RU2009126653A - MEANS FOR RESTORING LOST MEMORY IN NORM AND PATHOLOGY IN PATIENTS OF ALL AGE GROUPS BASED ON N, N'-SUBSTITUTED 3,7-DIAZABICYCLO [3.3.1] NONAN, A PHARMACEUTICAL COMPOSITION BASED ON IT - Google Patents
MEANS FOR RESTORING LOST MEMORY IN NORM AND PATHOLOGY IN PATIENTS OF ALL AGE GROUPS BASED ON N, N'-SUBSTITUTED 3,7-DIAZABICYCLO [3.3.1] NONAN, A PHARMACEUTICAL COMPOSITION BASED ON IT Download PDFInfo
- Publication number
- RU2009126653A RU2009126653A RU2009126653/15A RU2009126653A RU2009126653A RU 2009126653 A RU2009126653 A RU 2009126653A RU 2009126653/15 A RU2009126653/15 A RU 2009126653/15A RU 2009126653 A RU2009126653 A RU 2009126653A RU 2009126653 A RU2009126653 A RU 2009126653A
- Authority
- RU
- Russia
- Prior art keywords
- dimethyl
- diazabicyclo
- bis
- carbonyl
- nonan
- Prior art date
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- 0 Cc1n[n](CC2=CC(IC)=C*(*)C=C2)c(*)c1 Chemical compound Cc1n[n](CC2=CC(IC)=C*(*)C=C2)c(*)c1 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
1. Применение производных N,N'-замещенных 3,7-диазабицикло[3.3.1]нонанов, в том числе оснований и их солей с фармакологически приемлемыми кислотами, общей формулой (1) в качестве средства для восстановления утраченной памяти в норме и патологии у пациентов всех возрастных групп ! ! в которой HY здесь и далее представляет фармакологически приемлемую кислоту; ! Е представляет карбонильную группу, CHR, где R представляет Н, низший алкил, циклоалкил, арил, аралкил, гетероарил, гидроксил, нитро-группу, галоген, алкокси, ацил, или группу общей формулы: ! -(CH2)n-Q, ! в которой n=1-10, a Q выбран из группы, состоящей из: !этенила, необязательно моно- или дизамещенного низшим алкилом или галогеном; ! циклоалкила; ! арила; ! гетероарила; ! галогена; ! группы COOR5, в которой R5 представляет Н, алкил, фенил; ! группы CH2OR5, в которой R5 имеет значения, определенные выше; ! группы NR6R7, в которой R6 и R7 могут быть одинаковыми или различными и каждый независимо представляет: ! Н, алкил, циклоалкил, аралкил; ! один из заместителей R6 или R7 может представлять группу C(O)R5, в которой R5 имеет значения, определенные выше; ! R1 представляет Н, низший алкил, циклоалкил, арил, аралкил, гетероарил, гидроксил, галоген, алкокси, ацил, нитро-группу, нитрил или группу общей формулы: ! -(CH2)n-W, ! в которой n имеет значения, определенные выше, a W выбран из группы, состоящей из: ! этенила, необязательно моно- или дизамещенного низшим алкилом или галогеном; ! циклоалкила; ! арила; ! гетероарила; ! галогена; ! группы COOR8, в которой R8 представляет Н, алкил, фенил; !группы CH2OR8, в которой R8 имеет значения, определенные выше; ! группы NR9R10, в которой R9 и R10 могут быть одинаковыми или различными, и каждый неза 1. The use of derivatives of N, N'-substituted 3,7-diazabicyclo [3.3.1] nonanes, including bases and their salts with pharmacologically acceptable acids, general formula (1) as a means to restore lost memory in normal and pathological conditions in patients of all age groups! ! in which HY hereinafter represents a pharmacologically acceptable acid; ! E represents a carbonyl group, CHR, where R represents H, lower alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, hydroxyl, nitro, halogen, alkoxy, acyl, or a group of the general formula:! - (CH2) n-Q,! in which n = 1-10, a Q is selected from the group consisting of:! ethenyl, optionally mono- or disubstituted with lower alkyl or halogen; ! cycloalkyl; ! aryl; ! heteroaryl; ! halogen; ! COOR5 groups in which R5 represents H, alkyl, phenyl; ! a CH2OR5 group in which R5 is as defined above; ! the NR6R7 group in which R6 and R7 may be the same or different and each independently represents:! H, alkyl, cycloalkyl, aralkyl; ! one of the substituents R6 or R7 may represent a group C (O) R5 in which R5 is as defined above; ! R1 represents H, lower alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, hydroxyl, halogen, alkoxy, acyl, nitro, nitrile or a group of the general formula:! - (CH2) n-W,! in which n has the meanings defined above, a W is selected from the group consisting of:! ethenyl optionally mono- or disubstituted with lower alkyl or halogen; ! cycloalkyl; ! aryl; ! heteroaryl; ! halogen; ! COOR8 groups in which R8 represents H, alkyl, phenyl; ! the group CH2OR8 in which R8 is as defined above; ! groups NR9R10, in which R9 and R10 may be the same or different, and each
Claims (11)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2009126653/15A RU2417082C2 (en) | 2009-07-14 | 2009-07-14 | N, n '-substituted 3, 7-diazabicyclo[3,3,1]nonane drug for memory regeneration in health and disease in patients of all age groups, based pharmaceutical composition and method of application thereof |
