WO2012122899A1 - 检测装置 - Google Patents

检测装置 Download PDF

Info

Publication number
WO2012122899A1
WO2012122899A1 PCT/CN2012/071858 CN2012071858W WO2012122899A1 WO 2012122899 A1 WO2012122899 A1 WO 2012122899A1 CN 2012071858 W CN2012071858 W CN 2012071858W WO 2012122899 A1 WO2012122899 A1 WO 2012122899A1
Authority
WO
WIPO (PCT)
Prior art keywords
chamber
sample
test
hole
detection
Prior art date
Application number
PCT/CN2012/071858
Other languages
English (en)
French (fr)
Inventor
汪建锋
胡海鹏
吴银飞
Original Assignee
艾博生物医药(杭州)有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 艾博生物医药(杭州)有限公司 filed Critical 艾博生物医药(杭州)有限公司
Publication of WO2012122899A1 publication Critical patent/WO2012122899A1/zh

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/08—Ergonomic or safety aspects of handling devices
    • B01L2200/082—Handling hazardous material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/025—Displaying results or values with integrated means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0609—Holders integrated in container to position an object
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0858—Side walls

Definitions

  • the present invention relates to a device for detecting a sample, and more particularly to a device for collecting and detecting a sample. Background technique
  • body fluid testing is a relatively common test. It is a common method to collect a test liquid sample using a detecting device or a test cup and determine whether the liquid sample contains an analyte. Such a test device or test cup generally requires the sample cup to be collected in the sample container. The person skilled in the art inserts the test reagent strip and immerses a portion of the reagent strip in the sample. After some time, the reagent strip is taken out and the test result is read. In this way, the technician may be exposed to the sample, the crisis is healthy or the sample is contaminated.
  • test devices such as those described in U.S. Patent 7,560,272, which, when used, collects fluid samples, such as urine, into a collection chamber of a test device in a concealed condition.
  • the fluid sample is tested in contact with the test element in the test chamber, such as drug screening.
  • This device has its own inherent defects.
  • the testee does not want to be tested for real results for some purpose.
  • the testee can first take a non-self-fluid sample such as water. For example, tap water is added to the test device, the dummy sample is discarded after the false sample test, and then the fluid sample is added to the collection chamber and handed to the professional tester.
  • the test results obtained in this way are not valid because of the "false" of the testee.
  • test device It is necessary to provide a "one-step" test device that can avoid the test subject from being falsified and make the test result real and effective, and the test device has a simple structure, low production cost, and simple operation steps, and can also avoid testing in advance. Summary of the invention
  • the present invention provides an improved sample receiving and detecting device.
  • Using the detection device can avoid the subject being "false”, such as replacing the sample or performing a fake sample test first, and then Replace with your own real sample.
  • the invention provides a detection device that includes a sample collection chamber and a detection chamber for collecting a fluid sample, which may include one or more test elements.
  • the sample collection chamber includes an opening for collecting a fluid sample, a cavity bottom, and a sidewall connecting the opening and the cavity bottom;
  • the test element includes a fluid sample application area and a test area, and a portion adjacent to the collection chamber opening further includes a pass A bore through which the collection chamber is in fluid communication with the sample application region of the test element.
  • the through holes are open on the walls constituting the detection chamber.
  • the test device further includes a protective cover that prevents the fluid sample from contacting the test element or contacting the sample application area of the test element directly through the through hole in the test chamber when the fluid sample is collected.
  • the sample application area of the test element is located adjacent the through hole in the detection chamber.
  • the test device further includes a cover that covers the opening, and when the test device is inverted, the fluid sample located in the collection chamber contacts the test element in the detection chamber through the through hole of the detection chamber.
  • the through hole is located between the maximum collection fluid height of the collection chamber and the opening.
  • the detection chamber is located within the collection chamber.
  • the apparatus further includes a buffer chamber through which the detection chamber communicates with the collection chamber.
  • the buffer chamber further comprises a through hole, and the fluid in the collecting chamber can enter the buffer chamber through the through hole in the buffer chamber, and the fluid entering the buffer chamber can enter the detecting chamber through the through hole in the detecting chamber and the test component contact.
  • the fluid in the collection chamber first enters the buffer chamber through the through hole of the buffer chamber and then enters the detection chamber through the through hole of the detection chamber.
  • the buffer chamber is juxtaposed in parallel with the detection chamber in the collection chamber, or the buffer chamber is located in close proximity with the detection chamber in the collection chamber.
  • the buffer chamber and/or the detection chamber may both be located outside of the collection chamber. More preferably, the passage formed in the through hole on the detecting chamber and the through hole in the buffer chamber is substantially parallel to the detecting chamber. In a preferred form, the through holes in the buffer chamber are located on the sides of the test element or on the sides of the test element or they are not on the same line, or on either side of the plate holding the test element. In some aspects, a portion of the sidewall of the collection chamber forms a portion of the sidewall of the detection chamber, or a portion of the sidewall of the detection chamber forms a portion of the sidewall of the buffer chamber.
  • the detecting chamber is a rectangular parallelepiped
  • the buffering chamber is close to the detecting chamber, and the size and shape are similar to the detecting chamber, wherein the through hole on the detecting chamber is located near the long side of the rectangular parallelepiped, and the through hole on the buffering chamber is located Near the other long side, both of the through holes are near the opening of the collection chamber.
  • the test chamber may contain one or more test elements for detecting a plurality of test components in the sample.
  • the test element is a test strip.
  • the test components are placed on a test board.
  • the present invention provides a detecting device comprising a collecting chamber for collecting a fluid sample, the collecting chamber comprising an opening, a cavity bottom and a side wall connecting the opening and the bottom of the cavity; and a detecting chamber comprising at least one in the detecting chamber a test element comprising a sample application area and a test area; a cover covering the opening of the collection chamber; wherein the device further includes a sample application area adjacent to the opening for allowing liquid in the collection chamber to enter the test element A through hole, wherein the sample application region is located in the vicinity of the through hole.
  • the through hole is located on the detection cavity.
  • the detection chamber is located within the collection chamber and shares a portion of the sidewall with the collection chamber.
  • the test device further includes a protective cover that prevents the fluid sample from contacting the test element or the sample application area of the test element directly through the through hole in the test chamber when the fluid sample is collected.
  • the detecting device further includes a buffer chamber, and the buffer chamber is located between the detecting chamber and the collecting chamber, and the buffer chamber includes a through hole communicating with the collecting chamber.
  • a test board is included in the detection chamber, at least one test element is disposed on the test board, and the through hole of the buffer chamber is located downstream of the through hole of the detection chamber.
  • the through hole of the buffer cavity and the through hole of the detection cavity are located on both sides of the test board.
  • the testing device further includes a protective cover that prevents the fluid sample from entering the buffer chamber directly through the through hole in the buffer chamber when the fluid sample is collected.
