WO2012125181A1 - Système d'administration de gouttes oculaires stériles en cartouches en bandoulière à pattes de rétraction de paupières - Google Patents

Système d'administration de gouttes oculaires stériles en cartouches en bandoulière à pattes de rétraction de paupières Download PDF

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Publication number
WO2012125181A1
WO2012125181A1 PCT/US2011/051826 US2011051826W WO2012125181A1 WO 2012125181 A1 WO2012125181 A1 WO 2012125181A1 US 2011051826 W US2011051826 W US 2011051826W WO 2012125181 A1 WO2012125181 A1 WO 2012125181A1
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WO
WIPO (PCT)
Prior art keywords
dispensing
ampoule
eyedrop
ampoules
dispenser housing
Prior art date
Application number
PCT/US2011/051826
Other languages
English (en)
Inventor
Alvin J. Marx
Original Assignee
Marx Alvin J
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2011/028235 external-priority patent/WO2011113028A2/fr
Application filed by Marx Alvin J filed Critical Marx Alvin J
Publication of WO2012125181A1 publication Critical patent/WO2012125181A1/fr
Priority to US14/024,527 priority Critical patent/US9549847B2/en
Priority to US15/414,414 priority patent/US20170196732A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye

Definitions

  • the present invention relates generally to the field of eyedrop dispensing devices.
  • the present invention relates more specifically to devices for facilitating the proper positioning of an eyedrop dispensing device and the automated dispensing of a fixed quantity of sterile eyedrop solution.
  • a bottle of eyedrop solution includes a drop dispenser that is built into the exit orifice of the container. To dispense the solution, the user squeezes the bottle forcing solution out of the exit orifice and into his or her eye.
  • Many users have trouble with dispensing eyedrops from standard dispensing bottles. The user has a tendency to blink when the drop is about to enter the eye, causing the drop to miss the eye and land on a closed lid or to one side of the eye. Therefore, eyedrop solution is frequently wasted due to the user blinking during the attempted application and the user ends up with eyedrop solution streaming down his or her face. Problems also occur when the user dispenses too much eyedrop solution (too many drops) accidentally.
  • the user may also think that they have dispensed a drop of solution properly when they may not have. Normally, the eye will only hold about 0.6 of a drop. Therefore, some of the drop will typically go onto the eyelid. It is extremely difficult for the user to know whether the proper 60% of the drop actually landed in the eye. In addition, the size of a drop for a given solution may vary significantly in size.
  • Thomas Keen in his U.S. Patent No. 4,543,096, discloses a dispenser with an eyelid opening device. The user is required to place a pair of lid spreading legs on the edge of the eyelids dangerously close to the eye and then press a lever arm to keep the eyelids apart. It is nearly impossible to exert enough pressure on the edge of the eyelid to keep the eye open without injuring the eye.
  • Thomas Sherman in his U.S. Patent No. 6,371,945, discloses an attachment for a bottle that includes a ring intended to help align the bottle with the eye. However, no attempt is made to hold the eyelids open.
  • Gary Campagna in his U.S. Patent No.
  • None of the above cited devices safely holds the user's eyelids open while dispensing eyedrops from a standard eyedrop bottle. Additionally, none of the above mentioned patents describe a device that allows the user to dispense a portioned amount of eyedrop solution in an automatic and repeatable fashion. None of the above cited inventions dispenses a precise amount of eyedrop solution and simultaneously holds the user's eyelids open while doing so.
  • the eyedrop solution is kept sterile until it is ready to be dispensed.
  • Another object of the present invention is to provide a mechanism that delivers individual measured dosages of an eyedrop solution from a sterile ampoule packet contained on a multi-ampoule packet band within the dispensing device.
  • Another object of the present invention is to provide an eyedrop dispensing device that automatically detects whether the user has properly positioned the dispensing device over the eye before activating the automatic dispensing system.
  • the present invention provides an automated eyedrop delivery system comprising an enclosure housing electronic and electromechanical components for the automated dispensing of eyedrop solution from a number of individually measured and packaged eyedrop solution ampoules.
  • the dispensing device includes an activation button as well as a number of LED indicators to facilitate the user's recognition of the condition of the device and of the eyedrop dispensing action.