PCT/EP2010/004299 WO2011006653A1 (en) | 2009-07-14 | 2010-07-14 | An agent for restoring lost memory on the basis of n,n'-substituted 3,7-diazabicyclo[3.3.1] nonanes |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2009126653/15A RU2417082C2 (en) | 2009-07-14 | 2009-07-14 | N, n '-substituted 3, 7-diazabicyclo[3,3,1]nonane drug for memory regeneration in health and disease in patients of all age groups, based pharmaceutical composition and method of application thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2009126653A true RU2009126653A (en) | 2011-01-20 |
RU2417082C2 RU2417082C2 (en) | 2011-04-27 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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RU2009126653/15A RU2417082C2 (en) | 2009-07-14 | 2009-07-14 | N, n '-substituted 3, 7-diazabicyclo[3,3,1]nonane drug for memory regeneration in health and disease in patients of all age groups, based pharmaceutical composition and method of application thereof |
Country Status (2)
Country | Link |
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RU (1) | RU2417082C2 (en) |
WO (1) | WO2011006653A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2012138254A2 (en) * | 2011-04-06 | 2012-10-11 | Zapolsky Maxim Eduardovich | 4,4'-biphenylamide derivatives having a pharmacological activity, and medicaments based thereon |
WO2012148308A1 (en) * | 2011-04-26 | 2012-11-01 | Zapolsky Maxim Eduardovich | Pharmacologically active alicyclic ν,ν'-substituted 3,7-diazabicyclo[3.3.1]nonane derivatives and drugs based thereon |
RU2480470C2 (en) * | 2011-04-06 | 2013-04-27 | Максим Эдуардович Запольский | Tricyclic derivatives of n,n'-substituted 3,7-diazabicyclo[3,3,1]nonanes, having pharmacological activity, and medicinal agents based thereon |
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KR101391809B1 (en) | 2011-11-02 | 2014-05-21 | 인제대학교 산학협력단 | A Composition comprising 2,4,6,8-tetrakis (2-methoxyphenyl)-3,7-diazabicyclo[3.3.1] nonan-9-one as an active ingredient for treating and preventing cancer disease |
RU2613071C1 (en) * | 2015-09-18 | 2017-03-15 | Общество с ограниченной ответственностью "Цикломеморин" | N,n'-substituted 3,7-diazabicyclo[3.3.1]nonanes, pharmaceutical compositions based thereon and use thereof |
BR112020021194A2 (en) | 2018-04-18 | 2021-03-23 | Constallation Pharmaceuticals, Inc. | modulators of methyl modifying enzymes, compositions and uses thereof |
CN112262143A (en) | 2018-05-21 | 2021-01-22 | 星座制药公司 | Modulators of methyl-modified enzymes, compositions and uses thereof |
WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9726630D0 (en) * | 1997-12-18 | 1998-02-18 | Glaxo Group Ltd | Kv2.1 Antagonists |
DE60018312T2 (en) * | 1999-12-14 | 2005-08-18 | Neurosearch A/S | NEW HETEROARYL DIAZABIZYKLOALKANE |
JP2004538268A (en) * | 2001-06-01 | 2004-12-24 | ニューロサーチ、アクティーゼルスカブ | Novel heteroaryl-diazabicycloalkanes as CNS-modulators |
RU2333211C1 (en) | 2006-11-01 | 2008-09-10 | Институт физиологически активных веществ Российской Академии наук | N,n'-substituted 3,7-diazabicyclo[3,3,1]nonanes with pharmacological effect, pharmacological compositions on their base, and application method |
TWI454262B (en) * | 2006-11-02 | 2014-10-01 | Targacept Inc | Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloalkanes |
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2009
- 2009-07-14 RU RU2009126653/15A patent/RU2417082C2/en active
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2010
- 2010-07-14 WO PCT/EP2010/004299 patent/WO2011006653A1/en active Application Filing
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012138254A2 (en) * | 2011-04-06 | 2012-10-11 | Zapolsky Maxim Eduardovich | 4,4'-biphenylamide derivatives having a pharmacological activity, and medicaments based thereon |
WO2012138254A3 (en) * | 2011-04-06 | 2012-12-13 | Zapolsky Maxim Eduardovich | Pharmacologically active 4,4'-biphenylamide derivatives and drugs based thereon |
RU2480470C2 (en) * | 2011-04-06 | 2013-04-27 | Максим Эдуардович Запольский | Tricyclic derivatives of n,n'-substituted 3,7-diazabicyclo[3,3,1]nonanes, having pharmacological activity, and medicinal agents based thereon |
WO2012148308A1 (en) * | 2011-04-26 | 2012-11-01 | Zapolsky Maxim Eduardovich | Pharmacologically active alicyclic ν,ν'-substituted 3,7-diazabicyclo[3.3.1]nonane derivatives and drugs based thereon |
RU2489436C2 (en) * | 2011-04-26 | 2013-08-10 | Максим Эдуардович Запольский | Alicyclic derivatives of n,n'-substituted 3,7-diazabicyclo[3,3,1]nonanes, having pharmacological activity, and medicinal agents on their basis |
US9067940B2 (en) | 2011-04-26 | 2015-06-30 | Maxim Eduardovich Zapolsky | Alicyclic derivatives of N,N'-substituted 3,7-diazabicyclo[3.3.1]nonanes and medicaments based thereon |
EA025448B1 (en) * | 2011-04-26 | 2016-12-30 | Максим Эдуардович ЗАПОЛЬСКИЙ | Alicyclic n,n'-substituted 3,7-diazabicyclo[3.3.1]nonane derivatives and use thereof |
Also Published As
Publication number | Publication date |
---|---|
WO2011006653A1 (en) | 2011-01-20 |
RU2417082C2 (en) | 2011-04-27 |
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