  • the purpose of adding a buffer chamber on the outside of the detection chamber is that after collecting the fluid sample in the collection chamber, moving the test device may cause the fluid sample in the collection chamber to slosh and splash into the detection chamber to cause an early reaction, because even if liquid is spilled
  • the spilled liquid also enters the buffer chamber first, and the liquid entering the buffer chamber is located in the buffer chamber and does not enter the detection chamber, thus indirectly protecting the test chamber.
  • the detection chamber and the buffer chamber are located in the collection chamber.
  • the present invention provides a method of detecting a sample, the method comprising:
  • a detection device comprising: a fluid sample collection chamber comprising an opening for collecting a fluid sample, a cavity bottom, and a sidewall connecting the opening and the cavity bottom; the detection chamber comprising at least one test element; the test element comprising a sample application area and a test area; wherein the sample application area is adjacent to the collection chamber opening; wherein the detection chamber further includes a through hole near the opening of the sample collection chamber, and the sample application area is in fluid communication with the sample collection chamber through the through hole;
  • the reverse detection device allows the collection chamber and the test chamber to stand upside down
  • the setting of the invention can effectively prevent the test subject from "fake” and is easy to operate, and the entire test can be completed in "one step”.
  • FIG. 1 is an exploded perspective view of a device in an embodiment of the present invention
  • Figure 2 is a structural view of the assembly chamber and the sealing body assembled in the apparatus of Figure 1; and a separation from the cover;
  • FIG. 3A is a schematic structural view of a detecting chamber or a buffer chamber of the apparatus of FIG. 1;
  • FIG. 3B is a perspective structural view of the closing body;
  • Figure 4 is a cross-sectional view of the apparatus of Figure 1;
  • Figure 5 is a cross-sectional view showing the test of the apparatus of the present invention.
  • Figure 6 is a flow chart showing the process of detecting the apparatus of the present invention, wherein D indicates a change in the liquid level.
  • Apparatus 100 cover 10, sealing body 20; test element 40, application area 41, test area 42, absorption area 43, test plate 30, collection chamber 54, collection chamber opening 51; side wall 50, cavity bottom 52, Test result reading window 53; buffer chamber bottom 68, detection chamber bottom 78, buffer chamber side wall 62, detection chamber side wall 63, detection chamber side wall 64, detection chamber 70; buffer chamber 60, sealing body 20, occlusion Element 21, portion 25 of the sealed buffer chamber, portion 24 sealing the detection chamber; welding faces 85, 86, 88; liquid level D; inverted fulcrums A, B, (:.
  • sample refers to any substance that needs to be assayed for the presence and/or analysis of the concentration of the analyte, or the substance that needs to determine the presence and/or amount of one or more samples of the analyte. Or substances that require a qualitative assessment.
  • the sample can be a fluid sample, such as a liquid sample.
  • Liquid Samples include body fluids such as blood, serum, plasma, saliva, urine, tears, semen, and bone marrow; liquid samples can also be water samples such as sea water, river water, river water, etc., or from domestic water, municipal or industrial water, runoff. Water or sewage; samples can be food samples such as milk and wine.
  • Mucus, semi-solid or solid samples can be used to make samples such as liquids, eluates, suspensions or leachates.
  • a throat or genital sample can be immersed in a liquid to make a sample.
  • the sample may include a liquid, a mixture of solids and gases, or any related mixture, such as a cell suspension in a diluent or solution.
  • Samples include biological materials such as cells, microorganisms, organelles, and biochemical complexes.
  • Liquid samples can be prepared from solid, semi-solid or highly viscous materials such as soil, feces, tissues, organs, biological fluids or other non-liquid samples in nature.
  • these solid or semi-solid samples can be mixed with a suitable solution such as a diluent.
  • a suitable solution such as a diluent.
  • the sample can be macerated, frozen and thawed, or other extraction methods can form a liquid sample.
  • the remaining particulate matter can be removed using conventional methods such as filtration or precipitation.
  • the sample is urine and the device is used to detect the amount of drug in the urine.
  • test component is any component that can perform tests.
  • the test component is a test strip.
  • the test strip can include a pair of substances with specific binding thereon for immunoassays.
  • the test strip can be a chemical test strip that judges the result by color change or other signal changes after the test is completed.
  • Samples suitable for detection by the present invention include, but are not limited to, body fluids, samples isolated from biological tissues or body fluids.
  • the sample can be saliva, blood, serum, plasma, urine, feces, spinal fluid, vaginal secretions, mucus and tissue.
  • the test element is not limited to one, and two or more test elements may be simultaneously located in the detecting device to separately test different components in the sample.
  • the test component can also be placed on a test board. detailed description
  • the apparatus 100 includes a detection chamber 70, a sample collection chamber 54, and a detection chamber 70 located within the sample collection chamber 54.
  • the sample collection chamber includes an opening 51 for collecting a fluid sample, connecting the chamber bottom 52 and the side wall 50 of the opening 51.
  • a through hole 80 is also included in the device.
  • the through hole 80 is located on the wall of the detecting chamber, through which the fluid sample in the collecting chamber 54 flows into the detecting chamber 70, and the through hole 80 is close to the opening of the collecting chamber. 51.
  • the "close to the opening” may be that the through hole is located below the opening, and any position above the bottom of the collection chamber may be located at any position between the openings 1/2, 2/3, 3/4 of the height of the collection chamber.
  • the through hole may be located on the side wall 63 of the detection chamber.
  • the position of the through hole 80 is preferably at a position above the height of the maximum collection fluid sample in which the collection chamber is pre-set so that when the fluid sample is collected, the fluid sample cannot enter the detection chamber before the device is inverted.
  • the test chamber 70 includes a test element, and the sample application area 41 of the test element is adjacent to the through hole 80 of the detection chamber 70.
  • the sample application area 41 of the test element referred to herein is a relative position adjacent to the through hole 80. It means that the fluid sample in the detection chamber is directly or indirectly after the detection chamber is inverted or the entire detection device is inverted. By entering the detection chamber along with the through hole 80 of the detection chamber, the fluid sample first contacts the sample application region 41 after entering the detection chamber, and then contacts the detection region 42. Preferably, the contact area 43 is finally contacted.
  • the test element can be relatively parallel to the detection chamber in the detection chamber, vertically in the detection chamber or otherwise located in the detection chamber.
  • the detection chamber 70 can only be in fluid communication with the collection chamber 54 through the through hole 80, and the remaining portion is sealed relative to the detection chamber, that is, the fluid in the collection chamber 54 can only enter the detection chamber through the through hole 80.
  • the opening is facing upward, and then the opening is sealed by the cover 10, at this time, since the collected fluid sample is generally at a position below the through hole 80 at the maximum height of the collection chamber, the fluid sample cannot Immediately enter the detection chamber directly, so the detection cannot be performed immediately.
  • the sample is collected at the position where the cover is located, at which time the fluid enters the detection chamber 70 through the through hole 80 and contacts the sample application area of the test element 40. 41.
  • the fluid then wets the detection zone 42 up the test strip (in the direction of the cavity bottom 52 to the opening) and determines whether the analyte is present in the fluid sample by reading the assay results on the detection zone. Since the entire detection chamber is only in communication with the detection chamber through the through hole 80, when the liquid flows from the collection chamber into the detection chamber, the gas in the detection chamber is sealed by the fluid sample to form a gas column, and the pressure is collected in the chamber due to the balance of internal and external pressure. The fluid sample does not fill the entire detection chamber, so smooth detection is possible.
