WO2012153349A3 - Rasagiline and its pharmaceutically acceptable salts - Google Patents

Rasagiline and its pharmaceutically acceptable salts Download PDF

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Publication number
WO2012153349A3
WO2012153349A3 PCT/IN2012/000329 IN2012000329W WO2012153349A3 WO 2012153349 A3 WO2012153349 A3 WO 2012153349A3 IN 2012000329 W IN2012000329 W IN 2012000329W WO 2012153349 A3 WO2012153349 A3 WO 2012153349A3
Authority
WO
WIPO (PCT)
Prior art keywords
rasagiline
pharmaceutically acceptable
acceptable salts
acid addition
microns
Prior art date
Application number
PCT/IN2012/000329
Other languages
French (fr)
Other versions
WO2012153349A2 (en
WO2012153349A9 (en
Inventor
Shriprakash Dhar Dwivedi
Ashok Prasad
Mayur Ramnikbhai Patel
Original Assignee
Cadila Healthcare Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Limited filed Critical Cadila Healthcare Limited
Priority to EP12766333.4A priority Critical patent/EP2705021A2/en
Publication of WO2012153349A2 publication Critical patent/WO2012153349A2/en
Publication of WO2012153349A3 publication Critical patent/WO2012153349A3/en
Publication of WO2012153349A9 publication Critical patent/WO2012153349A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
    • C07C309/34—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
    • C07C309/35—Naphthalene sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to Rasagiline acid addition salts having a particle size D(90) greater than 250 microns and D(50) greater than 100 microns, with the proviso that acid addition salt is not mesylate. The invention also discloses a process for the preparation of such Rasagiline acid addition salts.
PCT/IN2012/000329 2011-05-04 2012-05-04 Rasagiline and its pharmaceutically acceptable salts WO2012153349A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP12766333.4A EP2705021A2 (en) 2011-05-04 2012-05-04 Rasagiline and its pharmaceutically acceptable salts

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1382/MUM/2011 2011-05-04
IN1382MU2011 2011-05-04
IN3169MU2011 2011-11-09
IN3169/MUM/2011 2011-11-09

Publications (3)

Publication Number Publication Date
WO2012153349A2 WO2012153349A2 (en) 2012-11-15
WO2012153349A3 true WO2012153349A3 (en) 2013-03-21
WO2012153349A9 WO2012153349A9 (en) 2014-02-13

Family

ID=46939731

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2012/000329 WO2012153349A2 (en) 2011-05-04 2012-05-04 Rasagiline and its pharmaceutically acceptable salts

Country Status (2)

Country Link
EP (1) EP2705021A2 (en)
WO (1) WO2012153349A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014192022A1 (en) * 2013-05-20 2014-12-04 Cadila Healthcare Limited Pharmaceutical compositions of rasagiline

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010007181A2 (en) * 2008-07-18 2010-01-21 Medichem, S.A. New salt forms of an aminoindan derivative
WO2011009873A2 (en) * 2009-07-20 2011-01-27 Medichem, S.A. New form of an aminoindan mesylate derivative

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL92952A (en) 1990-01-03 1994-06-24 Teva Pharma R-enantiomers of n-propargyl-1-aminoindan compounds, their preparation and pharmaceutical compositions containing them
IL111240A (en) 1993-10-18 2001-10-31 Teva Pharma Salts of r(+) - enantiomers of n- propargyl-1-aminoindan and pharmaceutical compositions comprising them
MX2007010233A (en) 2005-02-23 2007-11-07 Teva Pharma Rasagiline formulations of improved content uniformity.
EP1892233A1 (en) 2006-08-18 2008-02-27 Ratiopharm GmbH New salts of the active component rasagiline
DK2101569T3 (en) 2006-12-14 2012-01-30 Teva Pharma Crystalline solid rasagiline base
EP1987816A1 (en) 2007-04-30 2008-11-05 Ratiopharm GmbH Adsorbate of a rasagiline salt with a water-soluble inactive ingredient
WO2009118657A2 (en) 2008-03-28 2009-10-01 Medichem, S.A. Polymorphic form of an aminoindan mesylate derivative
WO2011012140A2 (en) 2008-07-11 2011-02-03 Synthon Bv Polymorphs of rasagiline hydrochloride
WO2010111264A2 (en) 2009-03-24 2010-09-30 Dr. Reddy's Laboratories Ltd. Rasagiline formulations
JP2012532843A (en) 2009-07-09 2012-12-20 ラティオファーム ゲーエムベーハー Rasagiline salt and preparation thereof
US8741962B2 (en) 2009-11-26 2014-06-03 Usv Limited Process for preparation of Rasagiline and salts thereof
EP2519496A2 (en) 2009-12-30 2012-11-07 Actavis Group Ptc Ehf Solid state forms of rasagiline salts
WO2011092717A2 (en) 2010-02-01 2011-08-04 Alkem Laboratories Ltd. Rasagiline mesylate having large particle size and a process for preparation thereof
WO2011095985A2 (en) 2010-02-02 2011-08-11 Glenmark Generics Limited Rasagiline salts and processes for the preparation thereof
WO2011121607A2 (en) 2010-03-29 2011-10-06 Cadila Healthcare Limited Rasagiline and its pharmaceutically acceptable salts
GB201005626D0 (en) 2010-04-01 2010-05-19 Isis Innovation Biological cell system instability investigation apparatus and method

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010007181A2 (en) * 2008-07-18 2010-01-21 Medichem, S.A. New salt forms of an aminoindan derivative
WO2011009873A2 (en) * 2009-07-20 2011-01-27 Medichem, S.A. New form of an aminoindan mesylate derivative

Also Published As

Publication number Publication date
EP2705021A2 (en) 2014-03-12
WO2012153349A2 (en) 2012-11-15
WO2012153349A9 (en) 2014-02-13

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