WO2012144854A3 - 리코찰콘 ａ의 신규 용도 - Google Patents
리코찰콘 ａ의 신규 용도 Download PDFInfo
- Publication number
- WO2012144854A3 WO2012144854A3 PCT/KR2012/003066 KR2012003066W WO2012144854A3 WO 2012144854 A3 WO2012144854 A3 WO 2012144854A3 KR 2012003066 W KR2012003066 W KR 2012003066W WO 2012144854 A3 WO2012144854 A3 WO 2012144854A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pharmaceutical
- food composition
- ampk
- present
- hepatocytes
- Prior art date
Links
- KAZSKMJFUPEHHW-UHFFFAOYSA-N (2E)-3-[5-(1,1-dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hdyroxyphenyl)-2-propen-1-one Natural products COC1=CC(O)=C(C(C)(C)C=C)C=C1C=CC(=O)C1=CC=C(O)C=C1 KAZSKMJFUPEHHW-UHFFFAOYSA-N 0.000 title abstract 2
- IUCVKTHEUWACFB-UHFFFAOYSA-N Licochalcone A Natural products COC1=CC=C(C(C)(C)C=C)C=C1C=CC(=O)C1=CC=C(O)C=C1 IUCVKTHEUWACFB-UHFFFAOYSA-N 0.000 title abstract 2
- KAZSKMJFUPEHHW-DHZHZOJOSA-N Licochalcone A Chemical compound COC1=CC(O)=C(C(C)(C)C=C)C=C1\C=C\C(=O)C1=CC=C(O)C=C1 KAZSKMJFUPEHHW-DHZHZOJOSA-N 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 102100036009 5'-AMP-activated protein kinase catalytic subunit alpha-2 Human genes 0.000 abstract 3
- 101000783681 Homo sapiens 5'-AMP-activated protein kinase catalytic subunit alpha-2 Proteins 0.000 abstract 3
- 206010012289 Dementia Diseases 0.000 abstract 2
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 2
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 2
- 208000008589 Obesity Diseases 0.000 abstract 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 2
- 210000001789 adipocyte Anatomy 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000010706 fatty liver disease Diseases 0.000 abstract 2
- 210000003494 hepatocyte Anatomy 0.000 abstract 2
- 230000037356 lipid metabolism Effects 0.000 abstract 2
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 2
- 235000020824 obesity Nutrition 0.000 abstract 2
- 231100000240 steatosis hepatitis Toxicity 0.000 abstract 2
- 238000009825 accumulation Methods 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000004132 lipogenesis Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Food Science & Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Polymers & Plastics (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
본 발명은 리코찰콘 A를 유효성분으로 함유하는, AMPK 관련 질환, 구체적으로, 지질대사 이상, 고지혈증, 대사증후군, 비만, 지방간, 또는 퇴행성질환 (특히, 치매)의 예방,개선 또는 치료를 위한 약학적 또는 식품 조성물, 및 그의 용도를 제공한다. 본 발명에 따른 약학적 또는 식품 조성물은 지방세포의 분화 및 지방세포에서 지방 축적, 간세포에서 지방생합성을 유의적으로 감소시키고, 간세포에서 AMPK를 활성화하는 작용효과를 나타낸다. 따라서, AMPK 관련 질환, 구체적으로, 지질대사 이상, 고지혈증, 대사증후군, 비만, 지방간, 또는 퇴행성질환 (특히, 치매)의 예방 또는 치료에 유용하다.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12774686.5A EP2700402A4 (en) | 2011-04-21 | 2012-04-20 | NEW USES OF LICOCHALCONE A |
| EP15160846.0A EP2942056B1 (en) | 2011-04-21 | 2012-04-20 | Novel uses of licochalcone a |
| CN201280018883.8A CN103547262A (zh) | 2011-04-21 | 2012-04-20 | 甘草查耳酮a的新用途 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020110037180A KR101060942B1 (ko) | 2011-04-21 | 2011-04-21 | 리코찰콘 ａ의 신규 용도 |