  • the detection device of the present invention does not test immediately after collecting the sample (and is tested immediately as described in U.S. Patent 7,560,272), but After the collection is completed, the detection is performed after the device is inverted, so that when only the cavity is collected by the test subject without the cover body, the test subject cannot perform the test itself; thereby avoiding the suspicion of fraud.
  • it can be carried out in one step at the time of detection; it is simple and convenient.
  • a shielding element 21 may be included on the outside of the through hole, and the shielding element 21 may be located on the detection cavity, thus forming a protective cover.
  • the shielding element 21 can be tapered, hat-shaped, or tongue-shaped.
  • the occlusion element can function to collect fluid samples when the detection device is inverted.
  • the through holes 80 connecting the detection chamber 70 and the collection chamber 54 may be one or more, and the shape of the same holes may be any shape.
  • one shielding structure 21 may be disposed at each of the through holes, or several through holes may be disposed under one of the shielding structures.
  • the test element can be one or a plurality of test elements for different analytes, which can be placed on the test board 30, which is located in the detection chamber.
  • the shutter element 21 can be located directly on the wall of the detection chamber.
  • the side wall of the collection chamber corresponding to the test element detection zone can be transparent so that the test results on the test component within the test chamber can be viewed from the outside. More preferably, the side wall of the collection chamber corresponding to the test element is a planar structure rather than a normal arc shape, which facilitates scanning the test results on the test element with the scanning machine after the test is completed. Of course, the entire side wall enclosing the collection chamber is a transparent material such as a transparent plastic.
  • a buffer chamber 60 may be further disposed on the outer side of the detection chamber.
  • the buffer chamber 60 abuts the detection chamber 70.
  • the buffer chamber further includes a through hole 90 connecting the buffer chamber and the detecting chamber 54 to form a wall of the buffer chamber 60. 62 faces the collection chamber 54.
  • the detection chamber 70 is indirectly communicated with the collection chamber 54 through the buffer chamber 60.
  • the buffer chamber 60 can be in fluid communication with the collection chamber 54 only through the through-holes 90.
  • the through hole 90 is preferably located near the opening 51, for example, near the sample application area of the test element, and the position of the through hole 90 has the same variety of positions as the through hole 80. Of course, it is preferably located at the collection.
  • the cavity is set above the maximum collected fluid sample.
  • the positional setting with respect to the through hole 80 connecting the buffer chamber and the test chamber can be freely much.
  • the main function of adding a buffer chamber 60 outside the detection chamber 70 is: If there is no buffer chamber, after collecting the liquid in the collection chamber, the collection chamber 54 containing the fluid sample is required to be short-distance (for example, from the toilet to the toilet).
  • the laboratory is transported to the laboratory.
  • the fluid sample may be shaken during transport, so the fluctuating fluid may directly enter the through hole 80 in the test chamber, thereby contaminating the test chamber or the test element in the test chamber.
  • the fluctuating fluid first enters the buffer chamber 60.
  • the amount of the fluctuating fluid is relatively small, if there is a fluctuating fluid, they are collected at the buffer chamber bottom 68. Since the through hole 80 connecting the buffer chamber and the detecting chamber is located close to the opening 51, it is not because of a small amount The fluid overflows to contaminate the detection chamber or test element.
  • the inverted manner is arbitrary, and any position on the cover can be inverted as a fulcrum.
  • Fig. 6 shows a mode that is caused when the operation is performed. In this mode, point C serves as an inverted fulcrum.
  • the fluid sample may first enter the buffer chamber through the through hole 90 in the buffer chamber (when the through hole 90 on the buffer chamber is located below and serves as the inverted fulcrum B), but Fluid entering the buffer chamber does not enter the detection chamber.
  • the collecting chamber shown in Fig. 3 if the inversion is made as the fulcrum A at the place where the through hole 80 is inserted, it is safer since the buffer chamber has no liquid to enter.
  • the blocking element 21 is also included in the through hole 90 of the buffer chamber. It will of course be understood that in such an arrangement, it is not necessary to provide the blocking element 21 on the through hole 80 in the detecting chamber 70. Of course, the blocking element 21 may not be provided on the through hole 90 of the buffer chamber. Because of the action of the buffer chamber, there is less impact on the test components in the test chamber without obstructing the components.
  • the present invention also provides a method of producing the test device for more convenient fabrication of the device of the present invention and assembly of the device of the present invention.
  • the method includes the steps of: providing a collection chamber as shown in Figure 3B, separating the detection chamber 70 or the detection chamber 70 with the buffer chamber 60 within the collection chamber.
  • the bottom 68 of the detection chamber and the bottom 78 of the buffer chamber share a bottom with the collection chamber (as shown in Figure 4).
  • the detection chamber 70 and the buffer chamber 60 are rectangular openings, while the detection chamber and the buffer chamber are surrounded by side walls 64, 63, 62 and a portion of the side wall 50 of the collection chamber.
  • a notch 91 is formed in the wall of the buffer chamber, and a notch 80 is formed in the wall 63 common to the detecting chamber and the buffer chamber.
  • the two notches are sealed by the sealing cover 20 to form the through holes 80 in the detecting chamber and the through holes 90 in the buffer chamber respectively; in Fig. 3B, they are located on both sides of the test board or on opposite sides of the buffer chamber.
  • the assembled test plate 30 with the test element 40 is then inserted into the test chamber with the sample application area of the test element located adjacent the gap 81.
  • a sealing body 20 is provided, which is shaped like a detection chamber or a detection chamber with a buffer chamber, and can be sealed at the opening of the detection chamber or at the same time to seal the detection chamber and the buffer chamber.
  • the sealing body 30 can also be a plastic material.
  • the sealing chamber and the buffer chamber opening are sealed by welding to form two independent cavities: a detecting chamber 70 and a buffer chamber 60, and the two chambers pass through the gaps 801 and 91.
  • the two through holes 80 and 90 are formed to communicate (Fig. 2, 4).
  • the sealing body includes two plane regions. Fields 24 and 25 correspond to the openings of the buffer chamber and the detection chamber, respectively.
  • the sealing body can comprise a blocking element 21 corresponding to the through hole 91, and the sealing body and the shielding element 21 can be formed at one time.
  • Such a device first uses a collection chamber to receive a fluid sample during use, preferably the height of the collected fluid sample does not exceed the through hole 90 in the buffer chamber 60.
  • a fluid sample such as urine
  • the excess fluid sample will also flow into the buffer chamber 60 through the through hole 90, and since the through hole 80 in the detection chamber is located near the opening 51, That is, away from the cavity bottom 52, liquid entering the buffer chamber 60 does not enter the detection chamber 70.
  • the tester covers the lid 10 to the opening 51 (Fig. 4, 2), and then inverts the detecting device. At this time, the fluid sample passes through the communication buffer chamber 60 and the collecting chamber 54.
  • the through hole 90 and the through hole 80 connecting the buffer chamber 60 and the detecting chamber 70 enter the detecting chamber 70 to contact the sample applying region 41 of the test element, and the sample entering the applied region sequentially passes through the detecting region 42 and the sample absorbing region 43 (if any) Word);
  • the final test is completed, the whole process is shown in Figure 6.