  • the main body of the eyedrop delivery device includes a battery power supply, as well as electronic control circuitry for carrying out the method of eyedrop dispensing.
  • a sprocket drive motor directs the advancement of a loop cartridge comprising an oval band containing a number of eyedrop solution ampoules so as to move each of the ampoules one at a time into position for dispensing.
  • a cam drive motor rotates a cam which strikes a push rod that directs a dispensing hammer onto the flexible wall of the individual ampoule reservoir that is in position for dispensing.
  • the cartridge component containing the bandolier shaped (oval) band retaining the individual ampoule packets is positioned within and covered by a cartridge cover which fits over the delivery device housing and engages the appropriate sprocket drive and cam drive components.
  • the entire device is configured with an eyelid retracting leg assembly that includes two J-shaped flex eyelid retracting legs covered with cushioned skin engaging material.
  • the user holds the eyedrop delivery device in one hand, compressing the eyelid leg assembly together, then places the cushioned skin contacting material on the orbital ridge above and below the user's eye, and then releases the spring loaded eyelid retracting legs to facilitate the maintenance of the eye in an open condition. While holding the device in this manner, the user pushes the activation button with a finger of his free hand.
  • a process that initially detects whether the device is appropriately oriented to ensure that the eyedrop falls into the eye, then automatically advances the bandolier cartridge component to the next full eyedrop ampoule for dispensing.
  • the programmed control electronics direct the rotation of the cam component to move an ampoule dispensing hammer which compresses the ampoule aligned for dispensing and thereby discharging a dose of solution from the device.
  • Various additional condition indicators are provided within the system to facilitate the user's operation of the device and the accurate and complete dispensing of the eyedrop solution into the user's eye.
  • Fig. 1 is a perspective view of a preferred embodiment of the eyedrop delivery system of the present invention shown fully assembled.
  • Fig. 2 is a front elevational view of the preferred embodiment of the eyedrop delivery system of the present invention fully assembled.
  • Fig. 3 is a side elevational view of the preferred embodiment of the eyedrop delivery system of the present invention fully assembled.
  • Fig. 4 is an exploded assembly view of the preferred embodiment of the eyedrop delivery system of the present invention.
  • Fig. 5 is a front elevational view of the preferred embodiment of the eyedrop delivery system of the present invention shown without the cartridge cover and ampoule strip in place.
  • Fig. 6 is a partial cross-sectional side view of the preferred embodiment of the eyedrop delivery system of the present invention showing the internal electronic and electromechanical components.
  • Fig. 7 is an exploded assembly view of a portion of the preferred embodiment of the eyedrop delivery system of the present invention showing the electromechanical components.
  • Fig. 8 A is a detailed front plan view of the preferred embodiment of the ampoule strip of the present invention shown in an initial position with the caps of the ampoules positioned on the ampoule nozzles.
  • Fig. 8B is a detailed front plan view of the preferred embodiment of the ampoule strip of the present invention shown rotated into a dispensing position with one of the ampoule caps off.
  • Fig. 9 is a detailed partial cross-sectional view of the preferred embodiment of the ampoule strip of the present invention.
  • Fig. 10 is a detailed cross-sectional view of the preferred embodiment of a single ampoule of the present invention shown with the cap off and the ampoule wall compressed.
  • Fig. 11 is a flowchart of the eyedrop dispensing method associated with the system of the present invention.
  • Fig. 12 is a perspective view of a preferred method of use of the device of the present invention.
  • FIG. 1 a perspective view of a preferred embodiment of the eyedrop delivery system of the present invention in a fully assembled configuration.
  • Eyedrop delivery device 10 is shown to comprise main housing 12 with cartridge cover 14 positioned thereon.
  • the dispensing assembly is positioned on an eyelid retracting assembly made up primarily of first flex leg 16a and second flex leg 16b.
  • Each of the flex legs 16a & 16b extend and terminate in first and second eyelid retracting feet 18a & 18b.
  • This eyelid retracting assembly structure is comprised of a pair of curved bands of resilient, semi-rigid, plastic material that serve to support the housing components described above and to facilitate the retention of the eyelids in an open condition ready to receive the drop of eyedrop solution from an individual ampoule within the device.
