WO2012154078A1 - Composition pharmaceutique à action antibactérienne à usage parentéral et procédé de fabrication - Google Patents

Composition pharmaceutique à action antibactérienne à usage parentéral et procédé de fabrication Download PDF

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Publication number
WO2012154078A1
WO2012154078A1 PCT/RU2011/000781 RU2011000781W WO2012154078A1 WO 2012154078 A1 WO2012154078 A1 WO 2012154078A1 RU 2011000781 W RU2011000781 W RU 2011000781W WO 2012154078 A1 WO2012154078 A1 WO 2012154078A1
Authority
WO
WIPO (PCT)
Prior art keywords
antibiotic
glycopeptide
pharmaceutical composition
silicon dioxide
highly dispersed
Prior art date
Application number
PCT/RU2011/000781
Other languages
English (en)
Russian (ru)
Inventor
Виктор Львович ЛИМОНОВ
Константин Валентинович ГАЙДУЛЬ
Александр Валерьевич ДУШКИН
Original Assignee
Limonov Viktor Lvovich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Limonov Viktor Lvovich filed Critical Limonov Viktor Lvovich
Publication of WO2012154078A1 publication Critical patent/WO2012154078A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

L'invention concerne la pharmacologie, la chimie, la médecine vétérinaire et l'industrie pharmaceutique et porte sur un procédé de fabrication de préparations composites originales à action antibactérienne à usage parentéral qui présentent une efficacité thérapeutique améliorée dans le traitement des formes graves de maladies infectieuses inflammatoires. La composition pharmaceutique de l'invention comprend en tant que principe actif l'antibiotique glycopeptide et le dioxyde de silicium nanostructuré finement dispersé mécaniquement activés. L'invention porte sur un procédé de fabrication de la composition pharmaceutique ci-décrite, qui consiste à mélanger l'antibiotique glycopeptide à du dioxyde de silicium nanostructuré; le mélangeage se distingue en ce que le mélange de ces substances ayant un rapport massique de 10 :1 à 70 :1 est soumis à un traitement mécanique par impact et frottement visant à augmenter la part massique de la fraction finement dispersée. Le mélange obtenu est utilisé pour préparer des solutions injectables.
PCT/RU2011/000781 2011-05-11 2011-10-05 Composition pharmaceutique à action antibactérienne à usage parentéral et procédé de fabrication WO2012154078A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EA201100736A EA021847B1 (ru) 2011-05-11 2011-05-11 Фармацевтическая композиция антимикробного действия для парентерального применения, способ ее получения
EA201100736 2011-05-11

Publications (1)

Publication Number Publication Date
WO2012154078A1 true WO2012154078A1 (fr) 2012-11-15

Family

ID=45540663

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2011/000781 WO2012154078A1 (fr) 2011-05-11 2011-10-05 Composition pharmaceutique à action antibactérienne à usage parentéral et procédé de fabrication

Country Status (2)

Country Link
EA (1) EA021847B1 (fr)
WO (1) WO2012154078A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070275068A1 (en) * 2004-09-09 2007-11-29 Johan Martens Controlled Release Delivery System for Bio-Active Agents
EP1313451B1 (fr) * 2000-08-31 2009-03-11 Jagotec AG Particules broyees

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA013864B1 (ru) * 2008-08-29 2010-08-30 Лимонова, Анастасия Викторовна Способ повышения антимикробной активности цефалоспориновых антибиотиков

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1313451B1 (fr) * 2000-08-31 2009-03-11 Jagotec AG Particules broyees
US20070275068A1 (en) * 2004-09-09 2007-11-29 Johan Martens Controlled Release Delivery System for Bio-Active Agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HETRICK, EVAN M.: "Antimicrobial and wound healing properties of nitric oxide-releasing xerogels and silica nanoparticles.", THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, 2008, pages 241 *

Also Published As

Publication number Publication date
EA021847B1 (ru) 2015-09-30
EA201100736A1 (ru) 2012-01-30

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