| KR10-2011-0037180 | 2011-04-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2012144854A2 WO2012144854A2 (ko) | 2012-10-26 |
| WO2012144854A3 true WO2012144854A3 (ko) | 2013-03-07 |
Family
ID=44934002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/KR2012/003066 WO2012144854A2 (ko) | 2011-04-21 | 2012-04-20 | 리코찰콘 ａ의 신규 용도 |
Country Status (4)
| Country | Link |
|---|---|
| EP (2) | EP2700402A4 (ko) |
| KR (1) | KR101060942B1 (ko) |
| CN (1) | CN103547262A (ko) |
| WO (1) | WO2012144854A2 (ko) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106420902B (zh) * | 2016-10-13 | 2020-01-03 | 北京大学 | 胀果甘草提取物及甘草查耳酮a的保肝活性及药物新用途 |
| KR20240011490A (ko) | 2022-07-19 | 2024-01-26 | (주)네오크레마 | 감초 유래 리코칼콘 a를 유효성분으로 포함하는 dpp4 과발현 당뇨병 예방 또는 치료용 약학 조성물 |
| WO2024047248A1 (en) * | 2022-09-02 | 2024-03-07 | Institut National de la Santé et de la Recherche Médicale | Use of nrf2 activators for the treatment of cerebral small vessel disease |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04297418A (ja) * | 1991-02-07 | 1992-10-21 | Sumitomo Metal Ind Ltd | 血小板凝集抑制剤および白血球活性化抑制剤 |
| KR20070044602A (ko) * | 2005-10-25 | 2007-04-30 | 주식회사 바이오뉴트라 | 구운 감초 추출물을 함유하는 염증성 혈관손상, 혈관경화억제 또는 혈전증 억제용 조성물 |
| KR100950445B1 (ko) * | 2009-10-26 | 2010-04-02 | 주식회사 중앙백신연구소 | 감초로부터 얻은 조류, 돼지 인플루엔자 및 신종플루에 대한 항바이러스제 |
| KR20100077553A (ko) * | 2008-12-29 | 2010-07-08 | 주식회사 바이오뉴트라 | 리코칼콘 ａ를 포함하는 항염증 조성물 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003037316A1 (fr) * | 2001-10-11 | 2003-05-08 | Kaneka Corporation | Ligands de recepteurs actives par le proliferateur de peroxisome et procede de fabrication correspondant |
| JP5246833B2 (ja) * | 2005-12-16 | 2013-07-24 | 独立行政法人産業技術総合研究所 | アディポネクチン産生増強剤 |
| KR101034624B1 (ko) | 2009-06-17 | 2011-05-12 | 울산대학교 산학협력단 | 디디에이에이치를 활성화시키는 감초 유래의 칼콘 화합물 및 이를 유효성분으로 하는 췌장 베타세포 사멸 및 당뇨병성 신증의 예방 또는 치료용 조성물 |
-
2011
- 2011-04-21 KR KR1020110037180A patent/KR101060942B1/ko not_active IP Right Cessation
-
2012
- 2012-04-20 EP EP12774686.5A patent/EP2700402A4/en not_active Withdrawn
- 2012-04-20 WO PCT/KR2012/003066 patent/WO2012144854A2/ko active Application Filing
- 2012-04-20 CN CN201280018883.8A patent/CN103547262A/zh active Pending
- 2012-04-20 EP EP15160846.0A patent/EP2942056B1/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04297418A (ja) * | 1991-02-07 | 1992-10-21 | Sumitomo Metal Ind Ltd | 血小板凝集抑制剤および白血球活性化抑制剤 |
| KR20070044602A (ko) * | 2005-10-25 | 2007-04-30 | 주식회사 바이오뉴트라 | 구운 감초 추출물을 함유하는 염증성 혈관손상, 혈관경화억제 또는 혈전증 억제용 조성물 |
| KR20100077553A (ko) * | 2008-12-29 | 2010-07-08 | 주식회사 바이오뉴트라 | 리코칼콘 ａ를 포함하는 항염증 조성물 |
| KR100950445B1 (ko) * | 2009-10-26 | 2010-04-02 | 주식회사 중앙백신연구소 | 감초로부터 얻은 조류, 돼지 인플루엔자 및 신종플루에 대한 항바이러스제 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2700402A4 (en) | 2014-10-01 |
| KR101060942B1 (ko) | 2011-08-30 |
| EP2700402A2 (en) | 2014-02-26 |
| WO2012144854A2 (ko) | 2012-10-26 |
| EP2942056B1 (en) | 2019-05-29 |
| EP2942056A1 (en) | 2015-11-11 |
| CN103547262A (zh) | 2014-01-29 |
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