  • the eyelid retracting structure accomplishes this by providing flexible, but resilient legs that terminate in soft cushioned feet that are positioned on the upper and lower orbital rim sites of the user's eye.
  • first flex leg 16a and second flex leg 16b extend from near a common point of attachment (away from their point of attachment) to the housing components of eyedrop delivery device 10.
  • Each flex leg 16a & 16b extends downward to terminate in a "J" shaped eyelid retracting foot.
  • First eyelid retracting foot 18a terminates first flex leg 16a
  • second eyelid retracting foot 18b terminates second flex leg 16b.
  • each of the eyelid retracting feet 18a & 18b are covered on at least one face with soft, resilient cushioned material so as to gently engage the skin of the user at the upper and lower orbital sites against which the device and delivery system is placed.
  • first and second when referring to the flex legs and eyelid retracting feet, are arbitrary designations herein and do not reflect a specific orientation of the device.
  • the device is designed to be utilized in conjunction with either eye and with either hand of the user.
  • the upper curved sections of flex legs 16a & 16b, on either side of main housing 12, provide the necessary spring resiliency to the eyelid retracting structure so as to allow the user to squeeze the first and second eyelid retracting feet 18a & 18b together for placement of the device against the face about the eye and thereafter release the legs slightly so as to allow for the expansion of the eyelid retracting structure and the corresponding opening of, or retention of the open condition of, the eye of the user.
  • activation button 20 is shown as a surface mounted button positioned on top of main housing 12.
  • Cartridge cover 14 is shown positioned on and attached to main housing 12 by way of cartridge cover clips 24, one on each side of main housing 12.
  • FIG. 2 a front elevational view of the preferred embodiment of the present invention, again shown assembled, with cartridge cover 14 in place over the main housing (not seen in this view).
  • the profile structures of the eyelid spreading components first and second flex legs 16a & 16b, and first and second eyelid retracting feet 18a & 18b
  • the manner in which resiliency is imparted to these components can also be seen, given the curved structures that extend from the base of eyedrop delivery device 10 which are positioned and oriented to facilitate the placement of the device.
  • the legs are first compressed and the feet positioned just inside the upper and lower orbital ridges.
  • Activation button 20 is again shown at a top position on eyedrop delivery device 10 accessible for the user to activate the system when delivery device 10 has been properly positioned and oriented over the user's eye.
  • the user is provided with a view of LED drop indicator 22, as well as an LED battery indicator (not shown), positioned on the bottom of eyedrop delivery device 10. The manner of the function of these LED indicators visible to the user while the device is positioned over the eye is described in more detail below.
  • Fig. 3 is a side elevational view of the preferred embodiment of the eyedrop delivery system of the present invention, again shown in a fully assembled configuration.
  • Eyedrop delivery device 10 is made up primarily of main housing 12 with cartridge cover 14 positioned thereon and attached by means of cartridge cover clips 24.
  • first flex leg 16a and first eyelid retracting foot 18a are visible.
  • LED drop indicator 22 and LED battery indicator 26 Positioned on the bottom of main housing 12 are LED drop indicator 22 and LED battery indicator 26.
  • the device of the present invention provides a very simple and straightforward set of indicators and controls to the user. After the user has properly positioned and placed the device against the face over the eye in the manner described above, both visible and audible indicators provide information regarding the proper orientation and battery condition of the device. Operation of the device is then a simple matter of the user pressing activation button 20 with a finger of the hand that is not holding the eyedrop delivery device 10 against the face.
  • One goal of the present invention is to make the delivery of a single drop (or a fixed incremental quantity) of eyedrop solution to the eye in a definitive manner that leaves no doubt in the user that the drop has been delivered to the proper place on the surface of the eye, thereby eliminating the need for re- administration of an eyedrop that may not have been properly administered.
  • Fig. 4 is an exploded assembly view of eyedrop delivery device 10 showing the manner in which the user may remove cartridge cover 14 and then remove and replace ampoule strip 42.
  • This assembly view of Fig. 4 also discloses some of the mechanical components that serve to advance the individual eyedrop solution dosages contained on ampoule strip 42.
  • the oval or bandolier shaped strip is pre-packaged with individual ampoule reservoirs 50 filled with the appropriate dosage of eyedrop solution.