Description

检测装置
技术领域
本发明涉及检测样本的装置， 尤其是集收集和检测样本于一体的装置。 背景技术
在医疗诊断领域，体液检测是比较常见的检测。利用检测装置或者检测杯来 收集检测液体样本， 并判断液体样本中是否含有被分析物， 是一种比较普遍的方 法。这样的检测装置或者检测杯一般要求样本杯收集在样本容器内，相关技术人 员插入检测试剂条并使试剂条的一部分浸没在样本中，若干时间后取出试剂条并 读取检测结果。这种方式的检测， 技术人员可能会接触到样本， 危机健康或者使 样本受污染。
目前， 存在一些 "一步"法测试装置， 例如美国专利 7560272 所描述的装 置， 使用时， 一旦被测试的人在隐蔽情况下把流体样本， 例如尿液， 收集流体样 本到测试装置的收集腔中， 流体样本就和检测腔内的测试元件接触进行测试化 验，例如毒品筛查。这种装置却有其固有的缺陷，例如，被测试者为了某种目的， 并不希望自己被测试出真实的结果，在隐蔽情况下，被测试者可以先把水等非自 身的流体样本， 例如自来水， 加入到测试装置， 进行假样本测试后丢弃假样本， 然后再把自己的流体样本加入到收集腔中交给专业测试者。这样获得的测试结果 因为被测试者的 "作假"而非真实有效。
国际专利申请， 公开号 W02010/12119也公开了另一种测试装置， 该装置为 了解决当收集的样本很少的情况下也可以顺利得到测试。但是， 这样的装置在样 本量正常或偏多的情况下，装置的晃动会让流体样本溅起或部分被溅到测试元件 上进行非正常的提前测试。
这就有必要提供一种可以避免被测试者进行作假而让测试结果真实有效，同 时测试装置结构简单， 制作成本低廉， 操作步骤简单的 "一步"法测试装置， 另 外也可以避免提前进行测试。 发明内容
为了解决上述问题， 本发明提供了一种改进的样本收检测装置。 使用该检 测装置可以避免被测试者 "作假"， 例如替换样本或先进行假样本测试， 然后在 替换为自己真实的样本。
一方面，本发明提供一种检测装置， 该装置包括用于收集流体样本的样本收 集腔和检测腔， 检测腔里可以包括一个或多个测试元件。
在一个方式中， 样本收集腔包括用于收集流体样本的开口， 腔底， 以及连 接开口和腔底的侧壁； 测试元件包括流体样本施加区域和测试区域， 靠近收集 腔开口的地方还包括一通孔，收集腔通过该通孔与测试元件的样本施加区域流体 连通。 优选的， 通孔开于构成检测腔的壁上。 优选的， 测试装置还包括一个保护 罩， 当收集流体样本的时候，保护罩可以避免流体样本直接通过检测腔上的通孔 与测试元件接触或者与测试元件的样本施加区域接触。优选的，测试元件的样本 施加区域位于检测腔上通孔的附近。
在一个实施方式中， 该测试装置还包括一个盖合开口的盖体， 当测试装置 被倒置后，位于收集腔内的流体样本通过检测腔的通孔与检测腔内的测试元件接 触。 优选的， 通孔位于收集腔最大收集流体高度和开口之间。
在另一个实施方式中， 检测腔位于收集腔内。 在另一个方式中， 该装置还 包括一个缓冲腔， 检测腔通过缓冲腔与收集腔连通。优选的， 缓冲腔还包括一个 通孔， 收集腔内的流体可以通过缓冲腔中的通孔进入缓冲腔中，进入缓冲腔中的 流体可以通过检测腔上的通孔进入检测腔并与测试元件接触。 在另一个方式中， 收集腔内的流体先通过缓冲腔的通孔进入缓冲腔中，然后通过检测腔的通孔进入 检测腔中。在优选的方式中， 缓冲腔与检测腔平行并列位于收集腔中， 或者缓冲 腔与检测腔紧靠在一起位于收集腔中。 可选的， 缓冲腔和 /或检测腔可以都位于 收集腔之外。 更优选的， 检测腔上的通孔与缓冲腔上的通孔所形成的通道与检 测腔大体平行。在一个优选的方式中， 缓冲腔上的通孔与检测腔上通孔位于测试 元件的两侧或他们不位于同一直线上， 或者位于保持有测试元件的板的两侧。在 一些方式中， 收集腔的部分侧壁构成检测腔的部分侧壁， 或者检测腔的部分侧壁 构成缓冲腔的部分侧壁。在另一些方式中， 检测腔为长方体， 缓冲腔与检测腔紧 靠在一起， 并且大小形状与检测腔相似，其中检测腔上的通孔位于长方体的靠近 长边， 缓冲腔上的通孔位于另一长边附近， 同时两各个通孔都靠近收集腔的开口 附近。
检测腔内可以包含一个或多个测试元件，用于检测样本中多种检测成分。一 些实施方式中， 测试元件为试纸条。在一些方式中， 测试元件被设置在一个测试 板上。
另一方面，本发明提供一种检测装置， 该装置包括用于收集流体样本的收集 腔， 收集腔包括开口， 腔底以及连接开口和腔底的侧壁； 检测腔， 检测腔中包括 至少一个测试元件，测试元件包括样本施加区域和测试区域； 一个盖合收集腔开 口的盖体； 其中，装置在靠近开口的附近还包括一个能够让收集腔里的液体进入 测试元件上的样本施加区域的通孔，其中样本施加区域位于通孔的附近。优选的， 该通孔位于检测腔上。
在一个优选的方式中，检测腔位于收集腔内并与收集腔共用部分侧壁。优选 的， 测试装置还包括一个保护罩， 当收集流体样本的时候， 保护罩可以避免流体 样本直接通过检测腔上的通孔与测试元件接触或者与测试元件的样本施加区域 接触。
在另一个优选的方式中，检测装置还包括一个缓冲腔， 同时缓冲腔位于检测 腔与收集腔之间， 缓冲腔上包括一个与收集腔连通的通孔。更优选的， 在检测腔 内包括一个测试板，测试板上布置了至少一个测试元件， 同时缓冲腔的通孔位于 检测腔通孔的下游。 优选的， 缓冲腔的通孔和检测腔的通孔位于测试板的两侧。 优选的， 测试装置还包括一个保护罩， 当收集流体样本的时候， 保护罩可以避免 流体样本直接通过缓冲腔上的通孔进入缓冲腔中。在检测腔的外侧增加一个缓冲 腔的目的在于当收集好流体样本在收集腔后，移动测试装置可能引起收集腔内的 流体样本晃动而溅进检测腔中引起提前反应， 因为就算有液体溅出，被溅出的液 体也首先进入缓冲腔中， 而进入缓冲腔的液体位于缓冲腔内而不会进入检测腔， 这样间接对测试腔起到保护作用。 优选的， 检测腔和缓冲腔位于收集腔中。
另一方面， 本发明提供一种检测样本的方法， 该方法包括：
提供一个检测装置， 该装置包括样： 流体样本收集腔， 包括用于收集流体样本 的开口， 腔底， 以及连接开口和腔底的侧壁； 检测腔， 包括至少一个测试元 件； 该测试元件包括样本施加区域和测试区域； 其中样本施加区域靠近所述 的收集腔开口； 其中， 检测腔在靠近样本收集腔开口的地方还包括一通孔， 样本施加区域通过该通孔与样本收集腔流体连通；
通过收集腔的开口收集流体样本； 盖合盖体到开口上密封收集腔；
倒转检测装置让收集腔和测试间倒立；
读取测试元件测试区上的测试结果。 有益效果
