WO2012134086A3 - Three-dimensional nanofiber scaffold for tissue repair and preparation method thereof - Google Patents

Three-dimensional nanofiber scaffold for tissue repair and preparation method thereof Download PDF

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Publication number
WO2012134086A3
WO2012134086A3 PCT/KR2012/001925 KR2012001925W WO2012134086A3 WO 2012134086 A3 WO2012134086 A3 WO 2012134086A3 KR 2012001925 W KR2012001925 W KR 2012001925W WO 2012134086 A3 WO2012134086 A3 WO 2012134086A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
tissue repair
nanofiber scaffold
dimensional nanofiber
scaffold
Prior art date
Application number
PCT/KR2012/001925
Other languages
French (fr)
Korean (ko)
Other versions
WO2012134086A2 (en
Inventor
정성린
권일근
김천호
양대혁
이정복
박하나
Original Assignee
경희대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 경희대학교 산학협력단 filed Critical 경희대학교 산학협력단
Priority to US14/008,408 priority Critical patent/US9242024B2/en
Publication of WO2012134086A2 publication Critical patent/WO2012134086A2/en
Publication of WO2012134086A3 publication Critical patent/WO2012134086A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/36—After-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/05—Alcohols; Metal alcoholates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
    • C08L89/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/14—Polymer mixtures characterised by other features containing polymeric additives characterised by shape
    • C08L2205/16—Fibres; Fibrils
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Dispersion Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Artificial Filaments (AREA)
  • Nonwoven Fabrics (AREA)
  • Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)

Abstract

The present invention relates to a scaffold for tissue repair, and more specifically to a three-dimensional nanofiber scaffold for tissue repair which can increase thickness and porosity of tissue using a simple method through ultra-sonication, and a preparation method thereof.
PCT/KR2012/001925 2011-03-29 2012-03-16 Three-dimensional nanofiber scaffold for tissue repair and preparation method thereof WO2012134086A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/008,408 US9242024B2 (en) 2011-03-29 2012-03-16 Three-dimensional nanofiber scaffold for tissue repair and preparation method thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2011-0028363 2011-03-29
KR20110028363A KR101186093B1 (en) 2011-03-29 2011-03-29 Fibrous 3-dimensional scaffold for tissue regeneration and method for manufacturing the same

Publications (2)

Publication Number Publication Date
WO2012134086A2 WO2012134086A2 (en) 2012-10-04
WO2012134086A3 true WO2012134086A3 (en) 2013-01-03

Family

ID=46932056

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/001925 WO2012134086A2 (en) 2011-03-29 2012-03-16 Three-dimensional nanofiber scaffold for tissue repair and preparation method thereof

Country Status (3)

Country Link
US (1) US9242024B2 (en)
KR (1) KR101186093B1 (en)
WO (1) WO2012134086A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101527469B1 (en) * 2013-11-04 2015-06-11 연세대학교 산학협력단 A Method for Fabrication of Porous fiber microstructure with various 3-dimensional Structures
US9132405B2 (en) 2014-02-12 2015-09-15 Ut-Battelle, Llc Method of synthesizing silica nanofibers using sound waves
KR101453796B1 (en) * 2014-03-14 2014-10-27 동아대학교 산학협력단 Nano-micro hybridfiber-based cell culture construct and assay chip comprising the same
CA2962927C (en) 2014-09-29 2023-04-25 Board Of Regents Of The University Of Nebraska Nanofiber structures and methods of synthesis and use thereof
ES2584405A1 (en) * 2016-06-08 2016-09-27 Universitat Politècnica De València Non-woven bioelastomer compound (Machine-translation by Google Translate, not legally binding)
AU2017335828B2 (en) 2016-09-28 2023-07-13 Board Of Regents Of The University Of Nebraska Nanofiber structures and methods of use thereof
US11738116B2 (en) 2017-06-09 2023-08-29 Board Of Regents Of The University Of Nebraska Expanded nanofiber structures comprising electrospun nanofibers and a plurality of holes and methods of making and use thereof
KR101947154B1 (en) * 2017-06-23 2019-02-12 포항공과대학교 산학협력단 Fabrication method and device for three-dimensional electrospun scaffold
KR101943307B1 (en) * 2017-06-29 2019-01-29 강원대학교산학협력단 Flexible Bioelectrode based on Nanoporous Membrane with High Specific Surface Area for Bio-signal Acquisition And Manufacturing Method Thereof
WO2019060393A1 (en) * 2017-09-19 2019-03-28 Board Of Regents Of The University Of Nebraska Nanofiber structures and methods of use thereof
KR102199703B1 (en) 2018-10-26 2021-01-11 계명대학교 산학협력단 Multi-layer bio-scaffold using 3D printing and method of manufacturing the same
KR102265451B1 (en) * 2018-11-30 2021-06-15 한국생산기술연구원 3-Dimensional fibrous scaffold, and method for preparing the same
KR102364168B1 (en) 2019-12-05 2022-02-17 부산대학교 산학협력단 Scaffolds for bone regeneration and method for producing the same
KR102125979B1 (en) 2020-02-04 2020-06-25 주식회사 나노바이오시스템 Cell culture scaffold for tissue regeneration and kit including the same
US20210246575A1 (en) * 2020-02-07 2021-08-12 University Of Georgia Research Foundation, Inc. Methods and devices for making nanofibers and nanofiber scaffolds
KR102499287B1 (en) 2020-07-09 2023-02-10 전남대학교산학협력단 Plasma-assisted flexible multi-scale topographic patches for engineering cellular behavior and tissue regeneration
CN115282334A (en) * 2022-01-10 2022-11-04 上海市第六人民医院 Piezoelectric type amino acid biological scaffold and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090034202A (en) * 2007-10-02 2009-04-07 주식회사 에이엠오 Nanofibers comprising naturalplant extract or naturalplant essential oil and method for producing the same
KR20090041271A (en) * 2007-10-23 2009-04-28 재단법인서울대학교산학협력재단 Method of controlling pore structure of nanofirous scaffold for tissue engineering and scaffold using the same
KR20090127371A (en) * 2007-03-29 2009-12-10 이 아이 듀폰 디 네모아 앤드 캄파니 Production of nanofibers by melt spinning
KR20110009702A (en) * 2008-05-13 2011-01-28 리써치 트라이앵글 인스티튜트 Porous and non-porous nanostructures and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130008542A (en) * 2010-03-02 2013-01-22 토탈 리서치 앤드 테크놀로지 펠루이 Nanocomposites with improved homogeneity

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090127371A (en) * 2007-03-29 2009-12-10 이 아이 듀폰 디 네모아 앤드 캄파니 Production of nanofibers by melt spinning
KR20090034202A (en) * 2007-10-02 2009-04-07 주식회사 에이엠오 Nanofibers comprising naturalplant extract or naturalplant essential oil and method for producing the same
KR20090041271A (en) * 2007-10-23 2009-04-28 재단법인서울대학교산학협력재단 Method of controlling pore structure of nanofirous scaffold for tissue engineering and scaffold using the same
KR20110009702A (en) * 2008-05-13 2011-01-28 리써치 트라이앵글 인스티튜트 Porous and non-porous nanostructures and application thereof

Also Published As

Publication number Publication date
WO2012134086A2 (en) 2012-10-04
US20140024760A1 (en) 2014-01-23
KR101186093B1 (en) 2012-09-27
US9242024B2 (en) 2016-01-26

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