  • main housing 12 of eyedrop delivery device 10 is shown with cartridge cover 14 removed.
  • the eyelid retracting components are again shown to be integrated into the structure of main housing 12 to facilitate the placement and positioning of the device over the user's eye.
  • Dispensing gate 41 represents a cut-out in the curved structure of the eyelid retracting assembly to the user's eye that permits the movement of a dispensed drop from the dispensing assembly to the user's eye in a manner described in more detail below.
  • Main housing 12 is again shown to comprise activation button 20 positioned at a top oriented external point. With cartridge cover 14 removed, cartridge cover clips 24 are shown to be released from cover clip recesses 40 on either side of main housing 12. Underneath cartridge cover 14 on main housing 12 are a number of components that serve to partially retain and guide ampoule strip 42 during operation of the eyedrop delivery device 10.
  • Mechanism cover 34 serves to isolate the ampoule strip cartridge system from the internal electromechanical workings of the device within main housing 12.
  • Strip guide base 35 supports ampoule strip guide 28 and defines an oval circumference channel within which ampoule strip 42 rotates or moves.
  • the perimeter of ampoule strip guide 28 is formed with strip installation alignment cutouts 36 that correspond to each of the individual ampoules 50 positioned on ampoule strip 42.
  • Drive sprocket 30 extends through one side of ampoule strip guide 28 and retains a number of sprocket posts 32 which engage ampoule strip sprocket teeth 48 on ampoule strip 42.
  • ampoule strip 42 is positioned over ampoule strip guide 28 around strip guide base 35 the ampoule strip is free to rotate or move as controlled and driven by drive sprocket 30 in a manner described in more detail below.
  • FIG. 4 Also shown in the view of Fig. 4 are the individual ampoule reservoirs 50 positioned on the inside face of ampoule strip 42, as well as ampoule caps 46 which cover dispensing nozzles (not seen in this view) until a particular ampoule is positioned and ready for dispensing. Tethered ampoule caps 46 are removed from these dispensing nozzles one at a time as the selected ampoule moves into position over dispensing gate 41. The removal of each ampoule cap 46 is carried out one at a time by hook arm 38. The manner of dislodging ampoule cap 46 in order to expose the ampoule dispensing nozzle is described in more detail below.
  • FIG. 5 is a front elevational view of the preferred embodiment of the eyedrop delivery system of the present invention shown without the cartridge cover and ampoule strip in place.
  • Eyedrop delivery device 10 in this view is again shown to be structured primarily of main housing 12 integrated with the eyelid retracting structures comprising first and second flex leg 16a & 16b, as well as first and second eyelid retracting feet 18a & 18b.
  • dispensing gate 41 is shown positioned between the two sides of the eyelid retracting assembly.
  • LED drop indicator 22 is shown positioned adjacent dispensing gate 41 where it is visible to the user while the dispensing device is being used.
  • Main housing 12 is, in this view, covered by mechanism cover 34 positioned behind ampoule strip guide 28.
  • Drive sprocket 30 extends through ampoule strip guide 28 and presents sprocket posts 32 in a forward orientation so as to engage the ampoule strip sprocket teeth on the ampoule strip (not shown).
  • Hook arm 38 is shown in profile in this view, positioned to appropriately engage the ampoule caps positioned around the perimeter of the ampoule strip.
  • FIG. 6 provides a partial cross-sectional side view of the preferred embodiment of the eyedrop delivery system of the present invention, disclosing in greater detail both the electromechanical components of the device, and the manner in which the dispensing of a single dosage of eyedrop solution is achieved.
  • Eyedrop delivery device 10 as shown in Fig. 6 again comprises main housing 12 fitted with cartridge cover 14.
  • the eyelid retracting components are shown integrated into the lower edge of main housing 12, and in this view are represented by second flex leg 16b and second eyelid retracting foot 18b.
  • Within main housing 12 are positioned and secured a variety of electronic and electromechanical devices that serve to carry out the operation of the system of the present invention.
  • Activation button 20 is shown to extend through the upper wall of main housing 12 where it engages activation switch 62.
  • Switch 62 is preferably a momentary switch that signals the processor circuitry on PC board 66 that the user intends to activate the device. The functionality associated with this initial pressing of activation button 20 and the start of the process for delivering a quantity of eyedrop solution is described in more detail below.