本发明设置可以有效防止被测试者 "作假"并且操作简单， 只要 "一步" 就可以完成整个检测。
附图说明
图 1是本发明的一个具体实施方式中的装置的分解示意图；
图 2是图 1装置中组装好的收集腔和密封体的结构图； 以及与盖体的分离示 意图；
图 3A是图 1装置的检测腔或缓冲腔结构示意图； 图 3B为封闭体的立体结构 图；
图 4是图 1装置的剖面图；
图 5是本发明的装置进行测试的剖面图；
图 6是本发明的装置进行检测过程流程图图， 其中 D表示液面得变化。
附图标志说明
本发明装置 100， 盖体 10， 密封体 20; 测试元件 40， 施加区域 41， 测 试区域 42， 吸收区域 43， 测试板 30， 收集腔 54， 收集腔开口 51 ; 侧壁 50， 腔底 52， 测试结果读取窗口 53 ; 缓冲腔腔底 68， 检测腔腔底 78， 缓冲 腔侧壁 62， 检测腔侧壁 63， 检测腔侧壁 64， 检测腔 70; 缓冲腔 60， 密封体 20， 遮挡元件 21， 密封缓冲腔的部分 25， 密封检测腔的部分 24; 焊接面 85， 86， 88； 液面 D; 倒立支点 A， B， （：。
详细描述
下面对液体样本收集装置的结构或这些所使用的技术术语做进一步的说明 一些具体的实施方式， 这些说明并不是对本发明的进一步限制。
样本
本发明指的 "样本"指的是需要化验是否存在和（或）分析被分析物质浓度 的任何物质， 或需要确定一种或多种样本是否存在和（或）数量的被分析物质的 物质， 或需要进行定性评估的物质。 样本可以是流体样本， 例如液体样本。 液体 样本包括体液， 比如血液、 血清、 血浆、 唾液、 尿、 眼泪、 精液和骨髓； 液体样 本也可以是水样本， 比如海水、 江水、 河水等， 或者来自家庭用水、 市政用水或 工业水资源、 径流水或污水； 样本可以是食物样本， 比如牛奶和酒。 粘液、 半固 体或固体样本可以用来制作液体、 洗出液、 悬浮液或浸出液等样本。 例如， 喉咙 或生殖器试样可以浸泡在液体中制成样本。样本可以包括液体、固体和气体的混 合物或任何相关的混合物， 比如稀释液或溶液中的细胞悬浮液。样本包括生物物 质， 比如细胞、微生物、细胞器和生化复合物。液体样本可以从诸如土壤、粪便、 组织、器官、 生物体液或其它自然界中非液体样本等固体、半固体或高粘度物质 制取。例如， 这些固体或半固体样本可以与稀释液一类适当的溶液混合。样本可 以被浸软、冷冻和解冻， 或者其他提取方法形成液体样本。剩余的颗粒状物质可 以使用过滤或沉淀等传统的方法去除。一个具体实施例中， 该样本为尿液， 该装 置用于检测尿液中毒品的含量。
测试元件
"测试元件"是任何可执行测试的元件。 在一个实施例中， 测试元件是测试 条。该测试条可包括在其上用于免疫分析的具有特异性结合的物质对。测试条可 以是一种在检测完成后通过颜色变化或者其他信号变化判断结果的化学测试条。 适用本发明进行检测的样本包括但不限于体液， 从生物组织或体液中分离的样 本。 例如， 样本可以是唾液， 血液， 血清， 血浆， 尿， 排泄物， 脊髓液， 阴道分 泌液， 黏液和组织。测试元件不限于一个， 可以是两个或多个测试元件同时位于 检测装置中，分别测试样本中不同组分。测试元件还可以被设置在一个测试板上。 具体实施方式
在以下的详细描述中，附图和对应的文字说明仅仅是以举例的方式说明本发 明可能实行的特定具体方案的方式。我们并不排除本发明还可以在不违背本发明 权利要求范围内的任何其他具体实施方式。
如图 1-5为本发明的一些具体实施方式。本发明的一个具体实施例中， 该装 置 100包括检测腔 70， 样本收集腔 54， 检测腔 70位于样本收集腔 54内。 样本 收集腔包括收集流体样本的开口 51， 连接腔底 52和开口 51的侧壁 50。 在装置 上还包括一个通孔 80， 例如通孔 80位于检测腔的壁上， 通过该通孔 80让收集 腔 54内的流体样本流入到检测腔 70中， 并且通孔 80靠近收集腔的开口 51。 这 里所说的 "靠近开口"可以是通孔位于开口以下， 收集腔底部以上的任意位置， 可以位于收集腔高度的 1/2、 2/3、 3/4处到开口之间的任意位置上； 通孔可以位 于检测腔的侧壁 63上。当然，通孔 80的位置最好是在收集腔预先设置最大收集 流体样本高度之上的某一个位置， 这样当收集流体样本后，流体样本不能在装置 未被倒置前就进入检测腔内。 在一个优选的方式中， 检测腔 70中包括一个测试 元件， 测试元件的样本施加区域 41靠近检测腔 70的通孔 80。 这里所说的测试 元件的样本施加区 41域靠近通孔 80是一个相对位置的设置，它所指的是当检测 腔被倒置或整个检测装置被倒置后，检测腔里的流体样本直接或间接通过连同检 测腔的通孔 80进入检测腔里， 进入检测腔后流体样本先接触样本施加区域 41， 然后再接触检测区域 42。 优选的， 最后接触吸收区域 43。 测试元件在检测腔可 以与检测腔相对平行， 竖直地位于检测腔中或其他方式位于检测腔中。
检测腔 70只能通过通孔 80与收集腔 54流体连通， 其余部分相对于检测腔 为密封， 也就是说， 收集腔 54内的流体只能通过通孔 80进入检测腔内。 这样， 当用开口 51接收流体样本后，开口朝上，然后用盖体 10密封开口后，这个时候， 由于收集的流体样本在收集腔的最大高度一般处于通孔 80以下的位置， 流体样 本不能马上直接进入检测腔， 所以检测并不能马上进行。 当倒转密封的收集腔 51后或倒置整个装置后 （图 5)， 样本在盖体所在的位置汇集起来， 这个时候流 体通过通孔 80进入检测腔 70后， 并接触测试元件 40的样本施加区域 41， 然后 流体沿着测试条向上 （沿着腔底 52到开口的方向）湿润检测区域 42， 通过读取 检测区域上的化验结果来判断流体样本中是否存在被分析物质。因为整个检测腔 只有通过通孔 80与检测腔连通， 当液体从收集腔流入到检测腔中， 在检测腔内 的气体被流体样本密封形成一个气体柱， 由于内外压力的平衡，所以收集腔内的 流体样本不会充满整个检测腔， 因此可以进行顺利的检测。通过这样的方式， 由 于测试元件不同于传统检测装置的放置方式，本发明的检测装置在收集好样本后 不会马上进行测试 （而不同于美国专利 7560272所描述的那样马上进行测试）， 而是收集好后，倒置装置后才进行检测， 这样当只给被测试者收集腔而没有盖体 的情况下， 被测试者自己不能进行检测化验； 从而避免的作假的嫌疑。 另外， 在 检测的时候只需要一步就可以进行； 这样简单， 方便。
