GB201005626D0 - Biological cell system instability investigation apparatus and method - Google Patents

Biological cell system instability investigation apparatus and method

Info

Publication number
GB201005626D0
GB201005626D0 GBGB1005626.5A GB201005626A GB201005626D0 GB 201005626 D0 GB201005626 D0 GB 201005626D0 GB 201005626 A GB201005626 A GB 201005626A GB 201005626 D0 GB201005626 D0 GB 201005626D0
Authority
GB
United Kingdom
Prior art keywords
cell system
stimulation
period
response
biological cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1005626.5A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Priority to GBGB1005626.5A priority Critical patent/GB201005626D0/en
Publication of GB201005626D0 publication Critical patent/GB201005626D0/en
Priority to PCT/GB2011/000499 priority patent/WO2011121307A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/37—Monitoring; Protecting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/3629—Heart stimulators in combination with non-electric therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A61B5/346—Analysis of electrocardiograms
    • A61B5/349—Detecting specific parameters of the electrocardiograph cycle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/3621—Heart stimulators for treating or preventing abnormally high heart rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/37—Monitoring; Protecting
    • A61N1/3702—Physiological parameters

Abstract

An apparatus is disclosed comprising: a stimulator for applying periodic stimulation to a biological cell system under investigation; a sensor for sensing the response of the cell system to the stimulation and producing an output; a controller adapted to: consistently change the period of the stimulation applied by the stimulator such that the period is either decreasing or increasing such that the state of the cell system passes from or to a region of monostability of response with respect to stimulation; and then reverse the direction of the change in period such that the period is respectively consistently increasing or decreasing; and an analyzer arranged to analyze the senor output to assess the location of a transition between the cell system having regular rhythm response and potentially irregular rhythm response with respect to stimulation.
GBGB1005626.5A 2010-04-01 2010-04-01 Biological cell system instability investigation apparatus and method Ceased GB201005626D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GBGB1005626.5A GB201005626D0 (en) 2010-04-01 2010-04-01 Biological cell system instability investigation apparatus and method
PCT/GB2011/000499 WO2011121307A1 (en) 2010-04-01 2011-03-31 Biological cell system instability investigation apparatus and method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1005626.5A GB201005626D0 (en) 2010-04-01 2010-04-01 Biological cell system instability investigation apparatus and method

Publications (1)

Publication Number Publication Date
GB201005626D0 true GB201005626D0 (en) 2010-05-19

Family

ID=42228833

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1005626.5A Ceased GB201005626D0 (en) 2010-04-01 2010-04-01 Biological cell system instability investigation apparatus and method

Country Status (2)

Country Link
GB (1) GB201005626D0 (en)
WO (1) WO2011121307A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2705021A2 (en) 2011-05-04 2014-03-12 Cadila Healthcare Limited Rasagiline and its pharmaceutically acceptable salts

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6021345A (en) 1991-05-17 2000-02-01 Cedars-Sinai Medical Center Methods for detecting propensity for fibrillation using an electrical restitution curve
US6094593A (en) 1991-05-17 2000-07-25 Cedars-Sinai Medical Center Method and apparatus for detecting prospenity for ventricular fibrillation using action potential curves
US7047067B2 (en) * 2002-05-31 2006-05-16 Uab Research Foundation Apparatus, methods, and computer program products for evaluating a risk of cardiac arrhythmias from restitution properties

Also Published As

Publication number Publication date
WO2011121307A1 (en) 2011-10-06

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)