  • Sprocket drive motor 60 is shown within main housing 12 oriented so as to extend sprocket drive shaft 70 forward to retain drive sprocket 30 which directs and controls the rotation of drive sprocket 30, thereby rotating or advancing the ampoule strip.
  • batteries 64 which in the preferred embodiment comprise three AAA replaceable batteries. These batteries provide the electrical power necessary to not only run the system electronics, but also to power sprocket drive motor 60 and cam drive motor 68.
  • Cam drive motor 68 is connected by way of a cam shaft to cam 72 seen from the side in this view. Cam 72 rotates on and engages the top of a push rod, which in the view of Fig. 6 is surrounded by push rod spring 74. The bottom or hammer end of the push rod engages the top of one of the ampoule reservoirs 50 positioned on the interior circumferential surface of the ampoule strip.
  • PC board 66 shown positioned adjacent cam drive motor 68 in the view of Fig. 6, is connected to LED battery indicator 26 and LED drop indicator 22.
  • Microprocessor 67 programmed for carrying out the functionality of the present invention is also positioned on PC board 66 which receives power from batteries 64, directs the necessary signal current to the LED indicators, and the necessary drive current to each of the drive motors contained within main housing 12.
  • the system of the present invention advances the ampoule strip incrementally around an oval track, positioning in turn each of the individual ampoules on the ampoule strip at a bottom orientation whereby the rotation of cam 72 and the movement of the push rod downward directs the dispensing of a quantity of eyedrop solution from a single ampoule through the dispensing nozzle for that ampoule and out from the housing.
  • Fig. 7 provides an assembly view of a sub-assembly of the eyedrop delivery device 10 designated here as 10A, since the ampoule strip and the cartridge cover are not shown in this view.
  • main housing 12 is again shown to position activation button 20 at a top orientation thereof, and to have cover clip recesses 40 positioned on either side to receive and retain the cartridge cover (not shown).
  • sprocket drive motor 60 and cam drive motor 68 Positioned within main housing 12 are sprocket drive motor 60 and cam drive motor 68.
  • Sprocket drive shaft 70 extends from sprocket drive motor 60 and cam shaft 82 extends from cam drive motor 68.
  • Batteries 64 are shown positioned between the two drive motors.
  • Mechanism cover 34 is shown to be an oval plate that may be fixed in position over main housing 12 with a pair of apertures therethrough to allow sprocket drive shaft 70 and cam shaft 82 to operationally extend through mechanism cover 34 to their point of attachment with drive sprocket 30 and cam 72 respectively.
  • Positioned on a lower side of mechanism cover 34 is push rod guide 84 which slidingly retains, and allows the up and down movement of, push rod 86 against the return force of push rod spring 74.
  • push rod spring 74 holds push rod 86 captive between the top surface of push rod guide 84 and the rotating edge of cam 72.
  • cam shaft 82 directs the rotation of oblong shaped cam 72 in a manner that allows push rod 86 to raise and lower and thereby direct the hammer end of push rod 86 into the aligned ampoule for dispensing of the eyedrop solution.
  • ampoule strip guide 28 Positioned over mechanism cover 34 is ampoule strip guide 28 with strip guide base 35. As can be seen in Fig. 7, one end of ampoule strip guide 28 defines a large round aperture through which drive sprocket 30, having sprocket posts 32, may extend. When drive sprocket 30 is attached to sprocket drive shaft 70, sprocket posts 32 are positioned so as to extend slightly above (forward from) the surface of ampoule strip guide 28. In this manner, the ampoule strip sprocket teeth may slide along the forward facing surface of ampoule strip guide 28 while engaging in turn sprocket posts 32 positioned on rotating drive sprocket 30. This arrangement provides for positive engagement between the ampoule strip and the drive sprocket such that controlled rotation of drive sprocket 30 directs the movement of the ampoule strip in increments to align individual ampoules for dispensing.
  • Sprocket drive motor 60 and cam drive motor 68 are, in the preferred embodiment, DC stepping motors that allow for precise incremental rotation of their respective drive shafts for precise rotation of either drive sprocket 30 or cam 72.