在一个优选的方式中，为了避免在收集样本的时候避免接收的样本进入检测 腔造成对测试元件的污染或被溅入到测试元件上提前进行检测，在通孔的外边可 以包括一个遮挡元件 21，遮挡元件 21可以位于检测腔上，这样形成一个保护罩。 遮挡元件 21可以为锥形、 帽形， 舌形。 另外， 当倒置检测装置后， 遮挡元件可 以起到汇集流体样本的作用。 当然， 连接检测腔 70与收集腔 54的通孔 80可以 是一个或多个， 同孔的形状可以任何形状。 有理由认为， 当连通收集腔 54与检 测腔 70的通孔 80为多个的时候， 每个通孔处可以设置一个遮挡结构 21， 或者 几个通孔被设置在一个遮挡结构下。 另外， 测试元件可以为一个， 也可以是分别 针对不同被分析物质的多个测试元件，这些测试元件可以被放置在测试板 30上， 测试板位于检测腔中。 当然， 遮挡元件 21可以直接位于检测腔的壁上。
在一个优选的方式中，收集腔的侧壁对应测试元件检测区的位置可以为透明 的， 这样可以从外面观察检测腔内测试元件上的测试结果。更优选的， 对应测试 元件的收集腔侧壁为平面结构而不是普通的圆弧形状，这样可以便于在测试完成 后用扫描机器扫描测试元件上的测试结果。当然， 整个围成收集腔的侧壁为透明 材料， 例如为透明塑料。
另外， 在靠近检测腔的外侧还可以包括一个缓冲腔 60， 缓冲腔 60紧靠检测 腔 70， 在缓冲腔上还包括一个连接缓冲腔与检测腔 54的通孔 90， 构成缓冲腔 60的壁 62面对收集腔 54。 这样， 检测腔 70就间接通过缓冲腔 60与收集腔 54 相连通。 同样的， 缓冲腔 60可以只通过通孔 90与收集腔 54流体连通。优选的， 通孔 90最好位于靠近开口 51的附近，例如位于靠近测试元件样本施加区域附近， 通孔 90的位置与通孔 80的位置同样具有多样的选择， 当然， 它最好也是位于收 集腔设置的最大收集流体样本的的上方。 当然， 通孔 90的位置高度设置好后， 相对于连通缓冲腔和测试腔的通孔 80 的位置设置可以自由很多。 在检测腔 70 外增加一个缓冲腔 60的主要作用为： 如果没有缓冲腔体， 当收集腔收集好液体 后， 由于经常性的需要把盛有流体样本的收集腔 54短距离 （例如从厕所到化验 室）运输到化验处， 运输过程中流体样本可能会被震动， 所以波动的流体可能会 直接进入检测腔上的通孔 80， 从而污染检测腔或检测腔里的测试元件。 为了解 决此问题， 当设置一个缓冲腔的时候， 波动的流体则先进入缓冲腔 60内， 由于 波动的流体量比较小， 所以如果有波动的流体， 则它们汇集在缓冲腔底 68处。 由于连接缓冲腔和检测腔的通孔 80位于靠近开口 51的地方，就不会因为少量的 流体溢出而污染检测腔或测试元件。
另外，由于在操作的时候需要倒置整个检测装置，有时候并不是规则的倒置。 因为测试装置整体为圆柱形，倒置的方式是随意的， 盖体上的任意位置可作为支 点进行倒置，图 6显示在进行操作时导致的一个方式， 本方式中 C点作为倒置的 支点。 在一方面， 在进行倒置的过程中， 流体样本可能先通过缓冲腔上的通孔 90进入到缓冲腔中 （当缓冲腔上的通孔 90位于下方并作为倒置的支点 B 的时 候）， 但是进入到缓冲腔的流体不会进入检测腔腔中。 相反， 图 3所示的收集腔 的情况下， 如果在靠进通孔 80的地方作为支点 A进行倒置， 由于缓冲腔没有液 体进入就比较安全些。
优选的， 在缓冲腔的通孔 90上也包括遮挡元件 21， 当然可以理解， 在这样 的设置中， 检测腔 70上的通孔 80上就没有必要再设置遮挡元件 21。 当然， 在 缓冲腔的通孔 90上也可以不设置遮挡元件 21。 因为缓冲腔的作用， 没有遮挡元 件的情况下也不太会对检测腔里的测试元件造成影响。
在一些优选的方式中，为了更加方便的制作本发明的装置以及组装该发明的 装置， 本发明还提供一个生产该测试装置的方法。该方法包括如下步骤： 提供如 图 3B所示的收集腔， 在收集腔内隔离出检测腔 70或者带有缓冲腔 60的检测腔 70。 检测腔的底 68和缓冲腔的底 78与收集腔共用一个底 （如图 4所示）。 而在 靠近开口 51的地方， 检测腔 70和缓冲腔 60为长方形的开口， 同时检测腔与缓 冲腔由侧壁 64， 63， 62和收集腔的部分侧壁 50围城。在缓冲腔的壁上开一缺口 91，在检测腔与缓冲腔公用的壁 63上开一个缺口 80。这两个缺口被密封盖体 20 密封后分别形成检测腔上的通孔 80和缓冲腔上的通孔 90; 在图 3B中， 他们位 于测试板的两侧或者位于缓冲腔的对立两侧。 然后在把组装好的带有测试元件 40的测试板 30插入到检测腔中， 让测试元件的样本施加区域位于靠近缺口 81 的附近。 图 3B所显示的部分装置可以一次性注塑成型或多次成型后进行密封组 装。 另外提供一个密封体 20， 他的形状和检测腔或者与带有缓冲腔的检测腔类 似， 可以密封在检测腔上开口的地方或者同时密封检测腔和缓冲腔。 密封体 30 也可以为塑料材料，通过焊接的形式密封检测腔和缓冲腔开口，就形成了两个独 立的腔体： 检测腔 70和缓冲腔 60， 两个腔通过在缺口 801和 91地地方形成的 两个通孔 80和 90连通（图 2， 4)。 具体的讲， 如图 3A， 密封体包括两个平面区 域 24和 25分别对应缓冲腔和检测腔的开口， 两平面区域与侧壁 62， 63， 64接 触并焊接连接， 焊接面 85， 86， 88密封检测腔和缓冲腔。 当然更好的方式中， 密封体可以包括一个与通孔 91对应的遮挡元件 21， 密封体与遮挡元件 21可以 一次性成型。
这样的装置在使用过程中， 首先用收集腔来接收流体样本，最好是收集的流 体样本的高度不要超过缓冲腔 60上的通孔 90的地方。当然， 如果不注意稍微多 收集了流体样本， 例如尿液， 多余的流体样本也会通过通孔 90流入到缓冲腔 60 中， 又由于检测腔上的通孔 80位于靠近开口 51的地方， 也就是远离腔底 52的 地方， 进入缓冲腔 60里的液体也不会进入检测腔 70中。 收集好后， 传输或送到 实验室进行化验， 化验者把盖子 10盖合到开口 51上 （图 4， 2)， 然后倒置检测 装置， 这个时候流体样本通过连通缓冲腔 60和收集腔 54的通孔 90以及连通缓 冲腔 60与检测腔 70的通孔 80进入检测腔 70中与测试元件的样本施加区域 41 接触， 进入施加区域的样本依次通过检测区域 42和样本吸收区域 43 (如果有的 话）； 最终完成测试， 整个流程如图 6所示。

