC EXP BIOL MED, vol. 182, 1986, pages 159 - 165
S. J. POLYAK ET AL: "Identification of hepatoprotective flavonolignans from silymarin", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 107, no. 13, 15 March 2010 (2010-03-15), pages 5995 - 5999, XP055035626, ISSN: 0027-8424, DOI: 10.1073/pnas.0914009107 *
SAMARANAYAKE MD; WICKRAMASINGHE SM; ANGUNAWELA P. ET AL.: "Inhibition of chemically induced liver carcinogenesis in Wistar rats by garlic (Allium sativum", PHYTOTHER RES., vol. 14, 2000, pages 564 - 7
SARMA DN; BARRETT ML; CHAVEZ ML ET AL.: "Safety of green tea extracts : a systematic review by the US Pharmacopeia", DRUG SAF, vol. 31, no. 6, 2008, pages 469 - 84
SHARMA RD; RAGHURAM TC; RAO NS: "Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes", EUR J CLIN, vol. 44, no. 4, April 1990 (1990-04-01), pages 301 - 6, XP009047500
SHARMA RD; RAO NS; RAGHURAM TC: "Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes", EUR.CLINIC NUTRITION, vol. 44, 1990, pages 301 - 305
SHEETS, M.S. ET AL.: "Studies of the effect of acemannan on retrovirus infections: Clinical stabilization of feline leukemia virus-infected cats", MOL. BIOTHER., vol. 3, no. 1, 1991, pages 41 - 5
SIMSEK, U.G.M. CIFTCI; T. GULER; O.N. ERTAS: "The effect of dietary antibiotic and aniseoil supplementation on body weight, carcass characteristics and organoleptic analysis of meat in broiler", REVUE. MED. VET., vol. 158, no. 10, 2007, pages 514 - 518
SPERONI, E. ET AL.: "Efficacy of different Cynara scolymus preparations on liver complaints", J. ETHNOPHARMACOL, vol. 86, no. 2-3, June 2003 (2003-06-01), pages 203 - 11
SUBRAMONIAM A ET AL: "DEVELOPMENT OF PHYTOMEDICINES FOR LIVER DISEASES", INDIAN JOURNAL OF PHARMACOLOGY, MEDKNOW PUBLICATIONS AND MEDIA PVT. LTD, IN, vol. 31, no. 3, 1 June 1999 (1999-06-01), pages 166 - 175, XP009006981, ISSN: 0253-7613 *
SUNBUL J.HAMODI; FIRAS M.AL-KHALANI: "Compared Between Anise Seeds (Pimpinella Anisum L.) And Roselle flowers by Their Affected on Production Performance of Broiler", ADVANCES IN ENVIRONMENTAL BIOLOGY, vol. 5, no. 2, 2011, pages 461 - 464
SUR P; DAS M; GOMES A ET AL.: "Trigonella foenum graecum (fenugreek) seed extract as an antineoplastic agent", PHYTOTHER RES, vol. 15, 2001, pages 257 - 259
SURESH, D.; SRINIVASAN, K.: "Influence of curcumin, capsaicin, and piperine on the rat liver drug-metabolizing enzyme system in vivo and in vitro", CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1 December 2006 (2006-12-01)
UTRILLA M P: "NATURAL PRODUCTS WITH HEPATOPROTECTIVE ACTION", METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, PROUS, BARCELONA, ES, vol. 18, no. SUPPLEMENT B, 20 September 1996 (1996-09-20), pages 11 - 12, XP009073373, ISSN: 0379-0355 *
VALERIO F; DE BELLIS P; LONIGRO SL ET AL.: "In vitro and in vivo survival and transit tolerance of potentially probiotic strains carried by artichokes in the gastrointestinal tract", APPL ENVIRON.MICROBIOL., vol. 72, no. 4, 2006, pages 3042 - 3045, XP055072015, DOI: doi:10.1128/AEM.72.4.3042-3045.2006
VARGHESE, LEYON ET AL.: "Silibinin Efficacy Against Human Hepatocellular Carcinoma", CLINICAL CANCER RESEARCH, 1 December 2005 (2005-12-01)
VENABLES, MICHELLE C; VENABLES, MICHELLE C; HULSTON, CARL J; COX, HANNAH R; JEUKENDRUP, ASKER E: "Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans", AMERICAN JOURNAL OF CLINICAL NUTRITION, vol. 87, no. 3, March 2008 (2008-03-01), pages 778 - 784
WAGONER J; NEGASH A; KANE OJ ET AL.: "Multiple effects of silymarin on the hepatitis C virus lifecycle", HEPATOLOGY, vol. 51, no. 6, 2010, pages 1912 - 1921
WOMBLE, D.; HELDERMAN, J.H.: "Enhancement of all-responsiveness of human lymphocytes by acemannan", INT. J IMMUNOPHARMACOL, vol. 10, no. 8, 1988, pages 967 - 74
WONDRAK GT; VILLENEUVE NF; LAMORE SD; BAUSE AS; JIANG T; ZHANG DD: "The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2- dependent antioxidant response in human epithelial colon cells.", MOLECULES, vol. 15, no. 5, 7 May 2010 (2010-05-07), pages 3338 - 55
WRIGHT CI; VAN-BUREN L; KRONER CI; KONING MM: "Herbal medicines as diuretics: a review of the scientific evidence", J ETHNOPHARMACOL., vol. 114, no. 1, 31 July 2007 (2007-07-31), pages 1 - 31, XP022266034, DOI: doi:10.1016/j.jep.2007.07.023
XIAOFU WANG ET AL.: "Curcumin inhibits neurotensin-mediated interleukin-8 production and migration ofHCTI 16 human colon cancer cells", CLINICAL CANCER RESEARCH, vol. 12, no. 18, 15 September 2006 (2006-09-15)
YADAV UC; MOORTHY K; BAQUER NZ: "Effects of sodium-orthovanadate and Trigonella foenum-graecum seeds on hepatic and renal lipogenic enzymes and lipid profile during alloxan diabetes", J BIOSCI, vol. 29, 2004, pages 81 - 91
ZIDOM C; JÖHRER K; GANZERA M; SCHUBERT B; SIGMUND EM; MADER J; GREIL R; ELLMERER EP; STUPPNER H: "Polyacetylenes from the Apiaceae vegetables carrot, celery, fennel, parsley, and parsnip and their cytotoxic activities", J AGRIC FOOD CHEM., vol. 53, no. 7, 6 April 2005 (2005-04-06), pages 2518 - 23
ZIELINSKA-PRZYJEMSKA M; WIKTOROWICZ K: "An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species", PHYTOTHER RES., vol. 20, no. 2, February 2006 (2006-02-01), pages 115 - 9

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