  • the incremental operation of sprocket drive motor 60 is necessary in order to provide just the right rotation of drive sprocket 30 and therefore just the right rotation and advancement of the ampoule strip so as to sequentially orient and position one ampoule dispensing nozzle after the other in the proper orientation for eyedrop dispensing action. This process of orientation and the manner of moving the ampoule strip into position is described in more detail below.
  • cam drive motor 68 is a DC stepping motor that incrementally rotates cam 72 from its two extreme positions; where push rod 86 is fully elevated under the force of push rod spring 74 or fully depressed when cam 72 forces it downward against push rod spring 74.
  • precise incremental rotation of cam shaft 82 as driven by cam drive motor 68 is essential for the proper operation and full dispensing action of the device.
  • Figs. 8A & 8B are detailed front views of the dispensing port components of the preferred embodiment of the ampoule strip of the present invention shown first in an initial position with each of the ampoule caps in place (Fig. 8A), each ampoule cap sealed airtight, and second in a dispensing position with one of the ampoule caps removed for dispensing (Fig. 8B).
  • a small portion of main housing 12 is shown near the bottom, or dispensing end, of the device.
  • Dispensing gate 41 is oriented so as to allow for the passage of the eye drop solution out from the device into the user's eye in the manner described above.
  • ampoule strip 42 advances a number of individual eyedrop solution ampoules one at a time into position for dispensing.
  • Ampoule strip 42 is comprised of a flat band through which are positioned a number of ampoule reservoirs 50 and dispensing nozzles 88, as well as corresponding ampoule strip sprocket teeth 48.
  • the sprocket teeth 48 are provided to engage the sprocket posts of the drive sprocket, not seen in the views of Figs. 8A & 8B.
  • On the outside of ampoule strip 42 are positioned corresponding dispensing nozzles (covered in the view of Fig. 8A) onto which are positioned a number of ampoule caps 46.
  • a first ampoule cap 46a is shown positioned as it is initially placed over and retained on the associated dispensing nozzle when the ampoule strip is first inserted into the dispensing device.
  • the ampoule strip 42 is placed within the device and oriented so that ampoule sprocket teeth 48 appropriately engage the posts of the drive sprocket and a single one of the ampoules is oriented in the lowest downward dispensing position.
  • FIG. 8B shows the next step in the process, where hook arm 38 has dislodged the ampoule cap 46n from the dispensing nozzle 88n now in a position to appropriately dispense the eyedrop solution from its ampoule reservoir 50 when the system directs the push rod (not shown) down onto ampoule reservoir 50 in the manner described. Further advancement of ampoule strip 42, as directed by the drive sprocket, positions hook arm 38 appropriately for removal of the next ampoule cap, in this case the + 1 ampoule cap 46n+l. In this manner, the operation of the device progresses, although it is anticipated that the user directs the delivery of one dose eyedrop solution from a single ampoule during each use.
  • the system remains in the position shown in Fig. 8B until the user next activates the device, which thereafter directs the removal of the next ampoule cap and the rotation of the next dispensing nozzle into position.
  • Figs. 9 & 10 show in greater detail the preferred embodiment of the ampoule strip construction of the present invention.
  • Figs. 9 & 10 are detailed cross-sectional views of a portion of the ampoule strip showing the construction of the ampoule reservoirs and the ampoule caps that are progressively removed for dispensing.
  • Fig. 9 represents three such ampoule components laid out flat for clarity.
  • First and second ampoule reservoirs 50a & 50b are shown in line followed by a third or ampoule reservoir 50n, all positioned on the inside surface of ampoule strip 42.
  • first ampoule strip sprocket tooth 48a is followed by second ampoule strip sprocket tooth 48b followed by ampoule strip sprocket tooth 48n.
  • first, second and dispensing nozzles On the outward face of ampoule strip 42 are positioned first, second and dispensing nozzles, 88a, 88b & 88n. Each of these dispensing nozzles has a drop aperture represented in this view by first drop aperture 86a, second drop aperture 86b, and drop aperture 86n.
  • each of the nozzles is covered by its own ampoule cap comprising first ampoule cap 46a, second ampoule cap 46b, and ampoule cap 46n.