Claims

权 利 要 求 书
样本收集腔， 包括用于收集流体样本的开口， 腔底， 以及连接开口和腔底 的侧壁；
检测腔，包括至少一个测试元件； 该测试元件包括样本施加区域和测试区 域； 其中样本施加区域靠近所述的收集腔开口；
其中，检测腔在靠近样本收集腔开口的地方还包括一通孔，样本施加区域 通过该通孔与样本收集腔流体连通。
2. 如权利要求 1所述的装置， 当该检测装置被倒置后， 收集腔内的流体通过 该通孔流入到检测腔内与测试元件的样本施加区域接触。
3. 如权利要求 1所述的检测装置，其特征在于，所述检测腔位于样本收集腔 内。
4. 如权利要求 1所述的样本检测装置， 所述的测试元件被设置在测试板上， 测 试板位于检测腔中。
5. 如权利要求 1所述的样本检测装置， 所述的检测腔上的通孔处还包括一遮挡 结构。
6. 如权利要求 1或 3所述的样本检测装置，其特征在于，该装置还包括缓冲腔， 收集腔通过缓冲腔与检测腔连通。
7. 如权利要求 6所述的检测装置， 其特征在于， 缓冲腔位于收集腔内， 并与检 测腔一起位于收集腔的同侧。
8. 如权利要求 7所述的检测装置，其特征在于， 缓冲腔在靠近收集腔开口的 地方包括一通孔， 缓冲腔上的通孔与检测腔上的通孔流体连通。
9. 如权利要求 8所述的检测装置，其特征在于，在缓冲腔的通孔外包括一个 保护罩，该保护罩可以避免收集腔在接收流体样本的时候流体样本通过缓 冲腔的的通孔进入检测腔并接触测试元件的样本施加区域。
10.如权利要求 6所述的检测装置，其中， 收集腔内的流体样本先经过缓冲腔 的通孔进入缓冲腔，然后再通过检测腔上的通孔进入检测腔中与测试元件 接触。
11.一种检测装置， 该装置包括：
用于收集流体样本的收集腔， 收集腔包括开口， 腔底， 以及连接开口和腔底 权 利 要 求 书 的侧壁；
检测腔， 检测腔中包括至少一个测试元件， 测试元件包括样本施加区域和测 试区域；
盖合收集腔开口的盖体；
其中， 装置在靠近开口的附近还包括一个能够让收集腔里的液体进入测试元 件的样本施加区域的通孔， 其中样本施加区域位于通孔的附近。
12.根据权利要求 11所述的检测装置，其中测试装置还包括一个保护罩， 当收集 流体样本的时候， 保护罩可以避免流体样本直接通过检测腔上的通孔与测试 元件接触或者与测试元件的样本施加区域接触。
13.根据权利要求 11所述的检测装置，其中检测装置还包括一个缓冲腔， 同时缓 冲腔位于检测腔与收集腔之间， 缓冲腔上包括一个与收集腔连通的通孔。
14.根据权利要求 13所述的检测装置，其中测试元件位于测试板上， 缓冲腔的通 孔和检测腔的通孔位于测试板的两侧。
15.一种检测样本的方法， 该方法包括：
提供一个检测装置， 该装置包括样： 流体样本收集腔， 包括用于收集流体样 本的开口， 腔底， 以及连接开口和腔底的侧壁； 检测腔， 包括至少一个测试 元件； 该测试元件包括样本施加区域和测试区域； 其中样本施加区域靠近所 述的收集腔开口； 其中， 检测腔在靠近样本收集腔开口的地方还包括一通孔， 样本施加区域通过该通孔与样本收集腔流体连通；
通过收集腔的开口收集流体样本；
盖合盖体到开口上密封收集腔；
倒转检测装置让收集腔和测试间倒立；
读取测试元件测试区上的测试结果。
PCT/CN2012/071858 2011-03-15 2012-03-02 检测装置 WO2012122899A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2011100641933A CN102680276A (zh) 2011-03-15 2011-03-15 检测装置
CN201110064193.3 2011-03-15

