WO2012153964A3 - 지질 프로파일을 이용한 비소세포성 폐암의 조직학적 분류를 위한 정보를 제공하는 방법 - Google Patents

지질 프로파일을 이용한 비소세포성 폐암의 조직학적 분류를 위한 정보를 제공하는 방법 Download PDF

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Publication number
WO2012153964A3
WO2012153964A3 PCT/KR2012/003571 KR2012003571W WO2012153964A3 WO 2012153964 A3 WO2012153964 A3 WO 2012153964A3 KR 2012003571 W KR2012003571 W KR 2012003571W WO 2012153964 A3 WO2012153964 A3 WO 2012153964A3
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WO
WIPO (PCT)
Prior art keywords
small
cell lung
lipid profile
lung carcinoma
sample
Prior art date
Application number
PCT/KR2012/003571
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English (en)
French (fr)
Other versions
WO2012153964A2 (ko
Inventor
김학균
김광표
조재일
이건국
Original Assignee
국립암센터
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 국립암센터 filed Critical 국립암센터
Priority to KR1020137025091A priority Critical patent/KR101384693B1/ko
Publication of WO2012153964A2 publication Critical patent/WO2012153964A2/ko
Publication of WO2012153964A3 publication Critical patent/WO2012153964A3/ko

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer

Abstract

본 발명은 작은 양의 조직샘플만으로도 비소세포성 폐암의 조직학적 유형을 보다 정확하고도 저비용으로 용이하게 분류하는 것을 목적으로 한다. 이러한 목적을 달성하기 본 발명은 지질 프로파일을 이용한 비소세포성 폐암의 조직학적 분류를 위한 정보를 제공하는 방법에 대한 것으로서, (a) 기질(matrix)과 인체 조직을 혼합하여 시료(sample)를 준비하는 단계와, (b) 준비된 시료에 대하여 질량분석을 수행하는 단계와, (c) 질량분석에 의하여 확보된 데이터에서 지질 프로파일에 대한 정보인 제1 지질 프로파일 데이터를 선별하는 단계 및 (d) 선암(adenocarcinoma) 조직 및 편평세포상피암 (squamous cell carcinoma) 조직 중에서 선택된 적어도 어느 하나의 지질 프로파일에 대한 정보인 제2 지질 프로파일 데이터와 제1 지질 프로파일 데이터를 비교함으로써 시료가 선암(adenocarcinoma) 및 편평세포상피암 (squamous cell carcinoma) 중의 어느 하나에 해당한다는 정보를 제공하는 단계를 포함한다.
PCT/KR2012/003571 2011-05-09 2012-05-07 지질 프로파일을 이용한 비소세포성 폐암의 조직학적 분류를 위한 정보를 제공하는 방법 WO2012153964A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020137025091A KR101384693B1 (ko) 2011-05-09 2012-05-07 지질 프로파일을 이용한 비소세포성 폐암의 조직학적 분류를 위한 정보를 제공하는 방법

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20110043640 2011-05-09
KR10-2011-0043640 2011-05-09

Publications (2)

Publication Number Publication Date
WO2012153964A2 WO2012153964A2 (ko) 2012-11-15
WO2012153964A3 true WO2012153964A3 (ko) 2013-03-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/003571 WO2012153964A2 (ko) 2011-05-09 2012-05-07 지질 프로파일을 이용한 비소세포성 폐암의 조직학적 분류를 위한 정보를 제공하는 방법

Country Status (2)

Country Link
KR (1) KR101384693B1 (ko)
WO (1) WO2012153964A2 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101389382B1 (ko) 2013-05-20 2014-04-29 국립암센터 인지질을 이용한 암의 진단 방법
KR101408217B1 (ko) * 2013-05-22 2014-06-17 국립암센터 질량분석패턴을 이용한 원발성간내담도암 및 전이성간암의 감별법
US20200341004A1 (en) * 2017-10-27 2020-10-29 Frontier Diagnostics, Llc Mass spectrometry methods for carcinoma assessments
CN114295706A (zh) * 2021-09-28 2022-04-08 岛津企业管理（中国）有限公司 一种基于统计学的非靶向非小细胞肺癌的病理分型方法
CN114199980B (zh) * 2021-11-08 2024-02-20 岛津企业管理（中国）有限公司 一种基于质谱成像技术的肺癌分型判断系统

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002008760A1 (en) * 2000-07-19 2002-01-31 Biotron Limited Method of identifying cancer markers and uses therefor in the diagnosis of cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2457437A1 (en) * 2001-08-03 2003-02-20 Biotron Limited A novel cancer marker and uses therefor in the diagnosis of cancer
JP5422785B2 (ja) * 2008-09-12 2014-02-19 国立大学法人名古屋大学 質量分析法を利用した複数癌腫の血液検出のための方法および生物マーカー

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002008760A1 (en) * 2000-07-19 2002-01-31 Biotron Limited Method of identifying cancer markers and uses therefor in the diagnosis of cancer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JACKSON, S. N. ET AL.: "Direct profiling of tissue lipids by MALDI-TOFMS.", J. CHROMATOGR. B, vol. 877, 2009, pages 2822 - 2829 *
LEE, G. K. ET AL.: "Lipid MALDI profile classifies non-small cell lung cancers according to the histologic type.", LUNG CANCER, vol. 76, no. 2, 17 November 2011 (2011-11-17), pages 197 - 203 *
SEELEY, E. H. ET AL.: "MALDI imaging mass spectrometry of human tissue: method challenges and clinical perspectives.", TRENDS BIOTECHNOL., vol. 29, no. 3, March 2011 (2011-03-01), pages 136 - 143 *
YANAGISAWA, K. ET AL.: "Proteomic patterns of tumour subsets in non-small-cell lung cancer.", LANCET, vol. 362, 9 August 2003 (2003-08-09) *

Also Published As

Publication number Publication date
KR20130140845A (ko) 2013-12-24
WO2012153964A2 (ko) 2012-11-15
KR101384693B1 (ko) 2014-04-14

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