  • Each ampoule cap is configured with a recess comprising a cap catch represented here by first cap catch 90a, second cap catch 90b, and cap catch 90n.
  • This loading of the device may involve the placement of the ampoule strip 42 followed by the placement and positioning of the cartridge cover over the strip.
  • the ampoule strip may be loosely held (but accurately positioned) within the cartridge cover so that the loading process may occur in a single step.
  • Fig. 10 discloses in greater detail the specific action by which a measured dose of an eyedrop solution is dispensed from an individual ampoule.
  • ampoule reservoir 50 is shown being compressed by dispensing hammer 96 which in the preferred embodiment represents the lower end of the push rod associated with the cam drive mechanism of the device.
  • Dispensing hammer 96 is directed into the bubble shaped wall of ampoule reservoir 50 in a manner that forces the liquid solution from the reservoir through the dispensing nozzle 88 out through drop aperture 86.
  • This arrangement allows the eyedrop solution contained within the ampoule reservoir 50 to be maintained in a generally sterile condition up to the point when ampoule cap 46 is removed as described above.
  • Fig. 10 discloses in greater detail the specific action by which a measured dose of an eyedrop solution is dispensed from an individual ampoule.
  • ampoule reservoir 50 is shown being compressed by dispensing hammer 96 which in the preferred embodiment represents the lower end of the push rod associated with the cam drive mechanism of the device.
  • ampoule cap 46 is shown to comprise cap catch 90, as well as retainer strap 94 which is attached to the outer surface of ampoule strip 42.
  • Retainer strap 94 is designed to have a shape memory such that once ampoule cap 46 is released from its position over dispensing nozzle 88, it removes ampoule cap 46 sufficiently out of the way to allow dispensing drop 98 to easily fall from drop aperture 86 and out from the device.
  • Ampoule cap 46 is initially retained with an airtight seal on dispensing nozzle 88 against this shape memory of retainer strap 94 by way of retention ridge 92 positioned circumferentially around dispensing nozzle 88 and associated internally to the structure of ampoule cap 46.
  • Fig. 11 provides a brief overview flowchart of the method of operation of the dispensing device system of the present invention.
  • Step 108 if the battery and tilt angle are appropriate, then the microprocessor starts the drive motor for the ampoule strip. If at Step 112 the correct tilt angle is not present, than an audio signal beeps in short bursts until the correct angle is achieved. This ensures that when a quantity of eyedrop solution is dispensed from an ampoule, it falls by gravity through the opening in the main housing of the device into the user's eye and not to the side.
  • Step 110 if the microprocessor determines that battery power is low, the low battery LED turns on (visible to the user) and an audio signal beeps once. In the preferred embodiment of the present invention, the device will not operate beyond the indicator steps when the battery is low. Clearly, proper positioning of the ampoule strip and proper rotation of the dispensing cam are essential to the accurate and complete dispensing of the proper quantity of eyedrop solution from an ampoule.
  • Step 108 if the microprocessor determines that the battery and tilt angle are appropriate, it initiates the drive motor.
  • the drive motor rotates the ampoule strip one increment and stops at Step 114.
  • Step 116 a cover cap positioned near the base of the device is removed from an individual ampoule as it moves into its dispensing position.
  • Step 118 the dispensing cam motor starts and the cam causes the push rod to impact and press on the top of an individual ampoule.
  • One dosage drop is expressed from that ampoule at Step 120, and because of the appropriate tilt angle, exits the device and is directed properly into the eye of the user.
  • the plunger push rod
  • the device shuts down, this deactivation being indicated at Step 124 when the LED indicator turns off.
  • Fig. 12 for a description of the manner in which the eyedrop delivery device 10 of the invention is utilized in order to accurately dispense a drop of solution into the user's eye.
  • the user Oriented in the manner shown in Fig. 12, the user holds the device with the thumb 130 and forefinger 132 engaging first flex leg 16a and second flex leg 16b respectively in a manner that allows the user to initially squeeze the flex legs towards each other and then allow them to return to an extended position once the device has been placed against the skin of the user above the inferior orbital ridge and below the superior orbital ridge of the eye.
  • the device of the present invention imitates the action of a user that might utilize a thumb and forefinger to hold open the eyelids around the eye while a drop is being dispensed.