Publications (1)

Publication Number Publication Date
WO2012122899A1 true WO2012122899A1 (zh) 2012-09-20

Family

ID=46812540

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2012/071858 WO2012122899A1 (zh) 2011-03-15 2012-03-02 检测装置

Country Status (2)

Country Link
CN (1) CN102680276A (zh)
WO (1) WO2012122899A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2991766B1 (en) * 2013-04-30 2018-01-17 Microtri Limited Bodily fluid specimen collection and assay device
CN105842434B (zh) * 2016-03-16 2018-08-07 杭州安旭科技有限公司 一种样本收集检测装置
CN109154554A (zh) * 2016-05-27 2019-01-04 卓金星 微生物检测系统
CN107782883A (zh) * 2016-08-26 2018-03-09 艾博生物医药(杭州)有限公司 一种流体样本的收集检测装置
GB2580132B (en) * 2018-12-21 2021-06-30 Waterscope Ltd Cartridge for the analysis of liquids

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4976923A (en) * 1989-05-12 1990-12-11 Rhode Island Hospital Sample container
US5429804A (en) * 1994-07-15 1995-07-04 Sayles; Philip W. One-step testing device
CN101017169A (zh) * 2006-07-26 2007-08-15 艾博生物医药(杭州)有限公司 生物样本分析装置
CN101074930A (zh) * 2006-01-06 2007-11-21 保罗·欣顿 独立式试样收集和测试装置
CN201210157Y (zh) * 2008-05-30 2009-03-18 杭州中肽生化有限公司 一种尿液检测装置
US20100266449A1 (en) * 2009-04-16 2010-10-21 John Wu Invertable assaying device with fluid level adjusting cover
CN101876661A (zh) * 2009-05-08 2010-11-03 艾博生物医药(杭州)有限公司 分析液体样本中被分析物的装置
CN202141727U (zh) * 2011-03-15 2012-02-08 艾博生物医药(杭州)有限公司 检测装置

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN201417273Y (zh) * 2009-03-18 2010-03-03 艾博生物医药(杭州)有限公司 诊断检测装置

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4976923A (en) * 1989-05-12 1990-12-11 Rhode Island Hospital Sample container
US5429804A (en) * 1994-07-15 1995-07-04 Sayles; Philip W. One-step testing device
CN101074930A (zh) * 2006-01-06 2007-11-21 保罗·欣顿 独立式试样收集和测试装置
CN101017169A (zh) * 2006-07-26 2007-08-15 艾博生物医药(杭州)有限公司 生物样本分析装置
CN201210157Y (zh) * 2008-05-30 2009-03-18 杭州中肽生化有限公司 一种尿液检测装置
US20100266449A1 (en) * 2009-04-16 2010-10-21 John Wu Invertable assaying device with fluid level adjusting cover
CN101876661A (zh) * 2009-05-08 2010-11-03 艾博生物医药(杭州)有限公司 分析液体样本中被分析物的装置
CN202141727U (zh) * 2011-03-15 2012-02-08 艾博生物医药(杭州)有限公司 检测装置

Also Published As

Publication number Publication date
CN102680276A (zh) 2012-09-19

Similar Documents

Publication Publication Date Title
US7758815B2 (en) Specimen collection, storage, transportation and assaying device
US6576193B1 (en) Device and method for collecting and testing fluid specimens
AU2004291923B2 (en) Sample collection cup with integrated activatable sample analysis system
US6406922B2 (en) Device for the testing of body fluid samples
TWI550274B (zh) 微流體檢驗裝置及其運作方法
WO2012122899A1 (zh) 检测装置
US7507373B2 (en) Assay device for the testing of fluid samples
US20070259442A1 (en) Assay device and process for the testing of fluid samples
JP2007511768A (ja) 封止可能なサンプル保存リザーバを備える流体サンプル分析装置
EP1028806A1 (en) Device and methods for single step collection and assaying of biological fluids
CN106662573B (zh) 用于确定尿液中的分析物和/或化学－物理参数、以及确定尿液中尿沉淀的容器；以及使用该容器进行全尿分析的方法
US20050019222A1 (en) Device and method for preparing particles for analysis
WO2008156491A2 (en) Devices and methods for analysis of samples with depletion of analyte content
CN202141727U (zh) 检测装置
WO2020260250A1 (en) Lateral flow immunoassay device
CA2063986A1 (en) Method and apparatus for rapid immunoassays
JP6190472B2 (ja) 新規のＰｏＣ検査システムおよび方法
US11878297B2 (en) Fluid specimen testing
JP7064069B2 (ja) マイクロサンプリングチップ
ES2962697T3 (es) Dispositivo de examen de muestras de heces y procedimiento de examen de muestras de heces
JP2009097864A (ja) 血液検査用マイクロチップおよびその使用方法
CA3225688A1 (en) Device for assay system, system and method
WO2020140185A1 (en) Assay device
EP4090960A1 (en) Solid state ion selective electrodes
KR20220160929A (ko) 재활용 방지형 체액분석용 키트

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12757951

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 12757951

Country of ref document: EP

Kind code of ref document: A1