WO2012138254A3 - Pharmacologically active 4,4'-biphenylamide derivatives and drugs based thereon - Google Patents

Pharmacologically active 4,4'-biphenylamide derivatives and drugs based thereon Download PDF

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Publication number
WO2012138254A3
WO2012138254A3 PCT/RU2012/000238 RU2012000238W WO2012138254A3 WO 2012138254 A3 WO2012138254 A3 WO 2012138254A3 RU 2012000238 W RU2012000238 W RU 2012000238W WO 2012138254 A3 WO2012138254 A3 WO 2012138254A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmacologically active
drugs based
biphenylamide
derivatives
neurodegenerative diseases
Prior art date
Application number
PCT/RU2012/000238
Other languages
French (fr)
Russian (ru)
Other versions
WO2012138254A2 (en
Inventor
Максим Эдуардович ЗАПОЛЬСКИЙ
Николай Серафимович ЗЕФИРОВ
Владимир Александрович ПАЛЮЛИН
Мстислав Игоревич ЛАВРОВ
Алексей Сергеевич МОРОЗОВ
Вера Леонидовна ЛАПТЕВА
Original Assignee
Zapolsky Maxim Eduardovich
Zefirov Nikolay Serafimovich
Palyulin Vladimir Alexandrovich
Lavrov Mstislav Igorevich
Morozov Alexey Sergeevich
Lapteva Vera Leonidovna
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zapolsky Maxim Eduardovich, Zefirov Nikolay Serafimovich, Palyulin Vladimir Alexandrovich, Lavrov Mstislav Igorevich, Morozov Alexey Sergeevich, Lapteva Vera Leonidovna filed Critical Zapolsky Maxim Eduardovich
Publication of WO2012138254A2 publication Critical patent/WO2012138254A2/en
Publication of WO2012138254A3 publication Critical patent/WO2012138254A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

The invention relates to medicine and pharmacology. The novel 4,4'-biphenylamide derivatives are pharmacologically active and can be used as new effective allosteric modulators of АМРА receptors for treating Alzheimer's, Parkinson's and other neurodegenerative diseases. Also claimed are drugs for treating cognitive disorders, behavioural and mood disorders, deficit-type psychiatric disorders, attention deficit-hyperactivity disorder and other neurodegenerative diseases.
PCT/RU2012/000238 2011-04-06 2012-04-02 4,4'-biphenylamide derivatives having a pharmacological activity, and medicaments based thereon WO2012138254A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2011113045 2011-04-06
RU2011113045/15A RU2456266C1 (en) 2011-04-06 2011-04-06 4,4'-biphenylamide derivatives showing pharmacological activity, and based drug preparations

Publications (2)

Publication Number Publication Date
WO2012138254A2 WO2012138254A2 (en) 2012-10-11
WO2012138254A3 true WO2012138254A3 (en) 2012-12-13

Family

ID=46847377

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2012/000238 WO2012138254A2 (en) 2011-04-06 2012-04-02 4,4'-biphenylamide derivatives having a pharmacological activity, and medicaments based thereon

Country Status (2)

Country Link
RU (1) RU2456266C1 (en)
WO (1) WO2012138254A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006110173A2 (en) * 2004-10-05 2006-10-19 Smithkline Beecham Corporation Novel compounds
WO2007031791A1 (en) * 2005-09-16 2007-03-22 Arrow Therapeutics Limited Biphenyl derivatives and their use in treating hepatitis c
WO2010137351A1 (en) * 2009-05-29 2010-12-02 Raqualia Pharma Inc. Aryl substituted carboxamide derivatives as calcium or sodium channel blockers
RU2009126653A (en) * 2009-07-14 2011-01-20 Учреждение Российской Академии наук Институт физиологически активных веществ РАН (ИФАВ РАН) (RU) MEANS FOR RESTORING LOST MEMORY IN NORM AND PATHOLOGY IN PATIENTS OF ALL AGE GROUPS BASED ON N, N'-SUBSTITUTED 3,7-DIAZABICYCLO [3.3.1] NONAN, A PHARMACEUTICAL COMPOSITION BASED ON IT

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201041580A (en) * 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006110173A2 (en) * 2004-10-05 2006-10-19 Smithkline Beecham Corporation Novel compounds
WO2007031791A1 (en) * 2005-09-16 2007-03-22 Arrow Therapeutics Limited Biphenyl derivatives and their use in treating hepatitis c
WO2010137351A1 (en) * 2009-05-29 2010-12-02 Raqualia Pharma Inc. Aryl substituted carboxamide derivatives as calcium or sodium channel blockers
RU2009126653A (en) * 2009-07-14 2011-01-20 Учреждение Российской Академии наук Институт физиологически активных веществ РАН (ИФАВ РАН) (RU) MEANS FOR RESTORING LOST MEMORY IN NORM AND PATHOLOGY IN PATIENTS OF ALL AGE GROUPS BASED ON N, N'-SUBSTITUTED 3,7-DIAZABICYCLO [3.3.1] NONAN, A PHARMACEUTICAL COMPOSITION BASED ON IT

Also Published As

Publication number Publication date
RU2456266C1 (en) 2012-07-20
WO2012138254A2 (en) 2012-10-11

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