  • This use of the present device allows the user a free hand to actually control the dispensing of the eyedrop rather than being required to hold open the eye with one hand in a typically inadequate manner.
  • the device of the present invention is configured in a sufficiently compact form as to allow the user to push the activation button on the device with the hand that is not holding the device. In any case, once properly positioned and oriented, the user pushes the activation button and causes the device to accurately dispense a single dose of solution into the eye while the eyelids are being retained in an open position by way of the spring force in the flex leg components.

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  • Engineering & Computer Science (AREA)
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  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention concerne un système d'administration de gouttes oculaires conçu pour la distribution séquentielle automatisée de solution sous forme de gouttes à partir d'ampoules. Le dispositif de distribution comporte un commutateur d'activation et des indicateurs visuels et audibles pour faciliter la distribution. Le système comporte une batterie et des circuits de commande électroniques pour réaliser le procédé de distribution. Un moteur d'entraînement à pignon dirige la progression d'une bande de cartouche à boucle contenant des ampoules de solution en gouttes, déplaçant une à une chacune des ampoules vers la position de distribution. Un moteur d'entraînement à came fait tourner une came afin d'amener une tige-poussoir pour comprimer l'ampoule. Le système comporte un ensemble pattes de rétraction de paupières, deux pattes étant souples en forme de J avec des pieds en prise avec peau rembourrée. Le système détecte initialement si le dispositif est activé et orienté correctement. Le système avance automatiquement le composant cartouche vers l'ampoule à gouttes oculaires suivante le mettant en position de distribution. Pendant ce temps, le bout de l'ampoule est écarté.
PCT/US2011/051826 2010-03-11 2011-09-15 Système d'administration de gouttes oculaires stériles en cartouches en bandoulière à pattes de rétraction de paupières WO2012125181A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US14/024,527 US9549847B2 (en) 2010-03-11 2013-09-11 Bandolier cartridge sterile eyedrop delivery system with eyelid retracting legs and eyedrop delivery confirmation
US15/414,414 US20170196732A1 (en) 2010-03-11 2017-01-24 Strip Cartridge Sterile Eyedrop Delivery System with Eyelid Retracting Legs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US2011/028235 WO2011113028A2 (fr) 2010-03-11 2011-03-11 Système de distribution de gouttes oculaires incrémentiel automatique doté de pattes de rétraction de paupières
USPCT/US2011/028235 2011-03-11

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/028235 Continuation-In-Part WO2011113028A2 (fr) 2008-02-05 2011-03-11 Système de distribution de gouttes oculaires incrémentiel automatique doté de pattes de rétraction de paupières

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/024,527 Continuation-In-Part US9549847B2 (en) 2010-03-11 2013-09-11 Bandolier cartridge sterile eyedrop delivery system with eyelid retracting legs and eyedrop delivery confirmation

Publications (1)

Publication Number Publication Date
WO2012125181A1 true WO2012125181A1 (fr) 2012-09-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/051826 WO2012125181A1 (fr) 2010-03-11 2011-09-15 Système d'administration de gouttes oculaires stériles en cartouches en bandoulière à pattes de rétraction de paupières

Country Status (1)

Country Link
WO (1) WO2012125181A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040039355A1 (en) * 2002-08-26 2004-02-26 Gonzalez Jose M. Fluid dispensing devices and methods
US20050261641A1 (en) * 2002-09-26 2005-11-24 Warchol Mark P Method for ophthalmic administration of medicament
US20090259204A1 (en) * 2008-04-14 2009-10-15 Shabty Galdeti Method and Device for Applying Eye Drops
US20100022971A1 (en) * 2008-02-05 2010-01-28 Marx Alvin J Precision lid retracting eyedropper device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040039355A1 (en) * 2002-08-26 2004-02-26 Gonzalez Jose M. Fluid dispensing devices and methods
US20050261641A1 (en) * 2002-09-26 2005-11-24 Warchol Mark P Method for ophthalmic administration of medicament
US20100022971A1 (en) * 2008-02-05 2010-01-28 Marx Alvin J Precision lid retracting eyedropper device
US20090259204A1 (en) * 2008-04-14 2009-10-15 Shabty Galdeti Method and Device for Applying Eye Drops

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